Article
Food Science & Technology
Piotr K. Krajewski, Kinga Tyczynska, Klaudia Bardowska, Piotr Olczyk, Magdalena Krajewska, Jacek C. Szepietowski
Summary: Itch is a common symptom of chronic dermatoses and can be associated with systemic disorders. This study found that itch is a significant burden in renal transplant recipients (RTR), with higher prevalence of anxiety and depression among those experiencing itch. The severity of itch was positively correlated with anxiety, depression, and stigmatization. The results highlight the importance of addressing itch relief in a holistic approach to RTR patients.
Review
Medicine, General & Internal
Hani Oweira, Ali Ramouz, Omid Ghamarnejad, Elias Khajeh, Sadeq Ali-Hasan-Al-Saegh, Rajan Nikbakhsh, Christoph Reissfelder, Nuh Rahbari, Arianeb Mehrabi, Mahmoud Sadeghi
Summary: Multiple factors influence graft rejection after kidney transplantation, including donor and recipient characteristics, as well as pre- and post-operative parameters. Identifying these risk factors helps reduce the risk of rejection and improve graft survival.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Transplantation
Gregory L. Hundemer, Anand Srivastava, Kirolos A. Jacob, Neeraja Krishnasamudram, Salman Ahmed, Emily Boerger, Shreyak Sharma, Kapil K. Pokharel, Sameer A. Hirji, Marc Pelletier, Kassem Safa, Win Kulvichit, John A. Kellum, Leonardo Riella, David E. Leaf
Summary: Renal transplant recipients have a higher risk of acute kidney injury following cardiac surgery compared to non-RTRs, especially those with deceased donor status and higher preoperative calcineurin inhibitor trough levels.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Immunology
Shoko Ishikawa, Masayuki Tasaki, Kazuhide Saito, Yuki Nakagawa, Masahiro Ikeda, Kota Takahashi, Yoshihiko Tomita
Summary: This study investigated the incidence of CMV infection in the chronic phase after kidney transplantation and found that 10-20% of patients had CMV infections in each year after transplantation. The study also showed that CMV viremia in the chronic phase was significantly associated with graft loss.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Medicine, General & Internal
Gabriel Kanhouche, Gustavo Rocha Feitosa Santos, Henry Campos Orellana, Attilio Galhardo, Ana Carolina Buso Faccinetto, Manoela Linhares Machado Barteczko, Luiz Sergio F. de Carvalho, Julia Bernardi Taddeo, Renato Demarchi Foresto, Valdir Ambrosio Moises, Helio Tedesco-Silva, Jose Medina Pestana, Adriano Henrique Pereira Barbosa
Summary: In the population of kidney transplant recipients, Delayed Graft Function (DGF) increases the risk of Transplant Renal Artery Stenosis (TRAS) by more than 3-fold. In the subgroup analysis, DGF and Diabetes Mellitus (DM) are independent risk factors for stenosis in the body artery. Adding other factors to hypertension and renal dysfunction may improve diagnostic accuracy.
Article
Urology & Nephrology
Marcel G. Naik, Wolfgang Arns, Klemens Budde, Fritz Diekmann, Frank Eitner, Wilfried Gwinner, Nils Heyne, Jan Steffen Jurgensen, Christian Morath, Udo Riester, Katharina M. Heller, Michael Fischereder
Summary: The study retrospectively analyzed 726 renal transplant recipients converted to sirolimus, showing lower cancer incidence rates after conversion. Patients with prior malignancy were older but had lower cancer rates after conversion. Renal function and graft survival were better in all cancer types compared to patients converted to sirolimus without cancers. Patient survival was largely dependent on tumor entity.
CLINICAL KIDNEY JOURNAL
(2021)
Review
Medicine, Research & Experimental
Milosz Miedziaszczyk, Ilona Idasiak-Piechocka
Summary: Tacrolimus and omeprazole are commonly used drugs in kidney transplant patients. However, simultaneous administration may lead to drug interactions, affecting the pharmacokinetics of tacrolimus and potentially causing adverse reactions. It is important to address these interactions and find appropriate solutions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Nutrition & Dietetics
I-Hsin Lin, Te-Chih Wong, Tuyen Van Duong, Shih-Wei Nien, I-Hsin Tseng, Hsu-Han Wang, Yang-Jen Chiang, Shwu-Huey Yang
Summary: This study investigated the association between dietary quality indices and recurrent chronic kidney disease (rCKD) in Taiwanese post-renal transplant recipients (RTRs). The results showed that RTRs with higher dietary quality indices were older, had higher eGFRs, and had lower odds of rCKD.
FRONTIERS IN NUTRITION
(2023)
Article
Multidisciplinary Sciences
Christine Firth, Fadi Shamoun, Michael Apolinario, Elisabeth S. Lim, Nan Zhang, Mira T. Keddis
Summary: This study retrospectively assessed the safety of using direct oral anticoagulants (DOACs) compared to warfarin in renal transplant recipients, and the results showed that DOACs did not have inferior bleeding or mortality outcomes.
Article
Immunology
Taylor A. Melanson, Karie Mersha, Rachel E. Patzer, Roshan P. George
Summary: Loss to follow-up (LFU) is a critical issue for adolescent and young adult renal transplant recipients, with institution transfer being a significant risk factor. Recipients peaked in LFU at the age of 20, and those who transferred institutions had 3.36 times greater odds of LFU compared to those who did not transfer. Additional research on the relationship between age, institution transfer, and LFU in this population is necessary.
Article
Multidisciplinary Sciences
Jong Joo Moon, Yong Woo Kim, Baek-Lok Oh, Kyungdo Han, Dong Ki Kim, Kwon Wook Joo, Yon Su Kim, Ki Ho Park, Hajeong Lee, Yong Chul Kim, Jin Wook Jeoung
Summary: This nationwide cohort study found that the incidence of primary open-angle glaucoma (POAG) was higher in patients with end stage renal disease (ESRD) and kidney transplantation recipients (KTRs) compared to healthy controls, but adjusting for confounding factors did not show a significant increase in risk. The incidence of primary angle-closure glaucoma (PACG) was higher in ESRD patients compared to healthy controls, while KTRs had a lower risk of PACG compared to ESRD patients.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Maria Smyrli, Pantelis A. Sarafidis, Charalampos Loutradis, Maria Korogiannou, Ioannis N. Boletis, Smaragdi Marinaki
Summary: The prevalence of mild hyperkalaemia is relatively high while moderate or severe hyperkalaemia is low in stable kidney transplant recipients. Male gender and the use of RAAS blockers are associated with increased odds of hyperkalaemia, while higher eGFR and non-K+-sparing diuretics are associated with decreased odds of hyperkalaemia.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Pediatrics
Margret E. Bock, Leslie Wall, Carly Dobrec, Mary Chandran, Jens Goebel
Summary: Dyslipidemia after kidney transplantation is a common and historically underappreciated complication, especially in pediatric recipients. Reliable management of dyslipidemia not only requires awareness of applicable guidelines and methods, but also attention to additional needs and opportunities in comprehensive care.
PEDIATRIC NEPHROLOGY
(2021)
Article
Transplantation
Jutta S. Swolinsky, Ricarda M. Hinz, Carolin E. Markus, Eugenia Singer, Friederike Bachmann, Fabian Halleck, Susanne Kron, Marcel G. Naik, Danilo Schmidt, Martin Obermeier, Pimrapat Gebert, Geraldine Rauch, Siegfried Kropf, Michael Haase, Klemens Budde, Kai-Uwe Eckardt, Timm H. Westhoff, Kai M. Schmidt-Ott
Summary: This study investigated the utility of NGAL and CPT in predicting long-term graft survival in kidney transplant recipients. The results showed that NGAL had the best predictive ability for graft loss, with an AUC > 0.7 within 5 years. However, compared to the conventional marker eGFR, NGAL did not consistently provide added value.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Davide Bolignano, Marta Greco, Pierangela Presta, Alfredo Caglioti, Nazareno Carullo, Mariateresa Zicarelli, Daniela Patrizia Foti, Francesco Dragone, Michele Andreucci, Giuseppe Coppolino
Summary: MBG levels in chronic kidney transplant recipients are influenced by sodium balance, renal impairment, and the severity of left ventricular hypertrophy (LVH). Therefore, MBG may represent an important missing link between reduced graft function and pathological cardiac remodeling, and hold important prognostic value for improving cardio-renal risk assessment.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Immunology
Evaldo Favi, Paolo Molinari, Carlo Alfieri, Giuseppe Castellano, Mariano Ferraresso, Donata Cresseri
Summary: The use of eculizumab in kidney transplantation has reduced the incidence of relapsing aHUS, but the management of aHUS transplant candidates with anti-CFH antibodies is still debated. We present a case of a successful kidney transplant in a patient with elevated anti-CFH antibodies, using eculizumab and obinutuzumab. The patient had a good outcome with undetectable anti-CFH antibodies, B-cell depletion, and no signs of aHUS activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Andrea Costantino, Letizia Morlacchi, Maria Francesca Donato, Andrea Gramegna, Elisa Farina, Clara Dibenedetto, Mariarosaria Campise, Matteo Redaelli, Marta Perego, Carlo Alfieri, Francesco Blasi, Pietro Lampertico, Evaldo Favi
Summary: COVID-19 vaccination hesitancy exists among solid organ transplant recipients, with concerns about adverse events and perceived lack of efficacy being the main reasons. Establishing appropriate and targeted patient-doctor communication strategies, as well as implementing specific vaccination campaigns, is crucial to reduce COVID-19-related morbidity and mortality.
Article
Surgery
Gionata Spagnoletti, Zoe Larghi Laureiro, Alberto Maria Fratti, Arianna Maiorana, Maria Carmen Garganese, Milena Pizzoferro, Carlo Dionisi-Vici, Marco Spada
Summary: This study presents a case of a five-month-old child with focal congenital hyperinsulinism (CHI) who underwent pylorus-preserving pancreatoduodenectomy. The surgical procedure involved multiple steps, including pancreatico-jejunostomy, hepaticojejunostomy, and pylorus-preserving antecolic duodeno-jejunostomy. The surgery was successful, with immediate normalization of blood glucose levels and discharge from the hospital after 19 days.
FRONTIERS IN SURGERY
(2023)
Article
Endocrinology & Metabolism
Diego Martinelli, Giulio Catesini, Benedetta Greco, Alessia Guarnera, Chiara Parrillo, Evelina Maines, Daniela Longo, Antonio Napolitano, Francesca De Nictolis, Sara Cairoli, Daniela Liccardo, Stefania Caviglia, Anna Sidorina, Giorgia Olivieri, Barbara Siri, Roberto Bianchi, Gionata Spagnoletti, Luca Dello Strologo, Marco Spada, Carlo Dionisi-Vici
Summary: Liver and liver/kidney transplantation have positive effects on the neurological outcome of patients with methylmalonic aciduria. Improved biomarkers were observed in plasma, while biomarkers of mitochondrial dysfunction decreased in cerebrospinal fluid. Neurocognitive evaluation showed significant cognitive improvement and brain changes at MRI. Early transplantation is recommended due to long-term complications and low quality of life.
JOURNAL OF INHERITED METABOLIC DISEASE
(2023)
Article
Pediatrics
Gionata Spagnoletti, Zoe Larghi Laureiro, Giuseppe Marincola, Isabella Guzzo, Luca Dello Strologo, Marco Spada
Summary: A retrospective analysis of 32 consecutive pediatric kidney transplant surgeries was conducted to evaluate the systematic use of magnetic ureteral double J stent (mDJS). The results showed that the use of mDJS in these patients was safe and feasible. The systematic use of this device contributes to a reduction in the need for general anesthesia and hospitalization rate.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Oncology
Pierluca Piselli, Diego Serraino, Claudia Cimaglia, Lucrezia Furian, Luigi Biancone, Ghil Busnach, Nicola Bossini, Paola Todeschini, Maurizio Iaria, Franco Citterio, Mariarosaria Campise, Massimiliano Veroux, Giuseppe Tisone, Vincenzo Cantaluppi, Margherita Mangino, Simona Simone, Davide Argiolas, Andrea Ambrosini, Francesco Pisani, Flavia Caputo, Martina Taborelli
Summary: This cohort study examined cancer incidence among 11,418 Italian recipients of kidney transplantation over a 25-year period. The study found a decreased risk of Kaposi's sarcoma, but no significant changes in the incidence of other cancers over time. It highlights the need for continued cancer prevention efforts in kidney transplant recipients.
Article
Public, Environmental & Occupational Health
Francesca Leonardis, Lara Gitto, Evaldo Favi, Angelo Oliva, Roberta Angelico, Annapaola Mitterhofer, Irene Cacciola, Domenico Santoro, Tommaso Maria Manzia, Giuseppe Tisone, Roberto Cacciola
Summary: This study applies the Keynesian principle to Kidney Transplantation (KT) and explores the financial resources that can be obtained from the activity. The results show that the savings generated from KT exceed the costs of Organ Donation (OD) and have the potential for growth. These savings can contribute to the financial self-sufficiency of the Organ Donation and Transplantation (ODT) service.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Endocrinology & Metabolism
Benedetta Greco, Stefania Caviglia, Diego Martinelli, Teresa Grimaldi Capitello, Daniela Liccardo, Francesca De Nictolis, Andrea Pietrobattista, Martina Huemer, Simone Piga, Giorgia Olivieri, Gionata Spagnoletti, Marco Spada, Carlo Dionisi-Vici
Summary: This study aimed to investigate the impact of liver transplantation on health-related quality of life (HRQoL) in inborn errors of metabolism. The results showed that liver transplantation significantly improved HRQoL in both patients and parents, with younger patients experiencing greater improvements.
JOURNAL OF INHERITED METABOLIC DISEASE
(2023)
Article
Medicine, General & Internal
Roberta Angelico, Laura Keci, Laura Tariciotti, Alessandro Anselmo, Evaldo Favi, Tommaso Maria Manzia, Giuseppe Tisone, Roberto Cacciola
Summary: Native nephrectomies in patients scheduled for a kidney transplant can be difficult due to the timing and magnitude of the procedures. A case study is presented where a laparoscopic hand-assisted native nephrectomy was performed simultaneously with a living donor kidney transplant contralaterally.
Review
Surgery
Matteo Abinti, Evaldo Favi, Carlo Maria Alfieri, Francesca Zanoni, Silvia Armelloni, Mariano Ferraresso, Vincenzo Cantaluppi, Giuseppe Castellano
Summary: Kidney transplantation is the best treatment for end-stage kidney disease, but early diagnosis of graft injury and improving graft outcomes remain challenging. Extracellular vesicles have shown potential as precise markers of damage and therapeutic targets in the field of kidney transplantation. They can be used to determine organ quality and aging, identify transplant-related pathologies, and are suitable for drug delivery and therapy development.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Immunology
Mohamed Zahran, Francesca Leonardis, Ismail Mohamed, Evaldo Favi, Roberta Angelico, Tommaso Manzia, Giuseppe Tisone, Roberto Cacciola
Article
Medicine, General & Internal
Carlo Alfieri, Evaldo Favi, Edoardo Campioli, Elisa Cicero, Paolo Molinari, Mariarosaria Campise, Maria Teresa Gandolfo, Anna Regalia, Donata Cresseri, Piergiorgio Messa, Giuseppe Castellano
Summary: The prevalence of NODAT in Italian kidney transplant recipients is relatively high, and it is associated with patient age and early post-transplant events such as steroid abuse.
MEDICINA-LITHUANIA
(2022)
Review
Infectious Diseases
Evaldo Favi, Giuliano Santolamazza, Francesco Botticelli, Carlo Alfieri, Serena Delbue, Roberto Cacciola, Andrea Guarneri, Mariano Ferraresso
Summary: Current knowledge on Leishmania infection after kidney transplantation is limited. We performed a systematic review and selected 70 studies with a total of 159 cases of Leishmaniasis in kidney transplant recipients. Most patients were adult, male, and Caucasian. The main treatment options included pentavalent antimonial and liposomal amphotericin B, but the results were mixed. Overall, the outcomes were concerning, with several patients dying or losing their transplant.
TROPICAL MEDICINE AND INFECTIOUS DISEASE
(2022)
Meeting Abstract
Transplantation
Carlo Maria Alfieri, Paolo Molinari, Maria Teresa Gandolfo, Anna Regalia, Donata Cresseri, Evaldo Favi, Giuseppe Castellano
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Luca Nardelli, Antonio Scalamogna, Piergiorgio Messa, Maurizio Gallieni, Roberto Cacciola, Federica Tripodi, Giuseppe Castellano, Evaldo Favi
Summary: Kidney transplantation is the best treatment option for end-stage renal disease, but limited organ supply leads to prolonged dialysis for most candidates. A personalized and flexible approach may be more appropriate, and current data supports the use of peritoneal dialysis over hemodialysis in patients awaiting kidney transplantation.
MEDICINA-LITHUANIA
(2022)
