Article
Biochemistry & Molecular Biology
Kuan-Tseng Lee, Chen-Yeon Chu, Shen-Shih Chiang
Summary: The study revealed that LCP fruit powder has anti-dementia effects on A beta-induced Alzheimer's mice, improving learning and memory abilities while reducing oxidative stress, brain atrophy, and A beta plaque deposition.
Article
Chemistry, Applied
Guo-Dong Shen, Yin-Yan Zhang, Nian-Qi Yang, Tong Yang, Ting Wang, Shi-Cheng Lu, Jin-Yun Wang, Yun-Song Wang, Jing-Hua Yang
Summary: Six amides, including a new N-alkylamide (1), four known N-alkylamides (2-5), and one nicotinamide (6) were isolated from Litsea cubeba (Lour.) Pers., a pioneer herb in traditional medicine. The structure of the compounds was determined through NMR experiments and comparison with literature data. Cubebamide (1), a new cinnamoyltyraminealkylamide, exhibited significant anti-inflammatory activity against NO production with an IC50 value of 18.45 μM. In-depth virtual screening and molecular docking revealed the binding mode of the active compound inside the 5-LOX enzyme. This research suggests that L. cubeba and the isolated amides have potential for developing lead compounds in the prevention of inflammatory diseases.
NATURAL PRODUCT RESEARCH
(2023)
Article
Agricultural Engineering
Ziwei Pan, Shengnan Liu, Yi Cun Chen, Yang Dong Wang, Qing Gu, Dafeng Song
Summary: The essential oil of Litsea cubeba has repellent and lethal effects on Drosophila, primarily through neurotoxicity caused by altered enzyme activities and disruption of homeostasis by aldehyde oxidation reactions. It has broad potential applications in fruit pest control.
INDUSTRIAL CROPS AND PRODUCTS
(2022)
Article
Food Science & Technology
Ying Li, Xiaoci Zhuang, Xinrui Wu, Chaoying Qiu, Yong Wang
Summary: This study systematically investigated the valorization pathway of biowastes generated from Litsea cubeba essential oil processing. Ultrasound-assisted extraction significantly improved the extraction rate, and a combination of alkali deacidification and activated clay achieved the best results for treating L. cubeba kernel oils.
Article
Biochemistry & Molecular Biology
Yufei Qiu, Yong Wang, Ying Li
Summary: This study investigated the influence of solvent-free microwave extraction (SFME) and hydrodistillation (HD) techniques on the extraction of Litsea cubeba fruit essential oils. It was found that the SFME method significantly improved the oil yield, especially for fruits harvested in July. Furthermore, the SFME method selectively extracted certain monoterpene hydrocarbons and showed better potential for skin whitening.
Article
Chemistry, Applied
Ruijie Ni, Peng Wang, Ping Zhan, Honglei Tian, Ting Li
Summary: The study investigated the effects of different frying temperatures on the aroma of fried mountain pepper oil (FPO) using various analytical methods. Results showed significant differences in aroma among four FPO samples, with FPO3 demonstrating superiority in sensory attributes. A total of 16 and 20 aroma-active compounds were identified using DFA and OAV, respectively, and aroma recombination models suggested a combination of OAV and DFA closely resembled the FPO aroma. Omission tests confirmed the significant contributions of 11 compounds to the characteristic aroma of FPO.
Review
Plant Sciences
Yuqi Zhang, Zhenze Pan, Kaiwen Wu, Ganming Yan, Huiyou Xu, Qianfeng Gong, Lin Ni
Summary: Litsea cubeba, a member of the Lauraceae family, is a deciduous shrub with various medicinal properties. Its fruits, leaves, roots, and bark are utilized for treating conditions such as spleen-stomach deficiency, dysphagia, and unidentified tumors. The chemical composition of Litsea cubeba includes alkaloids, flavonoids, lignans, terpenes, and their glycosides, with aporphine alkaloids being the most prominent. Recent studies have highlighted the wide range of pharmacological activities exhibited by Litsea cubeba, such as antitumor, antioxidant, antimicrobial, anti-inflammatory, and hypoglycemic effects. This article provides a comprehensive summary of the chemical composition and pharmacological activities of Litsea cubeba, as well as an exploration of their mechanisms of action, serving as a valuable reference for the development and utilization of Litsea cubeba chemical components.
RECORDS OF NATURAL PRODUCTS
(2023)
Article
Chemistry, Applied
Xin-Yi Wang, Bi-Tao Li, Zheng-Qi Wen
Summary: The chemical composition of essential oil from the fruits and leaves of wild Litsea cubeba in Baoshan region, Yunnan Province of China was analyzed for the first time. The major components in the fruit oil were neral, geranial, and citronella, while the leaf oil contained linalool, limonene, beta-bisabolene, neral, and caryophyllene oxide as the major components. This study also revealed that beta-bisabolene was found as the principal constituent in Litsea species for the first time.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemical Research Methods
Yu Guo, Yan Li, Zhuang Li, Li Jiang, Xifeng Cao, Wenbin Gao, Jun Wang, Duqiang Luo, Fengli Chen
Summary: The DES-HMAHD method successfully isolated essential oil with higher antioxidant activity and different components from Litsea cubeba fruits, showing higher separation efficiency and economic value compared to traditional methods.
JOURNAL OF CHROMATOGRAPHY A
(2021)
Article
Food Science & Technology
Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Chaiyavat Chaiyasut
Summary: This study summarizes the composition, pharmacological and economic importance of Litsea cubeba essential oil. The essential oil of Litsea cubeba exhibits antioxidant, antimicrobial, and antiproliferative activities and can be used as a pesticide, repellent, and fragrance agent in cosmetics.
FOOD SCIENCE AND TECHNOLOGY
(2022)
Article
Chemistry, Applied
Tran Thanh Hung, Luong Thi My Ngan, Hoang Viet, Nguyen Van Minh Hoang, Tran Trung Hieu
Summary: The main chemical compositions of Litsea cubeba fruit essential oil collected in Kon Tum Province, Vietnam were geranial (32.0%), neral (24.3%), citronellal (14.2%), and limonene (10.1%). Twenty-four compounds of the essential oil were identified and compared with those from previous reports in India, China, and Malaysia. The essential oil exhibited high levels of growth inhibition and moderate bactericidal activity against seven test Helicobacter pylori strains, including resistant strains to multiple antibiotics. It also suppressed bacterial biofilm formation and inhibited the activity of H. pylori-urease.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2023)
Article
Food Science & Technology
Jun-Hwan Park, Hoi-Seon Lee, Namhyun Chung
Summary: The essential oil extracted from Litsea cubeba fruits showed acaricidal and repellent activities against unfed nymphs and adults of Haemaphysalis longicornis, with 3,7-dimethyl-2,6-octadienal being the most effective compound. It suggests that 3,7-dimethyl-2,6-octadienal could be a promising natural candidate for developing new sustainable acaricidal and repellent agents.
APPLIED BIOLOGICAL CHEMISTRY
(2021)
Article
Food Science & Technology
Vasileios Bampidis, Giovanna Azimonti, Maria de Lourdes Bastos, Henrik Christensen, Mojca Fasmon Durjava, Maryline Kouba, Marta Lopez-Alonso, Secundino Lopez Puente, Francesca Marcon, Baltasar Mayo, Alena Pechova, Mariana Petkova, Fernando Ramos, Yolanda Sanz, Roberto Edoardo Villa, Ruud Woutersen, Paul Brantom, Andrew Chesson, Johannes Westendorf, Paola Manini, Fabiola Pizzo, Birgit Dusemund
Summary: The EFSA Panel on Additives and Products or Substances used in Animal Feed concluded that litsea berry oil is safe as a sensory additive in feed and water for drinking for all animal species, with different safe concentrations for each species. Skin and eye irritation should be noted, but using the additive in animal feed is not expected to pose a risk to the environment.
Article
Microbiology
Ngoc Tung Quach, Quang Huy Nguyen, Thi Hanh Nguyen Vu, Thi Thu Hang Le, Thi Thu Thuy Ta, Tien Dat Nguyen, Thuoc Van Doan, The Van Nguyen, Tat Thanh Dang, Xuan Canh Nguyen, Hoang Ha Chu, Quyet Tien Phi
Summary: The study evaluated the bioactivities of metabolites synthesized by endophytic actinomycete strain LCP18 in the Vietnamese medicinal plant Litsea cubeba towards bacterial pathogens and cancer cell lines. The identified plant-derived compounds showed antibacterial activity and cytotoxic effects against bacterial pathogens and human lung cancer cell lines, highlighting their potential applications in combating infections and inhibiting cancer cells.
BRAZILIAN JOURNAL OF MICROBIOLOGY
(2021)
Article
Forestry
Kuan-Feng Huang, Yi-Ru Lee, Yen-Hsueh Tseng, Sheng-Yang Wang, Fang-Hua Chu
Article
Forestry
Hui-Ling Hsieh, Li-Ting Ma, Sheng-Yang Wang, Fang-Hua Chu
Article
Plant Sciences
Yan-Liang Lin, Yi-Ru Lee, Nai-Wen Tsao, Sheng-Yang Wang, Jei-Fu Shaw, Fang-Hua Chu
JOURNAL OF NATURAL PRODUCTS
(2015)
Article
Plant Sciences
Chieh-Yin Chen, Shih-Chang Chien, Nai-Wen Tsao, Chiem-Sing Lai, Ya-Yun Wang, Wen-Wei Hsiao, Fang-Hua Chu, Yueh-Hsiung Kuo, Sheng-Yang Wang
Article
Biotechnology & Applied Microbiology
Mei-Ju May Chen, Li-Kai Chen, Yu-Shing Lai, Yu-Yu Lin, Dung-Chi Wu, Yi-An Tung, Kwei-Yan Liu, Hsueh-Tzu Shih, Yi-Jyun Chen, Yan-Liang Lin, Li-Ting Ma, Jian-Long Huang, Po-Chun Wu, Ming-Yi Hong, Fang-Hua Chu, June-Tai Wu, Wen-Hsiung Li, Chien-Yu Chen
Article
Forestry
Nai-Wen Tsao, Ying-Hsuan Sun, Shih-Chang Chien, Fang-Hua Chu, Shang-Tzen Chang, Yueh-Hsiung Kuo, Sheng-Yang Wang
Article
Agriculture, Multidisciplinary
Yu-Han Chen, Ting-Feng Yeh, Fang-Hua Chu, Fu-Lan Hsu, Shang-Tzen Chang
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2015)
Article
Biochemistry & Molecular Biology
Yen Lin, Yu-Ying Kao, Zenn-Zong Chen, Fang-Hua Chu, Jeng-Der Chung
JOURNAL OF PLANT BIOCHEMISTRY AND BIOTECHNOLOGY
(2014)
Article
Plant Sciences
Chi-Hsiang Wen, Shih-Shun Lin, Fang-Hua Chu
PLANT AND CELL PHYSIOLOGY
(2015)
Article
Multidisciplinary Sciences
Yan-Liang Lin, Li-Ting Ma, Yi-Ru Lee, Shih-Shun Lin, Sheng-Yang Wang, Tun-Tschu Chang, Jei-Fu Shaw, Wen-Hsiung Li, Fang-Hua Chu
Article
Forestry
Yan-Liang Lin, Yi-Ru Lee, Wen-Ke Huang, Shang-Tzen Chang, Fang-Hua Chu
TREE GENETICS & GENOMES
(2014)
Article
Forestry
Li-Jen Hsu, Fang-Hua Chu
TREE GENETICS & GENOMES
(2015)
Article
Chemistry, Medicinal
Chi-Jung Chen, K. J. Senthil Kumar, Yu-Ting Chen, Nai-Wen Tsao, Shih-Chang Chien, Shang-Tzen Chang, Fang-Hua Chu, Sheng-Yang Wang
NATURAL PRODUCT COMMUNICATIONS
(2015)
Article
Chemistry, Medicinal
Shih-Chang Chien, Yen-Hsueh Tseng, Wei-Ning Hsu, Fang-Hua Chu, Shang-Tzen Chang, Yueh-Hsiung Kuo, Sheng-Yang Wang
NATURAL PRODUCT COMMUNICATIONS
(2014)
Article
Chemistry, Medicinal
Hui-Chun Wang, Yen-Hsueh Tseng, Hui-Rong Wu, Fang-Hua Chu, Yueh-Hsiung Kuo, Sheng-Yang Wang
NATURAL PRODUCT COMMUNICATIONS
(2014)