Review
Immunology
Diego Catalan, Miguel Andres Mansilla, Ashley Ferrier, Lilian Soto, Kristine Oleinika, Juan Carlos Aguillon, Octavio Aravena
Summary: Regulatory B cells play a crucial role in maintaining immune tolerance and preventing exacerbated inflammatory responses. In addition to IL-10, other molecules such as IL-35, TGF-beta, and cell surface proteins like CD1d and PD-L1 are utilized by Bregs to regulate immune responses.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Eman H. Ibrahim, Mostafa Aly, Christian Morath, Douaa M. Sayed, Naruemol Ekpoom, Gerhard Opelz, Caner Susal, Volker Daniel
Summary: Healthy controls had higher Bregs compared to ESRD patients and transplant recipients. Higher Bregs were associated with higher GFR and lower CRP, while most Treg subsets were lower with higher levels of immunosuppressive drugs.
IMMUNITY INFLAMMATION AND DISEASE
(2021)
Editorial Material
Immunology
Karoliina Tuomela, Megan K. Levings
Summary: A recent study reveals that lactic acid, through a pH-dependent mechanism, promotes the differentiation of conventional CD4(+) T cells into Tregs, contributing to the accumulation of Tregs within tumors. This finding adds to the understanding of lactic acid's role in maintaining an immunosuppressive tumor microenvironment.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Hematology
Julian Swatler, Laura Turos-Korgul, Marta Brewinska-Olchowik, Sara De Biasi, Wioleta Dudka, Bac Viet Le, Agata Kominek, Salwador Cyranowski, Paulina Pilanc, Elyas Mohammadi, Dominik Cysewski, Ewa Kozlowska, Wioleta Grabowska-Pyrzewicz, Urszula Wojda, Grzegorz Basak, Jakub Mieczkowski, Tomasz Skorski, Andrea Cossarizza, Katarzyna Piwocka
Summary: Leukemic extracellular vesicles play a role in stimulating immunosuppressive Tregs and promoting leukemia growth. The study identifies Rab27a-dependent secretion of leukemic EVs as a potential therapeutic target in myeloid neoplasms.
Article
Multidisciplinary Sciences
Alejandro J. Cagnoni, Maria Laura Giribaldi, Ada G. Blidner, Anabela M. Cutine, Sabrina G. Gatto, Rosa M. Morales, Mariana Salatino, Martin C. Abba, Diego O. Croci, Karina V. Marino, Gabriel A. Rabinovich
Summary: Colorectal cancer is a common malignancy with limited response to immunotherapy, prompting the need for new biomarkers and therapeutic targets. Gal-1, as an endogenous glycan-binding protein, has been found to influence the activity of CD8(+) regulatory T cells in CRC, suggesting a potential immunotherapeutic approach for this disease.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Review
Oncology
Maximilian Haist, Henner Stege, Stephan Grabbe, Matthias Bros
Summary: Immunotherapy has shown benefits for advanced cancer patients, but many still do not respond to treatment. The accumulation of immunosuppressive cell populations like MDSC and Treg in the tumor microenvironment contributes to immune resistance and limits the effectiveness of immunotherapy.
Article
Medicine, General & Internal
Dana E. Rollison, Jane L. Messina, Basil S. Cherpelis, Neil A. Fenske, Michael J. Schell, Dennis O. Adeegbe, Yayi Zhao, Rossybelle P. Amorrortu, Afua A. Akuffo, Rebecca S. Hesterberg, Pearlie K. Epling-Burnette
Summary: Higher levels of circulating CCR4(hi) Tregs are associated with an increased risk of subsequent cuSCC, especially among highly UV-exposed individuals. This suggests potential opportunities for screening, prevention, and treatment based on the biology of Tregs in UVR-associated skin damage.
FRONTIERS IN MEDICINE
(2021)
Article
Immunology
Muhammed Yuksel, Farinaz Nazmi, Dima Wardat, Sebahat Akgul, Esra Polat, Murat Akyildiz, Cigdem Arikan
Summary: This study investigated the immune profile and response to immunosuppressive therapy in children with autoimmune hepatitis (AIH). The results showed that AIH patients had lower frequencies of certain immune cells before treatment, and a long-lasting scarcity of regulatory B cells after treatment. The effects of different immunosuppressive drugs on IL-10+ B cells varied.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biology
Debin Cheng, Zhao Zhang, Zhenzhou Mi, Weidong Tao, Dong Liu, Jun Fu, Hongbin Fan
Summary: This study investigates the role of regulatory T cells (Tregs) in osteosarcoma (OS) using single-cell RNA sequencing data. The study shows that Tregs play a crucial role in promoting OS tumor growth and progression through cellular communication with other cell types. Additionally, a prognostic model based on Tregs-specific genes is constructed, and high Tregs risk OS patients are found to be sensitive to certain drugs. Immunohistochemistry validates the expression of these genes in OS tissues.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Immunology
Memnon Lysandrou, Panagiota Stamou, Dionysia Kefala, Chryso Pierides, Maria Kyriakou, Nikolaos Savvopoulos, Panayiota Christofi, Anastasia Papadopoulou, Evangelia Yannaki, Paul Costeas, Alexandros Spyridonidis
Summary: Regulatory T cells (Tregs) are essential mediators of tolerance in immune responses. This study focuses on induced Tregs (iTregs) generated from T cells using hypomethylation agents (HAs). It is found that the suppressive properties of these iTregs are predominantly confined in an emergent population expressing the immunomodulatory molecule HLA-G. Through high-throughput RNA-sequencing analysis, distinct transcriptional upregulation and enrichment of immune-response-related pathways are observed in these iTregs. Furthermore, ectopic expression of myeloid suppressor genes is detected, suggesting the involvement of myeloid-specific molecular mechanisms in the function of HA-iTregs.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Paola de Candia, Claudio Procaccini, Claudia Russo, Maria Teresa Lepore, Giuseppe Matarese
Summary: Regulatory T cells, as key metabolic sensors, play a crucial role in controlling immune state and have promising therapeutic potential for autoimmune and metabolic disorders.
Article
Oncology
Mohamed H. S. Awwad, Abdelrahman Mahmoud, Heiko Bruns, Hakim Echchannaoui, Katharina Kriegsmann, Raphael Lutz, Marc S. Raab, Uta Bertsch, Markus Munder, Anna Jauch, Katja Weisel, Bettina Maier, Niels Weinhold, Hans Juergen Salwender, Volker Eckstein, Mathias Haenel, Roland Fenk, Jan Duerig, Benedikt Brors, Axel Benner, Carsten Mueller-Tidow, Hartmut Goldschmidt, Michael Hundemer
Summary: The study reveals that SLAMF7 is a marker for suppressive CD8(+) Tregs in multiple myeloma, and anti-SLAMF7 antibodies can enhance anti-tumoral immune responses by depleting these T cells.
Article
Immunology
Hui Li, Hou-Rong Cai
Summary: This study found that in patients with DM-ILD undergoing immunosuppressive therapy, positive microbiological results may be associated with higher inflammatory markers, lower CD4 + T cell counts, higher serum FK-506 concentration, and longer hospital stay.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Oncology
Agnieszka Goral, Marta Sledz, Aneta Manda-Handzlik, Adrianna Cieloch, Alicja Wojciechowska, Mieszko Lachota, Agnieszka Mroczek, Urszula Demkow, Radoslaw Zagozdzon, Katarzyna Matusik, Malgorzata Wachowska, Angelika Muchowicz
Summary: The crosstalk between Treg and neutrophils may play an important role in CLL progression by interfering with the immune response.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2023)
Article
Microbiology
Sabina Davidsson, Jessica Carlsson, Larry Greenberg, Jonny Wijkander, Bo Soderquist, Ann Erlandsson
Summary: Our study suggests that C. acnes may contribute to an immunosuppressive tumor environment by recruiting Tregs and increasing the expression of immunosuppressive mediators. Furthermore, the presence of C. acnes infection in prostate cancer patients is associated with higher infiltration of Tregs, indicating a potential role of C. acnes in promoting prostate cancer progression. If confirmed, targeting C. acnes may provide a new avenue for prostate cancer treatment.
MICROBIOLOGY SPECTRUM
(2021)
