Article
Biochemistry & Molecular Biology
Eman K. Aldous, Salman M. Toor, Aijaz Parray, Yasser Al-Sarraj, Ilhame Diboun, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Naveed Akhtar, Sajitha Pananchikkal, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: This study conducted comprehensive circulating miRNA profiling in patients with ischemic stroke and identified a panel of miRNAs with potential diagnostic and prognostic significance. A multivariate classifier based on this miRNA panel showed high sensitivity and specificity in differentiating between stroke patients and healthy controls, and it outperformed other available biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: Transient ischemic attack (TIA) is a temporary neurologic deficit caused by ischemic insult to the brain, spinal cord, or retina. TIA is associated with a high risk of impending acute ischemic stroke (AIS), a condition characterized by focal infarction in the brain, spinal cord, or retina. This study investigated the differences in circulating microRNA profiles between AIS and TIA patients and identified a panel of differentially regulated microRNAs. Furthermore, a multivariate classifier was developed that could potentially be used as a biomarker to distinguish AIS and TIA patients. Understanding the molecular pathways in AIS compared to TIA may have important implications for therapeutic targeting in clinical translation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Oh Young Bang, Eun Hee Kim, Mi Jeong Oh, Jaein Yoo, Gyun Sik Oh, Jong-Won Chung, Woo-Keun Seo, Gyeong-Moon Kim, Myung-Ju Ahn, Seong Wook Yang, OASIS-CANCER Study
Summary: This study aimed to evaluate the potential use of extracellular-vesicle-incorporated miRNAs as biomarkers for cancer-related stroke. The results showed that miR-205-5p, miR-645, and miR-646 were specifically incorporated into microvesicles in patients with cancer-related stroke, cancer controls, and stroke controls. The expression levels of these miRNAs could be used to differentiate patients with cancer-stroke from cancer-controls and stroke controls. Further studies are needed to confirm the diagnostic role of miRNAs in stroke patients and to investigate the roles of miRNAs in cancer patients.
Article
Cardiac & Cardiovascular Systems
Salman M. Toor, Eman K. Aldous, Aijaz Parray, Naveed Akhtar, Yasser Al-Sarraj, Essam M. Abdelalim, Abdelilah Arredouani, Omar El-Agnaf, Paul J. Thornalley, Sajitha V. Pananchikkal, Ghulam Jeelani Pir, Raheem Ayadathil Thazhhe Kuni, Ashfaq Shuaib, Nehad M. Alajez, Omar M. E. Albagha
Summary: This study conducted comprehensive circulating miRNA profiling in ischemic stroke patients with and without type 2 diabetes mellitus, identifying 5 differentially regulated miRNAs between the two groups. The findings offer insights into potential pathways associated with stroke and diabetes comorbidity.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Clinical Neurology
Gerrit M. Grosse, Anselm A. Derda, Ricarda D. Stauss, Lavinia Neubert, Danny D. Jonigk, Mark P. Kuehnel, Maria M. Gabriel, Ramona Schuppner, Mathias Wilhelmi, Christian Baer, Johann Bauersachs, Claudia Schrimpf, Thomas Thum, Karin Weissenborn
Summary: This study did not find strong associations between specific circulating miRs and symptomatic state in a group of patients with carotid stenosis. Further research is needed to understand the role of circulating miRs as targets in advanced carotid atherosclerosis.
FRONTIERS IN NEUROLOGY
(2021)
Article
Oncology
Camila Meirelles S. Silva, Mateus C. Barros-Filho, Deysi Viviana T. Wong, Julia Bette H. Mello, Livia Maria S. Nobre, Carlos Wagner S. Wanderley, Larisse T. Lucetti, Heitor A. Muniz, Igor Kenned D. Paiva, Hellen Kuasne, Daniel Paula P. Ferreira, Maria Perpetuo S. S. Cunha, Carlos G. Hirth, Paulo Goberlanio B. Silva, Rosane O. Sant'Ana, Marcellus Henrique L. P. Souza, Josiane S. Quetz, Silvia R. Rogatto, Roberto Cesar P. Lima-Junior
Summary: By screening miRNAs in plasma, we identified four miRNAs as potential biomarkers for the early detection of colorectal cancer, presenting high performance and easy applicability in clinical practice.
Article
Clinical Neurology
Houchao Sun, Xiaogang Zhang, Jingxi Ma, Zhao Liu, Yunwen Qi, Li Fang, Yongling Zheng, Zhiyou Cai
Summary: The study found that circulating sCD163 levels were significantly higher in patients with acute ischemic stroke compared to healthy controls, and patients with higher sCD163 concentrations had better functional outcomes. Plasma sCD163 levels were positively correlated with NIHSS scores and infarction volume at baseline, and improvements in NIHSS scores, while negatively associated with the risk of poor functional outcomes.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Chen Chen, Linjing Wang, Li Wang, Qi Liu, Chunying Wang
Summary: This study revealed that the expression of CASC15 was increased and levels of miR-338-3p were decreased in acute ischemic stroke (AIS) patients. CASC15 may serve as a potential diagnostic biomarker for AIS patients and exert neuroprotective roles through the miR-338-3p/ETS1 axis. The findings highlight the importance of CASC15/miR-338-3p/ETS1 axis in cell viability, apoptosis, and neuroinflammation in AIS.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Hematology
Aranzazu Chamorro-Jorganes, Walid K. Sweaad, Rajesh Katare, Marie Besnier, Maryam Anwar, N. Beazley-Long, Graciela Sala-Newby, Inigo Ruiz-Polo, Dhananjie Chandrasekera, Alison A. Ritchie, Andrew Benest, Costanza Emanueli
Summary: The research revealed that METTL3 regulates m(6)A RNA methylation in endothelial cells and is essential for angiogenesis, potentially through influencing the processing of let-7e and miR-17-92 cluster.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Article
Immunology
Tahereh Donyavi, Farah Bokharaei-Salim, Hossein Bannazadeh Baghi, Khadijeh Khanaliha, Mahrokh Alaei Janat-Makan, Bahareh Karimi, Javid Sadri Nahand, Hamed Mirzaei, AliReza Khatami, Saba Garshasbi, Majid Khoshmirsafa, Seyed Jalal Kiani
Summary: This study aimed to identify specific miRNA profiles that can be used as biomarkers to differentiate acute COVID-19 cases, healthy individuals, and those in the post-acute phase. The results showed that miR-29a-3p, miR-146a-3p, and let-7b-3p were significantly elevated in COVID-19 patients compared to healthy individuals, with potential for high sensitivity and specificity in COVID-19 diagnosis and monitoring. MiR-29a-3p and miR-146a-3p also showed promise as biomarkers for distinguishing acute from post-acute phases of COVID-19.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Genetics & Heredity
Danyang Li, Lifang Li, Fei Quan, Tianfeng Wang, Si Xu, Shuang Li, Kuo Tian, Meng Feng, Ni He, Liting Tian, Biying Chen, Huixue Zhang, Lihua Wang, Jianjian Wang
Summary: This study identified CLEC4D and CD163 as immune biomarkers of IS, and a classification model was constructed and verified. The results also showed a strong correlation between CLEC4D and neutrophil proportion.
FRONTIERS IN GENETICS
(2022)
Article
Behavioral Sciences
Yi Xie, Xingfeng Zhuo, Kai Xing, Zhenqian Huang, Hongquan Guo, Pengyu Gong, Xiaohao Zhang, Yun Li
Summary: This study aimed to evaluate the association between Lipocalin-2 (LCN2) levels and early neurological deterioration (END) in acute ischemic stroke patients, as well as their impact on clinical recovery. The results showed that higher serum LCN2 levels were associated with increased risk of END and 90-day poor functional outcome. The study demonstrated the importance of circulating LCN2 as a potential marker for predicting clinical worsening and unfavorable outcomes in ischemic stroke patients.
BRAIN AND BEHAVIOR
(2023)
Article
Clinical Neurology
Christa Meisinger, Dennis Freuer, Timo Schmitz, Michael Ertl, Philipp Zickler, Markus Naumann, Jakob Linseisen
Summary: This cross-sectional study aimed to evaluate potential associations between the etiologic subtypes of ischemic stroke and blood-based proteins. The study found that stromal-cell-derived-factor 1 alpha (SDF-1a) showed significantly higher serum levels in cardioembolic stroke compared with large vessel atherosclerotic stroke, while interleukin-6 (IL-6) and macrophage migration inhibitory factor (MIF) levels were significantly lower in the small vessel stroke subtype compared to the large vessel stroke subtype.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hailong Yu, Xin Chen, Xin Guo, Danni Chen, Li Jiang, Yajie Qi, Jun Shao, Luhang Tao, Jing Hang, Guangyu Lu, Yingzhu Chen, Yuping Li
Summary: This study aimed to investigate the role of serum xanthine oxidase (XO) levels in the pathogenesis of acute ischemic stroke (AIS). The results showed that the serum level of XO was significantly higher in AIS patients compared to healthy controls and was an independent risk factor for AIS. Serum XO level also had predictive value for stroke progression and prognosis in AIS patients.
Article
Biochemistry & Molecular Biology
Chien-Hsien Lo, Li-Ching Li, Shun-Fa Yang, Chin-Feng Tsai, Yao-Tsung Chuang, Hsiao-Ju Chu, Kwo-Chang Ueng
Summary: This study investigated the role of miRNAs in modulating fibrotic molecular mechanisms in response to hypoxic conditions, and found that miR-let-7a, miR-let-7e, and miR-133a play important roles in hypoxia-related atrial fibrosis by inhibiting collagen expression and post-transcriptional repression by the JNK pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)