Article
Surgery
Hisanobu Higashi, Hiroshi Yagi, Kohei Kuroda, Kazuki Tajima, Hideaki Kojima, Kotaro Nishi, Toshinori Morisaku, Kazuya Hirukawa, Kazumasa Fukuda, Kentaro Matsubara, Minoru Kitago, Masahiro Shinoda, Hideaki Obara, Shungo Adachi, Kumiko Nishimura, Tohru Natsume, Masatoshi Tomi, Alejandro Soto-Gutierrez, Yuko Kitagawa
Summary: This study engineered a human-scale transplantable liver graft using a porcine liver-derived scaffold and evaluated its performance for 28 days using a preclinical large animal model. The results showed improvement in liver function after transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Engineering, Biomedical
Da-Hyun Kim, Jungho Ahn, Hyun Kyoung Kang, Min-Soo Kim, Nam-Gyo Kim, Myung Geun Kook, Soon Won Choi, Noo Li Jeon, Heung-Myong Woo, Kyung-Sun Kang
Summary: Liver tissue engineering with vascular reconstruction using decellularized liver scaffolds showed enhanced liver-specific functions and perfusable vessel networks, providing a promising strategy for liver failure treatment.
Article
Immunology
Hillary J. Braun, Dominic Amara, Amy M. Shui, Peter G. Stock, Ryutaro Hirose, Francis L. Delmonico, Nancy L. Ascher
Summary: This study assesses the outcomes of international liver transplant patients based on their citizenship status, revealing significant disparities in access to and outcomes of liver transplantation.
Article
Cardiac & Cardiovascular Systems
Richard C. Daly, Andrew N. Rosenbaum, Joseph A. Dearani, Alfredo L. Clavell, Naveen L. Pereira, Barry A. Boilson, Robert P. Frantz, Atta Behfar, Shannon M. Dunlay, Richard J. Rodeheffer, John A. Schirger, Timucin Taner, Manish J. Gandhi, Julie K. Heimbach, Charles B. Rosen, Brooks S. Edwards, Sudhir S. Kushwaha
Summary: This study demonstrates the successful transplantation using a heart-after-liver transplantation protocol, which provides profound immunologic protection and prevents adverse immunological outcomes in highly sensitized patients requiring combined heart-liver transplantation. The results show near-elimination of donor specific antibodies and minimal rejection episodes, leading to favorable long-term patient and graft outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Nutrition & Dietetics
Shaghayegh Mottaghi, Hamed Nikoupour, Mohammad Firoozifar, Seyed Soroush Jalali, Akram Jamshidzadeh, Afsaneh Vazin, Mojtaba Shafiekhani
Summary: The aim of this study was to evaluate the effect of taurine supplementation on post-liver transplantation delirium. The results showed that taurine can significantly reduce the incidence of post-transplant delirium. Receiving placebo and longer stay in the intensive care unit (ICU) were identified as independent risk factors.
CLINICAL NUTRITION
(2022)
Review
Gastroenterology & Hepatology
Andrea Schlegel, Hynek Mergental, Constantino Fondevila, Robert J. Porte, Peter J. Friend, Philipp Dutkowski
Summary: With increasing demand for donor livers, there is a need to expand the number and quality of available organs. Dynamic preservation approaches have shown benefits in improving liver function and reducing complications. However, some livers still do not meet viability tests even with modern perfusion techniques. To optimize machine liver perfusion, extended perfusion with ex situ treatment and the use of stem cells or molecules targeting repair mechanisms are promising options. Bioengineering techniques can also be used to develop optimized organs during machine perfusion. This review discusses current strategies to improve donor liver quality and the challenges and benefits associated with different perfusion strategies.
JOURNAL OF HEPATOLOGY
(2023)
Review
Gastroenterology & Hepatology
Florent Artru, David Goldberg, Patrick S. Kamath
Summary: The authors debate whether patients with acute-on-chronic liver failure grade 3 (ACLF-3) should have higher liver transplant priority. They present a clinical case of a 62-year-old male with decompensated alcohol-associated cirrhosis and multiple comorbidities. The patient is at an exceedingly high risk of death without liver transplantation based on the severity of his liver disease and multiorgan failure.
JOURNAL OF HEPATOLOGY
(2023)
Review
Engineering, Biomedical
Robert Tatum, Daniella Wong, Paulo Martins, Vakhtang Tchantchaleishvili
Summary: This article evaluates the current status and future possibilities of artificial organ engineering, focusing on the features of mobility, compatibility, functionality, and material composition. The authors suggest that improving existing technologies and promoting multidisciplinary cooperation are necessary for advancing the field of artificial organs.
Review
Biochemistry & Molecular Biology
Rebecca Panconesi, Mauricio Flores Carvalho, Matteo Mueller, David Meierhofer, Philipp Dutkowski, Paolo Muiesan, Andrea Schlegel
Summary: Assessment and prediction of liver function is crucial due to the increase of donor risk and majority of marginal organs. Traditional tests require prolonged diagnostic time and are difficult to assess, while dynamic organ preservation strategies offer an opportunity to evaluate organs before implantation through analysis of recirculating perfusates, bile, and perfused liver tissue.
Review
Gastroenterology & Hepatology
Riccardo De Carlis, Paolo Muiesan, Burcin Taner
Summary: DCD grafts pose risks of complications and graft loss after liver transplantation due to prolonged functional donor warm ischaemia time. Improved outcomes have been achieved through stringent donor selection criteria and utilization of organ perfusion technologies. These technologies also enable liver function assessment and precise graft-recipient selection.
JOURNAL OF HEPATOLOGY
(2023)
Review
Surgery
Dieter Broering, Mark L. Sturdevant, Ahmed Zidan
Summary: Living donation is a crucial resource for organ transplantation, and advancements in minimally invasive surgical techniques are improving safety and outcomes for living donors. The introduction of robotic platforms with advanced instruments is allowing for better emulation of open surgeries in a closed abdomen, potentially leading to wider adoption of minimally invasive donor surgeries.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Jonathan Merola, Michael L. Schilsky, David C. Mulligan
Summary: The COVID-19 pandemic has significantly impacted organ transplantation processes, requiring new practice paradigms to address the challenges. These changes have affected the ability to treat organ failure patients and achieve expected outcomes for liver transplant recipients.
HEPATOLOGY COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Serban Puia-Negulescu, Fanny Lebosse, Jean-Yves Mabrut, Xavier Muller, Guillaume Rossignol, Teresa Antonini, Domitille Erard, Sylvie Radenne, Marielle Guillet, Jean-Christophe Souquet, Kayvan Mohkam, Mickael Lesurtel
Summary: Liver transplantation for patients with nonresectable liver metastases from colorectal cancer, although historically perceived poorly, is being revisited due to recent advances in chemotherapy and immunosuppression. Promising results have been shown in new data, which are currently undergoing validation in ongoing clinical trials. Given the scarcity of liver grafts, new tools are being explored to expand the donor pool for this indication.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, General & Internal
Mark Ly, Ngee-Soon Lau, Catriona Mckenzie, James G. Kench, Doruk Seyfi, Avik Majumdar, Ken Liu, Geoffrey Mccaughan, Michael Crawford, Carlo Pulitano
Summary: Histological assessment of bile duct injury is limited in predicting post-transplant biliary strictures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Mohamed Rela, Ashwin Rammohan
Summary: Liver transplantation is widely accepted as a treatment for end-stage liver disease, but the increasing demand for organs has led to a gap between supply and demand. The East tends to focus on living donor liver transplantation, while the West concentrates on optimizing the use of cadaveric livers. The differing approaches have resulted in varying levels of acceptance and utilization in different regions.
JOURNAL OF HEPATOLOGY
(2021)