期刊
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
卷 3, 期 11, 页码 2716-2725出版社
AMER CHEMICAL SOC
DOI: 10.1021/acssuschemeng.5b00568
关键词
ZnO; Mechanochemistry; Cytotoxicity; Bionanomaterials
资金
- Spanish MICINN [RYC-2009-04199]
- MEC [CTQ2011-28954-C02-02]
- Consejeria de Ciencia e Innovacion, Junta de Andalucia [P10-FQM-6711]
Mechanochemically synthesized ZnO-polysaccharide nanohybrids prepared from fungal polysaccharides were proved to exhibit remarkable surface properties and structures for biomedical applications. The synthesized ZnO nanomaterials possessed an unprecedented low cytotoxicity against human cell lines A549 and SH-SYSY (EC50: 50-100 mu g mL(-1)) as compared to commercial ZnO nanomaterials due to the stability and low release of Zn2+ and reduced interaction nanoparticle/cells due to the high biocompatibility of the nanohybrids.
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