Article
Chemistry, Multidisciplinary
Lorenzo Ceccarelli, Laura Marchetti, Milena Rizzo, Aldo Moscardini, Valentina Cappello, Eleonora Da Pozzo, Miriam Romano, Chiara Giacomelli, Paolo Bergese, Claudia Martini
Summary: This study reports a workflow for the extraction and characterization of different types of EVs from adult and embryonic microglia cell lines. The authors found differences in quantity and dispersion between EVs derived from different cell lines. Moreover, EVs derived from one cell line were able to interfere with the proliferation of glioblastoma cells, which correlated with different levels of miRNAs involved in neuroinflammation and tumor progression. These findings fill a research gap in the field of microglia EVs and emphasize the need for better characterization of EVs' features and biological effects.
Article
Oncology
Huy Phuoc Quang Nguyen, Woo Kyun Bae, Myong Suk Park, Ik-Joo Chung, Taek-Keun Nam, Jae-Uk Jeong, Tung Nguyen Thanh Uong, Duck Cho, Sang-Ki Kim, Meesun Yoon
Summary: This study aims to investigate the efficacy of adoptive natural killer (NK) cell immunotherapy in combination with chemoradiotherapy for colorectal cancer (CRC). The results demonstrate that the combination of low-dose chemoradiotherapy and NK cell therapy can significantly enhance primary tumor control and improve survival outcomes.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2023)
Article
Environmental Sciences
Junkai Xie, Li Lin, Oscar F. Sanchez, Chris Bryan, Jennifer L. Freeman, Chongli Yuan
Summary: Exposure to low-dose atrazine (ATZ) prior to differentiation can result in long-lasting changes in the epigenome of neurons and increase the risks of SNCA-related Parkinson's Disease.
ENVIRONMENTAL POLLUTION
(2021)
Article
Biochemistry & Molecular Biology
Manal Alfwuaires, Hany Elsawy, Azza Sedky
Summary: This study suggests that ACN can inhibit the activation of STAT3 and suppress the expression of genes associated with HCC, making it a promising therapeutic compound for the treatment of HCC and other cancers.
Article
Pharmacology & Pharmacy
Yinan Shi, Chenxin Gu, Tongtong Zhao, Yangfan Jia, Changlei Bao, Ang Luo, Qiang Guo, Ying Han, Jian Wang, Stephen M. Black, Ankit A. Desai, Haiyang Tang
Summary: Prolonged rapamycin treatment activates PDGFR signaling partially via mTORC2 inhibition. Combination therapy with rapamycin and imatinib may be a more effective strategy for the treatment of PAH, reducing proliferation and migration of hPASMCs and attenuating pulmonary hypertension in pre-clinical studies.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Oncology
Zihao Dai, Zongren Wang, Kai Lei, Junbin Liao, Zhenwei Peng, Manxia Lin, Ping Liang, Jie Yu, Sui Peng, Shuling Chen, Ming Kuang
Summary: Ablative treatment using irreversible electroporation (IRE) can induce CD8(+) T cell immunity to suppress hepatocellular carcinoma (HCC) growth. Research indicates that vaccination using IRE-processed H22 lysates can prevent tumorigenesis and alleviate immunosuppression.
Article
Multidisciplinary Sciences
Wenhui Wang, Pengyu Liu, Marla Lavrijsen, Shan Li, Ruyi Zhang, Shanshan Li, Wesley S. van de Geer, Harmen J. G. van de Werken, Maikel P. Peppelenbosch, Ron Smits
Summary: AXIN1 mutations enhance beta-catenin signaling in HCC cell lines; AXIN1 and AXIN2 synergistically control beta-catenin signaling; Tankyrase inhibitors may serve as a therapeutic option, but may not solely affect beta-catenin signaling in HCC cells.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Minsik Park, Joohwan Kim, Taesam Kim, Suji Kim, Wonjin Park, Kwon-Soo Ha, Sung Hwan Cho, Moo-Ho Won, Jeong-Hyung Lee, Young-Guen Kwon, Young-Myeong Kim
Summary: The study revealed that low-dose doxorubicin can inhibit tumor growth and metastasis by inducing REDD1 expression to impair the function of tumor-associated endothelial cells. REDD1 was found to suppress the transcription of vascular endothelial growth factor receptor by inhibiting mTORC1-dependent translation, thus inhibiting tumor angiogenesis and lymphangiogenesis.
EXPERIMENTAL AND MOLECULAR MEDICINE
(2021)
Article
Oncology
Megha Gautam, Reema Gabrani
Summary: The study found that the combination of naringenin (NAG) and temozolomide (TMZ) enhances the cytotoxic effects on glioblastoma multiforme (GBM) cells, significantly reducing cell migration and single-cell colony formation.
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Yuyi Qian, Qiufang Liu, Panli Li, Yaobao Han, Jianping Zhang, Jiaojiao Xu, Jingwen Sun, Aihua Wu, Shaoli Song, Wei Lu
Summary: Transarterial radioembolization (TARE) is an effective treatment for intermediate-stage hepatocellular carcinoma (HCC). A highly tumor-specific I-131-TARE agent with long-time retention has been developed using tyrosine-modified poly(vinyl alcohol) drug-eluting microbeads (Tyr-PVA-DEBs). This agent allows localized delivery of high-radiation doses to tumors following a single low-dose injection, showing potential for clinical application in treating HCC.
Article
Biochemistry & Molecular Biology
Emilia Lekholm, Mikaela M. Ceder, Erica C. Forsberg, Helgi B. Schioth, Robert Fredriksson
Summary: The study investigated gene expression of SV2A, SV2B and SV2C in two human neuroblastoma cell lines after differentiation, showing that different treatments affect different SV2 isoforms. Synergistic expression patterns between SV2B and CHAT, as well as SV2C and DAT, were observed, providing insights into the regulation of SV2 in neuronal cells.
CELLULAR & MOLECULAR BIOLOGY LETTERS
(2021)
Article
Multidisciplinary Sciences
Michael L. Bittner, Rosana Lopes, Jianping Hua, Chao Sima, Aniruddha Datta, Heather Wilson-Robles
Summary: The study demonstrates the effectiveness of Cryptotanshinone (CT) in combating cancer and inducing apoptosis in human and canine cancer cells. Results verified CT's high efficacy in inhibiting cancer cell survival, showing its potential application across different cancer cell lines.
Article
Oncology
Yen-Hao Chen, Chih-Chi Wang, Yen-Yang Chen, Jing-Houng Wang, Chao-Hung Hung, Yuan-Hung Kuo
Summary: This study investigated the efficacy and safety of low-dose nivolumab in the management of hepatocellular carcinoma. The results suggest that low-dose nivolumab may be an alternative option for patients with advanced HCC who cannot afford the high cost of immune checkpoint inhibitors in real-world practice.
Article
Plant Sciences
Gloria A. Guillen-Melendez, Sheila A. Villa-Cedillo, Raymundo A. Perez-Hernandez, Uziel Castillo-Velazquez, Daniel Salas-Trevino, Odila Saucedo-Cardenas, Roberto Montes-de-Oca-Luna, Christian A. Gomez-Tristan, Aime Jazmin Garza-Arredondo, Diana Elisa Zamora-Avila, Maria de Jesus Loera-Arias, Adolfo Soto-Dominguez
Summary: The study demonstrated the cytotoxic effects of Acalypha monostachya extracts on human tumor cell lines, showing potential antineoplastic effects. The extracts induced morphological changes in tumor cells, with the methanolic and hexane extracts exhibiting stronger cytotoxic effects.
Review
Pathology
Abdulkadir Isidan, Ali Yenigun, Daiki Soma, Eric Aksu, Kevin Lopez, Yujin Park, Arthur Cross-Najafi, Ping Li, Debjyoti Kundu, Michael G. House, Sanjukta Chakraborty, Shannon Glaser, Lindsey Kennedy, Heather Francis, Wenjun Zhang, Gianfranco Alpini, Burcin Ekser
Summary: Cholangiocarcinoma (CCA) is a common liver tumor with limited treatment options and low survival rate. CCA cell lines are invaluable tools for studying the disease and have unique characteristics reflecting genotype, gender, and patient-related factors. They are crucial for the use of novel technologies like organoid models.
AMERICAN JOURNAL OF PATHOLOGY
(2022)