Article
Biology
Shu-Hsien Lin, Kun-Ta Wu, Chih-Chi Wang, Kuang-Tzu Huang, Kuang-Den Chen, Li-Wen Hsu, Hock-Liew Eng, King-Wah Chiu
Summary: This study aimed to differentiate the etiology of acute jaundice following living donor liver transplantation by examining the hepatic microRNA expression patterns in various liver graft pathologies. The study found that different pathologies were associated with distinct microRNA expression patterns, suggesting that these patterns may be useful for differential diagnosis of acute jaundice after liver transplantation.
Article
Acoustics
Mengrong He, Qiaofeng Jin, Cheng Deng, Wenpei Fu, Jia Xu, Lingling Xu, Yishu Song, Rui Wang, Wenyuan Wang, Lufang Wang, Wuqi Zhou, Boping Jing, Yihan Chen, Tang Gao, Mingxing Xie, Li Zhang
Summary: Ultrasound-targeted microbubble destruction (UTMD) technique can increase the abundance of AR-related miRNAs in the blood, enabling non-invasive monitoring of AR after heart transplantation.
ULTRASOUND IN MEDICINE AND BIOLOGY
(2023)
Article
Genetics & Heredity
Wenjing Wang, Wen Li, Li Cao, Bo Wang, Chang Liu, Yannan Qin, Bo Guo, Chen Huang
Summary: Acute rejection (AR) is a common and serious complication of liver transplantation (LT). This study identified serum extracellular vesicle (EV) microRNAs (miRNAs) as potential biomarkers for AR in LT patients. The results showed that miR-223 and let-7e-5p were up-regulated, while miR-199a-3p was down-regulated, in AR patients compared to non-AR patients. These miRNAs can serve as promising diagnostic biomarkers for AR in patients subjected to liver transplant.
FRONTIERS IN GENETICS
(2022)
Article
Health Care Sciences & Services
Hongmei Jiang, Hui Guo, Bo Yang, Yuanyuan Zhao, Lai Wei, Zhishui Chen, Dong Chen
Summary: This case series explores the characteristics and outcomes of acute AMR in liver transplant recipients with autoimmune liver disease (ALD). The incidence of acute AMR in ALD patients was higher compared to non-ALD recipients. Individualized therapies based on clinical manifestations resulted in good prognoses for most patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Hsien-Jen Chiang, Ming-Chung Chou, Yi-Hsuan Chuang, Chun-Wei Li, Chih-Che Lin, Hock-Liew Eng, Chao-Long Chen, Yu-Fan Cheng
Summary: The objective of this study is to evaluate the diagnostic performance of BOLD MRI in patients with ACR post-liver transplant and to monitor treatment response.
EUROPEAN RADIOLOGY
(2022)
Article
Immunology
Yi Chen, Wenmin Zhang, Hui Bao, Wubing He, Lihong Chen
Summary: The study found that HMGB1 expression is upregulated in liver allografts during acute rejection, leading to increased inflammatory cell infiltration and DC maturation, ultimately promoting T cell proliferation and differentiation. Inhibition of HMGB1 with glycyrrhizic acid during liver preservation was shown to reduce inflammation, hepatocyte damage, and prolong allograft survival time, suggesting a potential therapeutic target to prevent acute rejection in liver transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Palak Shah, Sean Agbor-Enoh, Pramita Bagchi, Christopher R. deFilippi, Angela Mercado, Gouqing Diao, Dave J. P. Morales, Keyur B. Shah, Samer S. Najjar, Erika Feller, Steven Hsu, Maria E. Rodrigo, Sabra C. Lewsey, Moon Kyoo Jang, Charles Marboe, Gerald J. Berry, Kiran K. Khush, Hannah A. Valantine, GRAfT Investigators
Summary: By analyzing and studying miR expression data in heart transplant patients, miR panels with high diagnostic accuracy for acute rejection can be developed, providing a new non-invasive method for clinical monitoring of heart transplant.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2022)
Article
Cardiac & Cardiovascular Systems
Richard C. Daly, Andrew N. Rosenbaum, Joseph A. Dearani, Alfredo L. Clavell, Naveen L. Pereira, Barry A. Boilson, Robert P. Frantz, Atta Behfar, Shannon M. Dunlay, Richard J. Rodeheffer, John A. Schirger, Timucin Taner, Manish J. Gandhi, Julie K. Heimbach, Charles B. Rosen, Brooks S. Edwards, Sudhir S. Kushwaha
Summary: This study demonstrates the successful transplantation using a heart-after-liver transplantation protocol, which provides profound immunologic protection and prevents adverse immunological outcomes in highly sensitized patients requiring combined heart-liver transplantation. The results show near-elimination of donor specific antibodies and minimal rejection episodes, leading to favorable long-term patient and graft outcomes.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Immunology
Hao Wang, Chenxuan Li, Zhiwei Xiong, Ting Li
Summary: A study found that luteolin (LUT), a natural component, can significantly protect the structure and function of liver grafts, prolong recipient rat survival, ameliorate T cell infiltration, and downregulate proinflammatory cytokines. LUT also inhibits CD4+ T cell proliferation and Th cell differentiation, while increasing the proportion of Tregs, which is crucial for its immunosuppressive effect. This discovery may have important implications for improving immunosuppressive regimens for organ transplantation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Engineering, Multidisciplinary
Jan Lerut, Samuele Iesari
Summary: Perfect surgical techniques and adequate immunosuppression are crucial for graft and patient survival in liver transplantation. The current standard immunosuppression regimen is a triple-drug combination of a calcineurin inhibitor, antimetabolites, and short-term steroids. However, the optimal immunosuppression regimen is still unclear due to diverse study designs and changing definitions of rejection. Future trials should consider multiple endpoints and comprehensive evaluation of patient and graft survival, acute and chronic rejection, and long-term side effects.
Article
Genetics & Heredity
Wu Wu, Menghao Wang, Chunming Li, Zhu Zhu, Yang Zhang, Di Wu, Zhibing Ou, Zuojin Liu
Summary: In this study, we constructed a related ceRNA network using the GSE36798 dataset in the GEO database to explore the molecular mechanism of acute rejection after liver transplantation in rats. Through experimental validation and analysis, a potential regulatory axis was identified. These findings are expected to provide new strategies for the treatment and prevention of acute rejection in the clinical setting.
FRONTIERS IN GENETICS
(2022)
Review
Medicine, General & Internal
Elena Yukie Uebayashi, Hideaki Okajima, Miki Yamamoto, Eri Ogawa, Tatsuya Okamoto, Hironori Haga, Etsurou Hatano
Summary: Antibody-mediated rejection (AMR) of liver allograft transplantation has gained clinical awareness as a potential cause of chronic liver injury and graft failure. The accurate incidence, diagnostic criteria, and treatment protocols of chronic AMR in pediatric patients remain unclear and further research is needed.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Yuanyi Mang, Shengning Zhang, Jiaojiao Zhao, Jianghua Ran, Yingpeng Zhao, Laibang Li, Yang Gao, Wang Li, Guoyu Chen, Jun Ma, Li Li, Fukai Bao
Summary: The pre-sensitized post liver transplant rat model can be used to observe accelerated liver rejection and acute antibody-mediated rejection (AMR), indicating its potential for further study on AMR mechanisms.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Xinxue Zhang, Jun Ma, Han Li, Lin Zhou, Zhe Liu, Shaocheng Lyu, Qiang He, Xianliang Li
Summary: The study revealed the significant role of CD8+ regulatory T cells (Tregs) and FGl2 in acute rejection (AR) of rat liver transplantation. Findings showed the accumulation of CD8+CD45RClow Tregs in allografts, the alleviation of AR with the presence of FGL2, and the prolongation of survival time in recipients, suggesting FGL2 and CD8+CD45RClow Tregs as potential therapeutic targets for AR in liver transplantation.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Sara Assadiasl, Nuala Mooney, Mohammad Hossein Nicknam
Summary: Cytokines play crucial roles in autoimmune, allergic, and infectious diseases, as well as allograft rejection. Recent advances in novel anti-cytokine agents and gene therapy for immunomodulatory cytokines have shown significant improvements in managing dysregulated cytokine secretion and overexpression.
Article
Surgery
Yuanfei Peng, Zheng Wang, Xiaoying Wang, Feiyu Chen, Jian Zhou, Jia Fan, Yinghong Shi
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2019)
Article
Biochemistry & Molecular Biology
Pei-Yao Fu, Bo Hu, Xiao-Lu Ma, Zhang-Fu Yang, Min-Cheng Yu, Hai-Xiang Sun, Ao Huang, Xin Zhang, Jian Wang, Zhi-Qiang Hu, Chen-Hao Zhou, Wei-Guo Tang, Ren Ning, Yang Xu, Jian Zhou
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Surgery
Cheng Huang, Xiao-Dong Zhu, Guo-Ming Shi, Ying-Hao Shen, Guang-Yu Ding, Jia-Bin Cai, Jian Zhou, Jia Fan, Hui-Chuan Sun
Article
Genetics & Heredity
Hui Song, Jue Yang, Yongqiang Zhang, Jianjiang Zhou, Yanmei Li, Xiaojiang Hao
Article
Oncology
Xiu-Tao Fu, Kang Song, Jian Zhou, Ying-Hong Shi, Wei-Ren Liu, Guo-Ming Shi, Qiang Gao, Xiao-Ying Wang, Zhen-Bin Ding, Jia Fan
CANCER CELL INTERNATIONAL
(2019)
Article
Oncology
Meng Duan, Shyamal Goswami, Jie-Yi Shi, Lin-Jie Wu, Xiao-Ying Wang, Jia-Qiang Ma, Zhao Zhang, Yang Shi, Li-Jie Ma, Shu Zhang, Rui-Bin Xi, Ya Cao, Jian Zhou, Jia Fan, Xiao-Ming Zhang, Qiang Gao
CLINICAL CANCER RESEARCH
(2019)
Article
Chemistry, Multidisciplinary
Jian Zhou, Jie Yu, Hui Liao, Yongde Zhang, Xuegang Luo
SEPARATION SCIENCE AND TECHNOLOGY
(2020)
Article
Gastroenterology & Hepatology
Shao-Lai Zhou, Dan Yin, Zhi-Qiang Hu, Chu-Bin Luo, Zheng-Jun Zhou, Hao-Yang Xin, Xin-Rong Yang, Ying-Hong Shi, Zheng Wang, Xiao-Wu Huang, Ya Cao, Jia Fan, Jian Zhou
Article
Oncology
Yi Yang, Qing Chen, Hai-Yan Piao, Biao Wang, Gui-Qi Zhu, Er-Bao Chen, Kun Xiao, Zheng-Jun Zhou, Guo-Ming Shi, Ying-Hong Shi, Wei-Zhong Wu, Jia Fan, Jian Zhou, Zhi Dai
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Oncology
Xiao-Lu Ma, Min-Na Shen, Bo Hu, Bei-Li Wang, Wen-Jing Yang, Li-Hua Lv, Hao Wang, Yan Zhou, An-Li Jin, Yun-Fan Sun, Chuan-Yan Zhang, Shuang-Jian Qiu, Bai-Shen Pan, Jian Zhou, Jia Fan, Xin-Rong Yang, Wei Guo
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2019)
Article
Materials Science, Multidisciplinary
Jian Zhou, Jie Lian, Yingchun Ding, Yan Gao, Wenkun Zhu
RESULTS IN PHYSICS
(2019)
Letter
Gastroenterology & Hepatology
Guo-Ming Shi, Jiping Wang, Xiao-Wu Huang, Xiao-Yong Huang, Yi-Feng He, Yuan Ji, Yi Chen, Dong Wu, Jia-Cheng Lu, Qi-Man Sun, Wei-Ren Liu, Ting Wang, Liu-Xiao Yang, Ying-Yong Hou, Ying-Hong Shi, Jian Sun, Yong-Sheng Xiao, Zheng Wang, Jia Fan, Monica M. Bertagnolli, Jian Zhou
LIVER TRANSPLANTATION
(2021)
Article
Oncology
Ao Huang, De-Zhen Guo, Yu-Peng Wang, Guo-Huan Yang, Qi-Man Sun, Xin Zhang, Yi-Feng He, Kang Song, Xiao-Wu Huang, Xin-Rong Yang, Jia Fan, Jian Zhou, Jie Hu
Summary: The study demonstrated the significance of plasma microRNA panel for predicting and monitoring early tumor recurrence in hepatocellular carcinoma patients following liver transplantation. The positive status of microRNA panel was associated with a higher recurrence rate, and it changed from negative to positive earlier than AFP and DCP upon recurrence.
Article
Medicine, Research & Experimental
Feng Shi, Min Zhou, Li Shang, Qianqian Du, Yueshuo Li, Longlong Xie, Xiaolan Liu, Min Tang, Xiangjian Luo, Jia Fan, Jian Zhou, Qiang Gao, Shuangjian Qiu, Weizhong Wu, Xin Zhang, Ann M. Bode, Ya Cao
Article
Oncology
Yong Zhang, Shi-Ming Shi, Hua Yang, Liu-Xiao Yang, Zheng Wang, Xue-Dong Li, Dan Yin, Ying-Hong Shi, Ya Cao, Zhi Dai, Jian Zhou, Qing Chen