期刊
TRENDS IN BIOTECHNOLOGY
卷 32, 期 9, 页码 448-455出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2014.06.010
关键词
swarming; cooperation; nanoparticles; systems nanotechnology; cancer
资金
- Human Frontier Science Program
- National Institutes of Health (NIH) [U54CA151884]
- MIT-Harvard Center of Cancer Nanoteclmology Excellence
- Koch Institute Support (core) from National Cancer Institute [P30-CA14051]
Nanoparticles are designed to deliver therapeutics and diagnostics selectively to tumors. Their size, shape, charge, material, coating, and cargo determine their individual functionalities. A systems approach could help predict the behavior of trillions of nanoparticles interacting in complex tumor environments. Engineering these nanosystems may lead to biomimetic strategies where interactions between nanoparticles and their environment give rise to cooperative behaviors typically seen in natural self-organized systems. Examples include nanoparticles that communicate the location of a tumor to amplify tumor homing or self-assemble and disassemble to optimize nanoparticle transport. The challenge is to discover which nanoparticle designs lead to a desired system behavior. To this end, novel nanomaterials, deep understanding of biology, and computational tools are emerging as the next frontier.
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