期刊
TRENDS IN BIOTECHNOLOGY
卷 31, 期 10, 页码 581-593出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2013.06.006
关键词
glycosyl hydrolase; heterologous expression; synthetic biology; consolidated bioprocessing; cellulolytic activity; cellulosome; biomass; industrial processing
资金
- BMBF Forschungsinitiative 'BioEnergie-Forschung fur die Nutzung von Biomasse'
- Cluster of Excellence 'Tailor-made Fuels from Biomass'
- German federal government
- German state government
Improvement of cellulase expression has the potential to change the nature of the biofuel industry. Increasing the economic feasibility of cellulase systems would significantly broaden the range of practicable biomass conversion, lowering the environmental impact of our civilisations' fuel needs. Cellulases are derived from certain fungi and bacteria, which are often difficult to culture on an industrial scale. Accordingly, methods to recombinantly express important cellulases and other glycosyl hydrolase (GH) enzymes are under serious investigation. Herein, we examine the latest developments in bacterial, yeast, plant, and fungal expression systems. We discuss current strategies for producing cellulases, and evaluate the benefits and drawbacks in yield, stability, and activity of enzymes from each system, and the overall progress in the field.
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