Article
Peripheral Vascular Disease
Xiaohan Lu, Jiandong Zhang, Yi Wen, Jiafa Ren, Robert Griffiths, Nathan P. Rudemiller, Shintaro Ide, Tomokazu Souma, Steven D. Crowley
Summary: In this study, the researchers investigated the role of AT(1) receptors on CD11c(+) cells in the development of hypertension. They found that AT(1) receptor stimulation on dendritic cells (DCs) suppresses renal DC maturation and T cell activation, resulting in protection from sodium retention and blood pressure elevation. These findings provide insights into the pathogenesis of hypertension and offer new possibilities for its treatment.
Article
Medicine, Research & Experimental
Ting Zhao, Sheng Liu, Xinchun Ding, Erica M. Johnson, Nasser H. Hanna, Kanhaiya Singh, Chandan K. Sen, Jun Wan, Hong Du, Cong Yan
Summary: LAL deficiency in mice leads to an increase in CD11c+ cells with metabolic changes and oxidative stress. Pharmacological interventions targeting specific metabolic pathways can reduce the immune functions of these cells and reverse their tumor-promoting effects.
Article
Immunology
Lifei Hou, Koichi Yuki
Summary: This study reveals the importance of CD11c in maintaining T cell survival by showing that CD11c deficiency leads to defects in T cell development in mice.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Hoa Le Mai, Nicolas Degauque, Sabine Le Bot, Marie Rimbert, Karine Renaudin, Richard Danger, Florent Le Borgne, Clarisse Kerleau, Gaelle Tilly, Anais Vivet, Florent Delbos, Alexandre Walencik, Magali Giral, Sophie Brouard
Summary: The study found that the percentage and absolute number of CD28-CD8+ T cells were significantly increased in kidney transplant patients with antibody-mediated rejection (ABMR). Moreover, CD28-CD8+ T cells from patients with ABMR showed a more rigorous response to stimulation compared to their CD28+ counterparts. These findings suggest that differentiated CD28-CD8+ T cells, with increased frequency, number, and function, may play a role in the pathobiology of ABMR.
Article
Immunology
Hinda Najem, Anantha Marisetty, Craig Horbinski, James Long, Jason T. Huse, Isabella C. Glitza Oliva, Sherise D. Ferguson, Priya U. Kumthekar, Derek A. Wainwright, Peiwen Chen, Maciej S. Lesniak, Jared K. Burks, Amy B. Heimberger
Summary: The TME of LMD lacks CD3+ T cells but is enriched in immune suppression and innate immunity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Noriko Sato, Richard N. Bamford, Bonita R. Bryant, Yutaka Tagaya, Thomas A. Waldmann
Summary: When purified, naive T cells and regulatory T cells could not proliferate to the γC-cytokines IL-2, IL-7, or IL-15, despite expressing the cognate cytokine receptors. However, dendritic cells enabled their proliferation through cell-to-cell contact, independent of T cell receptor stimulation. This preconditioning effect activated specific cellular pathways and facilitated cytokine-mediated proliferation of T cells.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Daisuke Tsukui, Yoshitaka Kimura, Hajime Kono
Summary: Atherosclerosis complicates chronic inflammatory diseases by involving a shared physiological pathway regulated by spleen tyrosine kinase (SYK). SYK is found to be involved in atherosclerosis via the inflammatory response. Knockout of SYK gene in atherosclerosis-prone mice reduces atherosclerosis in vivo and ameliorates cell migration in macrophages. CD11c expression on SYK-knockout monocytes and macrophages is regulated by forkhead box protein O1 (FOXO1) through granulocyte-macrophage colony-stimulating factor (GM-CSF) stimulation, mediated by c-Jun amino-terminal kinase (JNK) signaling to FOXO1. Inhibiting FOXO1 alleviates atherosclerosis in mice, suggesting GM-CSF receptor/SYK/JNK/FOXO1/CD11c signaling and FOXO1 as potential therapeutic targets for atherosclerosis and inflammatory diseases.
Article
Immunology
Lianghui Diao, Alexandra Maximiliane Hierweger, Agnes Wieczorek, Petra Clara Arck, Kristin Thiele
Summary: The specific cross talk between pregnancy hormone progesterone and dendritic cells plays a crucial role in regulating the generation of regulatory T cells which are important for fetal development. Knockout of glucocorticoid receptor on dendritic cells improves placental function and fetal development, indicating a disrupted communication between glucocorticoids and dendritic cells favors a tolerant immune microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Florianne M. J. Hafkamp, Esther W. M. Taanman-Kueter, Toni M. M. van Capel, Tom Groot Kormelink, Esther C. de Jong
Summary: This study investigated the effects of Vitamin D3 on the differentiation of specific human T cells. The results showed that Vitamin D3 can restrict the development of Th17 cells, promote the development of regulatory T cells, and reduce the production of specific cytokines by dendritic cells. This provides potential for the use of Vitamin D3 as an adjuvant in the treatment of autoimmune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Urology & Nephrology
Kevin Louis, Paul Fadakar, Camila Macedo, Masaki Yamada, Michelle Lucas, Xinyan Gu, Adriana Zeevi, Parmjeet Randhawa, Carmen Lefaucheur, Diana Metes
Summary: This study used high dimensional flow cytometry to analyze the status of regulatory T cells and transitional B cells in kidney transplant recipients. It found that in patients with antibody-mediated rejection (ABMR), both cell types were significantly reduced in numbers, which correlated with inflammatory antibody responses, microvascular inflammation, and kidney allograft loss.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Susanne M. Brunner, Andrea Ramspacher, Caroline Rieser, Julia Leitner, Hannah Heil, Michael Ablinger, Julia Tevini, Monika Wimmer, Andreas Koller, Josefina Pinon Hofbauer, Thomas K. Felder, Johann W. Bauer, Barbara Kofler, Roland Lang, Verena Wally
Summary: This study aimed to evaluate the effects of topical diacerein on IMQ-induced psoriasis in mice. The results showed that diacerein significantly alleviated psoriasiform-like skin inflammation and reduced psoriasis-associated splenomegaly. The treatment also resulted in a decreased infiltration of CD11c(+) dendritic cells into the skin and spleen.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Farah Abuazzam, Casey Dubrawka, Tarek Abdulhadi, Gwendolyn Amurao, Louai Alrata, Dema Yaseen Alsabbagh, Omar Alomar, Tarek Alhamad
Summary: Despite advances in immunosuppressive medications, antibody-mediated rejection (AMR) remains a major cause of kidney allograft failure. Recent developments in understanding the pathophysiology of AMR and new therapeutic options have emerged. Surveillance protocols using donor-derived cell-free DNA and gene profile testing have allowed for early detection of AMR. Ongoing clinical trials offer opportunities for improving outcomes in kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Louise Malle, Roosheel S. Patel, Marta Martin-Fernandez, O'Jay Stewart, Quentin Philippot, Sofija Buta, Ashley Richardson, Vanessa Barcessat, Justin Taft, Paul Bastard, Julie Samuels, Clotilde Mircher, Anne-Sophie Rebillat, Louise Maillebouis, Marie Vilaire-Meunier, Kevin Tuballes, Brad R. Rosenberg, Rebecca Trachtman, Jean-Laurent Casanova, Luigi D. Notarangelo, Sacha Gnjatic, Douglas Bush, Dusan Bogunovic
Summary: Individuals with Down's syndrome (DS) exhibit multiple impairments such as cardiac, neurocognitive, and growth issues. They are also prone to severe infections and autoimmune disorders. This study reveals an autoimmune-prone state in DS characterized by persistent elevation of cytokines, chronic activation of CD4 T cells, and ongoing B cell activation. Furthermore, auto-antibodies targeting various organs and systems were detected in DS individuals' plasma, suggesting a breach in immune tolerance.
Article
Multidisciplinary Sciences
Manuela Sauter, Reinhard J. Sauter, Henry Nording, Chaolan Lin, Marcus Olbrich, Stella Autenrieth, Christian Gleissner, Martin Thunemann, Nadia Otero, Esther Lutgens, Zouhair Aherrahrou, Dennis Wolf, Lars Zender, Sven Meuth, Robert Feil, Harald F. Langer
Summary: This study investigated the role of CD11c(+) cells in atherosclerosis. The results showed that CD11c(+) cells alleviate atherosclerosis by secreting ApoE, and the level of ApoE derived from CD11c(+) cells is associated with the burden of atherosclerotic plaques.
Article
Immunology
Angela A. F. Gankema, Charita Furumaya, Sara Fernandez-Hermira, Mark Hoogenboezem, Hanke L. Matlung, Robin van Bruggen, Taco W. Kuijpers
Summary: Cancer is a major cause of death worldwide and its treatment outcome is influenced by various factors. In this study, it was found that small, damaged T cells are taken up by macrophages in the tumor microenvironment, while larger, actively proliferating T cells are not affected. This suggests a role of complement and macrophages in clearing suppressed T cells in cancer patients.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Khai Gene Leong, Elyce Ozols, John Kanellis, Shawn S. Badal, John T. Liles, David J. Nikolic-Paterson, Frank Y. Ma
Summary: The study demonstrated that the selective cyclophilin inhibitor GS-642362 effectively protected against acute kidney injury and renal fibrosis in mouse models. The treatment reduced cell death, inflammatory cell infiltration, and fibrosis, supporting further investigation of cyclophilin blockade in various kidney diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pathology
Keren Grynberg, Elyce Ozols, William R. Mulley, Roger J. Davis, Richard A. Flavell, David J. Nikolic-Paterson, Frank Y. Ma
Summary: The JNK1 pathway plays a specific role in IRI-induced proximal tubule cell death, leading to acute renal failure. Jnk1 deficient mice and conditional Jnk1 deletion in the proximal tubule showed significant protection against acute renal ischemia/reperfusion injury. JNK2 does not have a similar role in this process.
AMERICAN JOURNAL OF PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Tyrone L. R. Humphries, Kunyu Shen, Abishek Iyer, David W. Johnson, Glenda C. Gobe, David Nikolic-Paterson, David P. Fairlie, David A. Vesey
Summary: Coagulopathies in patients with diabetes and CKD are not fully understood. This study found that glucose availability affects TF synthesis in HTECs through PAR2 activation, and high glucose concentrations enhance this process while inhibiting PAR2, glycolysis, or glycosylation suppresses TF synthesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nursing
Kimberley Crawford, Jac Kee Low, Amelia K. Le Page, William Mulley, Rosemary Masterson, Joshua Kausman, Natasha Cook, Peter Mount, Elizabeth Manias
Summary: This study found that adolescents, young adults, mothers, and health professionals have different perspectives on the transition to adult care. Mothers perceived the process as more challenging, while health professionals emphasized the importance of equal engagement of parents with adolescents and young adults.
JOURNAL OF CHILD HEALTH CARE
(2022)
Review
Pathology
Ana B. Nunez-Nescolarde, David J. Nikolic-Paterson, Alexander N. Combes
Summary: Kidney organoids and tubuloids are suitable models for studying kidney diseases and can help elucidate the pathogenic mechanisms, but their use in complex diseases is still in the early stages.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Pathology
Keren Grynberg, Lifang Tian, Greg Tesch, Elyce Ozols, William R. Mulley, David J. Nikolic-Paterson, Frank Y. Ma
Summary: This study found that mice with established diabetes were more susceptible to acute kidney injury (AKI) associated with renal ischemia/reperfusion injury (IRI). The researchers identified JNK and SYK as potential therapeutic targets for anticipated AKI in patients with diabetes.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Review
Endocrinology & Metabolism
Lingyun Kong, Sofianos Andrikopoulos, Richard J. MacIsaac, Laura K. Mackay, David J. Nikolic-Paterson, Niloufar Torkamani, Neda Zafari, Evelyn C. S. Marin, Elif Ekinci
Summary: Diabetic kidney disease (DKD) is a prevalent complication of diabetes and a leading cause of end-stage kidney disease. Inflammation plays a crucial role in the progression of DKD, with the adaptive immune system potentially contributing to the disease development. Targeting the adaptive immune system, specifically T cells, may have therapeutic benefits in preventing the progression of DKD.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Article
Food Science & Technology
Khai Gene Leong, Elyce Ozols, John Kanellis, Frank Y. Ma, David J. Nikolic-Paterson
Summary: The study found that Cyclophilin D (CypD) facilitates aristolochic acid-induced acute kidney injury, but does not contribute to the transition from acute kidney injury to chronic kidney disease during ongoing exposure to aristolochic acid.
Editorial Material
Physiology
Patrick Ming-Kuen Tang, Haiyong Chen, Ying Tang, David J. Nikolic-Paterson, Hui Yao Lan
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cell Biology
James van der Wolde, Kotaro Haruhara, Victor G. Puelles, David Nikolic-Paterson, John F. Bertram, Luise A. Cullen-McEwen
Summary: This study investigated the progressive loss of podocytes during healthy aging and how the remaining podocytes respond to podocyte depletion at different ages. The results showed that podocyte number per glomerulus did not change in control mice during the examined time period but control mice at 18 months had the largest podocytes and the lowest podocyte density. Podocyte depletion at different ages resulted in different levels of albuminuria and glomerulosclerosis. In addition, the study found that the mTORC1-mediated podocyte hypertrophy played an important role in both physiological aging and adaptive settings.
CELL AND TISSUE RESEARCH
(2022)
Article
Genetics & Heredity
Jacqueline M. Ogier, Yujing Gao, Eileen M. Dunne, Michael A. Wilson, Sarath C. Ranganathan, Gregory H. Tesch, David JNikolic Paterson, Alain Dabdoub, Rachel A. Burt, Bryony A. Nayagam, Paul J. Lockhart
Summary: Aminoglycoside antibiotics can cause toxic effects on the sensory hair cells in the inner ear, leading to permanent hearing loss and vestibular impairment. This study investigates the potential of ASK1 inhibition as a novel strategy to prevent aminoglycoside ototoxicity, providing significant pre-clinical evidence.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Correction
Genetics & Heredity
Jacqueline M. Ogier, Yujing Gao, Eileen M. Dunne, Michael A. Wilson, Sarath C. Ranganathan, Gregory H. Tesch, David J. Nikolic Paterson, Alain Dabdoub, Rachel A. Burt, Bryony A. Nayagam, Paul J. Lockhart
JOURNAL OF MOLECULAR MEDICINE-JMM
(2022)
Article
Pediatrics
Yohei Ikezumi, Masatoshi Yoshikane, Tomomi Kondoh, Yuji Matsumoto, Naonori Kumagai, Masahiro Kaneko, Hiroya Hasegawa, Takeshi Yamada, Toshiaki Suzuki, David J. Nikolic-Paterson
Summary: This study showed that mizoribine can slow down the progression of kidney fibrosis in childhood IgA nephropathy by reducing the number of specific macrophage populations associated with fibrosis.
PEDIATRIC NEPHROLOGY
(2023)
Article
Urology & Nephrology
Jinhua Li, Xinli Qu, Chengnong Guan, Ning Luo, Huiting Chen, Andy Li, Hongjie Zhuang, Jiayi Yang, Hui Diao, Shuhan Zeng, Qing Wang, Jinjin Fan, Mengjie Jiang, Xiaoyan Bai, Zhiming Ye, Xiaoyun Jiang, Wei Chen, David J. Nikolic-Paterson, Xueqing Yu
Summary: Progressive fibrosis is a characteristic of chronic kidney disease, but effective treatments are lacking. The micropeptide regulator of b-oxidation (MOXI) is found to regulate kidney fibrosis. MOXI expression is up-regulated in human fibrotic kidney disease, and its deletion protects mice against fibrosis and inflammation. Antisense MOXI oligonucleotide treatment effectively reduces MOXI expression and protects against kidney fibrosis.
KIDNEY INTERNATIONAL
(2023)
Article
Multidisciplinary Sciences
Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Max Kam-Kwan Chan, Vivian Weiwen Xue, Xiao-Ru Huang, Calvin Sze-Hang Ng, Dongmei Zhang, Kam-Tong Leung, Chun-Kwok Wong, Tin-Lap Lee, Eric W-F Lam, David J. Nikolic-Paterson, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang
Summary: In this study, the researchers found that phenotype and function of tumor-associated neutrophils (TANs) are influenced by the microenvironment, resulting in different impact on tumor development as N1 or N2 state. They discovered that Smad3 activation is negatively correlated with N2 state and patient survival in NSCLC patients. In preclinical lung cancer models, targeting Smad3 reprogrammed TANs to an antitumor state (N1), suppressing tumor growth. Mechanistically, Smad3 regulated the maturity of TANs and maintained the N2 state through controlling genes related to cell fate determination. Thus, the findings suggest that Smad3 signaling could be a therapeutic target for cancer immunotherapy.
NATURE COMMUNICATIONS
(2023)