期刊
TRENDS IN BIOTECHNOLOGY
卷 30, 期 11, 页码 601-607出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2012.08.002
关键词
essential gene; synthetic biology; antimicrobial target; minimal genome
资金
- European Union 7th Framework Program, project NABATIVI
- DOE
- NSF
- DARPA
- NIH
- Wyss Institute
Essential genes are absolutely required for the survival of any living entity. Investigation of essential genes is therefore expected to advance tremendously our understanding of the universal principles of life. Determination of a minimal set of essential genes needed to sustain life also plays an important role in the emerging field of synthetic biology, whose goals include creation of a stringently controlled minimal cell with predesigned phenotypic traits. In addition, due to their indispensability for survival of bacteria, genes encoding essential cellular functions have great potential in medicine as promising targets for the development of novel antimicrobials. Here, we review recent advances in the investigation of essential genes, with emphasis on the practical applications in medicine and synthetic biology.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据