Review
Medicine, General & Internal
Tatsuya Okamoto, Hideaki Okajima, Elena Yukie Uebayashi, Eri Ogawa, Yosuke Yamada, Katsutsugu Umeda, Hidefumi Hiramatsu, Etsurou Hatano
Summary: With the advancement of immunosuppressive strategies, liver transplantation outcomes have improved significantly in children. However, Epstein-Barr virus infection and post-transplant lymphoproliferative diseases (PTLD), such as malignant lymphoma, remain serious complications that contribute to morbidity and mortality. Recently, early diagnosis through quantitative PCR and PET-CT testing, as well as treatment with rituximab, have shown promising results in achieving long-term remission. However, determining the optimal immunosuppression protocol after PTLD remission and finding treatments for refractory PTLD (e.g., PTL-NOS) are still areas of focus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Thomas Pfeiffer, Ifigeneia Tzannou, Mengfen Wu, Carlos Ramos, Ghadir Sasa, Caridad Martinez, Premal Lulla, Robert A. Krance, Lauren Scherer, Daniel Ruderfer, Swati Naik, Claire Bocchini, Iain P. Fraser, Badrish Patel, Dany Ward, Tao Wang, Helen E. Heslop, Ann M. Leen, Bilal Omer
Summary: This study aimed to evaluate the feasibility and safety of posoleucel in allo-HCT recipients infected with viral infections. The results showed that posoleucel had good tolerability and achieved significant efficacy in treating multiple viral infections.
CLINICAL CANCER RESEARCH
(2023)
Article
Multidisciplinary Sciences
Deborah K. Johnson, Kaylia M. Reynolds, Brian D. Poole, Matthew D. Montierth, Vera M. Todd, April Barnado, Mary F. Davis
Summary: Patients with autoimmune disorders have altered cancer risks compared to the general population, with a strong association between viral infection and increased cancer risk. SLE and MS patients are more susceptible to viral infections, and preventing viral infections through vaccination may help control cancer risk for these patients.
Article
Pediatrics
Elodie Cheyssac, Hamidou Savadogo, Nathan Lagoutte, Veronique Baudouin, Marina Charbit, Robert Novo, Anne-Laure Sellier-Leclerc, Marc Fila, Stephane Decramer, Elodie Merieau, Ariane Zaloszyc, Jerome Harambat, Gwenaelle Roussey
Summary: In this retrospective study, the effectiveness of valganciclovir (VGC) prophylaxis in preventing Epstein-Barr Virus (EBV) infection in pediatric kidney transplant recipients was investigated. The results showed that VGC prophylaxis did not decrease the incidence of EBV infection, but increased the risk of adverse effects such as neutropenia.
FRONTIERS IN PEDIATRICS
(2023)
Article
Pharmacology & Pharmacy
Hao Ji, Taihua Yang, Chunlai Li, Youwei Zhu, Zhigang Zheng, Jiaxu Zhang, Yuan Liu, Yijin Gao, Huimin Wu, Jinxing Jiang, Junekong Yong, Mengke Chen, Yuanjia Tang, Qiang Xia, Feng Xue
Summary: Post-transplant lymphoproliferative disorder (PTLD) is a serious complication after transplantation, with 80% of patients being positive for Epstein-Barr virus (EBV). However, monitoring EBV DNA load for preventing and diagnosing EBV-PTLD has limited accuracy. Therefore, there is an urgent need for new diagnostic molecular markers. This study discovered that BHRF1-1 and BART2-5p, elevated in EBV-PTLD patients, promote proliferation and suppress apoptosis. Mechanistically, they inhibit the tumor suppressor gene LZTS2 and activate the PI3K-AKT pathway. These findings suggest that BHRF1-1 and BART2-5p could serve as potential diagnostic markers and therapeutic targets for EBV-PTLD.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Surgery
Masaki Yamada, Camila Macedo, Kevin Louis, Tiange Shi, Douglas Landsittel, Christina Nguyen, Masayoshi Shinjoh, Marian G. Michaels, Brian Feingold, George V. Mazariegos, Michael Green, Diana Metes
Summary: Chronic Epstein-Barr virus (EBV) infection is a significant problem after pediatric organ transplantation, especially in heart transplant recipients with high viral load. This study analyzed the immune characteristics of CD8(+)/CD4(+) T cells in pediatric heart, kidney, and liver transplant recipients, and identified distinct phenotypic and transcriptomic profiles in heart HVL carriers. The results suggest different incidences of EBV complications and provide insights for risk stratification and clinical management in different types of transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Immunology
Mariann Gyoengyoesi, Dominika Lukovic, Julia Mester-Tonczar, Katrin Zlabinger, Patrick Einzinger, Andreas Spannbauer, Victor Schweiger, Katharina Schefberger, Eslam Samaha, Jutta Bergler-Klein, Martin Riesenhuber, Christian Nitsche, Christian Hengstenberg, Patrick Mucher, Helmuth Haslacher, Monika Breuer, Robert Strassl, Elisabeth Puchhammer-Stoeckl, Christian Loewe, Dietrich Beitzke, Ena Hasimbegovic, Thomas A. Zelniker
Summary: This study evaluated the reactivation of parvovirus-B19 and Herpesviridae family members in patients with long-COVID syndrome and found that vaccination with monovalent COVID-19 vaccines was associated with reduced fatigue and multiorgan symptoms. It also led to lower levels of DNA virus-related IgM, plasma IgG subfractions, cytomegalovirus IgG and IgM, and EBV IgM titers.
Article
Microbiology
Katherine A. Willard, Ashley P. Barry, Cliff I. Oduor, John Michael Ong'echa, Jeffrey A. Bailey, Ann M. Moormann, Micah A. Luftig
Summary: In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. These findings provide insight into viral and host factors involved in this process and the potential contribution of promiscuous lytic activity to the formation of EBV-associated diseases.
Article
Pediatrics
Song Mao, Liangxia Wu, Wenjing Shi
Summary: This study investigated the incidence, characteristics, and potential risk factors for liver injury in EBV infection. The results showed that cytomegalovirus infection and white blood cell count were independently associated with liver injury in EBV infection. Decision curve analysis revealed that white blood cell count had a higher value in predicting liver injury compared to other parameters.
ITALIAN JOURNAL OF PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Paulina Mertowska, Konrad Smolak, Sebastian Mertowski, Ewelina Grywalska
Summary: Interferons are immunomodulatory substances produced by the human immune system to fight infections. This review focuses on the interplay between the IFN system and medically important viruses such as HSV, influenza, HCV, LCMV, HIV, EBV, and SARS-CoV coronavirus, highlighting viral diversity. Research is ongoing to identify the specific genes and pathways involved in the antimicrobial response mediated by IFNs. Further interdisciplinary studies are needed to optimize their use in personalized therapeutics.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Virology
Lingtong Huang, Xuan Zhang, Lisha Pang, Peng Sheng, Yanqiu Wang, Fan Yang, Huili Yu, Xiaohan Huang, Yue Zhu, Ning Zhang, Hongliu Cai, Lingling Tang, Xueling Fang
Summary: This study aimed to assess the landscape and clinical features of viral reactivation in the early onset of severe pneumonia in ICU patients. The most common reactivated viruses in the lower respiratory tract of patients with severe pneumonia were cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1), and Epstein-Barr virus (EBV). Viral reactivation was associated with an increased risk of mortality.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Multidisciplinary Sciences
Emmanuela N. Bonglack, Joshua E. Messinger, Jana M. Cable, James Ch'ng, K. Mark Parnell, Nicolas M. Reinoso-Vizcaino, Ashley P. Barry, Veronica S. Russell, Sandeep S. Dave, Heather R. Christofk, Micah A. Luftig
Summary: The study found that EBV infection directly induced temporal expression of MCT1 and MCT4 in B lymphocytes, with MCT1 being crucial for early B cell proliferation and MCT4 upregulation leading to acquired resistance to MCT1 antagonism in LCLs. Dual inhibition of MCT1/4 resulted in growth arrest and lactate buildup in LCLs, suggesting a potential therapeutic approach for targeting viral lymphomas associated with EBV and KSHV.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Yunyun Hu, Ye Tian, Haonan Di, Chengfeng Xue, Yanping Zheng, Bin Hu, Qin Lin, Xiaomei Yan
Summary: This study utilized nanoflow cytometry to examine surface proteins on extracellular vesicles and found that EVSUM5 and EVSUM2 can effectively differentiate NPC patients from NPG patients, providing a more accurate diagnostic method.
ANALYTICAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Davide Maestri, Giorgia Napoletani, Andrew Kossenkov, Sarah Preston-Alp, Lisa B. Caruso, Italo Tempera
Summary: This study found that PARP1 affects the binding of CTCF/Cohesin, leading to disruption of the three-dimensional structure of EBV and altered viral gene expression. Additionally, different types of EBV latency exhibit distinct three-dimensional structures and variations in viral gene expression. The study also revealed differences in H3K27ac-enriched interactions and a link between the EBV genome and the human genome in cellular transformation.
NUCLEIC ACIDS RESEARCH
(2023)
Review
Virology
Guo-Long Bu, Chu Xie, Yin-Feng Kang, Mu-Sheng Zeng, Cong Sun
Summary: This review article discusses the tropism and molecular mechanism of EBV infection. The interactions between the virus and B cells and epithelial cells differ, and the entry process relies on heterogenous glycoprotein-receptor interactions.
Article
Transplantation
Selin Akad Dincer, Feride Iffet Sahin, Yunus Kasim Terzi, Kaan Gulleroglu, Esra Baskin, Mehmet Haberal
Summary: Functional polymorphisms of MMP2, MMP9, and TIMP2 genes are associated with renal allograft rejection and interstitial fibrosis in pediatric renal transplant recipients. These genetic variations could serve as important predictive biological markers for the follow-up of kidney transplant recipients.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Transplantation
Almila Sarigul Sezenoz, Gokhan Tortumlu, Imren Akkoyun, Sibel Oto, Mehmet Haberal
Summary: This study evaluated the retinal microvascular changes in pediatric patients who had undergone liver or renal transplant surgery and found that macular vessel density measurements were affected in these patients. Retinal optical coherence tomography and optical coherence tomography angiography measurements can provide a noninvasive window to the microcirculation in these patients.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Article
Gastroenterology & Hepatology
Khaled Warasnhe, Figen Ozcay, Halil Ibrahim Aydin, Gonca Ozgun, Serdar Ceylaner
Summary: Non-cirrhotic portal hypertension (NCPH) is rare in children. A novel mutation in the TRMT5 gene may be related to the development of familial idiopathic non-cirrhotic portal hypertension (INCPH).
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Surgery
Berivan Bitik, Bugra Hatipoglu, Burak Sayin, Aysenur Yalcintas Kanbur, Nurbanu Bursa, Cagdas Sahap Oygur, Handan Ozdemir, Turan Colak, Mehmet Haberal, Ahmet Eftal Yucel
Summary: This study reviewed the long-term survival outcomes of patients with familial Mediterranean fever (FMF)-related amyloidosis who underwent kidney transplantation (KT). The study found that the survival rate of these patients was lower compared to the control group, but there was no statistically significant difference. However, short- and long-term complications still need to be resolved.
CLINICAL TRANSPLANTATION
(2023)
Article
Transplantation
Aibolat Smagulov, Myltykbay Rysmakhanov, Yerlan Sultangereyev, Emre Karakaya, Aydincan Akdur, Ahmet Cagri Uysal, Pelin Borcek, Nadiar Mussin, Mehmet Haberal
Summary: This study was conducted to evaluate the positive effect of platelet-rich plasma on the healing process of an anastomotic wound in a rat model of ureterocystoanastomosis. The results showed that the use of platelet-rich plasma significantly increased tissue hydroxyproline levels, and there were no significant differences in epithelial damage, acute inflammation, or fibrosis between the platelet-rich plasma group and the control group.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Transplantation
Murat Muratoglu, Afsin Emre Kayipmaz, Cemil Kavalci, Mahir Kirnap, Gokhan Moray, Mehmet Haberal
Summary: The platelet-to-lymphocyte ratio is significantly elevated in renal transplant patients with infection. It can be used as an indicator of inflammation in these patients presenting to emergency departments. The platelet-to-lymphocyte ratio can be used in conjunction with other biomarkers to assess systemic inflammation.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Article
Acoustics
Funda Ulu Ozturk, Sehnaz Tezcan, Ebru Hatice Ayvazoglu Soy, Nihal Uslu, Mehmet Haberal
Summary: This study investigated the hepatic arterial Doppler ultrasound findings related to cholangitis after liver transplantation. It was found that the hepatic arterial flow, resistive index, and diameter decreased in patients with cholangitis after recovery. These findings can help in the early diagnosis of cholangitis and prevent graft loss.
JOURNAL OF CLINICAL ULTRASOUND
(2023)
Article
Pediatrics
Esra Baskin, Meraj Alam Siddiqui, Kaan Gulleroglu, Binnaz Handan Ozdemir, Aysun Caltik Yilmaz, Meric Yavuz Colak, Aydincan Akdur, Ebru Ayvazoglu Soy, Gokhan Moray, Mehmet Haberal
Summary: The long-term administration of eplerenone can attenuate chronic allograft nephropathy in pediatric renal transplant patients by maintaining stable kidney function and reducing urine protein-creatinine ratio.
PEDIATRIC TRANSPLANTATION
(2023)
Article
Ophthalmology
Mustafa Aksoy, Leyla Asena, Mustafa Agah Tekindal, Ebru Hatice Ayvazoglu Soy, Gursel Yilmaz, Mehmet Haberal
Summary: This study aimed to evaluate the changes in subfoveal choroidal thickness (SFCT), choroidal vascularity index (CVI), estimated glomerular filtration rate (GFR), mean arterial pressure (MAP), and intraocular pressure (IOP) after renal transplantation. The results showed a significant increase in SFCT with GFR, while CVI values did not change.
TURK OFTALMOLOJI DERGISI-TURKISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Transplantation
Alev Arslan, Gonul Parmaksiz, Zekiye Aytul Noyan, Kenan Caliskan, Sedat Yildirim, Mehmet Haberal
Summary: The aim of this study was to evaluate the gradual changes in left and right ventricle functions in children and young adults before and after renal transplant. The results showed that both systolic and diastolic dysfunctions of both ventricles were common in pediatric renal transplant recipients, and these dysfunctions usually decreased with time. However, improvements in right ventricle dysfunction were slower, even in optimally treated posttransplant patients.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2023)
Meeting Abstract
Immunology
Tugba Yanik Yalcin, Cigdem Erol, Emre Karakaya, Hande Arslan, Mehmet Haberal
Meeting Abstract
Immunology
Tugba Yanik Yalcin, Gulbahar Darilmaz Yuce, Ebru H. Ayvazoglu Soy, Ozlem Kurt Azap, Hande Arslan, Mehmet Haberal
Meeting Abstract
Immunology
Emre Karakaya, Aydincan Akdur, Ebru H. Ayvazoglu Soy, Burak Sayin, Gokhan Moray, Mehmet Haberal
Article
Transplantation
Esra Baskin, Begum Avci, Kaan Gulleroglu, Aydincan Akdur, Gokhan Moray, Mehmet Haberal
Summary: This study investigated the recurrence rates, risk factors, management strategies, and long-term graft function in pediatric renal transplant recipients with primary focal segmental glomerulosclerosis. Prophylactic plasma exchange and the combined plasma exchange-rituximab regimen resulted in low recurrence rates and good remission rates in this cohort.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2022)
Meeting Abstract
Pediatrics
Emre Karakaya, Aydincan Akdur, Ebru H. Ayvazoglu Soy, Esra Baskin, Gokhan Moray, Mehmet Haberal
PEDIATRIC TRANSPLANTATION
(2022)