Article
Integrative & Complementary Medicine
Jillian L. Capodice, Barbara M. Chubak
Summary: Traditional Chinese Medicine (TCM) is a comprehensive medical system that has been developed over thousands of years and is utilized in the treatment of COVID-19. This paper highlights the use of TCM in treating COVID-19, discussing concepts and challenges of integrating TCM into medical settings.
Review
Biochemistry & Molecular Biology
Matin Chehelgerdi, Fereshteh Behdarvand Dehkordi, Mohammad Chehelgerdi, Hamidreza Kabiri, Hosein Salehian-Dehkordi, Mohammad Abdolvand, Sharareh Salmanizadeh, Mohsen Rashidi, Anoosha Niazmand, Saba Ahmadi, Sara Feizbakhshan, Saber Kabiri, Nasimeh Vatandoost, Tayebeh Ranjbarnejad
Summary: The emergence of iPSCs has revolutionized stem cell research and opened up new avenues for cancer treatment. iPSCs provide a unique platform for investigating the origin of cancer and can be used for personalized treatment and drug testing. This review article discusses the science behind iPSCs, the limitations and challenges in iPSC-based cancer therapy, ethical and social implications, and a comparative analysis with other stem cell types for cancer treatment. It also explores the applications of iPSCs in tumorigenesis and the future of iPSC research in this field.
Review
Medicine, Research & Experimental
Qingru Sun, Shiyu Hu, Zhaohuan Lou, Jianli Gao
Summary: Inflammatory dermatosis is characterized by persistent inflammation and hard repair of the skin. Macrophage phenotype imbalance, caused by the increase of M1 macrophages or the decrease of M2 macrophages, is common in these skin conditions. Natural medicines/traditional Chinese medicines (TCMs) such as Shikonin and Angelica Dahurica have shown therapeutic effects by affecting macrophage polarization. This review provides insight into the polarization of macrophages in various inflammatory dermatosis and introduces potential therapeutic natural medicines/TCMs and their mechanisms of action.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Dustin Beyer, Jessica Hoff, Oliver Sommerfeld, Alexander Zipprich, Nikolaus Gassler, Adrian T. Press
Summary: This review investigates the impact of dysregulated host response on the liver, consequences for the immune response, and potential avenues for personalized therapeutics.
MOLECULAR MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Lei Li, Man Wang, Jikuai Chen, Juelin Chen, Yawei Wang, Minghao Zhao, Qing Song, Shuogui Xu
Summary: As global warming continues, heat waves are becoming more frequent and intense, leading to an increase in the incidence of heat stroke. Heat stroke is associated with significant morbidity and mortality, and further research is urgently needed to address this issue. Traditional Chinese medicine offers potential treatment methods, including herbal therapies and external treatments, which may provide clinical benefits and research directions for heat stroke.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Plant Sciences
Tingting Li, Si Gao, Wei Han, Zhenqiu Gao, Yundong Wei, Gang Wu, Wei Qiqiu, Li Chen, Yiping Feng, Shijiao Yue, Haixue Kuang, Xudong Jiang
Summary: Psoriasis is a chronic inflammatory dermatosis with increasing incidence. Chinese herbal medicine (CHM) has been considered as an alternative and efficient therapy for patients who are concerned about the side effects of synthetic drugs. CHM provides a diverse source for the development of anti-psoriatic drugs with fewer adverse reactions. This review comprehensively summarizes the existing therapeutic mechanisms of CHM in the treatment of psoriasis, including the suppression of oxidative stress, the inhibition of abnormal proliferation and differentiation, the inhibition of immune responses, and the suppression of angiogenesis. The positive reports about the treatment of psoriasis using CHM bring hope for its promising future in clinical therapy.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yi Cao, Long Xie, Kai Liu, Youdan Liang, Xiaolin Dai, Xian Wang, Jing Lu, Xumin Zhang, Xiaofang Li
Summary: With the aging population, hypertension has become a global health burden, and flavonoids in Chinese Herbal Medicine have been proven to have anti-hypertensive activities. However, more breakthrough studies are needed to support their clinical application for hypertension control.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Medicine, General & Internal
Nikola Zivadinovic, Regine Abrahamsen, Maiju Pesonen, Anthony Wagstaff, Kjell Toren, Paul K. Henneberger, Johny Kongerud, Anne Kristin Moeller Fell
Summary: This study aimed to analyze factors associated with non-participation in a population-based study of respiratory health in Norway. The results showed that gender, age, education level, smoking, and exposure to harmful substances were associated with loss to follow-up.
Review
Dermatology
Maximillian A. Weigelt, Raja Sivamani, Hadar Lev-Tov
Summary: The increasing legalization of Cannabis in the United States has sparked interest in the therapeutic potential of cannabinoids for human diseases. The skin's endocannabinoid system plays a key role in wound healing processes, and there is limited data on the use of cannabinoids for this purpose. Pre-clinical evidence supports the idea that cannabinoids may improve wound healing by modulating key molecular pathways, warranting further exploration in basic science, translational, and clinical studies.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Virology
Muhammad Shahzad, Huan Chen, Tasleem Akhtar, Ali Rafi, Muhammad Shoaib Zafar, Yong-Tang Zheng
Summary: This study explores the anti-HIV potential of various medicinal plant extracts and finds that they inhibit HIV replication in vitro with low cytotoxicity. These natural extracts have the potential to become complementary and alternative medicine for HIV infection.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Article
Pediatrics
Sheena Visram, Deirdre Leyden, Oceiah Annesley, Dauda Bappa, Neil J. Sebire
Summary: This article investigates the attitudes of children and young people towards the application of Artificial Intelligence (AI) in medicine and healthcare. It found that they were more open to certain applications of AI than others, with a focus on human-centeredness, governance, and trust. The article suggests that educational workshops and practical examples can help address concerns and build trust in AI.
PEDIATRIC RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Zhi-Hua Yang, Bin Wang, Qian Ma, Lin Wang, Ya-Xin Lin, Hai-Feng Yan, Zi-Xuan Fan, Hao-Jia Chen, Zhao Ge, Feng Zhu, Hui-Jie Wang, Bao-Nan Zhang, Hai-Dong Sun, Li-Min Feng
Summary: COVID-19 is an emergent infectious pneumonia caused by SARS-CoV-2, and Chinese patent medicines have played an important role in prevention and treatment with significant therapeutic efficacy. This study focuses on analyzing the potential targets, drug composition, and mechanisms of Chinese patent medicines to provide valuable information for their clinical application in COVID-19 treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemical Research Methods
Lidia Hermida-Nogueira, Angel Garcia
Summary: EVs released during blood component storage are still debated for their clinical impact in transfusions, but proteomics offers a valuable tool to study their cargo. Analyzing EVs with high coverage proteomic tools could provide insights into storage lesions and potential transfusion adverse reactions.
Review
Pharmacology & Pharmacy
Siu Kan Law, Yanping Wang, Xinchen Lu, Dawn Ching Tung Au, Wesley Yeuk Lung Chow, Albert Wing Nang Leung, Chuanshan Xu
Summary: Obesity is a global health threat and traditional Chinese medicine offers a potential solution, but there are still challenges that need to be addressed. Prodrugs could help overcome the deficiencies and provide insights for designing effective treatments for obesity.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Yueran Cui, Xuejiao Jiang, Juan Feng
Summary: Triptolide and celastrol, the main bioactive components of Tripterygium wilfordii Hook. F., have been found to have anti-inflammatory, immunosuppressive and anti-tumor effects, and can be used in the treatment of neurological diseases. This paper summarizes the preclinical studies of triptolide and celastrol in neurological diseases and reviews their mechanisms of action, toxicity, related derivatives, and nanotechnology-based carrier system.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zeynep Yilmaz, Matthew Halvorsen, Julien Bryois, Dongmei Yu, Laura M. Thornton, Stephanie Zerwas, Nadia Micali, Rainald Moessner, Christie L. Burton, Gwyneth Zai, Lauren Erdman, Martien J. Kas, Paul D. Arnold, Lea K. Davis, James A. Knowles, Gerome Breen, Jeremiah M. Scharf, Gerald Nestadt, Carol A. Mathews, Cynthia M. Bulik, Manuel Mattheisen, James J. Crowley
MOLECULAR PSYCHIATRY
(2020)
Article
Biochemical Research Methods
Sahar Gelfman, Quanli Wang, Yi-Fan Lu, Diana Hall, Christopher D. Bostick, Ryan Dhindsa, Matt Halvorsen, K. Melodi McSweeney, Ellese Cotterill, Tom Edinburgh, Michael A. Beaumont, Wayne N. Frankel, Slave Petrovski, Andrew S. Allen, Michael J. Bolandi, David B. Goldstein, Stephen J. Eglen
PLOS COMPUTATIONAL BIOLOGY
(2018)
Article
Genetics & Heredity
David Mataix-Cols, Bjarne Hansen, Manuel Mattheisen, Elinor K. Karlsson, Anjene M. Addington, Julia Boberg, Diana R. Djurfeldt, Matthew Halvorsen, Paul Lichtenstein, Stian Solem, Kerstin Lindblad-Toh, Jan Haavik, Gerd Kvale, Christian Ruck, James J. Crowley, Hyun Ji Noh, Anna K. Kahler, Elles de Schipper, Tetyana Zayats
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
(2020)
Article
Genetics & Heredity
Colin K. L. Phoon, Matthew Halvorsen, David B. Goldstein, Rachel Rabin, Frank Cecchin, Laura Crandall, Orrin Devinsky
MOLECULAR GENETICS & GENOMIC MEDICINE
(2020)
Article
Hematology
Karl C. Desch, Ayse B. Ozel, Matt Halvorsen, Paula M. Jacobi, Krista Golden, Mary Underwood, Marine Germain, David-Alexandre Tregouet, Pieter H. Reitsma, Clive Kearon, Lauren Mokry, J. Brent Richards, Frances Williams, Jun Z. Li, David Goldstein, David Ginsburg
Article
Multidisciplinary Sciences
Matthew Halvorsen, Ruth Huh, Nikolay Oskolkov, Jia Wen, Sergiu Netotea, Paola Giusti-Rodriguez, Robert Karlsson, Julien Bryois, Bjorn Nystedt, Adam Ameur, Anna K. Kahler, NaEshia Ancalade, Martilias Farrell, James J. Crowley, Yun Li, Patrik K. E. Magnusson, Ulf Gyllensten, Christina M. Hultman, Patrick F. Sullivan, Jin P. Szatkiewicz
NATURE COMMUNICATIONS
(2020)
Review
Psychology, Clinical
Laura Domenech, Carolina Cappi, Matt Halvorsen
Summary: Tourette syndrome is a severe neuropsychiatric disorder with a prevalence of 1% in children, and genetic factors play an important role in the overall risk architecture.
PSYCHOLOGICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Matthew Halvorsen, Jin Szatkiewicz, Poorva Mudgal, Dongmei Yu, Ashley E. Nordsletten, David Mataix-Cols, Carol A. Mathews, Jeremiah M. Scharf, Manuel Mattheisen, Mary M. Robertson, Andrew McQuillin, James J. Crowley
Summary: Tourette syndrome (TS) is a highly heritable neuropsychiatric disorder with complex genetic patterns. Genetic studies in a large affected British pedigree showed that the risk for TS in this family is associated with a higher load of common genetic variants rather than rare variants of strong effect.
MOLECULAR PSYCHIATRY
(2021)
Article
Neurosciences
Mathew Halvorsen, Jack Samuels, Ying Wang, Benjamin D. Greenberg, Abby J. Fyer, James T. McCracken, Daniel A. Geller, James A. Knowles, Anthony W. Zoghbi, Tess D. Pottinger, Marco A. Grados, Mark A. Riddle, O. Joseph Bienvenu, Paul S. Nestadt, Janice Krasnow, Fernando S. Goes, Brion Maher, Gerald Nestadt, David B. Goldstein
Summary: An analysis of the largest exome sequencing dataset of individuals with obsessive-compulsive disorder reveals that rare damaging coding variants play a role in disease risk, as supported by both case-control and de novo variant studies. This study provides insights into the genetic factors contributing to OCD and highlights the significance of rare coding variants in its development.
NATURE NEUROSCIENCE
(2021)
Article
Genetics & Heredity
Nora Strom, Jakob Grove, Sandra M. Meier, Marie Baekvad-Hansen, Judith Becker Nissen, Thomas Damm Als, Matthew Halvorsen, Merete Nordentoft, Preben B. Mortensen, David M. Hougaard, Thomas Werge, Ole Mors, Anders D. Borglum, James J. Crowley, Jonas Bybjerg-Grauholm, Manuel Mattheisen
Summary: The study found a high genetic correlation between obsessive-compulsive disorder (OCD) and other psychiatric disorders, with comorbidities such as major depressive disorder, attention-deficit hyperactivity disorder, and autism spectrum disorder showing significant genetic overlap. Polygenic risk scores (PRS) of various traits were associated with OCD across all subgroups, indicating both quantitative and qualitative polygenic heterogeneity among OCD comorbid subgroups.
FRONTIERS IN GENETICS
(2021)
Article
Psychiatry
Behrang Mahjani, Lambertus Klei, Manuel Mattheisen, Matthew W. Halvorsen, Abraham Reichenberg, Kathryn Roeder, Nancy L. Pedersen, Julia Boberg, Elles de Schipper, Cynthia M. Bulik, Mikael Landen, Bengt Fundin, David Mataix-Cols, Sven Sandin, Christina M. Hultman, James J. Crowley, Joseph D. Buxbaum, Christian Ruck, Bernie Devlin, Dorothy E. Grice
Summary: This study estimated the heritability of OCD using two homogeneous cohorts and found that common inherited risk variation accounted for most of the heritable variation in OCD. Contrary to previous studies, SNPs with low MAF also made meaningful contributions to the heritability of OCD. These results support the expectation of the polygenic model for OCD inheritance.
AMERICAN JOURNAL OF PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Matthew Halvorsen, Laura Gould, Xiaohan Wang, Gariel Grant, Raquel Moya, Rachel Rabin, Michael J. Ackerman, David J. Tester, Peter T. Lin, John G. Pappas, Matthew T. Maurano, David B. Goldstein, Richard W. Tsien, Orrin Devinsky
Summary: A study found enrichment of unique mutations in genes associated with cardiac and seizure disorders in SUDC patients, suggesting a potential genetic contribution to their death.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Psychology, Clinical
Zeynep Yilmaz, Katherine Schaumberg, Matthew Halvorsen, Erica L. Goodman, Leigh C. Brosof, James J. Crowley, Carol A. Mathews, Manuel Mattheisen, Gerome Breen, Cynthia M. Bulik, Nadia Micali, Stephanie C. Zerwas
Summary: This study found a genetic overlap between anorexia nervosa (AN), obsessive-compulsive disorder (OCD), and anxiety symptoms, with a potential sex-specific contribution of genetic risk. AN and AN/OCD polygenic scores (PGS) played a more prominent role in predicting eating disorder and anxiety symptoms, while OCD PGS had a smaller effect. The results also suggest that compulsive exercise may have a transdiagnostic genetic etiology.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Neurosciences
M. L. Davenport, E. Cornea, K. Xia, J. J. Crowley, M. W. Halvorsen, B. D. Goldman, D. Reinhartsen, M. DeRamus, R. Pretzel, M. Styner, J. H. Gilmore, S. R. Hooper, R. C. Knickmeyer
Article
Education, Scientific Disciplines
Laura MacDonald, Veronica A. Segarra, Amanda Solem
JOURNAL OF MICROBIOLOGY & BIOLOGY EDUCATION
(2019)