Article
Immunology
Su Woong Jung, Won-Hee Cho, Jung-Woo Seo, Yang-Gyun Kim, Ju-Young Moon, Jin Sug Kim, Chan-Duck Kim, Byung Ha Chung, Jae Berm Park, Yeong Hoon Kim, Sang-Ho Lee
Summary: Urine exosomal bkv-miR-B1-5p is associated with BK virus nephropathy and may serve as a predictive marker during the early posttransplant period.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Article
Immunology
Tingting Chen, Xiaoyu Li, Jina Wang, Xuanchuan Wang, Tongyu Zhu, Ruiming Rong, Cheng Yang
Summary: A 66-year-old Chinese man underwent deceased donor kidney transplantation and developed BKV nephropathy and acute TCMR post-transplant. Treatment with basiliximab improved the kidney graft status.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Daopeng Yang, Bowen Zhuang, Yan Wang, Gang Huang, Ming Xu, Manxia Lin, Wei Wang, Guangliang Huang, Changxi Wang, Xiaoyan Xie, Xiaohua Xie
Summary: High-frequency ultrasound characteristics are valuable for diagnosing BK polyomavirus-associated nephropathy (BKPyVAN) and distinguishing it from transplant rejection in kidney transplant recipients.
Article
Engineering, Environmental
Kushneet Kaur Sodhi, Dileep Kumar Singh
Summary: The presence of antibiotics in wastewater has ecotoxicological effects on living beings, especially fluoroquinolones. Research is focusing on finding effective methods for removing these antibiotics to prevent harm to the environment and living organisms.
JOURNAL OF WATER PROCESS ENGINEERING
(2021)
Article
Urology & Nephrology
Isaac E. Hall, Peter Philip Reese, Sherry G. Mansour, Sumit Mohan, Yaqi Jia, Heather R. Thiessen-Philbrook, Daniel C. Brennan, Mona D. Doshi, Thangamani Muthukumar, Enver Akalin, Meera Nair Harhay, Bernd Schroeppel, Pooja Singh, Francis L. Weng, Jonathan S. Bromberg, Chirag R. Parikh
Summary: A study on kidney transplant recipients found that deceased-donor AKI was independently associated with lower risk for BKV infection, contrary to the initial hypothesis. Data from the OPTN database also showed that donor AKI was linked to lower risk for graft failure attributed to BKV.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Surgery
Zachary A. Yetmar, Yogish C. Kudva, Maria Teresa Seville, Wendelyn Bosch, Patrick G. Dean, Janna L. Huskey, Pooja Budhiraja, Tambi Jarmi, Aleksandra Kukla, Elena Beam
Summary: This retrospective cohort study aims to investigate the epidemiology and outcomes of BK polyomavirus (BKV) infection in pancreas transplant recipients. The results showed that BKV DNAemia was common among pancreas transplant recipients, but lower than pancreas-kidney recipients. However, BKV DNAemia was not associated with adverse native kidney outcomes, but was associated with pancreas allograft failure.
CLINICAL TRANSPLANTATION
(2023)
Review
Genetics & Heredity
Margherita Borriello, Diego Ingrosso, Alessandra Fortunata Perna, Angela Lombardi, Paolo Maggi, Lucia Altucci, Michele Caraglia
Summary: Poliomavirus BK virus (BKV) is a highly infective virus that can cause asymptomatic infections. In renal transplanted recipients, BKV can lead to severe complications. Current treatments and prophylaxis options are limited, but increasing surveillance and early diagnosis show promise in improving outcomes.
Review
Virology
Sam Kant, Alana Dasgupta, Serena Bagnasco, Daniel C. Brennan
Summary: BK virus is a latent infection prevalent in humans, particularly in kidney transplant recipients due to dysfunctional cellular immune response. Screening for the virus has been effective in preventing nephropathy and graft loss, but diagnosis and treatment can be challenging. This in-depth review covers the virus's history, virology, epidemiology, cellular response, pathogenesis, screening and diagnostic methods, evidence-based treatment strategies, upcoming therapeutics, and the issue of re-transplantation in patients.
Article
Multidisciplinary Sciences
James McCaffrey, Vijesh J. Bhute, Mohan Shenoy
Summary: In pediatric kidney transplant recipients, BK virus infection is typically associated with younger age at transplantation, CMV-negative recipient serostatus, and higher levels of immunosuppression. Close monitoring of BK viremia and timely clinical intervention can lead to similar long-term outcomes for BKN patients compared to controls.
SCIENTIFIC REPORTS
(2021)
Review
Biochemistry & Molecular Biology
Ana R. Millanao, Aracely Y. Mora, Nicolas A. Villagra, Sergio A. Bucarey, Alejandro A. Hidalgo
Summary: Quinolones, with broad antibacterial spectrum, high oral bioavailability, and excellent tissue penetration, are one of the most widely used antimicrobials in clinics. However, overuse has led to the rise of resistance and threats to the effectiveness of this class of drugs in treating infections.
Article
Immunology
Christophe Masset, Simon Ville, Franck Halary, Benjamin Gaborit, Celine Bressolette-Bodin, Clement Deltombe, Amaury Dujardin, Lola Jacquemont, Sabine Lebot, Delphine Kervella, Lucille Figueres, Diego Cantarovich, Magali Giral, Maryvonne Hourmant, Gilles Blancho, Claire Garandeau, Aurelie Meurette, Jacques Dantal
Summary: This study reported two cases of BKV replication in kidney transplant recipients after non-severe SARS-CoV-2 infection. Even without severe symptoms, SARS-CoV-2 infection may disrupt the immune system leading to increased viral replication, highlighting the need for monitoring in kidney transplant recipients post-infection.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Virology
Baptiste Demey, Veronique Descamps, Claire Presne, Francois Helle, Catherine Francois, Gilles Duverlie, Sandrine Castelain, Etienne Brochot
Summary: In this study, the levels of bkv-miR-B1-3p and bkv-miR-B1-5p in urine were found to be potentially valuable markers for monitoring viral replication in kidney transplant recipients (KTRs), which could help prevent excessive reduction in immunosuppressive therapy. The study also observed a progressive reduction in BKPyV DNA load and subsequent disappearance of microRNAs in some KTRs with sustained BKPyV infection, while stability was seen in others over the first year post-transplantation.
Article
Environmental Sciences
Ambedkar Gandamalla, Saikumar Manchala, Atul Verma, Yen-Pei Fu, Vishnu Shanker
Summary: The study synthesized highly efficient zinc-aluminum layered double hydroxides with graphitic carbon nitride (ZALDH/CN) composites for the degradation of CIP under visible light. The ZALDH/CN composites showed a high synergistic effect with more specific surface area, leading to enhanced visible light adsorption capacity and catalytically active sites. The study demonstrated superior photocatalytic activity of ZALDH/CN composites for antibiotic pollutant CIP degradation under visible-light illumination.
Article
Immunology
Jiayu Guo, Bo Yu, Jilin Zou, Long Zhang, Tianyu Wang, Jiangqiao Zhou, Tao Qiu
Summary: An analysis of CYP3A5 gene polymorphism in 134 renal transplant recipients revealed a higher incidence of BKV infection in the fast metabolism genotype group compared to the slow metabolism genotype group, suggesting a potential relationship between CYP3A5 gene polymorphism and BKV infection.
TRANSPLANT IMMUNOLOGY
(2022)
Article
Surgery
Emma Cannon, Chara Ntala, Nicola Joss, Maeve Rahilly, Wendy Metcalfe, Marie O'Donnell, Paul J. Phelan
Summary: Kidney transplant recipients have an increased risk of developing urothelial carcinoma, and BK polyoma virus infection may play a role in this. A study found that kidney transplant recipients with a history of BKV infection developed rare micropapillary tumors, supporting the pathogenicity of BK virus in the development of these tumors.
CLINICAL TRANSPLANTATION
(2023)
Article
Immunology
D. Wojciechowski, S. Chandran, A. Webber, R. Hirose, F. Vincenti
TRANSPLANTATION PROCEEDINGS
(2017)
Article
Surgery
Fadi Issa, Samuel Strober, Joseph R. Leventhal, Tatsuo Kawai, Dixon B. Kaufman, Josh Levitsky, Megan Sykes, Valeria Mas, Kathryn J. Wood, Nancy Bridges, Lisbeth A. Welniak, Sindhu Chandran, Joren C. Madsen, Peter Nickerson, Anthony J. Demetris, Fadi G. Lakkis, Angus W. Thomson
Summary: The International Workshop on Clinical Transplant Tolerance focuses on the progress of studies involving immunosuppression minimization or withdrawal in solid organ transplantation. The latest workshop showcased clinical trials utilizing donor or recipient cell therapy in combination with organ transplantation to minimize or withdraw immunosuppressive drugs. Additionally, mechanisms of tolerance and potential predictors/biomarkers were discussed, as well as strategies to enhance safety and improve patient selection/risk stratification for clinical trials in hematopoietic cell transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Monica Fung, Charles Y. Chiu, Catherine DeVoe, Sarah B. Doernberg, Brian S. Schwartz, Charles Langelier, Timothy J. Henrich, Deborah Yokoe, John Davis, Steven R. Hays, Sindhu Chandran, Jasleen Kukreja, Dianna Ng, John Prostko, Russell Taylor, Kevin Reyes, Emma Bainbridge, Allison Bond, Peter Chin-Hong, Jennifer M. Babik
AMERICAN JOURNAL OF TRANSPLANTATION
(2020)
Article
Surgery
Dejan Dobi, Flavio Vincenti, Sindhu Chandran, John R. Greenland, Christopher Bowman, Adeline Chen, Henrik Junger, Zoltan G. Laszik
CLINICAL TRANSPLANTATION
(2020)
Article
Immunology
Monica Fung, Ashok Nambiar, Suchi Pandey, J. Matthew Aldrich, Justin Teraoka, Christopher Freise, John Roberts, Sindhu Chandran, Steven R. Hays, Emma Bainbridge, Catherine DeVoe, Annelys Roque Gardner, Deborah Yokoe, Timothy J. Henrich, Jennifer M. Babik, Peter Chin-Hong
Summary: Convalescent plasma treatment appears to be safe and potentially beneficial for immunosuppressed patients with COVID-19, as evidenced by clinical improvements in patients who received this therapy. Further data is needed to determine the efficacy of convalescent plasma as a primary or adjunctive therapy for COVID-19, especially for immunocompromised patients.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Article
Surgery
Sindhu Chandran, Joey Leung, Crystal Hu, Zoltan G. Laszik, Qizhi Tang, Flavio G. Vincenti
Summary: In this study, the blockade of IL-6 with tocilizumab showed promising results in controlling T cell alloimmune response in kidney transplant recipients by increasing Tregs frequency, dampening Teff function, and reducing graft inflammation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Genetics & Heredity
Arya Zarinsefat, George Hartoularos, Dmitry Rychkov, Priyanka Rashmi, Sindhu Chandran, Flavio Vincenti, Chun J. Yee, Minnie M. Sarwal
Summary: COVID-19 poses a significant threat to global health, with IL-6 playing a key role in the cytokine storm. Tocilizumab shows promise in treating COVID-19 by reducing expression of inflammatory genes and pathways, particularly in monocytes, as observed in single-cell RNA sequencing.
FRONTIERS IN GENETICS
(2021)
Editorial Material
Urology & Nephrology
Sindhu Chandran, David Wojciechowski
KIDNEY INTERNATIONAL REPORTS
(2020)
Review
Immunology
Michelle F. Huffaker, Srinath Sanda, Sindhu Chandran, Sharon A. Chung, E. William St Clair, Gerald T. Nepom, Dawn E. Smilek
Summary: The article reviews concepts evolved from the clinical trial experience of the Immune Tolerance Network, focusing on lessons learned from innovative mechanistic studies and new strategies for tolerance induction.
FRONTIERS IN IMMUNOLOGY
(2021)
Editorial Material
Surgery
Sindhu Chandran, Roslyn B. Mannon
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Editorial Material
Urology & Nephrology
Sindhu Chandran, Peter G. Stock
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Donald E. Hricik, Brian Armstrong, Tarek Alhamad, Daniel C. Brennan, Jonathan S. Bromberg, Suphamai Bunnapradist, Sindhu Chandran, Robert L. Fairchild, David P. Foley, Richard Formica, Ian W. Gibson, Karen Kesler, S. Joseph Kim, Roslyn B. Mannon, Madhav C. Menon, Kenneth A. Newell, Peter Nickerson, Jonah Odim, Emilio D. Poggio, Randall Sung, Ron Shapiro, Kathryn Tinckam, Flavio Vincenti, Peter S. Heeger
Summary: This study tested the effects of blocking TNFa during kidney transplantation. The results showed that there was no significant difference in eGFR at 24 months between the IFX and placebo groups, but the IFX group had higher rates of BK virus infection.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Surgery
Sindhu Chandran, Qizhi Tang
Summary: Interleukin-6 (IL-6), a crucial cytokine in T cell activation, plays a significant role in rejection and tolerance in kidney transplantation. Therapies targeting IL-6 signaling have shown clinical efficacy in autoimmune and inflammatory diseases. IL-6 inhibition primarily affects B cells, plasma cells, and HLA antibodies in kidney transplant recipients.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Editorial Material
Immunology
Megan Sykes, Sindhu Chandran, Tatsuo Kawai, Josh Levitsky, Markus Mapara, James Mathew, Angus Thomson, Kazuhiko Yamada
Meeting Abstract
Immunology
Arya Zarinsefat, Priyanka Rashmi, Andrea Da Silva, Tara Sigdel, Sindhu Chandran, Quizi Tang, Chun Ye, Flavio Vincenti, Minnie Sarwal