Article
Food Science & Technology
Frantisek Malir, Miroslav Louda, Jakub Toman, Vladimir Ostry, Darina Pickova, Jaroslav Pacovsky, Milos Brodak, Annie Pfohl-Leszkowicz
Summary: The study found OTA in kidney and tumor samples in the Czech Republic, with a correlation between the presence of OTA and OTA-DNA adducts. This provides some clues for exploring the relationship between OTA and kidney diseases and cancer.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Food Science & Technology
Wiem Chtioui, Sandrina Heleno, Quirico Migheli, Paula Rodrigues
Summary: This study evaluated the application of natural plant extracts for controlling Aspergillus carbonarius and OTA contamination in grapes. The results showed that cistus and orange peel extracts had strong antifungal activity against A. carbonarius, while eucalyptus extract effectively reduced OTA production. All tested extracts were able to reduce OTA content in grapes. These findings suggest that plant extracts could be a useful tool for preventing A. carbonarius contamination and OTA production.
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2023)
Article
Food Science & Technology
Hyun Jung Lee, Shufang Li, Kejia Gu, Dojin Ryu
Summary: The study showed that the reduction of OTA during the preparation of rice- and oat-based porridge can be effectively achieved through a simulated indirect steam process, especially when sodium bicarbonate and/or fructose are added.
Article
Chemistry, Applied
Kejia Gu, Dojin Ryu, Hyun Jung Lee
Summary: OTA is a nephrotoxin produced by certain fungal species and commonly found in agricultural commodities. This study examined the thermal stability of OTA in the presence of sugars commonly added to food products, finding that heating OTA with sugars led to changes in its degradation products, with fructose resulting in significantly lower OTA levels and a shift towards less toxic degradation products.
Article
Food Science & Technology
Ziqiang Zhang, Jingyi Xu, Xin Zhang, Jiajia Wang, Hui Xie, Yingying Sun, Qianwen Zhang, Zhaoyang Chang, Yumei Liu
Summary: The study found that selenomethionine has a protective effect on liver injury induced by Ochratoxin A (OTA), improving pathological damage and oxidative stress caused by OTA poisoning in rabbits.
Article
Chemistry, Analytical
Tae-Hun Kim, Ji-Hong Bong, Hong-Rae Kim, Won-Bo Shim, Min-Jung Kang, Jae-Chul Pyun
Summary: A one-step immunoassay using antibody complex with switching peptides is proposed for the rapid detection of OTA. Quantitative analysis of target analytes can be achieved by measuring the fluorescence signals of switching peptides without any washing steps. The direct dilution method is found to be effective for detecting OTA in wines, with a significantly reduced total analysis time.
JOURNAL OF ANALYTICAL SCIENCE AND TECHNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Shreenath Prasad, Barbara Streit, Christina Gruber, Christoph Gonaus
Summary: By supplementing pigs' feed with an enzyme, it is possible to degrade the toxic Ochratoxin A (OTA) into a non-toxic form that can be excreted, thus improving pig health, welfare, productivity, and food safety.
JOURNAL OF ANIMAL SCIENCE
(2023)
Article
Chemistry, Analytical
Lixia Lu, Wei Yuan, Qiang Xiong, Minhui Wang, Yuanjian Liu, Min Cao, Xiaohui Xiong
Summary: The paper introduces a novel detection platform for sensitive OTA detection to avoid false positives caused by the complexity of food matrix. With one-step grain pretreatment, the platform simplifies sample processing and enhances detection capability.
ANALYTICA CHIMICA ACTA
(2021)
Review
Food Science & Technology
Diana I. Meira, Ana I. Barbosa, Joel Borges, Rui L. Reis, Vitor M. Correlo, Filipe Vaz
Summary: Global population growth has a significant impact on the global food industry, posing a threat to food safety and quality. Mycotoxins, particularly Ochratoxin-A (OTA), are produced by fungus that contaminates various food species and products. OTA not only endangers food production but also poses potential toxicological risks to humans, leading to carcinogenic and neurological diseases. Therefore, the development of a selective, sensitive, and reliable OTA biodetection approach is crucial for ensuring food safety.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Food Science & Technology
Eva Cebrian, Felix Nunez, Mar Rodriguez, Silvia Grassi, Alberto Gonzalez-Mohino
Summary: The ripening process of dry-cured meat products involves the development of fungi on the surface, which can be beneficial or health-risky depending on the production of mycotoxins. Near-infrared spectroscopy coupled with Support Vector Machines-Discriminant Analysis models showed high potential for detecting OTA-producing moulds on dry-cured ham agar. Promising results were obtained for predicting OTA-producing species, demonstrating the efficiency of this approach for real-time monitoring of dry-cured ham surfaces.
Article
Food Science & Technology
Laura Pastor, Ariane Vettorazzi, Elizabeth Guruceaga, Adela Lopez de Cerain
Summary: The study shows that male and female rats respond differently to OTA treatment in terms of gene expression in the kidney over time. Females exhibit a progressive and consistent response, while males have an early response with more up-regulated genes. Key DEGs are related to metabolism enzymes and transporters, some of which also show basal sex differences.
Article
Food Science & Technology
Enrique Garcia-Perez, Dojin Ryu, Chan Lee, Hyun Jung Lee
Summary: Ochratoxin A (OTA) is a mycotoxin found in foods that can cause oxidative stress, leading to cytotoxicity in HepG2 cells, including an increase in ROS and a depletion of GSH. Additionally, OTA downregulates the mRNA level of catalase (CAT) and decreases CAT enzymatic activity in a dose-dependent manner.
Article
Biochemical Research Methods
Anna Niarakis, Tomas Helikar
Summary: The passage discusses the use of mechanistic computational models in studying regulatory mechanisms in biological processes, and presents a detailed protocol for model construction. The protocol outlines steps including defining scope, choosing validation criteria, selecting modeling approach, constructing and simulating the model.
BRIEFINGS IN BIOINFORMATICS
(2021)
Article
Food Science & Technology
Yaser I. Shoqairan, Isam A. Mohamed Ahmed, Salah A. Almaiman, Fahad Y. Al Juhaimi, Elfadil E. Babiker, Tawfiq S. Alsulami, Yasser Al Rujib, Abdulmohsen Al Jardan, Asmahan Azhari Ali
Summary: This study investigated the impacts of microwave (MW), ultraviolet (UV-C), and pulsed electric field (PEF) treatments on the OTA level in paprika powder. The results showed that PEF treatment exhibited the highest detoxification level of OTA and had the least effect on the physicochemical quality attributes of paprika powder.
LWT-FOOD SCIENCE AND TECHNOLOGY
(2023)
Article
Environmental Sciences
Ziqiang Zhang, Yingying Sun, Hui Xie, Jiajia Wang, Xin Zhang, Zhangyu Shi, Yumei Liu
Summary: The study investigated the protective effect and mechanism of selenomethionine (SeMet) on ochratoxin A (OTA)-induced nephrotoxicity in rabbits. The results showed that SeMet supplementation improved blood physiological indices, renal function decline, and pathological kidney injury caused by OTA poisoning in the rabbits. SeMet also increased antioxidant capacity, decreased oxidative stress and inflammation, and activated the Nrf2 signaling pathway.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Food Science & Technology
Marco Camardo Leggieri, Simone Decontardi, Paola Battilani
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2018)
Article
Food Science & Technology
M. Camardo Leggieri, A. Lanubile, C. Dall'Asta, A. Pietri, P. Battilani
WORLD MYCOTOXIN JOURNAL
(2020)
Article
Microbiology
Marco Camardo Leggieri, Paola Giorni, Amedeo Pietri, Paola Battilani
FRONTIERS IN MICROBIOLOGY
(2019)
Article
Microbiology
Marco Camardo Leggieri, Amedeo Pietri, Paola Battilani
Article
Food Science & Technology
Michail D. Kaminiaris, Marco Camardo Leggieri, Dimitrios Tsitsigiannis, Paola Battilani
Article
Plant Sciences
Antonio Logrieco, Paola Battilani, Marco Camardo Leggieri, Yu Jiang, Geert Haesaert, Alessandra Lanubile, George Mahuku, Akos Mesterhazy, Alejandro Ortega-Beltran, Marco Pasti, Irina Smeu, Adriana Torres, Jing Xu, Gary Munkvold
Article
Multidisciplinary Sciences
Roberta Arciuolo, Marco Camardo Leggieri, Giorgio Chiusa, Giuseppe Castello, Giuseppe Genova, Nicola Spigolon, Paola Battilani
Summary: The study investigated the effect of different abiotic factors on Diaporthe eres, with findings suggesting optimal temperatures for growth and development, as well as the importance of water activity for the fungal life cycle. The fitted data using nonlinear regression functions could be the basis for developing a predictive model for hazelnut infection by D. eres.
Article
Food Science & Technology
Marco Camardo Leggieri, Marco Mazzoni, Sihem Fodil, Maurizio Moschini, Terenzio Bertuzzi, Aldo Prandini, Paola Battilani
Summary: The study evaluated the potential use of an electronic nose for rapid identification of mycotoxin contamination in maize samples and found that it had high accuracy in distinguishing contamination levels above or below legal limits. Artificial neural network (ANN) was the best method with 78% and 77% accuracy for AFB1 and FBs, respectively, indicating that the e-nose supported by ANN could be a rapid and reliable tool for mycotoxin detection.
Review
Food Science & Technology
Marco Camardo Leggieri, Piero Toscano, Paola Battilani
Summary: The study found that climate change may increase the risk of aflatoxin contamination in maize, with the scientific community reacting and taking action. These studies suggest the need for improved predictive modeling, extension to different crops and geographic areas, and research on the impact of climate change on the co-occurrence of fungi and mycotoxins.
Article
Microbiology
Marco Camardo Leggieri, Marco Mazzoni, Paola Battilani
Summary: This study utilized a machine learning approach to predict mycotoxin contamination in maize fields, achieving an accuracy of over 75% which outperformed traditional statistical methods. The models developed here were shown to be robust, thanks to the large data set and good statistical scores applied.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Roberta Arciuolo, Giorgio Chiusa, Giuseppe Castello, Marco Camardo Leggieri, Nicola Spigolon, Paola Battilani
Summary: The aim of this study was to identify the fungi associated with Turkish hazelnuts and confirm the role of Diaporthe in causing kernel defects. The results showed that Diaporthe had a higher incidence and was positively correlated with hazelnut defects. However, Botryosphaeria was only associated with hidden defects and further research is needed to confirm this finding.
PLANT HEALTH PROGRESS
(2022)
Article
Food Science & Technology
Marco Camardo Leggieri, Marco Mazzoni, Terenzio Bertuzzi, Maurizio Moschini, Aldo Prandini, Paola Battilani
Summary: This study assessed the potential use of an electronic nose combined with CART to quickly distinguish between compliant and DON-contaminated wheat lots. The results showed that this method can be an effective and fast way to identify samples with DON contamination.
Article
Plant Sciences
Marco Camardo Leggieri, Roberta Arciuolo, Giorgio Chiusa, Giuseppe Castello, Nicola Spigolon, Paola Battilani
Summary: Researchers developed a mechanistic model called DEFHAZ to predict hazelnut defects. The model used meteorological and georeferenced data, and was validated by comparing predictions with observed data. The results showed that the model had an accuracy of over 80% and a false negative rate of less than 16%.
Article
Food Science & Technology
Laura Carbonell-Rozas, Linde van der Cruyssen, Chiara Dall'Asta, Marco Camardo Leggieri, Paola Battilani
Summary: Due to the impact of climate change, it is important to consider the potential accumulation of unexpected mycotoxins in susceptible matrices like apples. A fit-for-purpose LC-MS/MS method was proposed to determine co-occurring mycotoxins in apple purees, taking into account the fungal profile isolated from stored apple fruits. The method included fumonisins, Alternaria toxins, aflatoxins, and patulin. The preliminary survey revealed the occurrence of FB1 in apple purees and emphasized the need for monitoring mycotoxin co-occurrence in apples and apple-based products.
FOOD ANALYTICAL METHODS
(2023)
Article
Food Science & Technology
Erika A. Warnatzsch, David S. Reay, Marco Camardo Leggieri, Paola Battilani
FRONTIERS IN SUSTAINABLE FOOD SYSTEMS
(2020)
