Article
Surgery
Sarah C. McKay, Christy M. Dunst, Ahmed M. Sharata, Reid Fletcher, Kevin M. Reavis, Daniel Davila Bradley, Steven R. DeMeester, Dolores Muller, Brett Parker, Lee L. Swanstrom
Summary: The study demonstrates that POEM treatment for esophageal motility disorders has a long-term clinical success rate of nearly 80%, indicating that POEM is an effective treatment option with durable long-term efficacy for patients with achalasia.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Orthopedics
Raul Torres-Claramunt, Rodolfo Morales-Avalos, Simone Perelli, Jose Ramon Padilla-Medina, Joan Carles Monllau
Summary: Meniscal allograft transplantation (MAT) produces good functional results at a minimum 15-year follow-up, but degenerative arthritis in the affected compartment progresses during that period.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2023)
Article
Surgery
Paul H. Mcclelland, Mohsin Jawed, Krystyna Kabata, Michael E. Zenilman, Piotr Gorecki
Summary: This study prospectively reports weight loss and comorbidity resolution in patients undergoing LRYGB with at least 15-year follow-up. The results show durable weight loss and long-term resolution of obesity-related comorbidities after LRYGB for at least 15 years.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2023)
Review
Biology
Juan David Cala-Garcia, German Jose Medina-Rincon, Paula Andrea Sierra-Salas, Julio Rojano, Freddy Romero
Summary: This article provides an overview of the various mechanisms of mitochondrial dysfunction in idiopathic pulmonary fibrosis (IPF) and explores potential therapeutic interventions.
Article
Pediatrics
Sarah Jane Driscoll, Katie Heinz, Philippa Goddard, Maya Desai, Francis J. Gilchrist
Summary: This study reviewed the outcomes of CF newborn bloodspot screening in the West Midlands from November 1, 2006 to October 31, 2021, with 1075161 babies screened. Among them, 268 were diagnosed with CF, 33 with CFSPID, and 17 as CF carriers, giving a CF birth prevalence of 1 in 4012.
ARCHIVES OF DISEASE IN CHILDHOOD
(2023)
Article
Multidisciplinary Sciences
Sonia Bernardo, Ricardo Crespo, Sofia Saraiva, Rui Barata, Sara Goncalves, Paulo Nogueira, Helena Cortez-Pinto, Mariana Verdelho Machado
Summary: The study shows that 6% of long-term heavy drinkers without evidence of chronic liver disease progressed to CLD, with cancer being the main cause of death. Abstinence for at least 1 year was positively associated with both CLD-free survival and overall survival.
Review
Medicine, Research & Experimental
James May, Jane A. Mitchell, R. Gisli Jenkins
Summary: Idiopathic pulmonary fibrosis (IPF) is a progressive scarring disease of the lung with limited treatment options. This article proposes that vascular and endothelial cell abnormalities play a significant role in the pathobiology of IPF and calls for a comprehensive evaluation of these dysregulated pathways to find effective therapies and a cure for this devastating disease.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Immunology
Mengshu Cao, Lina Gu, Lili Guo, Mengying Liu, Tianzhen Wang, Ji Zhang, Huizhe Zhang, Yufeng Zhang, Yanchen Shi, Yichao Zhao, Xiaohua Qiu, Xianhua Gui, Miao Ma, Yaqiong Tian, Xiaoqin Liu, Fanqing Meng, Yonglong Xiao, Lingyun Sun
Summary: The level of GDF-15 is significantly elevated in patients with acute exacerbation of idiopathic pulmonary fibrosis (AE-IPF) and is related to disease severity and survival. Serum GDF-15 level may be a potential biomarker for AE occurrence and survival in IPF patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Anna Astashchanka, Kim M. Kerr, Jenny Z. Yang, Angela Bautista, Demosthenes G. Papamatheakis, David S. Poch, Nick H. Kim, Victor G. Pretorius, Michael M. Madani, Timothy M. Fernandes
Summary: This study retrospectively analyzed the risk factors and outcomes of patients undergoing repeat pulmonary thromboendarterectomy and compared them with those undergoing the first surgery. The results showed that patients in the repeat surgery group were younger, more likely to have a hypercoagulable state, and had higher preoperative right atrial pressure. Despite an increased risk of postoperative complications, repeat pulmonary thromboendarterectomy surgery can still achieve significant hemodynamic improvement in experienced centers.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2023)
Article
Critical Care Medicine
Sadudee Peerapornratana, Marco Fiorentino, Priyanka Priyanka, Raghavan Murugan, John A. Kellum
Summary: This study aimed to investigate the impact of kidney recovery on mortality, dialysis, and kidney transplantation up to 15 years after AKI. The findings showed that the recovery status of AKI at hospital discharge was associated with long-term mortality, with the highest mortality rate observed in patients who did not recover. These results have important implications for acute care, follow-up, and endpoint selection in clinical trials.
JOURNAL OF CRITICAL CARE
(2023)
Article
Biochemistry & Molecular Biology
Jing Gao, Weili Chu, Jiali Duan, Junlu Li, Wentao Ma, Chunling Hu, Mengying Yao, Lihua Xing, Yuejie Yang
Summary: Research indicates that survivors with pulmonary fibrosis after H1N1 influenza have lower health-related quality of life scores compared to age and sex-matched controls. The 6-minute walk test and CT scores continue to be affected by the condition even after 6 months, with improvements in walking distance and imaging findings during the initial 6-month period.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Gastroenterology & Hepatology
Emily R. Perito, Elodie Persyn, John Bucuvalas, Mercedes Martinez, Saeed Mohammad, James E. Squires, Anthony J. Demetris, Sandy Feng
Summary: A multicenter study of paired surveillance biopsies in a contemporary cohort revealed a steep increase in the prevalence and severity of fibrosis through 10 to 15 years after pediatric liver transplantation. However, the fibrosis prevalence and severity during the next 4 to 5 years remained stable, providing reassurance for children with consistently normal liver tests.
LIVER TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Robert Pruna-Guillen, Daniel Pereda, Manuel Castella, Elena Sandoval, Alessandro Affronti, Ana Garcia-Alvarez, Juan Perdomo, Cristina Ibanez, Paloma Jorda, Susanna Prat-Gonzalez, Jorge Alcocer, Clemente Barriuso, Jaume Llopis, Eduard Quintana
Summary: This study evaluated the outcomes of septal myectomy in patients over 65 years old, showing that the procedure is safe and effective with no perioperative mortality. Postoperatively, there was a high rate of obstruction resolution and a significant improvement in mitral regurgitation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Oncology
Bettina Drake, Aimee James, Heidi Miller, Akila Anandarajah, Kia L. Davis, Sheryll Jackson, Graham A. Colditz, Vetta Sanders Thompson
Summary: Breast cancer is a leading cause of death in women in the United States, with disparities existing in outcomes. Over the past 15+ years, Siteman Cancer Center has made efforts to address these disparities by partnering with community organizations and providing mobile mammography vans to improve community health outcomes.
Article
Respiratory System
Stephen M. Humphries, John A. Mackintosh, Helen E. Jo, Simon L. F. Walsh, Mario Silva, Lucio Calandriello, Sally Chapman, Samantha Ellis, Ian Glaspole, Nicole Goh, Christopher Grainge, Peter M. A. Hopkins, Gregory J. Keir, Yuben Moodley, Paul N. Reynolds, E. Haydn Walters, David Baraghoshi, Athol U. Wells, David A. Lynch, Tamera J. Corte
Summary: This study assessed the prognostic value of quantifying lung fibrosis extent using data-driven texture analysis (DTA) in a large cohort of idiopathic pulmonary fibrosis (IPF) patients. The results showed that the extent of fibrotic abnormality on baseline CT analyzed via DTA was associated with outcomes independent of pulmonary function.
Article
Respiratory System
John Wilson, Xiaojun You, Matt Ellis, Don S. Urquhart, Lokesh Jha, Margaret Duncan, Simon Tian, Ryan A. Harris, Tom Kotsimbos, Dominic Keating
Summary: This study investigated the impact of lumacaftor/ivacaftor on exercise tolerance in individuals with cystic fibrosis, with results suggesting that definitive conclusions cannot be drawn at this time. However, multicenter studies using CPET show promise for reliable assessments of exercise tolerance in this population.
JOURNAL OF CYSTIC FIBROSIS
(2021)
Article
Nutrition & Dietetics
Susannah J. King, Audrey C. Tierney, Deirdre Edgeworth, Dominic Keating, Elyssa Williams, Tom Kotsimbos, Brenda M. Button, John W. Wilson
Summary: Ivacaftor treatment led to initial gains in fat-free mass in the first month, with weight, BMI, and fat mass increases plateauing within the first 6 months and remaining stable over 2.5 years. The long-term metabolic and clinical implications of weight and fat mass gains are still unknown.
Article
Medicine, General & Internal
Peter J. Barry, Marcus A. Mall, Antonio Alvarez, Carla Colombo, Karin M. de Winter-de Groot, Isabelle Fajac, Kimberly A. McBennett, Edward F. McKone, Bonnie W. Ramsey, Sivagurunathan Sutharsan, Jennifer L. Taylor-Cousar, Elizabeth Tullis, Neil Ahluwalia, Lucy S. Jun, Samuel M. Moskowitz, Valentin Prieto-Centurion, Simon Tian, David Waltz, Fengjuan Xuan, Yaohua Zhang, Steven M. Rowe, Deepika Polineni
Summary: The study showed that Elexacaftor-ivacaftor-tezacaftor is effective in cystic fibrosis patients with Phe508del-gating or Phe508del-residual function genotypes, providing additional benefits compared to previous CFTR modulators.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Pediatrics
Lisa M. Wilson, Matthew J. Ellis, Rebecca L. Lane, John W. Wilson, Dominic T. Keating, Shapour Jaberzadeh, Brenda M. Button
Summary: The study developed a new incremental maximal step test (A-STEP) to assess exercise capacity in pwCF, avoiding floor or ceiling effects, while addressing space restrictions and infection prevention requirements.
PEDIATRIC PULMONOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Warren Clements, Georgina Venn, David McGiffin, Heather K. Moriarty, Tim Joseph, Gerard S. Goh, Helen Whitford, Dominic Keating
Summary: This study highlights the low but important incidence of massive hemoptysis in patients with CTEPH. Unlike other causes of hemoptysis, this unique cohort requires balancing anticoagulation and hemorrhage control. BAE is a viable option with a high degree of success.
RESPIRATORY MEDICINE
(2022)
Article
Respiratory System
Dirk Van Raemdonck, Laurens J. Ceulemans, Arne Neyrinck, Bronwyn Levvey, Gregory I. Snell
Summary: The shortage of pulmonary grafts has led to a renewed interest in lungs from DCDs, with controlled DCDs showing the most promise. New techniques are available for selecting high-quality donor lungs before transplantation. Many countries need to address barriers in the DCD pathway to fully utilize this potential lung donor pool.
THORACIC SURGERY CLINICS
(2022)
Article
Respiratory System
Audrey K. Grech, Dominic T. Keating, Daniel J. Garner, Matthew T. Naughton
Summary: This study observed that chronic carbon monoxide poisoning caused by vaping can lead to the development of cardiorespiratory disease. Further research on the safety of vaping and chronic CO exposure is needed.
RESPIROLOGY CASE REPORTS
(2022)
Letter
Medicine, General & Internal
Krita Sridharan, Dominic T. Keating
INTERNAL MEDICINE JOURNAL
(2022)
Article
Pediatrics
Lisa M. Wilson, Angela Potter, Carol Maher, Matthew J. Ellis, Rebecca L. Lane, John W. Wilson, Dominic T. Keating, Shapour Jaberzadeh, Brenda M. Button
Summary: This study evaluated the feasibility of the Alfred Step Test Exercise Protocol (A-STEP) for assessing exercise capacity in adults and children with cystic fibrosis (CF). The results showed that the A-STEP was a feasible and safe method for assessing exercise capacity, without floor or ceiling effects. In adults, lung function was found to be correlated with exercise capacity.
PEDIATRIC PULMONOLOGY
(2022)
Editorial Material
Respiratory System
Dominic Thomas Keating, John Taverner
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Sahan Chandrasekara, Edmund M. Lau, James Anderson, Nicholas Collins, Rachael Cordina, Carolyn Corrigan, Nathan Dwyer, John Feenstra, Mark Horrigan, Anne Keogh, Eugene Kotlyar, Melanie Lavender, Tanya McWilliams, Bronwen Rhodes, Peter Steele, Geoff Strange, Vivek Thakkar, Robert Weintraub, Helen Whitford, Kenneth Whyte, Trevor Williams, Jeremy Wrobel, Dominic T. Keating
Summary: This study analyzed registry data from pulmonary arterial hypertension patients in Australia and New Zealand and found that the use of vasoreactivity testing and calcium channel blockers is low. However, in patients who underwent vasoreactivity testing and received calcium channel blockers, the survival rate was high, supporting the guidelines promoting vasoreactivity testing.
HEART LUNG AND CIRCULATION
(2023)
Article
Cardiac & Cardiovascular Systems
David Ross Darley, Kris Nilsen, Jaideep Vazirani, Brigitte M. Borg, Bronwyn Levvey, G. Snell, Marshall Lawrence, Katrina O. Tonga
Summary: This study aims to describe and measure the association between airway oscillometry parameters and baseline lung allograft dysfunction (BLAD). The results showed that lower Xrs5 Z-score was independently associated with BLAD in stable lung transplant recipients. Lower Xrs5 Z-score was also associated with BLAD in recipients with chronic lung allograft dysfunction (CLAD).
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2023)
Article
Surgery
Joan P. Y. Sim, Kristopher Nilsen, Brigitte M. Borg, Bronwyn Levvey, Jaideep Vazirani, Samantha Ennis, Marshall Plit, Gregory I. Snell, David R. Darley, Katrina O. Tonga
Summary: This study assessed respiratory mechanics in patients with interstitial lung disease after single lung transplantation and double lung transplantation. The results showed that lung function was significantly lower after single lung transplantation compared to double lung transplantation, while resistance was similar but reactance was significantly worse. The model results were consistent with the actual measurements. These findings suggest the important role of elastic properties in the pathophysiology, and oscillometry may provide further insight into physiological changes after transplantation.
TRANSPLANT INTERNATIONAL
(2023)
Article
Respiratory System
Brenda M. Button, Lisa M. Wilson, Angela T. Burge, Lara Kimmel, Felicity Finlayson, Elyssa Williams, Anthony Talbot, Audrey Tierney, Susannah King, Anne E. Holland, Dominic Keating, Tom Kotsimbos, John W. Wilson
Summary: The study evaluated the utility of AWESCORE in adults with CF by measuring reliability, validity, and responsiveness, and found that this method is valid, reliable, and responsive to changes in health status in CF. AWESCORE can effectively differentiate between clinical stability and pulmonary exacerbation, and is moderately correlated with CFQ-R scores.
Article
Respiratory System
Susannah J. King, Dominic Keating, Elyssa Williams, Eldho Paul, Brigitte M. Borg, Felicity Finlayson, Brenda M. Button, John W. Wilson, Tom Kotsimbos
Summary: This study assessed the clinical utility of Lumacaftor/Ivacaftor (LUM/IVA) in adult CF patients with severe lung disease, showing benefits in reducing infective exacerbations requiring hospitalization, days of intravenous antibiotic usage, decline in pulmonary function, and improvement in nutritional parameters.