期刊
TRENDS IN BIOCHEMICAL SCIENCES
卷 35, 期 5, 页码 288-297出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tibs.2009.12.007
关键词
-
资金
- Canadian Institutes of Health Research (CIHR) [MOP-84523]
- Michael Smith Foundation for Health Research (MSFHR)
- Natural Sciences and Engineering Research Council of Canada
- Human Frontier Science Program (HFSP)
- Terry Fox Foundation [700044]
Actins and tubulins are abundant cytoskeletal proteins that support diverse cellular processes. Owing to the unique properties of these filament-forming proteins, an intricate cellular machinery consisting minimally of the chaperonin CCT, prefoldin, phosducin-like proteins, and tubulin cofactors has evolved to facilitate their biogenesis. More recent evidence also suggests that regulated degradation pathways exist for actin (via TRIM32) and tubulin (via parkin or cofactor E-like). Collectively, these pathways maintain the quality control of cytoskeletal proteins ('proteostasis'), ensuring the appropriate function of microfilaments and microtubules. Here, we focus on the molecular mechanisms of the quality control of actin and tubulin, and discuss emerging links between cytoskeletal proteostasis and human diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据