Article
Biochemistry & Molecular Biology
Beata Roka, Pal Tod, Tamas Kaucsar, Eva Nora Bukosza, Imre Voros, Zoltan V. Varga, Balazs Petrovich, Bence Agg, Peter Ferdinandy, Gabor Szenasi, Peter Hamar
Summary: Delayed contralateral nephrectomy improved kidney function after IR and decreased fibrosis progression. miRNAs play a crucial role in this process.
Article
Pharmacology & Pharmacy
Zengying Liu, Chen Guan, Chenyu Li, Ningxin Zhang, Chengyu Yang, Lingyu Xu, Bin Zhou, Long Zhao, Hong Luan, Xiaofei Man, Yan Xu
Summary: This study found that tilianin has a protective effect on I/R-induced AKI through the ERK/EGR1/BCL2L1 pathway by using bioinformatics analysis. It provides new insights into the protective effect and underlying molecular mechanisms of tilianin on I/R-induced AKI.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Geriatrics & Gerontology
Tamas Kaucsar, Beata Roka, Pal Tod, Phuong Thanh Do, Gabor Szenasi, Peter Hamar, Zoltan Hegediis
Summary: Elderly patients are more susceptible to acute kidney injury (AKI), with long noncoding RNAs (lncRNAs) playing a key role in cellular processes. This study found that both aging and ischemia-reperfusion injury (IRI) can affect the expression of renal lncRNAs, suggesting a versatile and complex role of lncRNAs in aging and kidney injury. Furthermore, significant changes were observed in the expression levels of lncRNAs in the control kidneys of old mice.
Article
Biochemistry & Molecular Biology
Eun Jung Park, Jihyun Je, Theodomir Dusabimana, Seung Pil Yun, Hye Jung Kim, Hwajin Kim, Sang Won Park
Summary: Renal ischemia reperfusion (IR) injury can lead to multiple organ failure, including the liver and intestine. The activation of mineralocorticoid receptor (MR) is involved in this process. This study demonstrated that the MR antagonist canrenoic acid (CA) protects against AKI-induced hepatic and intestinal injury through reducing oxidative stress, inflammatory response, and cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Physiology
Sheng He, Lili He, Fangran Yan, Junda Li, Xiaoting Liao, Maoyao Ling, Ren Jing, Linghui Pan
Summary: Through a comprehensive analysis of Gene Expression Omnibus data, this study identified the related genes and pathways in ischemia-reperfusion injury-acute kidney injury and provided potential biomarkers and new insights for early diagnosis and treatment.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Heng-Chih Pan, Yau-Hung Chen, Wei-Ching Fang, Vin-Cent Wu, Chiao-Yin Sun
Summary: KDM4C plays a critical role in kidney development and acute kidney injury (AKI). Knockdown of KDM4C leads to impaired kidney development and decreased cell survival in zebrafish and mouse models. Furthermore, KDM4C may exert a protective effect on cell survival in AKI by regulating mitochondrial dynamics and function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Izumi Nagayama, Kaori Takayanagi, Hajime Hasegawa, Akito Maeshima
Summary: In this study, the expression and localization of follistatin in normal and ischemic rat kidneys were examined, and urinary follistatin levels were measured to assess its potential as a biomarker for acute kidney injury. The results showed that follistatin was mainly localized in the distal tubules of the cortex in normal kidneys, while it was also present in the distal tubules of both the cortex and outer medulla in ischemic kidneys. Urinary follistatin levels were significantly increased in ischemic rats and correlated with the duration of ischemia, the follistatin-positive area, and the acute tubular damage area.
Article
Biochemistry & Molecular Biology
Karla Johanna Ruth Hoyer-Allo, Martin Richard Spaeth, Ruth Hanssen, Marc Johnsen, Susanne Brodesser, Kathrin Kaufmann, Katharina Kiefer, Felix Carlo Koehler, Heike Goebel, Torsten Kubacki, Franziska Grundmann, Bernhard Schermer, Jens Bruening, Thomas Benzing, Volker Burst, Roman-Ulrich Mueller
Summary: Research shows that caloric restriction (CR) can protect mice from renal ischemia-reperfusion injury (IRI) and significantly reduce AEA levels. However, in human trials, an increase in AEA levels was observed post-CR, unlike in mice and C. elegans. The study results suggest that CR modulates endocannabinoid levels in mice, but the CR-mediated renal protection is not dependent on this effect.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Jennifer S. Y. Li, Harry Robertson, Katie Trinh, Arti M. Raghubar, Quan Nguyen, Nicholas Matigian, Ellis Patrick, Angus W. Thomson, Andrew J. Mallett, Natasha M. Rogers
Summary: Ischemia reperfusion injury is a common cause of acute kidney injury. Adoptively transferred tolerogenic dendritic cells can successfully limit kidney injury and provide protection against ischemia reperfusion injury.
KIDNEY INTERNATIONAL
(2023)
Article
Biochemistry & Molecular Biology
Benedikt Kolbrink, Friedrich Alexander von Samson-Himmelstjerna, Maja Lucia Messtorff, Theresa Riebeling, Raphael Nische, Jessica Schmitz, Jan Hinrich Brasen, Ulrich Kunzendorf, Stefan Krautwald
Summary: Ferroptosis, a type of iron-dependent programmed cell death, plays a vital role in multiple diseases. However, there are no pharmacologic inhibitors of ferroptosis in clinical use. In this study, vitamin K1 was identified as an efficient inhibitor of ferroptosis, providing a new strategy for pharmacological control of this mode of cell death.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ha Nee Jang, Jin Hyun Kim, Myeong Hee Jung, Taekil Tak, Jung Hwa Jung, Seunghye Lee, Sehyun Jung, Se-Ho Chang, Hyun-Jung Kim
Summary: This study demonstrates that inflammasome-mediated inflammation accompanied by immune modulation and fibrosis is a potential target for EPCs as a treatment for IRI-induced AKI and prevention of progression to CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
Badr Khbouz, Francois Lallemand, Arianna Cirillo, Pascal Rowart, David Legouis, Nor Eddine Sounni, Agnes Noel, Pascal De Tullio, Sophie de Seigneux, Francois Jouret
Summary: This study investigates the protective effects and mechanisms of kidney-centered irradiation against renal ischemia-reperfusion injury (I/R). Kidney irradiation increased vascular surface in the renal parenchyma and conferred resistance against renal I/R damage. These findings suggest potential strategies for the treatment of ischemic acute kidney injury.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2022)
Review
Medicine, Research & Experimental
Fatemeh Sabet Sarvestani, Negar Azarpira, Ismail H. Al-Abdullah, Ali-Mohammad Tamaddon
Summary: Ischemia reperfusion injury can lead to tissue damage, especially during organ transplantation. By manipulating miRNAs level, they can be used as a biomarker for early diagnosis of IRI or suggestive to be therapeutic agents in clinical situation in future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Dan Xu, Pan-pan Chen, Pei-qing Zheng, Fan Yin, Qian Cheng, Zhuan-li Zhou, Hong-yan Xie, Jing-yao Li, Jia-yun Ni, Yan-zhe Wang, Si-jia Chen, Li Zhou, Xiao-xia Wang, Jun Liu, Wei Zhang, Li-min Lu
Summary: This study revealed that sustained activation of YAP in the post-acute phase of AKI is associated with renal functional deterioration and fibrosis, with KLF4 being responsible for this persistence. Blocking the activation of the KLF4-YAP pathway may be a way to prevent the transition of AKI into CKD.
ACTA PHARMACOLOGICA SINICA
(2021)
Article
Biochemistry & Molecular Biology
Johanna Stoermer, Wilfried Gwinner, Katja Derlin, Stephan Immenschuh, Song Rong, Mi-Sun Jang, Nelli Shushakova, Hermann Haller, Faikah Gueler, Robert Greite
Summary: This study investigated the effects of diclofenac on the progression of AKI and long-term renal consequences in the setting of pre-existing subclinical AKI. The results showed that diclofenac aggravated renal injury in a dose and time-dependent manner and even a single dose can cause progression to chronic kidney disease.