Article
Immunology
Fan Zhang, Saifu Yin, Yu Fan, Turun Song, Zhongli Huang, Jiayu Liang, Jiapei Wu, Youmin Yang, Tao Lin, Xianding Wang
Summary: This study found that the secretor status of both donors and recipients may have an impact on the outcomes of ABO incompatibility kidney transplantation. Recipients with weak secretor status may have better post-transplant renal function, while recipients from secretor donors had a lower incidence of graft rejection in the first year after transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Moon Young Oh, Haeryoung Kim, Nam-Joon Yi, Suyoung Hong, Jeong-Moo Lee, Sola Lee, Suk Kyun Hong, YoungRok Choi, Kwang-Woong Lee, Kyung-Suk Suh
Summary: This study found that the expression of dABOAg decreased over time in ABOi ALDLT, but patients with early rejection showed sustained expression. Therefore, dABOAg expression may be involved in the accommodation mechanism in ABOi transplantation.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Health Care Sciences & Services
Wei-Chen Lee, Chen-Fang Lee, Tsung-Han Wu, Hao-Chien Hung, Jin-Chiao Lee, Yu-Chao Wang, Chih-Hsien Cheng, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan
Summary: ABO incompatible living donor liver transplantation can be successful, but anti-ABO isoagglutinin rebound may lead to antibody-mediated rejection and graft loss. Adding bortezomib to the desensitization regimen can mitigate the risk of isoagglutinin rebound and prevent clinical AMR in patients with high isoagglutinin titers.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Pediatrics
Catherine de Magnee, Louise Brunee, Roberto Tambucci, Aurore Pire, Isabelle Scheers, Etienne M. Sokal, Pamela Baldin, Francis Zech, Stephane Eeckhoudt, Raymond Reding, Xavier Stephenne
Summary: ABO-incompatible living donor liver transplantation is a feasible option for pediatric end-stage liver disease, but it carries increased risks for the recipient, especially for children older than 1 year. C4d immunostaining may be a hallmark of acute humoral rejection in ABO-incompatible liver transplantation.
Article
Urology & Nephrology
Ga Young Heo, Yunyoung Jang, Hyungwook Choi, Yong Chul Kim, Seung Seok Han, Hyung Woo Kim, Juhan Lee, Kyu Ha Huh, Beom Seok Kim, Jaeseok Yang
Summary: Early antibody-mediated rejection has negative effects on ABO-incompatible kidney transplantation, leading to increased chronic antibody-mediated rejection and decreased graft survival.
JOURNAL OF NEPHROLOGY
(2023)
Review
Medicine, General & Internal
Lin-rui Dai, Xiao-hui Wang, Yi-bo Hou, Zhi-yu Zou, Song Chen, Wei-jie Zhang, Sheng Chang
Summary: With improved immunosuppressive regimens, ABO-incompatible kidney transplantation has seen increased success rates, but complex management of immunosuppression protocols and associated complications remain a challenge. Over-immunosuppression induced by desensitization combined with immunosuppressants can lead to infections, acute rejections, and ultimately the loss of the transplanted kidney.
FRONTIERS IN MEDICINE
(2023)
Article
Medicine, General & Internal
Seoung Hoon Kim, Young-Kyu Kim
Summary: This study reports a successful case of emergency, ABO-incompatible, adult-to-adult, living donor liver re-transplantation for late graft failure from chronic rejection complicated by pneumonia-related sepsis. The case demonstrates that satisfactory long-term outcomes can be achieved in selected patients through ABO-incompatible, adult-to-adult, living donor liver re-transplantation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Florian Kaelble, Caner Suesal, Luiza Pego da Silva, Claudius Speer, Louise Benning, Christian Nusshag, Lien Pham, Hien Tran, Matthias Schaier, Claudia Sommerer, Joerg Beimler, Arianeb Mehrabi, Martin Zeier, Christian Morath
Summary: Living donor kidney transplant recipients with pre-existing sensitization can achieve good graft outcomes with desensitization protocols, comparable to standard-risk recipients. Adequate patient selection and close immunological monitoring are crucial to minimize rejection episodes and graft loss.
FRONTIERS IN MEDICINE
(2021)
Article
Cell Biology
Fei Han, Qipeng Sun, Zhengyu Huang, Heng Li, Maolin Ma, Tao Liao, Zihuang Luo, Lingling Zheng, Nana Zhang, Nan Chen, Liangqing Hong, Ning Na, Qiquan Sun
Summary: The study reveals that donor plasma mitochondrial DNA (dmtDNA) levels are correlated with the occurrence of antibody-mediated rejection (ABMR) in renal allograft recipients. Higher dmtDNA levels are associated with acute rejection and ABMR, presenting dmtDNA as a potential predictive marker for ABMR in organ evaluation.
Article
Surgery
Masayuki Tasaki, Hiroaki Tateno, Takashi Sato, Azusa Tomioka, Hiroyuki Kaji, Hisashi Narimatsu, Kazuhide Saito, Yuki Nakagawa, Toshinari Aoki, Masami Kamimura, Takashi Ushiki, Manabu Okada, Yuko Miwa, Kiyohiko Hotta, Yutaka Yoshida, Kota Takahashi, Yoshihiko Tomita
Summary: In this study, a new method to measure antibody titer using a microarray of recombinant CD31 linked to ABO antigens was developed. The results showed that this method had higher sensitivity and specificity in predicting antibody-mediated rejection in kidney transplantation compared to traditional isohemagglutinin assays.
TRANSPLANT INTERNATIONAL
(2022)
Article
Surgery
Wei-Chen Lee, Chih-Hsien Cheng, Chen-Fang Lee, Hao-Chien Hung, Jin-Chiao Lee, Tsung-Han Wu, Yu-Chao Wang, Ting-Jung Wu, Hong-Shiue Chou, Kun-Ming Chan
Summary: A rapid preparation regimen with bortezomib injection and plasma exchange was designed to reduce isoagglutinin titers quickly for ABO-I LDLT in acute liver failure patients, leading to a high success rate in the transplant surgery.
CLINICAL TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Daqiang Zhao, Lan Zhu, Shengyuan Zhang, Zhiliang Guo, Lu Wang, Tianhui Pan, Rula Sa, Zhishui Chen, Jipin Jiang, Gang Chen
Summary: This study reports the first ABO-incompatible deceased donor kidney transplantation (ABOi DDKT) in an infant. The recipient was diagnosed with a Wilms tumor gene 1 (WT1) mutation and had received peritoneal dialysis before the transplant. No antibody removal treatment was performed, and the recipient had good graft function and normal development at 11 months post-transplant. ABOi DDKT without antibody removal treatment is a feasible option for kidney transplantation in small infants.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Andrew Bentall, Mylvaganam Jeyakanthan, Manjit Braitch, Christopher W. Cairo, Todd L. Lowary, Stephanie Maier, Anne Halpin, Bruce Motyka, Lu Zou, Lori J. West, Simon Ball
Summary: ABO-incompatible kidney transplantations require preemptive antibody reduction. A study on ABO-O recipients of ABO-A kidneys revealed that ABO-A trisaccharide is sufficient for IgM binding to all A-subtypes, with A-II being the major, but not the sole, antigen relevant to treatment and immune modulation. IgG binding to different A-subtypes exhibited varying degrees of specificity, with A-II showing the most reduced antibody levels posttransplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Medicine, General & Internal
Hyeyeon Cho, Jinyoung Bae, Hyun-Kyu Yoon, Ho-Jin Lee, Seong-Mi Yang, Suk Hyung Choe, Chul-Woo Jung, Kyung-Suk Suh, Won Ho Kim
Summary: High preoperative and postoperative peak Ig M isoagglutinin titers were significantly associated with the risk of acute kidney injury (AKI) in ABO-incompatible liver transplantation. However, no significant differences were observed in other clinical outcomes based on isoagglutinin titers. This suggests that high isoagglutinin titers may serve as a warning sign for AKI risk after liver transplantation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Moritz Benjamin Immohr, Payam Akhyari, Hug Aubin, Ralf Westenfeld, Arash Mehdiani, Raphael Romano Bruno, Nihat Firat Sipahi, Sophiko Erbel-Khurtsidze, Petra Reinecke, Igor Tudorache, Artur Lichtenberg, Udo Boeken
Summary: IGM-IVIG treatment is an effective method for addressing antibody-mediated graft rejection, showing significant results in restoring ventricular function and reducing malignant arrhythmias.
Article
Gastroenterology & Hepatology
Masaaki Hirata, Shintaro Yagi, Takero Shindo, Atsushi Yoshizawa, Gozo Kiguchi, Masakatsu Kaneshiro, Kimiko Yurugi, Yosuke Miyachi, Sena Iwamura, Siyuan Yao, Shinji Uemoto
Summary: Graft-versus-host disease (GVHD) following liver transplantation is rare but fatal. Donor-dominant one-way HLA matching at three HLA-A/B/DR loci should be avoided to prevent GVHD, while HLA-C/DQ/DP does not have a significant impact on GVHD in this study. It is important to determine HLA genotypes at the allele level for liver transplantation.
HEPATOLOGY RESEARCH
(2021)
Article
Immunology
Jiro Kusakabe, Shintaro Yagi, Kazunari Sasaki, Ryuji Uozumi, Hiroyasu Abe, Yusuke Okamura, Kojiro Taura, Toshimi Kaido, Shinji Uemoto
Summary: The study found that small-for-size grafts and large grafts in living-donor liver transplantation have similar outcomes, with a GRWR of 0.6% being a reasonable minimum requirement for graft volume. However, small grafts should be carefully indicated for high-risk cases.
Article
Gastroenterology & Hepatology
Rosanna Asselta, Elvezia M. Paraboschi, Alessio Gerussi, Heather J. Cordell, George F. Mells, Richard N. Sandford, David E. Jones, Minoru Nakamura, Kazuko Ueno, Yuki Hitomi, Minae Kawashima, Nao Nishida, Katsushi Tokunaga, Masao Nagasaki, Atsushi Tanaka, Ruqi Tang, Zhiqiang Li, Yongyong Shi, Xiangdong Liu, Ma Xiong, Gideon Hirschfield, Katherine A. Siminovitch, Marco Carbone, Giulia Cardamone, Stefano Duga, M. Eric Gershwin, Michael F. Seldin, Pietro Invernizzi
Summary: This study is the first comprehensive investigation of the chrX contribution to the genetics of an autoimmune liver disease, revealing a novel genome-wide significant locus related to PBC.
Editorial Material
Surgery
Mihai Oltean, Alexandru Nistor, Mats Hellstrom, Michael Axelsson, Shintaro Yagi, Eiji Kobayashi, Alberto Ballestin, Yelena Akelina, Norbert Nemeth
Letter
Immunology
Shinya Okumura, Shintaro Yagi, Yuhei Hamaguchi, Yuji Yoshioka, Siyuan Yao, Naoko Kamo, Kojiro Taura, Toshimi Kaido, Shinji Uemoto
Article
Multidisciplinary Sciences
Shintaro Yagi, Takashi Ito, Hisaya Shirai, Siyuan Yao, Yuki Masano, Eri Ogawa, Ryosuke Gabata, Shinji Uemoto, Eiji Kobayashi
Summary: The study confirmed the applicability of a high-resolution 3D video system in micro- and macro-borderless surgery, showing that the system was effective in various surgical procedures and improved precision and visualization in surgery.
Letter
Immunology
Jiro Kusakabe, Shintaro Yagi, Shinji Uemoto
Correction
Oncology
Ryohei Takei, Tomoharu Miyashita, Satoshi Takada, Hidehiro Tajima, Itasu Ninomiya, Hiroyuki Takamura, Sachio Fushida, Ai Harashima, Seiichi Munesue, Shintaro Yagi, Noriyuki Inaki, Tetsuo Ohta, Yasuhiko Yamamoto
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Ryohei Takei, Tomoharu Miyashita, Satoshi Takada, Hidehiro Tajima, Itasu Ninomiya, Hiroyuki Takamura, Sachio Fushida, Ai Harashima, Seiichi Munesue, Shintaro Yagi, Noriyuki Inaki, Tetsuo Ohta, Yasuhiko Yamamoto
Summary: Chronic inflammation plays a role in tumor development, including esophageal cancer. The study found that metformin could potentially suppress esophageal cancer by improving the immunosuppressive tumor microenvironment and immune evasion.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Gastroenterology & Hepatology
Tadahiro Takada, Shuji Isaji, Masahiro Yoshida, Akihiko Horiguchi, Hisami Ando, Shuichi Miyakawa, Seiki Kiriyama, Harumi Gomi, Shuntaro Mukai, Ryota Higuchi, Yuta Abe, Kohji Okamoto, Kenji Suzuki, Naoyuki Toyota, Shutaro Hori, Yuki Homma, Hiroyuki Kato, Akiko Umezawa, Jiro Hata, Dai Inoue, Motoyuki Kobayashi, Toshio Tsuyuguchi, Hirotoshi Maruo, Yusuke Kumamoto, Yukio Asano, Yuka Kondo, Satoshi Arakawa, Koji Asai, Yasuhisa Mori, Yukiko Nagamachi, Shugo Mizuno, Shintaro Yagi, Tetsuji Ohyama, Takeyuki Misawa, Keiji Sano, Takao Itoi, Nobuhiko Taniai, Michiaki Unno, Masakazu Yamamoto, Toshihiko Mayumi
Summary: This study introduced a modified Socratic method for educational seminars, focusing on a clinical scenario of moderate acute cholecystitis. By using lectures, videos, and interactive tools, participants engaged in repeated questioning and discussions, leading to a significant increase in the recognition rate of the topic. The method received high praise and is likely to be adopted by other academic societies in the future.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Correction
Gastroenterology & Hepatology
Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Nao Nishida, Seik-Soon Khor, Olivier Gervais, Yosuke Kawai, Masao Nagasaki, Katsushi Tokunaga, Ruqi Tang, Yongyong Shi, Zhiqiang Li, Brian D. Juran, Elizabeth J. Atkinson, Alessio Gerussi, Marco Carbone, Rosanna Asselta, Angela Cheung, Mariza de Andrade, Aris Baras, Julie Horowitz, Manuel A. R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Ann Spicer, Victoria L. Mulcahy, Jinyoung Byun, Younghun Han, Richard N. Sandford, Konstantinos N. Lazaridis, Christopher I. Amos, Gideon M. Hirsch, Michael F. Seldin, Pietro Invernizzi, Katherine A. Siminovitch, Xiong Ma, Minoru Nakamura, George F. Mells
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nadja Kroeger, Zoltan Czigany, Jipin Jiang, Mamdouh Afify, Pascal Paschenda, Kazuyuki Nagai, Shintaro Yagi, Rene H. Tolba
Summary: This study investigated the effects of fibrinolysis combined with Venous Systemic Oxygen Persufflation (VSOP) on the preservation of livers retrieved from donors after circulatory death (DCD). The results showed that the combination treatment improved microvascular flow, microperfusion velocity, and portal venous flow. It also reduced enzyme release and lactate dehydrogenase levels, indicating improved organ integrity and viability. The findings suggest that SK + VSOP combination treatment may be a potential therapeutic approach for DCD in the clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Siyuan Yao, Shintaro Yagi, Masaaki Hirata, Yosuke Miyachi, Eri Ogawa, Ryuji Uozumi, Takuya Sugimoto, Takashi Asahara, Shinji Uemoto, Etsuro Hatano
Summary: This prospective study investigated the changes in gut microbiota and associated intestinal environment during the early period after liver transplantation. The recipients showed dysbiosis and depletion of organic acid before transplantation, which were related to the severity of liver disease. The transplantation procedure caused minimal changes in gut microbiota and organic acid concentrations in the donors, while the recipients exhibited delayed recovery in these factors.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Masaaki Hirata, Shintaro Yagi, Takashi Ito, Yuki Masano, Shinya Okumura, Siyuan Yao, Yosuke Miyachi, Hikaru Aoki, Kaoru Katano, Etsuro Hatano
Summary: The present study describes an efficient five-step training protocol for rat liver transplantation (LT), which can be mastered within 3 months through continuous training. The training includes watching videos, performing actual operations, and achieving specific goals. Systematizing the training increases its efficiency, and determining the specific number of operations in advance helps maintain motivation.
EUROPEAN SURGICAL RESEARCH
(2023)
Article
Surgery
Kanta Jobara, Ayako Yamamori, Masato Shizuku, Nobuhiko Kurata, Yasuhiro Fujimoto, Hideki Muramatsu, Yoshiyuki Takahashi, Yasuhiro Ogura
Summary: A case of successful pediatric living-donor liver transplantation for sustained liver failure after resolution of infiltrative massive hepatic invasion in stage 4S neuroblastoma is presented.
SURGICAL CASE REPORTS
(2023)