期刊
TRENDS IN BIOTECHNOLOGY
卷 30, 期 6, 页码 342-349出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2012.03.006
关键词
synthetic biology; distributed computation; molecular circuit
资金
- Ministerio de Ciencia y Innovacion [BIO2009-07762, FIS2009-12365]
- James McDonnell Foundation
- CELLCOMPUT
- Santa Fe Institute
- Fundacion Marcelino Botin (FMB)
- ICREA Funding Source: Custom
Synthetic biology (SB) offers a unique opportunity for designing complex molecular circuits able to perform predefined functions. But the goal of achieving a flexible toolbox of reusable molecular components has been shown to be limited due to circuit unpredictability, incompatible parts or random fluctuations. Many of these problems arise from the challenges posed by engineering the molecular circuitry: multiple wires are usually difficult to implement reliably within one cell and the resulting systems cannot be reused in other modules. These problems are solved by means of a nonstandard approach to single cell devices, using cell consortia and allowing the output signal to be distributed among different cell types, which can be combined in multiple, reusable and scalable ways.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据