Article
Immunology
Zhenggang Zhang, Na Zhang, Junyu Shi, Chan Dai, Suo Wu, Mengya Jiao, Xuhuan Tang, Yunfei Liu, Xiaoxiao Li, Yong Xu, Zheng Tan, Feili Gong, Fang Zheng
Summary: The study revealed the significant role of IL-33/ST2 signaling in cardiac allograft vasculopathy, with opposite effects observed when either allografts or recipients had ST2 deficiency. The differential impact on immune cell infiltration by ST2 deficiency suggests a potential for different outcomes in post-heart transplant intervention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jan Novak, Tana Machackova, Jan Krejci, Julie Bienertova-Vasku, Ondrej Slaby
Summary: Congestive heart failure affects about 23 million people worldwide, and cardiac allograft transplantation is one of the last options for patients with terminal refractory heart failure. The prognosis of patients after heart transplantation is influenced by rejection and allograft vasculopathy, with monitoring requiring invasive and uncomfortable procedures. MiRNAs play a potential role in the pathophysiology of rejection and may be used in clinical practice for diagnosis and prediction of rejection occurrence.
Review
Immunology
Hanwen Zhang, Zhuonan Li, Wei Li
Summary: Macrophages, as a critical part of the immune system, play important roles in transplantation rejection. M1 and M2 macrophages have different functions in acute and chronic rejection, respectively, contributing to tissue damage and poor allograft survival.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
Brian A. Bergmark, Thomas A. Zelniker, Miae Kim, Mandeep R. Mehra, Garrick C. Stewart, Deborah S. Page, Erica L. Woodcome, Michael M. Givertz
Summary: Early aspirin use after orthotopic heart transplantation was associated with lower rates of cardiac allograft vasculopathy, particularly in patients with episodes of allograft rejection.
CLINICAL TRANSPLANTATION
(2021)
Article
Surgery
Victoria Gorbacheva, Ran Fan, Satoshi Miyairi, Robert L. Fairchild, William M. Baldwin III, Anna Valujskikh
Summary: Antibodies reactive to self-antigens are important in posttransplant immune responses. This study identifies DNA topoisomerase I as a novel self-antigen in transplant settings and demonstrates that autoantibodies enhance activation of donor-reactive T cells following renal transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Immunology
Jiho Han, Yasbanoo Moayedi, Erik J. Henricksen, Kian Waddell, Julien Valverde-Twiggs, Daniel Kim, Helen Luikart, Bing M. Zhang, Jeffrey Teuteberg, Kiran K. Khush
Summary: During the first year after heart transplantation, patients with primary graft dysfunction (PGD) had similar incidence of acute cellular rejection (ACR) and development of de novo donor-specific antibodies (DSAs), but a higher risk of cardiac allograft vasculopathy (CAV) compared with patients without PGD.
Article
Cardiac & Cardiovascular Systems
Carmela Napolitano, Giorgia Grutter, Paola Francalanci, Antonio Amodeo, Aurelio Secinaro
Summary: Heart transplant recipients undergo postoperative screening to exclude complications. Cardiac magnetic resonance imaging is a non-invasive tool for monitoring graft health. We describe a case of a female heart transplant recipient with worsening clinical condition.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Surgery
Vera Usuelli, Moufida Ben Nasr, Francesca D'Addio, Kaifeng Liu, Andrea Vergani, Basset El Essawy, Jun Yang, Emma Assi, Mayuko Uehara, Chiara Rossi, Anna Solini, Annalisa Capobianco, Elena Rigamonti, Luciano Potena, Massimo Venturini, Mario Sabatino, Lorena Bottarelli, Enrico Ammirati, Maria Frigerio, Eduardo Castillo-Leon, Anna Maestroni, Cinzia Azzoni, Cristian Loretelli, Andy Joe Seelam, Albert K. Tai, Ida Pastore, Gabriella Becchi, Domenico Corradi, Gary A. Visner, Gian Zuccotti, Nelson B. Chau, Reza Abdi, Marcus G. Pezzolesi, Paolo Fiorina
Summary: The study found that miR-21 is overexpressed in chronic allograft vasculopathy (CAV) in both murine and human samples, and targeting miR-21 delays the onset of CAV by reprogramming macrophage metabolism.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Article
Surgery
Eilon Ram, Robert Klempfner, Amir Peled, Yigal Kassif, Leonid Sternik, Jacob Lavee, Yael Peled
Summary: The study analyzed the impact of weight gain after heart transplantation on the development of cardiovascular disease, finding that weight gain, mainly contributed by fat mass, is associated with increased risk of cardiac allograft vasculopathy and rejection. Follow-up should focus on weight gain and preventive measures.
CLINICAL TRANSPLANTATION
(2021)
Article
Biochemistry & Molecular Biology
Yi-Wen Lin, Chien-Sung Tsai, Chun-Yao Huang, Yi-Ting Tsai, Chun-Ming Shih, Shing-Jong Lin, Chi-Yuan Li, Cheng-Yen Lin, Shih-Ying Sung, Feng-Yen Lin
Summary: This study explores the feasibility of far-infrared therapy in preventing vasculopathy induced by orthotopic allograft transplantation (OAT). The results show that far-infrared therapy can effectively inhibit smooth muscle cell proliferation and reduce inflammation, leading to decreased severity of vasculopathy in OAT recipients.
Article
Surgery
Oscar A. Mendiz, Paul Gamboa, Maria F. Renedo, Gustavo A. Lev, Liliana E. Favaloro, Alejandro M. Bertolotti
Summary: Cardiac allograft vasculopathy (CAV) is a fibro-proliferative disease affecting coronary arteries post-heart transplantation. Despite often being clinically silent, IVUS is a reliable and safe technique for detecting angiographically silent CAV in heart transplant patients, with potential long-term clinical impact. Further large multicenter studies are needed to validate these findings.
CLINICAL TRANSPLANTATION
(2021)
Article
Immunology
Ya-fei Qin, De-jun Kong, Hong Qin, Yang-lin Zhu, Guang-ming Li, Cheng-lu Sun, Yi-ming Zhao, Hong-da Wang, Jing-peng Hao, Hao Wang
Summary: This study investigated the synergistic effects of melatonin (MT) in combination with mesenchymal stromal cells (MSCs) in attenuating chronic allograft vasculopathy. The results showed that the combined therapy effectively ameliorated pathological changes, inhibited T cell proliferation, modulated immune cell populations, reduced circulating antibody levels, and decreased inflammatory cytokine levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Juan M. Ortega-Legaspi, Paco E. Bravo
Summary: This review provides an overview of the complex pathophysiology, detection, and treatment of cardiac allograft vasculopathy (CAV) beyond the first year post heart transplantation. Understanding CAV is crucial for improving long-term outcomes in heart transplant patients.
Article
Biotechnology & Applied Microbiology
Elisa Serafini, Anna Corti, Diego Gallo, Claudio Chiastra, Xian C. Li, Stefano Casarin
Summary: Cardiac allograft vasculopathy (CAV) is a coronary artery disease that affects heart transplant recipients. The etiology and evolution of CAV are largely unknown, and traditional animal models are limited and expensive. This study proposes agent-based models (ABMs) as a computational tool for deciphering the mechanobiological mechanisms driving vascular adaptation. The results indicate that inflammation and hemodynamic disturbances are the main driving factors, with hemodynamic factors playing a minor role.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Immunology
Zhe Yang, Fei Han, Tao Liao, Haofeng Zheng, Zihuan Luo, Maolin Ma, Jiannan He, Lei Li, Yongrong Ye, Rui Zhang, Zhengyu Huang, Yannan Zhang, Qiquan Sun
Summary: Artemisinin demonstrates significant immunosuppressive effects in rat cardiac transplantation model, attenuating rejection reactions and prolonging allograft survival. By targeting multiple effector cells, artemisinin effectively reduces T cell-mediated rejection and antibody-mediated rejection, showing potential for clinical use in transplant rejection prevention.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Surgery
D. H. Mallon, G. E. Riddiough, D. M. Summers, A. J. Butler, C. J. Callaghan, L. L. Bradbury, V. Bardsley, V. Broecker, K. Saeb-Parsy, N. Torpey, J. A. Bradley, G. J. Pettigrew
AMERICAN JOURNAL OF TRANSPLANTATION
(2015)
Article
Surgery
V. Kosmoliaptsis, M. Salji, V. Bardsley, Y. Chen, S. Thiru, M. H. Griffiths, H. C. Copley, K. Saeb-Parsy, J. A. Bradley, N. Torpey, G. J. Pettigrew
AMERICAN JOURNAL OF TRANSPLANTATION
(2015)
Article
Surgery
M. O. Hamed, Y. Chen, L. Pasea, C. J. Watson, N. Torpey, J. A. Bradley, G. Pettigrew, K. Saeb-Parsy
AMERICAN JOURNAL OF TRANSPLANTATION
(2015)
Article
Surgery
A. D. Barlow, M. O. Hamed, D. H. Mallon, R. J. Brais, F. M. Gribble, M. A. Scott, W. J. Howat, J. A. Bradley, E. M. Bolton, G. J. Pettigrew, S. A. Hosgood, M. L. Nicholson, K. Saeb-Parsy
AMERICAN JOURNAL OF TRANSPLANTATION
(2015)
Article
Radiology, Nuclear Medicine & Medical Imaging
F. E. Powell, S. J. F. Harper, C. J. Callaghan, A. Shaw, E. M. Godfrey, J. A. Bradley, C. J. E. Watson, G. J. Pettigrew
CLINICAL RADIOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
Anna J. Dare, Angela Logan, Tracy A. Prime, Sebastian Rogatti, Martin Goddard, Eleanor M. Bolton, J. Andrew Bradley, Gavin J. Pettigrew, Michael P. Murphy, Kourosh Saeb-Parsy
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2015)
Article
Surgery
B. Mirshekar-Syahkal, D. Summers, L. L. Bradbury, M. Aly, V. Bardsley, M. Berry, J. M. Norris, N. Torpey, M. R. Clatworthy, J. A. Bradley, G. J. Pettigrew
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)
Letter
Peripheral Vascular Disease
Mingzheng Aaron Goh, Jason M. Ali, Regin Lagaac, Adam D. Barlow, Gavin J. Pettigrew
JOURNAL OF VASCULAR ACCESS
(2016)
Article
Surgery
Mingzheng Aaron, Jason M. Ali, Satheesh Iype, Gavin J. Pettigrew
JOURNAL OF VASCULAR SURGERY
(2016)
Article
Cell Biology
Ines G. Harper, Jason M. Ali, Simon J. F. Harper, Elizabeth Wlodek, Jawaher Alsughayyir, Margaret C. Negus, M. Saeed Qureshi, Reza Motalleb-Zadeh, Kourosh Saeb-Parsy, Eleanor M. Bolton, J. Andrew Bradley, Menna R. Clatworthy, Thomas M. Conlon, Gavin J. Pettigrew
Article
Cell Biology
Jason M. Ali, Margaret C. Negus, Thomas M. Conlon, Ines G. Harper, M. Saeed Qureshi, Reza Motallebzadeh, Richard Willis, Kourosh Saeb-Parsy, Eleanor M. Bolton, J. Andrew Bradley, Gavin J. Pettigrew
Letter
Surgery
Veena Surendrakumar, Mohammad Ayaz Hossain, Gavin Pettigrew
JOURNAL OF VASCULAR SURGERY
(2017)
Article
Surgery
Irum Amin, Andrew J. Butler, Gail Defries, Neil K. Russell, Simon J. F. Harper, Asif Jah, Kourosh Saeb-Parsy, Gavin J. Pettigrew, Christopher J. E. Watson
TRANSPLANT INTERNATIONAL
(2017)
Review
Immunology
Jawaher Alsughayyir, Gavin J. Pettigrew, Reza Motallebzadeh
FRONTIERS IN IMMUNOLOGY
(2017)
Letter
Surgery
J. A. Richards, K. Jones, Z. Moinuddin, G. J. Pettigrew
AMERICAN JOURNAL OF TRANSPLANTATION
(2017)