Article
Immunology
Fabrizio Celesti, Andrea Gatta, Mariam Shallak, Anna Maria Chiaravalli, Michele Cerati, Fausto Sessa, Roberto S. Accolla, Greta Forlani
Summary: In an animal experimental system, vaccination with glioblastoma GL261 cells expressing CIITA showed successful protection against glioblastoma growth. The activation of MHC class II through CIITA led to rapid infiltration of CD4+ and CD8+ T cells, resulting in the rejection or retardation of tumor growth. This approach demonstrates the potential application of novel immunotherapeutic strategies in the clinical setting.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell & Tissue Engineering
Guanyin Chen, Dong Fan, Wangqian Zhang, Shuning Wang, Jintao Gu, Yuan Gao, Lei He, Weina Li, Cun Zhang, Meng Li, Yingqi Zhang, Zhaohui Liu, Qiang Hao
Summary: This study found that under hypoxic conditions, there was a significant increase in the expression of Mkx in MSCs. Mkx mediated hypoxia-induced tenogenic differentiation of MSCs but could not completely repress the proliferation of hypoxic MSCs.
STEM CELL RESEARCH & THERAPY
(2021)
Review
Immunology
Cornelia Heuberger, Johanna Pott, Kevin Joseph Maloy
Summary: Intestinal epithelial cells play a dual role in antigen presentation, potentially activating effector T cells while also suppressing immune responses through regulatory T cell activation. The expression of MHC class II on IECs is tightly regulated and its impact on immune responses can vary depending on the specific conditions and cellular context.
Article
Biochemistry & Molecular Biology
Bo Zhao, Lijun Sun, Qing Yuan, Zhenzhen Hao, Fei An, Wanting Zhang, Xiaoshuang Zhu, Bing Wang
Summary: The absence of BAP31 leads to an enlarged spleen and thymus in mice, accompanied by activated clustering and disrupted differentiation of CD4(+)T cells. In vitro co-culture studies show that the loss of BAP31 increases the expression of antigen presenting molecules, particularly MHC-II, on macrophages. These findings suggest that BAP31 regulates the activation and differentiation of CD4+T cells by modulating MHC class II molecule expression on macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Immunology
Shinya Hatano, Keiichiro Mine, Naoto Noguchi, Mitsuru Matsumoto, Yoshihiro Baba, Yasunobu Yoshikai
Summary: V gamma 6(+)gamma delta T cells, which are exclusive IL-17A producers, develop in the thymus during the perinatal stage. The loss of MHC class II leads to an expansion of IL-17A(+)V gamma 6(+)gamma delta T cells in the thymus.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Binkai Chi, Muhammet M. Oeztuerk, Christina L. Paraggio, Claudia E. Leonard, Maria E. Sanita, Mahtab Dastpak, Jeremy D. O'Connell, Jordan A. Coady, Jiuchun Zhang, Steven P. Gygi, Rodrigo Lopez-Gonzalez, Shanye Yin, Robin Reed
Summary: Mutations in RNA/DNA-binding proteins can cause ALS, but the exact disease mechanisms are still unclear. This study found that a group of ALS-associated proteins can affect the expression of genes involved in the MHC II antigen presentation pathway. Additionally, hematopoietic progenitor cells with mutations also exhibit disrupted MHC II expression. These findings suggest that the loss of the MHC II pathway may result in the immune system's failure to protect motor neurons from ALS-related damage.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Oncology
Simone Stupia, Christina Heeke, Alicia Bruggemann, Anne Zaremba, Beatrice Thier, Julia Kretz, Antje Sucker, Manuel Philip, Gennadiy Zelinskyy, Soldano Ferrone, Alexander Roesch, Susanne Horn, Eva Hadaschik, Dirk Schadendorf, Mirko Trilling, Ulf Dittmer, Klaus Griewank, Fang Zhao, Annette Paschen
Summary: Recent studies have shown that cytotoxic CD4 T cells can kill melanoma cells dependent on HLA class II (HLA-II). This study investigates the evolution of HLA-II-loss tumors that evade cytotoxic CD4 T cell activity and contribute to immunotherapy resistance. The findings highlight the importance of tumor cell-intrinsic HLA-II antigen presentation in disease control and suggest the need to overcome its down-regulation for better patient outcomes.
CLINICAL CANCER RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Carley Tasker, Jenny Patel, Vibha Jawa, Jad Maamary
Summary: A novel cell-based assay has been proposed for investigating the endosomal processing and MHC class II presentation capabilities of antigens, utilizing competition between epitopes for MHC class II binding and labeled soluble T cell receptors as detectors for epitope presentation.
Article
Immunology
Komal Dolasia, Faiza Nazar, Sangita Mukhopadhyay
Summary: PPE18 protein inhibits MHC class II-mediated antigen presentation by macrophages, leading to decreased activation of CD4 T cells and compromised adaptive immune responses. This study sheds light on the host-pathogen interaction and potential therapeutic strategies targeting PPE18.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Nyerhovwo Obarorakpor, Deep Patel, Reni Boyarov, Nansalmaa Amarsaikhan, Joseph Ray Cepeda, Doreen Eastes, Sylvia Robertson, Travis Johnson, Kai Yang, Qizhi Tang, Li Zhang
Summary: In spontaneous type 1 diabetes (T1D) non-obese diabetic (NOD) mice, the insulin B chain peptide 9-23 (B:9-23) can bind to the MHC class II molecule (IA(g7)) in register 3 (R3), creating a bimolecular IA(g7)/InsulinB:9-23 register 3 conformational epitope (InsB:R3). InsB:R3-specific chimeric antigen receptor (CAR) can guide CAR-expressing CD8 T cells to migrate to the islets and pancreatic lymph nodes. Regulatory T cells (Tregs) specific for an islet antigen can suppress autoimmune reactivity in islets and protect against T1D.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Endocrinology & Metabolism
Xiaoning Wang, Xin Zhang, Yidan Han, Xinwei Duan, Jianchang Wang, Hui Yan, Shanshan Wang, Yunteng Xu, Zaishi Zhu, Lili Wang, Yanfeng Huang, Qing Lin, Xue Tan, Junkuan Zhuo, Haifeng Zhang, Min Mao, Weiying Gou, Zhouping Yi, Xihai Li
Summary: Bone immunity regulates bone resorption and osteoclast differentiation, and has the potential to be a target for treating PMOP. The involvement of the major histocompatibility complex class II (MHC-II) molecule protein presentation pathway in PMOP needs further investigation.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Immunology
Kenneth Peuker, Anne Strigli, Daniele V. F. Tauriello, Alexander Hendricks, Witigo von Schonfels, Greta Burmeister, Mario Brosch, Alexander Herrmann, Sandra Krueger, Jessica Nitsche, Lea Juznic, Marc Marius Geissler, Andreas Hiergeist, Andre Gessner, Jakob Wirbel, Ruby Priyadarshini Ponnudurai, Antje Tunger, Rebekka Wehner, Daniel E. Stange, Juergen Weitz, Daniela E. Aust, Gustavo B. Baretton, Marc Schmitz, Christoph Rocken, Jochen Hampe, Sebastian Hinz, Georg Zeller, Triantafyllos Chavakis, Clemens Schafmayer, Eduard Batlle, Sebastian Zeissig
Summary: Bacterial sensing by intestinal tumor cells contributes to tumor growth through the calcineurin-NFAT axis, while its inhibition can activate CD8(+) T cell responses and inhibit colorectal cancer growth. This pathway also controls the expression of B7H3 and B7H4 by tumor cells, which inhibits CD8(+) T cell-dependent anti-tumor immunity.
Article
Biochemistry & Molecular Biology
M. Cortazar-Chinarro, A. Richter-Boix, P. Rodin-Morch, P. Halvarsson, J. B. Logue, A. Laurila, J. Hoglund
Summary: Microbiomes play a crucial role in determining the ecology and behavior of their hosts. This study investigated the effects of geography, evolutionary history, and host genetics on the skin microbiome diversity and structure in a widespread amphibian. The results showed that microbiome diversity was correlated with host genetic diversity, and the bacterial community composition varied between geographical clusters and specific host genetic variations.
Article
Oncology
Lei Zhan, Junhui Zhang, Jing Zhang, Xiaojing Liu, Suding Zhu, Yuchuan Shi, Yu He, Wenyan Wang, Yijing Wei, Zhenhai Tang, Guo Chen, Bing Wei, Yunxia Cao
Summary: In this study, the researchers found that upregulated autophagy and decreased expression of MHC-I and NLRC5 were associated with endometrial cancer (EC). Inhibition of autophagy was found to suppress MHC-I gene expression. They also discovered that LC3 interacted with NLRC5 to inhibit the NLRC5-mediated MHC-I antigen presentation pathway. These findings suggest that inhibiting LC3 and promoting NLRC5 may be a promising immunotherapy strategy for EC management.
Article
Biochemistry & Molecular Biology
Jieru Deng, Chunni Lu, Chuanxin Liu, Sara Oveissi, W. Douglas Fairlie, Erinna F. Lee, Pamuk Bilsel, Hamsa Puthalakath, Weisan Chen
Summary: The study demonstrates that IAV infection induces endogenous presentation of a viral epitope by MHC-II to CD4(+) T cells, dependent on de novo protein synthesis and the ER-Golgi network. Some antigenic peptides are of cytosolic origin in this process. Additionally, autophagy inhibitors and deletion of autophagy-related genes block most of the MHC-II-restricted endogenous IAV antigen presentation.
Article
Medicine, Research & Experimental
Jaesung Heo, Jun Eun Park, O. Kyu Noh, Yunmi Shin
Summary: Children with acute lymphoblastic leukemia (ALL) in South Korea have an increased risk of developing psychiatric disorders, particularly within the first year after diagnosis.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Article
Oncology
Kyung-Mi Kee, Soo-Hyun Kim, Seon-Young Yang, Jeong-U Shin, Yoon-Won Nam, Eun-Jung Jang, Hong-Tae Kim, Se-Min Lee, Sung-Ho Park, Dong-Wook Kim
Summary: This study analyzed the clinical significance of 3-month cytogenetic and molecular monitoring in chronic-phase chronic myeloid leukemia patients. It found that early cytogenetic and molecular responses can predict long-term outcomes such as major molecular response, deep molecular response, overall survival, and progression-free survival.
Letter
Immunology
Jia Kim, Young June Choe, Eun Jung Jang, Do Sang Lim, Yoo Yeon Kim, Ryu Kyung Kim, Seonju Yi, Sangwon Lee, Young Joon Park
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Seonju Yi, Young June Choe, Do Sang Lim, Hye Roen Lee, Jia Kim, Yoo-Yeon Kim, Ryu Kyung Kim, Eun Jung Jang, Sangwon Lee, Eunjoo Park, Seung-Jin Kim, Young-Joon Park
Summary: This study evaluated the effectiveness of nationwide vaccination campaigns using different vaccines in South Korea and found significant protection against severe disease and death from Covid-19 in the target population. However, there was a decreased protection against SARS-CoV-2 infection, highlighting the importance of continued surveillance and assessment.
Article
Gastroenterology & Hepatology
Woohyung Lee, Dae Wook Hwang, Ho-Seong Han, In Woong Han, Jin Seok Heo, Michiaki Unno, Masaharu Ishida, Hiroshi Tajima, Nobuyuki Nishizawa, Kohei Nakata, Yasuji Seyama, Yoshiya Isikawa, Ho Kyoung Hwang, Jin-Young Jang, Taeho Hong, Joon Seong Park, Hee Joon Kim, Chi-Young Jeong, Ippei Matsumoto, Hiroki Yamaue, Manabu Kawai, Masayuki Ohtsuka, Shugo Mizuno, Mitsuhiro Asakuma, Yuji Soejima, Teijiro Hirashita, Masayuki Sho, Yutaka Takeda, Jeong-Ik Park, Yong Hoon Kim, Hwa Jung Kim, Masakazu Yamamoto, Itaru Endo, Masafumi Nakamura, Yoo-Seok Yoon
Summary: The study aimed to evaluate the advantages of spleen preservation during laparoscopic distal pancreatectomy (LDP) for preventing infectious complications. By comparing the data of postoperative infectious complications in different groups, the study found that spleen preservation could lower the risk of infectious complications, but the risk may vary according to the surgeon's experience.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Virology
Eun Jung Jang, Young June Choe, Go-Woon Yun, Seongjin Wang, U. Jin Cho, Seonju Yi, Sangwon Lee, Young-Joon Park
Summary: This study analyzed national data from South Korea to better understand the epidemiology of SARS-CoV-2 reinfections. The findings suggest that the reinfection rate has increased with the emergence of new variants, and individuals who have received one dose of vaccination have the highest reinfection rate.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Letter
Medicine, General & Internal
Jia Kim, Young June Choe, Hyunju Lee, Eun Hwa Choi, Eun Jung Jang, Ryu Kyung Kim, Young-Joon Park
Article
Immunology
Eun Jung Jang, Young June Choe, Go-Woon Yun, Ryu Kyung Kim, Heegwon Jeong, Sangwon Lee, Young-Joon Park
Summary: This is a national observational study conducted in Korea to calculate the positive predictive value of SARS-CoV-2 rapid antigen tests in K-12 schools during the Omicron variant surge in March 2022. The weekly positive predictive value ranged from 86.4% to 93.2%. The highest positive predictive value was observed among elementary school students with symptoms (95.7%), while the lowest was among teachers/staff without symptoms (70.9%).
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Letter
Pediatrics
Eun Jung Jang, Young June Choe, Ryu Kyung Kim, Young-Joon Park
Article
Multidisciplinary Sciences
Eunjue Yi, Jun Eun Park, Jae Ho Chung, Chi Bum Ahn, Eugene Chung, O. Kyu Noh, Sungho Lee
Summary: The aim of this study was to determine the post treatment recurrence rates in pneumothorax patients under 35 without any comorbidities, based on treatment types, gender, and age categories. The study found that surgical intervention, male gender, and age under 20 were associated with higher recurrence rates.
SCIENTIFIC REPORTS
(2023)
Article
Medicine, General & Internal
Young June Choe, Jue Seong Lee, Yoon Lee, Kyu Hyun Park, Young Yoo, Gi-Jung Im, Sung Woo Lee, Jun Eun Park
Summary: As pediatric COVID-19 cases surged in South Korea in mid-2022, a Pediatric COVID-19 Module Clinic (PMC) was established through a public-private partnership. The first prototype children's modular clinic at Korea University Anam Hospital served as the COVID-19 PMC. From August 1 to September 30, 2022, a total of 766 children visited the COVID-19 PMC, with daily visits ranging from 10 to 47 in August and less than 13 in September. This model not only provided timely care for COVID-19 pediatric patients, but also ensured safe care for non-COVID-19 patients in the main hospital building, minimizing the risk of exposure to severe acute respiratory syndrome coronavirus 2 transmission. The study highlights the importance of spatial measures in mitigating COVID-19 transmission within hospitals, specifically in pediatric care.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Infectious Diseases
Jung Wan Park, Jiwon Lyu, Tae Hyun Ji, Shi Nae Yu, Min Hyok Jeon
Summary: Thromboembolism is a common complication in COVID-19 patients, but arterial occlusion is rare. We encountered a case of a 70-year-old male patient with Right common iliac arterial occlusion as a complication while treating him for confirmed COVID-19, despite the absence of any risk factors such as diabetes or smoking. It is important to carefully monitor for the occurrence of this complication in COVID-19 patients.
INFECTION AND CHEMOTHERAPY
(2023)
Article
Medicine, General & Internal
Jue Seong Lee, O. Kyu Noh, Jun Eun Park
Summary: This study investigated the incidence of growth retardation (GR) and its neonatal risk factors in patients with congenital heart disease (CHD) using nationwide population-based claims data. The study found that preterm birth, small for gestational age, and low birth weight were significant risk factors for GR. Appropriate monitoring and treatment programs are necessary for CHD neonates with these factors.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Seon Kyeong Park, Young June Choe, Eun Jung Jang, Ryu Kyung Kim, Sang-Won Lee, Geun-Yong Kwon, Jeeyeon Shin, Sang-Yoon Choi, Mi Jin Jeong, Young-Joon Park
Summary: We conducted a cohort study to evaluate the effectiveness of coronavirus disease 2019 vaccine combinations on severe acute respiratory syndrome coronavirus 2 critical infection and death among elderly population in Korea. From January to August 2022, the vaccine effectiveness against death was 96.1% for those who received 4 doses of mRNA vaccine, while it was 90.8% for those who received 1 dose of viral vector + 3 doses of mRNA vaccine.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Medicine, General & Internal
Yoo-Yeon Kim, Young June Choe, Jia Kim, Ryu Kyung Kim, Eun Jung Jang, Hyeryeon Lee, Seonju Yi, Sangwon Lee, Young-Joon Park
Summary: National cohort data from Korea during the COVID-19 delta and omicron periods showed that individuals who received three doses of the COVID-19 vaccine had a lower risk of severe infection (adjusted odds ratio [aOR], 0.05-0.08). The risk of death was also reduced during the omicron period compared to the delta period (aOR, 0.75; 95% confidence interval, 0.67-0.84).
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)