Review
Biochemistry & Molecular Biology
Martina Montanari, Giuseppina Martella, Paola Bonsi, Maria Meringolo
Summary: Disturbances in the glutamatergic system have been observed in autism spectrum disorder (ASD). This review summarizes evidence from patient samples, postmortem studies, and animal models to explore the role of glutamate in the pathophysiology of ASD and its potential as a therapeutic target.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Yuchen Hao, Estelle Toulme, Benjamin Koenig, Christian Rosenmund, Andrew J. R. Plested
Summary: Optical report of neurotransmitter release allows visualization of excitatory synaptic transmission. However, without targeting to synapses, the specificity of the fluorescent signal is uncertain. To address this, the reporter iGluSnFR was fused to glutamate receptor auxiliary proteins to target it to postsynaptic sites. This improved the properties of iGluSnFR and demonstrated the importance of subcellular targeting for optogenetic actuators and reporters.
Review
Neurosciences
Piotr Kaczmarski, Marcin Sochal, Dominik Strzelecki, Piotr Bialasiewicz, Agata Gabryelska
Summary: Glutamate and GABA are important neurotransmitters that play a crucial role in maintaining the brain's physiological functions. Disturbances in their balance can lead to various health problems, including neurodegeneration, affective disorders, and sleep disorders. The disruptions in glutamate and GABA function are also implicated in obstructive sleep apnea (OSA) and its comorbidities. Pharmacotherapy targeting GABA and glutamate may have an impact on the course of OSA, highlighting the potential of these neurotransmitters as therapeutic targets.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Neurosciences
Laura Wade-Bohleber, Niklaus Zolch, Mick Lehmann, Jutta Ernst, Andre Richter, Erich Seifritz, Heinz Boeker, Simone Grimm
Summary: This study investigated the neurobiological changes associated with psychodynamic psychotherapy in patients with major depressive disorder. The results showed that the levels of glutamine in the pregenual anterior cingulate cortex were related to the severity of symptoms before treatment. However, after 6 months of psychotherapy, the correlation between glutamine levels and symptom severity reversed.
NEUROPSYCHOBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Paolo Belardinelli, Franca Konig, Chen Liang, Isabella Premoli, Debora Desideri, Florian Mueller-Dahlhaus, Pedro Caldana Gordon, Carl Zipser, Christoph Zrenner, Ulf Ziemann
Summary: The effects of different anti-glutamatergic drugs on TMS-evoked EEG potentials and oscillations varied, with dextromethorphan increasing N45 TEP amplitude, perampanel reducing P60 TEP amplitude while increasing TIOs, and nimodipine showing no effects. The study demonstrates the importance of different neurotransmitter systems in regulating brain activity and highlights potential implications for neuropsychiatric disorders.
SCIENTIFIC REPORTS
(2021)
Review
Cell Biology
Pratik Chakraborty, Abhijit Dey, Abilash Valsala Gopalakrishnan, Kumari Swati, Shreesh Ojha, Anand Prakash, Dhruv Kumar, Rashmi K. Ambasta, Niraj Kumar Jha, Saurabh Kumar Jha, Saikat Dewanjee
Summary: In the mammalian brain, glutamate acts as the primary excitatory neurotransmitter and plays important roles in various brain functions. A complex glutamatergic network consisting of receptors, neurotransmitters, and other components regulates excitatory neurotransmission and synaptic plasticity. Dysfunctional glutamate receptors and components can lead to cognitive impairments and damage to neurons. Controlling glutamatergic transmission and modifying glutamate receptor function may be a potential therapeutic strategy for cognitive disorders.
AGEING RESEARCH REVIEWS
(2023)
Article
Neurosciences
Bing Zhang, Xili Yang, Luyu Ye, Rui Liu, Binglu Ye, Weijia Du, Fuyi Shen, Qian Li, Fan Guo, Jinqi Liu, Fei Guo, Yang Li, Zhendong Xu, Zhiqiang Liu
Summary: Ketamine demonstrates rapid antidepressant effects at subanaesthetic doses, but the understanding of its mechanism is still limited. By increasing the excitability of the mPFC, ketamine exerts its antidepressant effects, with a critical role played by the GABAergic system in the mPFC.
Article
Multidisciplinary Sciences
Jung-Hwan Choi, Lauren Bayer Horowitz, Niels Ringstad
Summary: The study reveals that in a C. elegans chemosensory circuit, regulation of neurotransmitter packaging via the antagonistic interaction between VGLUT and VST-1 influences synaptic glutamate signaling strength and neurotransmitter release, which in turn affects chemotaxis behavior.
NATURE COMMUNICATIONS
(2021)
Article
Neurosciences
Ashwin Kumaria, Keyoumars Ashkan
Summary: Despite aggressive surgical and adjuvant approaches, high grade gliomas have a poor prognosis. Recent studies have shown a linkage between neuronal electrical activity and glioma growth involving the PI3K-mTOR pathway. In particular, glutamate signalling has been found to promote glioma invasion and growth, suggesting that targeting glutamatergic signalling may be a potential treatment option in glioma.
Article
Clinical Neurology
Fernanda Ribeiro Marins, Marcelo Limborco-Filho, Jennifer A. Iddings, Carlos Henrique Xavier, Vinicia C. Biancardi, Javier E. Stern, Juan Ramiro Diaz, Stephen M. Oppenheimer, Jessica A. Filosa, Marco Antonio Peliky Fontes
Summary: The study highlights the role of a glutamatergic relay in the dorsomedial hypothalamic region (DMH) in mediating cardiovascular and autonomic responses activated by the posterior insular cortex (iIC). The findings suggest that the excitatory glutamatergic pathway from iIC to DMH plays a significant role in cardiovascular alterations observed after insular stroke.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Neurosciences
Sergi Ferre, Laura I. Sarasola, Cesar Quiroz, Francisco Ciruela
Summary: Adenosine plays a significant role in modulating striatal neurotransmission, which is mediated by A1 and A2A receptors. The modulation involves different components of the striatal microcircuit and the formation of heteromers. These heteromers have unique properties and provide fine-tune modulation of striatal glutamate release. Targeting these adenosine receptor heteromers may be important for drug development in neuropsychiatric disorders.
Review
Plant Sciences
Angeles Aroca, Inmaculada Garcia-Diaz, Margarita Garcia-Calderon, Cecilia Gotor, Antonio J. Marquez, Marco Betti
Summary: Photorespiration plays a fundamental role in plant metabolism and its regulation, including transcriptional and post-translational regulation, has been a topic of interest. The interconnections between photorespiration and nitrogen and sulfur metabolism have also been explored. Recent findings on sulfide signaling and protein persulfidation are discussed.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Clinical Neurology
J. Titulaer, O. Radhe, K. Danielsson, S. Dutheil, M. M. Marcus, K. Jardemark, T. H. Svensson, G. L. Snyder, M. Ericson, R. E. Davis, A. Konradsson-Geuken
Summary: Lumateperone is a novel drug approved for the treatment of schizophrenia and depressive episodes associated with bipolar depression. It simultaneously modulates key neurotransmitters and improves symptoms while enhancing prosocial behavior. The drug affects dopamine and glutamate signaling, potentially contributing to its effectiveness in improving mood-related symptoms.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2022)
Article
Horticulture
Dharmendra Prajapati, Anil Patani, Margi Patel, Daoud Ali, Saud Alarifi, Virendra Kumar Yadav, Jigna Tank, Ashish Patel
Summary: This study investigated the effects of atmospheric hydrogen sulfide deposition on soil sulfur nutrition in Brassica pekinensis plants. The research revealed the regulatory mechanisms involved in sulfate uptake and assimilation by studying gene expression levels of sulfate transporter genes and physiological changes. It was found that sulfur deficiency increased nitrate and amino acid concentrations in the plant, while decreasing biomass, chlorophyll content, and thiol content. However, this also increased the plants' capacity to take up sulfur from the atmosphere through foliar absorption. The expression levels of sulfate transporter genes were influenced by sulfur availability in the atmosphere, but not by excess sulfur levels up to 0.3μL l(-1).
Article
Agricultural Engineering
Kaiquan Wang, Mahmood Qaisar, Bilong Chen, Jinghong Xiao, Jing Cai
Summary: The study found that adjusting the hydraulic retention time appropriately can increase the production of sulfide (S-0) and improve the simultaneous removal of sulfide and nitrite. Under different HRT conditions, bacterial community richness and key gene expression will change, affecting the performance of the recirculation system.
BIORESOURCE TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Victor Vitvitsky, Pramod K. Yadav, Angelika Kurthen, Ruma Banerjee
JOURNAL OF BIOLOGICAL CHEMISTRY
(2015)
Article
Chemistry, Multidisciplinary
Pramod K. Yadav, Michael Martinov, Victor Vitvitsky, Javier Seravalli, Rudolf Wedmann, Milos R. Filipovic, Ruma Banerjee
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Chemistry, Multidisciplinary
Trever Bostelaar, Victor Vitvitsky, Jacques Kumutirna, Brianne E. Lewis, Pramod K. Yadav, Thomas C. Brunold, Milos Filipovic, Nicolai Lehnert, Timothy L. Stemmler, Ruma Banerjee
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2016)
Article
Biochemistry & Molecular Biology
Victor Vitvitsky, Pramod K. Yadav, Sojin An, Javier Seravalli, Uhn-Soo Cho, Ruma Banerjee
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Chemistry, Medicinal
Julie Trexel, Gi S. Yoon, Rahul K. Keswani, Cora McHugh, Larisa Yeomans, Victor Vitvitsky, Ruma Banerjee, Sudha Sud, Yihan Sun, Gus R. Rosania, Kathleen A. Stringer
JOURNAL OF PHARMACEUTICAL SCIENCES
(2017)
Article
Biochemistry & Molecular Biology
Victor Vitvitsky, Jan Lj Miljkovic, Trever Bostelaar, Bikash Adhikari, Pramod K. Yadav, Andrea K. Steiger, Roberta Torregrossa, Michael D. Pluth, Matthew Whiteman, Ruma Banerjee, Milos R. Filipovic
ACS CHEMICAL BIOLOGY
(2018)
Article
Biochemistry & Molecular Biology
Marouane Libiad, Pramod Kumar Yadav, Victor Vitvitsky, Michael Martinov, Ruma Banerjee
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Marouane Libiad, Victor Vitvitsky, Trever Bostelaar, Daniel W. Bak, Ho-Joon Lee, Naoya Sakamoto, Eric Fearon, Costas A. Lyssiotis, Eranthie Weerapana, Ruma Banerjee
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Pramod K. Yadav, Victor Vitvitsky, Hanseong Kim, Andrew White, Uhn-Soo Cho, Ruma Banerjee
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
Article
Multidisciplinary Sciences
Aleksandr V. Zaitsev, Michael V. Martinov, Victor M. Vitvitsky, Fazoil I. Ataullakhanov
SCIENTIFIC REPORTS
(2019)
Article
Biochemistry & Molecular Biology
Pramod Kumar Yadav, Victor Vitvitsky, Sebastian Carballal, Javier Seravalli, Ruma Banerjee
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Biochemistry & Molecular Biology
Victor Vitvitsky, Roshan Kumar, Marouane Libiad, Allison Maebius, Aaron P. Landry, Ruma Banerjee
Summary: The exogenously added hydrogen sulfide had a half-life of 3 to 4 minutes in human colonic epithelial cells, with a small fraction trapped as sulfane sulfur species. Sulfide stimulated aerobic glycolysis in cells, was sensitive to the mitochondrial NADH pool, and decreased ATP levels.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Sebastian Carballal, Victor Vitvitsky, Roshan Kumar, David A. Hanna, Marouane Libiad, Aditi Gupta, Jace W. Jones, Ruma Banerjee
Summary: This study demonstrates that H2S increases lipid synthesis in cells by affecting mitochondrial NAD(P)H pools and enabling reductive carboxylation of alpha-ketoglutarate. H2S also leads to time-dependent changes in various lipid classes, upregulating triglycerides while downregulating phosphatidylcholine.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Meeting Abstract
Biochemistry & Molecular Biology
Victor Vitvitsky, Marouane Libiad, Trever Bostelaar, Allison Maebius, Ho-Joon Lee, Costas A. Lyssiotis, Ruma Banerjee
Meeting Abstract
Biochemistry & Molecular Biology
Pramod Kumar Yadav, Michael Martinov, Victor Vitvitsky, Javier Seravalli, Rudolf Wedmann, Milos R. Filipovic, Ruma Banerjee