Review
Biology
Arnaud Del Bello, Emmanuel Treiner
Summary: Manipulating immune checkpoints could potentially lead to a state of specific hypo-responsiveness towards grafted organs, reducing the need for immunosuppressive medications and their associated toxicities.
Review
Oncology
Rosario Mazzola, Francesco Cuccia, Alessandro Bertani, Slavisa Tubin, Pier Giulio Conaldi, Stefanie Corradini, Maria Tolia, Markus Guba, Filippo Alongi
Summary: Radiotherapy in cancer patients with prior organ transplants poses challenges due to potential effects on immunosuppressive therapy and organ tolerance. This systematic review aims to assess the safety and efficacy of radiotherapy in these patients, focusing on modern treatment techniques.
Article
Immunology
Lauren E. Higdon, Claire E. Gustafson, Xuhuai Ji, Malaya K. Sahoo, Benjamin A. Pinsky, Kenneth B. Margulies, Holden T. Maecker, Jorg Goronzy, Jonathan S. Maltzman
Summary: Immune function changes with age, and infection with CMV accelerates these changes, resulting in increased mortality and impaired responses in elderly individuals. Following organ transplantation, CMV+ recipients show accelerated aging of CD8 T cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Ophthalmology
Gisung Son, Joo Yong Lee, June-Gone Kim, Yoon Jeon Kim
Summary: After conducting the study, it was found that the clinical manifestations of CMV retinitis differed between the SOT and HSCT groups, with different poor prognostic factors associated with each. The presence of concurrent CMV disease and foveal involvement were identified as factors associated with poor visual outcomes in CMV retinitis following transplantation in both the SOT and HSCT groups.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Review
Immunology
Priscila Ferreira Slepicka, Mahboubeh Yazdanifar, Alice Bertaina
Summary: This article discusses the conventional and unconventional immunological mechanisms underlying the development of immune tolerance in solid organ transplant (SOT) recipients, as well as how these mechanisms can inform clinical progress. Specifically, recent mechanistic studies elucidating the role of regulatory cells in dampening cytotoxic immune reactivity and fostering a tolerogenic environment are reviewed. The understanding of regulatory cells can shape graft engineering and other therapeutic strategies to improve long-term outcomes for patients receiving hematopoietic stem cell transplantation (HSCT) and SOT.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Surgery
Paul Gabarre, Christopher Loens, Yanis Tamzali, Benoit Barrou, Frederic Jaisser, Jerome Tourret
Summary: Understanding of the involvement of the gut microbiota in human health has significantly grown in recent decades, particularly in the fields of metabolism, inflammation, and immunology. Immunosuppressive treatments given to solid organ transplant recipients can cause changes in the gut microbiota that impact various physiological processes. Medications such as Tacrolimus and steroids induce dysbiosis and metabolic disorders, while Mycophenolate Mofetil can lead to gastrointestinal side effects.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Alice Bedin, Marie Carbonnel, Renaud Snanoudj, Antoine Roux, Sarah Vanlieferinghen, Claire Marchiori, Alexandre Hertig, Catherine Racowsky, Jean-Marc Ayoubi
Summary: A retrospective study on women under 40 who underwent solid organ transplantation showed that pregnancies after transplantation are feasible, but with increased risks of pre-eclampsia and premature birth, requiring close monitoring.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Margot Fodor, Julia Hofmann, Lukas Lanser, Giorgi Otarashvili, Marlene Puehringer, Theresa Hautz, Robert Sucher, Stefan Schneeberger
Summary: Organ transplantation survival rates have been improving due to advancements in the field, allowing for more patients with higher risk profiles to be added to waiting lists. Strategies to tackle organ shortage include the use of hypothermic and normothermic machine perfusion, as well as the implementation of hyperspectral imaging for assessing organ quality. Combining organ machine perfusion with hyperspectral imaging is seen as a prospective feasibility concept for the future of organ transplantation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Medicine, General & Internal
Joong-Yub Kim, Ahram Han, Hajeong Lee, Jongwon Ha, Kwang-Woong Lee, Kyung-Suk Suh, Nam-Joon Yi, Sangil Min, Suk Kyun Hong, Yong Chul Kim, YoungRok Choi, Jae-Joon Yim, Nakwon Kwak
Summary: Due to impaired cell-mediated immunity, solid organ transplantation (SOT) recipients are at increased risk of developing nontuberculous mycobacterial pulmonary disease (NTM-PD). The clinical course of NTM-PD in SOT patients and the impact of SOT on the prognosis of NTM-PD remain unclear.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Review
Biochemistry & Molecular Biology
Simon Mathis, Gabriel Putzer, Stefan Schneeberger, Judith Martini
Summary: The endothelial glycocalyx, a thin layer lining vascular endothelial cells, is damaged during solid organ transplantation, impacting organ function. Normothermic machine perfusion technology offers a potential solution for organ preservation and quality improvement by treating the glycocalyx during storage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pediatrics
Cal Robinson, Rahul Chanchlani, Abhijat Kitchlu
Summary: As life expectancy among pediatric solid organ transplant recipients improves, the risk of comorbid conditions such as malignancy post-transplantation has also increased. Different risk factors exist for PTLD, and skin and solid cancers, and optimal cancer treatment strategies depend on the specific cancer type, stage, and patient comorbidities. Lifestyle counseling regarding smoking avoidance and sun protection, as well as human papillomavirus vaccination, is important for cancer prevention in pediatric SOTRs.
PEDIATRIC NEPHROLOGY
(2021)
Article
Hematology
Zeinab Afify, Manuela Orjuela-Grimm, Christine Moore Smith, Mansi Dalal, James B. Ford, Pallavi Pillai, Joanna M. Robles, Sonika Reddy, Sarah McCormack, Matthew J. Ehrhardt, Tonya Ureda, Warren Alperstein, Holly Edington, Tamara P. Miller, Jeremy D. Rubinstein, Madison Kavanaugh, Andrew J. Bukowinski, Erika Friehling, Julie M. Rivers, Karen M. Chisholm, Lianna J. Marks, Clinton C. Mason
Summary: PSOT-BL is a clinically aggressive malignancy and a rare form of PTLD. Most patients developed PSOT-BL more than 2 years after transplantation. Heart and liver were the most frequently transplanted organs. The outcomes of intensive regimens for PSOT-BL patients are comparable to immunocompetent children with BL. Multi-institutional collaboration is important for collecting prospective data to determine the optimal treatment regimen.
BRITISH JOURNAL OF HAEMATOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Fabio Ius, Daniel Moscalenco, Dietmar Boethig, Igor Tudorache, Axel Haverich, Gregor Warnecke, Serghei Cebotari
Summary: This retrospective study examined patients who underwent cardiac valve operations after solid organ transplantation and found high prevalence of postoperative complications, especially in patients with endocarditis or undergoing concomitant transplantation and valve surgery. However, survival conditioned to hospital discharge was satisfactory.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2021)
Review
Immunology
Jin-Yu Sun, Rui Wu, Jiang Xu, Hui-Ying Xue, Xiao-Jie Lu, Jiansong Ji
Summary: The immune system plays a crucial role in recognizing and attacking non-self antigens, leading to immunity against infection. However, it also causes immune rejection during organ transplantation. Understanding the mechanisms of maternal-fetal immune tolerance can potentially improve transplantation outcomes by balancing immune tolerance and infection defense. Studies exploring the interconnection between immune tolerance in pregnancy and organ transplantation highlight the impact of pregnancy alloimmunization on transplant success.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Friederike Haeuser, Jens Mittler, Misra Simge Hantal, Lilli Greulich, Martina Hermanns, Annette Shrestha, Oliver Kriege, Tanja Falter, Uta D. Immel, Stephanie Herold, Brigitte Schuch, Karl J. Lackner, Heidi Rossmann, Markus Radsak
Summary: A combined digital droplet PCR (ddPCR)/pyrosequencing assay system was developed for molecular genetic diagnostic applications. The results of ddPCR were in good agreement with established markers, and it showed higher sensitivity and precision in quantification. The assay is expected to be suitable for various applications.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2023)
Article
Surgery
Ivo G. Tzvetanov, Mario Spaggiari, Kiara A. Tulla, Caterina Di Bella, Obi Okoye, Pierpaolo Di Cocco, Hoonbae Jeon, Jose Oberholzer, Pier Cristoforo Giulianotti, Enrico Benedetti
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Surgery
Mario Spaggiari, Kiara A. Tulla, Obi Okoye, Caterina Di Bella, Pierpaolo Di Cocco, Jorge Almario, Pearl Ugwu-Dike, Ivo G. Tzvetanov, Enrico Benedetti
TRANSPLANT INTERNATIONAL
(2019)
Review
Surgery
Pierpaolo Di Cocco, Obi Okoye, Jorge Almario, Enrico Benedetti, Ivo G. Tzvetanov, Mario Spaggiari
TRANSPLANT INTERNATIONAL
(2020)
Article
Surgery
Mario Spaggiari, Obi Okoye, Jorge Almario, Kiara Tulla, Pierpaolo Di Cocco, Enrico Benedetti, Ivo Tzvetanov
TRANSPLANT INTERNATIONAL
(2020)
Article
Immunology
Mario Spaggiari, Obi Okoye, Kiara Tulla, Pierpaolo Di Cocco, Jorge Almario, E. Benedetti, Ivo Tzvetanov
TRANSPLANTATION PROCEEDINGS
(2019)
Article
Immunology
Jorge A. Almario Alvarez, Obi Okoye, Kiara Tulla, Mario Spaggiari, Pierpaolo Di Cocco, Enrico Benedetti, Ivo Tzvetanov
TRANSPLANTATION PROCEEDINGS
(2020)
Article
Surgery
Mario Spaggiari, Pierpaolo Di Cocco, Kiara Tulla, Kerim B. Kaylan, Mario A. Masrur, Chandra Hassan, Jorge A. Alvarez, Enrico Benedetti, Ivo Tzvetanov
Summary: This study compared the safety and efficacy of combining robotic sleeve gastrectomy and robotic-assisted kidney transplant to robotic kidney transplant alone in obese patients, and found that the combined surgery was more effective in reducing body weight, despite longer operation time without increased risk of complications.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Immunology
Mario Spaggiari, Alicia Lichvar, Ivo Tzvetanov, Robert Carroll, Sujata Gaitonde, Suman Setty, Pierpaolo Di Cocco, Jorge A. Almario Alvarez, Enrico Benedetti
Summary: Intestinal transplantation is a treatment option for patients with irreversible intestinal failure. This case report describes a patient who underwent temporary desensitization using the donor spleen, which resulted in successful removal of DSAs and a positive post-transplant outcome. Further research is needed to evaluate the long-term efficacy of this strategy.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Surgery
Mario Spaggiari, Egor Petrochenkov, Angelika Gruessner, Giulia Bencini, Louis Drakwa, Pierpaolo Di Cocco, Jorge Almario-Alvarez, Alessandro Martinino, Enrico Benedetti, Ivo Tzvetanov
Summary: This study is a retrospective analysis of robotic-assisted kidney transplant from deceased donor kidneys. The results show that patients with high BMI may experience higher rates of delayed graft function and lower graft survival.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Meeting Abstract
Surgery
M. Spaggiari, K. A. Tulla, O. T. Okoye, C. Di Bella, P. Di Cocco, J. A. Almario Alvarez, I. G. Tzvetanov, E. Benedetti
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Meeting Abstract
Surgery
I. G. Tzvetanov, K. A. Tulla, O. T. Okoye, C. Di Bella, P. Di Cocco, J. A. Almario Alvarez, M. Spaggiari, E. Benedetti
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Meeting Abstract
Surgery
O. Okoye, M. Spaggiari, J. Almario, V. Qiao, K. Tulla, P. Di Cocco, E. Benedetti, I. Tzvetanov
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Meeting Abstract
Surgery
J. Almario, O. Okoye, M. Spaggiari, K. Jacob, P. Di Cocco, E. Benedetti, I. Tzvetanov
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Meeting Abstract
Surgery
Mario Spaggiari, Kiara Tulla, Caterina Di Bella, Pierpaolo Di Cocco, Jorge Almario, Jose Oberholzer, Ivo Tzvetanov, Enrico Benedetti
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
Meeting Abstract
Surgery
James Hendele, Caterina Di Bella, Kiara Tulla, Michael Kim, Pierpaolo Di Cocco, Jorge Almario, Enrico Benedetti, Ivo Tzvetanov, Mario Spaggiari
AMERICAN JOURNAL OF TRANSPLANTATION
(2019)
