期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 38, 期 7, 页码 364-371出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2013.04.006
关键词
helix-turn-helix; RNA; Z-DNA; RecQ; protein-DNA interaction; helicase
资金
- Human Frontier Science Program [RGY0072/2010]
- 'Momentum' Program of the Hungarian Academy of Sciences [LP2011-006/2011]
The winged helix domain (WHD) is a widespread nucleic-acid-binding protein structural element found in all kingdoms of life. Although the overall structure of the WHD is conserved, its functional properties and interaction profiles are extremely versatile. WHD-containing proteins can exploit nearly the full spectrum of nucleic acid structural features for recognition and even covalent modification or noncovalent rearrangement of target molecules. WHD functions range from sequence-recognizing keys in transcription factors and bulldozer-like strand-separating wedges in helicases to mediators of protein-protein interactions (PPIs). Further investigations are needed to understand the contribution of WHD structural dynamics to nucleic-acid-modifying enzymatic functions.
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