Article
Medicine, Research & Experimental
Yuwen Zhu, Yan Guo, Hong Liu, Anqi Zhou, Zhiwen Fan, Xi Zhu, Xiulian Miao
Summary: This study investigated the role of ubiquitin-specific peptidase 47 (USP47) in liver regeneration. The results showed that USP47 expression was up-regulated in hepatocytes isolated from mice subjected to partial hepatectomy or exposed to HGF treatment. E2F1 was identified as the primary regulator of USP47 transcription. USP47 was found to play an essential role in liver regeneration, as its inhibition impaired liver regeneration in mice and its over-expression enhanced hepatocyte proliferation in vitro and promoted liver regeneration in mice. A positive correlation between USP47 expression and hepatocyte proliferation was also observed in patients with acute liver failure.
Article
Food Science & Technology
Qinhui Liu, Qin Tang, Xinchun Liu, Min Tian, Xiandan Jing, Zongyun Feng, Xuping Yang
Summary: Studies have demonstrated the positive effect of highland barley ss-glucan (HBBG) on various liver diseases, including acute liver injury and liver regeneration. In this study, the researchers investigated the beneficial impact of HBBG on liver regeneration following partial hepatectomy (PH) using mouse models. They found that HBBG promoted hepatocyte proliferation and liver regeneration after PH by activating the STAT3-CyclinD1 signaling pathway. Furthermore, the intervention of HBBG decreased hepatocyte apoptosis in a liver injury model induced by CCl4.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Biotechnology & Applied Microbiology
Zeyuan Li, Bo Peng, Shilian Chen, Jiaping Li, Kai Hu, Lijuan Liao, Qiuli Xie, Mei Yao, Lixing Liang, Stephen Tomlinson, Guandou Yuan, Songqing He
Summary: This study compared the different mechanisms of liver regeneration and injury between partial hepatectomy (pHx) and extended hepatectomy (eHx) using transcriptome and metabolome analysis. The results showed that eHx caused more severe liver injury and lower survival rates compared to pHx. Analysis of differentially expressed genes (DEGs) and differentially produced metabolites (DPMs) suggested that cholesterol metabolism and insulin resistance pathways might be important for liver regeneration and mouse survival post-PHx and -eHx.
Article
Anatomy & Morphology
Ayaka Ohashi, Nanami Saito, Rena Kashimoto, Saya Furukawa, Sakiya Yamamoto, Akira Satoh
Summary: Axolotls have remarkable organ-level regeneration capability, and their liver regeneration mechanism is unique compared to other vertebrates.
DEVELOPMENTAL DYNAMICS
(2021)
Article
Plant Sciences
Shakeel Ahmad, Ihsan Muhammad, Guo Yun Wang, Muhammad Zeeshan, Li Yang, Izhar Ali, Xun Bo Zhou
Summary: The study demonstrated that under drought stress conditions, melatonin application can promote the growth of maize seedlings, alleviate oxidative damage, and enhance plant resistance to stress.
Article
Gastroenterology & Hepatology
Joaquim Javary, Nathalie Allain, Zakaria Ezzoukhry, Sylvaine Di Tommaso, Jean-William Dupuy, Pierre Costet, Nathalie Dugot-Senant, Frederic Saltel, Violaine Moreau, Pierre Dubus, Samira Benhamouche-Trouillet
Summary: Previous studies have shown that Reptin is crucial for hepatocyte proliferation in vivo and liver regeneration, as observed in the Reptin(LKO) mouse model. The impaired liver regeneration in Reptin(LKO) mice post partial hepatectomy is associated with decreased cyclin-A expression and mTORC1 and MAPK signaling. The progressive loss of Reptin invalidation in the model leads to atypical liver regeneration, with hypertrophic and proliferative hepatocytes replacing hypotrophic ones.
LIVER INTERNATIONAL
(2021)
Review
Biotechnology & Applied Microbiology
Yi Wu, Ning Li, Xinyu Shu, Wang Li, Xiaoyu Zhang, Dongyuan Lu, Mian Long
Summary: The liver is a complex organ with vital functions and regenerative capacity after tissue injury. Mechanical cues play a significant role in liver regeneration, including changes in hemodynamics and mechanical forces within the liver. Understanding the mechanotransductive pathways and mechanocrine responses can contribute to a comprehensive understanding of liver regeneration. Proper adjustment of mechanical loading may serve as an effective therapy for liver injury and diseases.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yang Chen, Sirong Shi, Bo Li, Tian Lan, Kefei Yuan, Jingsheng Yuan, Yongjie Zhou, Jiulin Song, Tao Lv, Yujun Shi, Bo Xiang, Taoran Tian, Tao Zhang, Jiayin Yang, Yunfeng Lin
Summary: This study explores the effects of tetrahedral framework nucleic acids (TFNAs) on hepatocyte proliferation and liver regeneration. It demonstrates that TFNA can promote hepatocyte proliferation and enhance liver regeneration by activating specific signaling pathways. The results suggest that TFNA shows potential as an effective therapeutic agent for treating acute liver injury, preventing the progression to acute liver failure and reducing mortality rate.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Yuan-E Lian, Yan-Nan Bai, Jian-Lin Lai, Ai-Min Huang
Summary: The study found that aberrant autophagy in fibrotic liver leads to impaired liver regeneration. Enhancement of autophagy improves hepatocyte proliferative capacity and restricts cellular hypertrophy and binuclearity ratio.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Gastroenterology & Hepatology
Adel Hammoutene, Marion Tanguy, Melanie Calmels, Riccardo Pravisani, Miguel Albuquerque, Christophe Casteleyn, Lotfi Slimani, Jeremy Sadoine, Chantal M. Boulanger, Valerie Paradis, Helene Gilgenkrantz, Pierre-Emmanuel Rautou
Summary: Patients with non-alcoholic fatty liver disease (NAFLD) have impaired liver regeneration due to a defect in autophagy of liver endothelial cells. This study aimed to determine the role of endothelial autophagy in liver regeneration following liver resection in NAFLD.
LIVER INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Shinpei Sugahara, Hiroaki Haga, Chisaki Ikeda, Naohiko Makino, Akiko Matsuda, Yasuharu Kakizaki, Kyoko Hoshikawa, Tomohiro Katsumi, Tetsuya Ishizawa, Toshikazu Kobayashi, Keita Maki, Fumiya Suzuki, Ryoko Murakami, Hidenori Sato, Yoshiyuki Ueno
Summary: Despite extensive study on liver regeneration, the impact of bile-derived extracellular vesicles (bile EVs) on hepatocytes remains unclear. Using a rat model of partial hepatectomy (PH), this study found that bile EVs released 12 hours after PH significantly promoted hepatocyte proliferation. Transcriptome analysis revealed an upregulation of genes promoting cell cycle progression in hepatocytes treated with PH24-EVs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Runbin Sun, Haokai Zhao, Shuzhen Huang, Ran Zhang, Zhenyao Lu, Sijia Li, Guangji Wang, Jiye Aa, Yuan Xie
Summary: The study investigated the dynamic metabolic changes during liver regeneration in mice using a metabolomic approach and regression analysis with different machine learning methods. The random forest method showed the best performance in predicting liver index, with several amino acid metabolic pathways and glucose metabolism pathway being the most influenced during liver regeneration.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gyeong-Seok Lee, Hee-Yeon Jeong, Hyeon-Gung Yang, Young-Ran Seo, Eui-Gil Jung, Yong-Seok Lee, Kung-Woo Nam, Wan-Jong Kim
Summary: Astragaloside IV showed anti-proliferative activity in regenerating liver tissue after 70% partial hepatectomy by down-regulating proliferative signals and genes related to DNA replication.
Article
Biotechnology & Applied Microbiology
Saisai Wei, Qiang Zheng, Yu Pan, Yunwan Xu, Jiacheng Tang, Xiujun Cai
Summary: The study revealed that liver regeneration leads to reprogramming of gene expression profiles, while core clock genes' rhythm remains stable. Performing partial hepatectomy in the evening may result in retarded liver regeneration due to the accumulation of DEC1.
Review
Medicine, Research & Experimental
Hayeong Jeong, Chanbin Lee, Min Jae Lee, Youngmi Jung
Summary: Chronic liver disease is a common global disease, particularly prevalent among adults aged 40-60. Liver transplantation, while considered effective, is limited by donor availability and potential side effects. Impaired liver regeneration can also lead to liver failure. Further research on liver regeneration and therapeutic strategies is needed.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Article
Pediatrics
Kutay Saglam, Tevfik Tolga Sahin, Sertac Usta, Cemalettin Koc, Emrah Otan, Cuneyt Kayaalp, Cemalettin Aydin, Sezai Yilmaz
Summary: Portal vein anastomotic complications related to size discrepancy are important causes of morbidity and mortality in pediatric liver transplantation. The use of interposed vein grafts can overcome portal flow problems, with preoperative portal vein thrombosis and insufficient flow being important factors affecting the success of liver transplant in children.
PEDIATRIC TRANSPLANTATION
(2022)
Review
Immunology
Arthur A. Cross-Najafi, Kevin Lopez, Abdulkadir Isidan, Yujin Park, Wenjun Zhang, Ping Li, Sezai Yilmaz, Sami Akbulut, Burcin Ekser
Summary: Recent studies on pig-to-nonhuman primate liver xenotransplantation have shown progress in achieving longer survival times. However, there are still challenges of thrombocytopenia and coagulation dysregulation. The current research aims to understand the biological mechanisms behind these issues and explore genetic modifications as potential solutions.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Sezai Yilmaz, Brian Carr, Sami Akbulut
Summary: Cholangiocarcinomas are most commonly found in the perihilar region, with surgical resection being the standard treatment. However, a strict patient selection and the Mayo protocol, incorporating neoadjuvant radiochemotherapy, staging laparotomy, and liver transplantation, have shown improved 5-year survival rates. Half of the patients with pCCA could not obtain a histopathological diagnosis before NRCT, and those with a diagnosis had lower 5-year survival rates.
JOURNAL OF GASTROINTESTINAL CANCER
(2022)
Article
Oncology
Kutay Saglam, Tevfik Tolga Sahin, Zeki Ogut, Volkan Ince, Sertac Usta, Sezai Yilmaz
Summary: Liver transplantation has significantly increased survival, but has also led to the development of de novo malignancies due to chronic immunosuppressive therapy. The most common de novo malignancy was found to be non-melanoma skin cancer, highlighting the importance of a strict surveillance program in the follow-up of liver transplant recipients.
JOURNAL OF GASTROINTESTINAL CANCER
(2022)
Article
Oncology
Emrah Sahin, Volkan Ince, Tolga T. Sahin, Ramazan Kutlu, Ramazan Pasahan, Sezai Yilmaz
Summary: The unexplained elevation of AFP after transplantation may indicate the possibility of brain metastasis. Performing cranial scanning with conventional imaging methods is more beneficial than using FDG PET.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Oncology
Kuntay Kaplan, Kemal Baris Sarici, Sertac Usta, Fatih ozdemir, Burak Isik, Sezai Yilmaz
Summary: Actinomyces is a rare bacterial infection that is often diagnosed late due to its slow and insidious course and lack of specific clinical and radiological findings. Cases with liver masses accompanied by previous abdominal surgery, abdominal trauma, high fever, and leukocytosis should consider the possibility of Actinomyces.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Surgery
Veysel Ersan, Sertac Usta, Cemalettin Aydin, Brian Carr, Sinan Karatoprak, Sezai Yilmaz
Summary: This study retrospectively examined the outcomes of non-transplant surgical approaches in patients with Bismuth-Corlette (BC) type IV perihilar cholangiocarcinoma (pCCA). The results showed that patients who underwent hepatectomy and had negative lymph nodes achieved the best survival rates. However, achieving high survival rates remains challenging in this patient population.
ACTA CHIRURGICA BELGICA
(2023)
Review
Oncology
Sami Akbulut, Ibrahim Umar Garzali, Abdirahman Sakulen Hargura, Ali Aloun, Sezai Yilmaz
Summary: The COVID-19 pandemic has led to modifications in the surveillance, screening, and management of hepatocellular carcinoma (HCC). High-risk patients were prioritized for surveillance, and the interval between screenings was delayed in some cases. Teleconferencing and remote consultations were adopted to reduce contact and spread of the virus. The treatment of early-stage HCC was also altered due to limited resources during the pandemic.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Oncology
Deniz Yavuz Baskiran, Talha Sarigoz, Adil Baskiran, Sezai Yilmaz
Summary: This study evaluated the significance of serum tumor markers in patients undergoing liver transplantation for viral and other etiologies of liver failure. The results showed that tumor marker levels vary according to etiology and severity of the disease. The diagnostic capabilities of these markers are reduced in end stage liver disease.
JOURNAL OF GASTROINTESTINAL CANCER
(2023)
Article
Immunology
Basak Kayhan, Zeynal Mete Karaca, Esra Canpolat, Veysel Ersan, Mehmet Gul, Saim Yologlu, Sezai Yilmaz
Summary: Chronic liver diseases have an impact on antibody production after vaccination, but co-administration of tetanus toxoid can increase antibody titer. Furthermore, non-viral chronic liver fibrosis also affects the frequency of Breg cells, which in turn affects the elevation of antibody levels.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2023)
Article
Immunology
Basri Satilmis, Sami Akbulut, Tevfik Tolga Sahin, Yasin Dalda, Adem Tuncer, Zeynep Kucukakcali, Zeki Ogut, Sezai Yilmaz
Summary: This study evaluated the course of liver regeneration after living donor hepatectomy using routine and regeneration-related biomarkers. The results showed that regenerative markers increased in a sustained fashion following the surgery, especially in right-lobe grafts, indicating progenitor-associated liver regeneration.
Article
Medicine, General & Internal
Sami Akbulut, Zeynep Kucukakcali, Hasan Saritas, Cigdem Bozkir, Murat Tamer, Musap Akyuz, Nazlican Bagci, Selver Unsal, Mehmet Serdar Akbulut, Tevfik Tolga Sahin, Cemil Colak, Sezai Yilmaz
Summary: The aim of this study was to compare liver transplant recipients with and without hepatocellular carcinoma (HCC) in terms of COVID-19-related depression, anxiety, and stress. The results showed that patients without HCC, females, those with chronic diseases, those exposed to COVID-19, and those not vaccinated against COVID-19 were more likely to experience anxiety, depression, and stress. These results are reliable.
Article
Medicine, General & Internal
Sami Akbulut, Fatma Hilal Yagin, Ipek Balikci Cicek, Cemalettin Koc, Cemil Colak, Sezai Yilmaz
Summary: This study aims to create a machine learning model that can accurately predict perforated and nonperforated acute appendicitis (AAp), and demonstrate the clinical interpretability of the model using explainable artificial intelligence (XAI). The results show that the model can accurately distinguish AAp patients from non-AAp individuals, as well as perforated and nonperforated AAp patients.
Article
Gastroenterology & Hepatology
Volkan Ince, Brian Carr, Sertac Usta, Veysel Ersan, Harika Gozukara Bag, Sezai Yilmaz
Summary: This study examined the impact of pre-transplant plasma lipid profiles on post-transplant tumor recurrence in patients with hepatocellular carcinoma. The results showed that low high-density lipoprotein cholesterol levels were significantly associated with portal vein thrombosis and poor post-transplant overall and disease-free survivals.
TURKISH JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Nurullah Dag, Mehmet Ozturk, Ahmet Sigirci, Sezai Yilmaz
Summary: This study aimed to evaluate the frequency of scoliosis and its risk factors in children after liver transplantation. The results showed an increased prevalence of scoliosis after pediatric liver transplantation, but the cause remains uncertain. The progression of scoliosis during the follow-up period was slow and no patients required surgical treatment.
EUROPEAN JOURNAL OF THERAPEUTICS
(2022)