Article
Pharmacology & Pharmacy
Yu Xiong, Xiaoxing Wang, Shu Li, Qian Zhang, Lijuan Guo, Wenhui Chen, Zhixia Zhao, Lihong Liu
Summary: This case report highlights a drug interaction in a lung transplant patient who self-administered Paxlovid for COVID-19 without discontinuing tacrolimus. The patient experienced tacrolimus toxicity due to the elevated plasma concentration caused by the interaction. Urgent medical intervention and dosage adjustment effectively managed the situation. Medication education for transplant patients is crucial in preventing such interactions.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Immunology
Juan Hu, Yong-Wei Yu, Dong-Sheng Han, Xue-Jie Li, Yi-Qi Zhang, Hong-Liu Cai, Yong-Hong Xiao, Xia Zheng
Summary: This study describes a lung transplant recipient who developed EBV-associated PTLD, highlighting the importance of monitoring EBV-DNA load as a sensitive indicator for early diagnosis and treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Gowri Shivasabesan, Bentley Logan, Xavier Brennan, Cindy Lau, Anagha Vaze, Michael Bennet, Natasha Gorrie, Feras Mirdad, Ricardo Deveza, Chung Mo Koo, Peter McCluskey, Peter Macdonald, Deborah Marriott, Kavitha Muthiah, Nila Dharan
Summary: This article presents the first published case of a successfully treated disseminated Aspergillus lentulus infection in a solid organ transplant recipient with invasive pulmonary disease, endophthalmitis, and a cerebral abscess. It highlights important challenges associated with the treatment of Aspergillus lentulus, particularly in relation to antifungal resistance and the toxicities associated with long-term antifungal therapy.
CLINICAL INFECTIOUS DISEASES
(2022)
Editorial Material
Critical Care Medicine
Daniel Loeb, Charles Spear, Don Hayes
Summary: This case describes a 27-year-old man with a history of bronchiolitis obliterans and lung transplantation who presented with worsening mental status and hypotension.
Review
Biochemistry & Molecular Biology
Silvia Preda, Lucian Calmac, Claudia Nica, Mihai Cacoveanu, Robert Tiganasu, Aida Badea, Alexandru Zaman, Raluca Ciomag (Ianula), Claudiu Nistor, Bogdan Severus Gaspar, Luminita Iliuta, Lucian Dorobantu, Vlad Anton Iliescu, Horatiu Moldovan
Summary: This paper discusses the challenges introduced by the inclusion of marginal donors in heart transplants and the effectiveness of transcatheter aortic valve implantation (TAVI) as a treatment.
Article
Urology & Nephrology
Izabela Zakrocka, Iwona Baranowicz-Gaszczyk, Wojciech Zaluska
Summary: Iron overload, such as haemochromatosis, can occur in heterozygotic HFE patients after kidney transplantation. Potential triggers of haemochromatosis in this group of patients include iron administration, infections, type of immunosuppression, and liver dysfunction. Treatment such as therapeutic phlebotomy can significantly improve graft function and resolve haemochromatosis symptoms.
Article
Medical Laboratory Technology
Alessia Guerra-Martinuzzi, Fernando Pampin-Conde, Eva Alvarez-Suarez, Teresa Pernas-Bodelo, Mar Calvo-Malvar
Summary: This case report describes an unexpected interference in tacrolimus monitoring using the modified ACMIA method in a kidney transplant recipient, highlighting the importance of careful interpretation of laboratory results and effective communication with clinicians.
CLINICA CHIMICA ACTA
(2023)
Article
Medicine, General & Internal
Bijun Xu, Weimin Zhang, Ximing Qian, Shiqiang Wang, Fan He
Summary: Patients may develop severe anemia due to B19V infection after heart transplantation, with diagnosis relying on viral DNA detection and successful treatment achieved with intravenous immunoglobulin.
Article
Public, Environmental & Occupational Health
Maha Alamri, Ahmed M. Albarrag, Haitham Khogeer, Jehad Alburaiki, Magid Halim, Reem S. Almaghrabi
Summary: A case of disseminated histoplasmosis in a heart transplant recipient outside known endemic areas was successfully treated with Liposomal Amphotericin and Itraconazole, showing significant improvement in symptoms, possibly due to reactivation of latent infection.
JOURNAL OF INFECTION AND PUBLIC HEALTH
(2021)
Article
Immunology
Evaldo Favi, Paolo Molinari, Carlo Alfieri, Giuseppe Castellano, Mariano Ferraresso, Donata Cresseri
Summary: The use of eculizumab in kidney transplantation has reduced the incidence of relapsing aHUS, but the management of aHUS transplant candidates with anti-CFH antibodies is still debated. We present a case of a successful kidney transplant in a patient with elevated anti-CFH antibodies, using eculizumab and obinutuzumab. The patient had a good outcome with undetectable anti-CFH antibodies, B-cell depletion, and no signs of aHUS activity.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jianghua Li, Qiyun Liu, Quanzhou Peng, Shaohong Dong
Summary: Primary cardiac lymphomas (PCLs) are extremely rare and have a poor prognosis. This case report describes a patient with a history of liver transplantation who developed a huge cardiac mass within a short period of time and passed away shortly after hospitalization. The diagnosis of diffuse large B-cell lymphoma (DLBCL) was confirmed postmortem using histological examination and non-invasive cardiac imaging.
FRONTIERS IN ONCOLOGY
(2022)
Article
Medicine, General & Internal
Yu-Jen Chen, Chien-Sung Tsai, Tsai-Wang Huang
Summary: Heart transplantation is recommended for patients with refractory heart failure. Chest pain post-transplantation is usually noncardiac, but tacrolimus-induced achalasia is a potential complication. Case reports suggest that laparoscopic Heller myotomy can successfully relieve symptoms.
WORLD JOURNAL OF CLINICAL CASES
(2021)
Article
Medicine, General & Internal
Dorina Supak, Balazs Meszaros, Marta Nagy, Daniel Gaspar, Laszlo J. Wagner, Zoltan Kukor, Sandor Valent
Summary: Studies on the effects of COVID-19 infection on immunocompromised patients and pregnant women are limited. This study reports a case of a kidney transplant woman who developed preeclampsia and underwent artificial termination of gestation after contracting COVID-19, highlighting the severe impact of COVID-19 on individuals with underlying conditions.
FRONTIERS IN MEDICINE
(2022)
Article
Immunology
Harpreet Singh Grewal, Renu K. Virk, Maggie E. Carroll, Luke J. Benvenuto, Hilary Robbins, Lori Shah, Frank D'Ovidio, Selim M. Arcasoy
Summary: Lung nodules or masses can occur after lung transplant and can be caused by various malignant or benign conditions, including opportunistic infections. In this study, we report the clinical course and management of a lung transplant recipient with pulmonary malakoplakia and provide a literature review. This is the first reported case of pulmonary malakoplakia in a lung allograft caused by Escherichia coli infection.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Immunology
Katherine W. W. Dewey, Bo Yen, Jose Lazo, Leslie Seijo, Ripal Jariwala, Rupal J. J. Shah, David Quan, Bethanne Carpenter, Jonathan Paul Singer, Karen Breen, Steven Hays, Rebecca Florez
Summary: This study showed that nirmatrelvir/ritonavir can be safely used in lung transplant recipients stabilized on tacrolimus with close monitoring of tacrolimus levels and appropriate dose adjustments. Further research is needed to determine the optimal therapeutic drug monitoring and tacrolimus dose following nirmatrelvir/ritonavir therapy in solid organ transplant recipients.
