期刊
TRENDS IN BIOTECHNOLOGY
卷 26, 期 6, 页码 285-287出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibtech.2008.03.005
关键词
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The generation of genomic data from mammoths and Neanderthals has reinvigorated discussion about whether extinct species could be brought back within the foreseeable future. However, post-mortem DNA decay rapidly reduces the number and quality of surviving DNA fragments, consequently increasing rates of sequencing error and forming a significant obstacle to accurate sequence reconstruction. Recent work has shown that it is possible to engineer a polymerase capable of using even highly damaged fragments as template sequences.
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