Article
Biochemistry & Molecular Biology
Max M. Maurer, Marius Ibach, Julius Plewe, Axel Winter, Paul Ritschl, Brigitta Globke, Robert oellinger, Georg Lurje, Wenzel Schoening, Johann Pratschke, Dennis Eurich
Summary: The objective of this study was to investigate the adherence, efficacy, and safety after converting stable liver transplant patients from IR-Tac to LCP-Tac. The results showed that LCP-Tac improved adherence and was safe for use in liver transplant patients.
Article
Health Care Sciences & Services
Chih-Yang Hsiao, Ming-Chih Ho, Cheng-Maw Ho, Yao-Ming Wu, Po-Huang Lee, Rey-Heng Hu
Summary: The study investigated the impact of tacrolimus blood concentration after five years of liver transplant on long-term patient survival outcomes, with findings suggesting that patients with a tacrolimus trough level of 4.6-10.2 ng/mL had significantly better long-term survival. The recommendation from the study is that adult liver transplant patients should maintain a tacrolimus level of no lower than 4.6 ng/mL for optimal long-term survival.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Microbiology
Ping-Chin Lai, Cheng-Hsu Chen, Long-Bin Jeng, Tung-Min Yu, Shang-Feng Tsai, Ming-Ju Wu, Shao-Bin Cheng, Sheng-Shun Yang, Teng-Yu Lee
Summary: The GZR/EBR single-tablet regimen for 12 weeks is highly effective and well tolerated in GT-1b HCV-infected liver or kidney transplant recipients, with generally easy management of drug-drug interactions.
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
(2022)
Article
Immunology
Yu-Chen Hsu, Chien-Hung Chen, Hui-Fu Huang, Ying-Te Lee, Meng-Chuan Wu, Chien-Wen Su, Huei-Chi Chou, Li-Fang Wang, Hsuan-Shu Lee, Shu-Wha Lin, Ping-Ning Hsu, Yao-Ming Wu, Jin-Chuan Sheu, Meng-Tzu Weng
Summary: This study found that high-dose tacrolimus in combination with PD1 blockade has an antitumor effect and reduces transplant rejection in mouse models of allograft skin transplantation and HCC. These results suggest that a clinical trial of PD1 inhibitors for HCC in liver transplantation is worth considering.
Article
Medicine, General & Internal
Jei-Wen Chang, Hui-Hsin Yang, Niang-Cheng Lin, Fang-Cheng Kuo, Tzu-Ching Lin, Hsin-Lin Tsai
Summary: This study identified risk factors for post-transplant fractures in liver transplant recipients, especially those who were aged ≥65 years, female, hepatitis C carriers, had a history of fractures within 1 year prior to transplant, alcoholism, and higher daily prednisolone dose. The use of tacrolimus and sirolimus/everolimus was associated with a decreased risk of fractures. The findings highlight the importance of identifying high-risk individuals and implementing preventive measures.
ANNALS OF MEDICINE
(2023)
Article
Medicine, General & Internal
Zhi-yu Zou, Lin-rui Dai, Yi-bo Hou, Chen-zhen Yu, Ren-jie Chen, Yan-yan Chen, Bin Liu, Hui-bo Shi, Nian-qiao Gong, Zhi-shui Chen, Song Chen, Sheng Chang, Wei-jie Zhang
Summary: This study found that an immunosuppressive regimen of SRL combined with low-dose ER-TAC is equally effective and safe as standard immunosuppressive regimens for renal transplant recipients, and may improve graft renal function and medication adherence.
FRONTIERS IN MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Afroditi Orfanidou, George V. Papatheodoridis, Evangelos Cholongitas
Summary: The combination of high genetic barrier NAs and HBIG is considered as the standard of care for preventing HBV recurrence after liver transplantation. Alternative routes of HBIG administration are being considered due to high cost.
LIVER INTERNATIONAL
(2021)
Article
Immunology
Bin Lou, Guanghua Ma, Feifei Lv, Quan Yuan, Fanjie Xu, Yuejiao Dong, Sha Lin, Yajun Tan, Jie Zhang, Yu Chen
Summary: The study aimed to evaluate HBV reinfection post-liver transplantation using biomarkers. Results showed that lower pretransplantation qHBcAb is associated with HBV infection, and baseline concentration of qHBcAb is a promising predictor for HBV recurrence in liver transplant patients, guiding antiviral treatment for HBV.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Yuan Liu, Rui Wang, Peizhen Wen, Wenbin An, Jinxin Zheng, Tao Zhang, Pengshan Zhang, Haoyu Wang, Fan Zou, Hui Pan, Junwei Fan, Zhihai Peng
Summary: This study investigated the genetic risk of patients with tacrolimus intolerance after liver transplantation. The results suggested that switching to cyclosporine (SFTC) may increase the risk of dyslipidemia and insulin resistance, while specific SNPs of CYP3A5 gene could be potential genetic risks for tacrolimus intolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Sihao Zheng, Yuanyang Chen, Zhiwei Wang, Yanjia Che, Qi Wu, Shun Yuan, Xiaohan Zhong
Summary: Matrine, an alkaloid derived from traditional Chinese herbs, has been found to have protective effects against oxidative stress injury and inflammation in heart transplantation, prolonging post-transplant survival and inhibiting inflammatory cell infiltration. Additionally, it can suppress DCs maturation, reduce oxidative damage and apoptosis in allograft hearts, and modulate NF-KB and ERK1/2 signaling pathways.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Amedeo De Nicolo, Michele Pinon, Alice Palermiti, Antonello Nonnato, Alessandra Manca, Jacopo Mula, Silvia Catalano, Francesco Tandoi, Renato Romagnoli, Antonio D'Avolio, Pier Luigi Calvo
Summary: The study aimed to describe the concentrations and variability of tacrolimus in whole blood and peripheral blood mononuclear cells (PBMC) in pediatric patients undergoing constant immunosuppressive maintenance therapy after liver transplantation. Variability in PBMC concentrations of tacrolimus was similar to the variability in whole blood, with weight-adjusted dose and age appearing as significant predictors of concentrations in both compartments. Seasonal variation of tacrolimus concentrations was observed in whole blood but not in PBMC within the same individual patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Gastroenterology & Hepatology
Takuya Genda, Takafumi Ichida, Eiji Tanaka, Satoshi Mochida, Yoshiyuki Ueno, Shuji Terai, Ayano Inui, Yoshihide Ueda, Hideki Ohdan, Hiroto Egawa, Koji Umeshita, Hiroyuki Furukawa, Yukihiro Inomata
Summary: This study aimed to clarify the characteristics and prognostic factors of patients with allograft liver failure awaiting deceased donor liver transplantation in Japan. It was found that recurrent HCV and PSC were major causes of allograft liver failure, and additional factors such as age, CTP score, MELD score, ALT levels, and causes of allograft failure were identified as independent risk factors associated with waitlist mortality.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Medicine, General & Internal
Yung-Fong Tsai, Fu-Chao Liu, Chun-Yu Chen, Jr-Rung Lin, Huang-Ping Yu
Summary: This study aimed to investigate the relationship between HCC recurrence and immunosuppressants after liver transplantation, and found that the use of mycophenolate mofetil significantly increased the risk of HCC recurrence. A strategy of minimizing mycophenolate mofetil dosage is recommended for achieving recurrence-free survival.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Man Xie, Qing Li, Bei Zhang, Qun Zhang, Qiu-Ju Tian, Hong Liu, Yun-jin Zang, Wei Rao
Summary: The prevalence of H. pylori infection among LT recipients was 19.6%, which increased with the postoperative time. H. pylori eradication with BQT was safe and effective in LT recipients.
Article
Immunology
Khalid Alswat, Elvy Soliman, Isam Salih, Ahmed Bashmail, Alexia Letierce, Ali Benmousa, Saad Alghamdi, Khalid Bzeizi, Saleh A. Alqahtani, Mohamed Shawkat, Dieter C. Broering, Waleed K. Al-Hamoudi
Summary: The study found that patients with autoimmune hepatitis receiving transplantation had relatively high long-term survival rates, especially those who underwent living donor transplantation. The significant predictors of graft survival included MELD score, donor age, donor type, and renal function.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Gastroenterology & Hepatology
Natalia Garcia Morales, Margarita Fernandez de la Varga, Javier Pumares Perez, Martin Menendez Rodriguez, Sagrario Gutierrez Morato, Carmen Castillo Cejas, Victoria Aguilera, Salvador Benlloch, Luis Menendez Rodriguez, Teresa Seoane Pillado, Noel Pin Vieito, Joaquin Cubiella
Summary: Inadequate social support is associated with higher mortality in the general population and in patients with chronic diseases. However, there is a lack of studies on social support in liver cirrhosis and its impact on prognosis. This study analyzed the impact of social support on the survival of patients with decompensated cirrhosis. The results showed that inadequate social support predicted lower survival rate, while adequate social support independently improved survival rate, regardless of clinical variables. Therefore, social intervention strategies should be considered in the management of liver cirrhosis.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Gastroenterology & Hepatology
Manuel Romero-Gomez, Rocio Aller, Javier Ampuero, Conrado Fernandez Rodriguez, Salvador Augustin, Raquel Latorre, Jesus Rivera-Esteban, Belen Martinez Urroz, Luisa Gutierrez Garcia Maria, Sonia Alonso Lopez, Agustin Albillos, Marta Hernandez, Isabel Graupera, Salvador Benlloch, Antonio Olveira, Javier Crespo, Jose Luis Calleja
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Article
Gastroenterology & Hepatology
Marina Berenguer, Mercedes Vergara, Carolina Almohalla, Alicia Hernandez, Sonia Blanco, Milagros Testillano, Eva Girona, Marta Casado, Miren Garcia, Maria -Vega Catalina, Carolina Munoz, Maria Luisa Gutierrez, Esther Molina, Miriam Romero, Alejandra Otero, Tania Hernaez-Alsina, Vanessa Bernal-Monterde, Sara Lorente, Helena Masnou, Lucia Bonet, Susana Soto, Concha Gisbert, Maria-Paz Valer, Judith Gomez, Gemma Pacheco, Julia Morillas, Martha Gonzalez, Nuria Dominguez, Maria Lazaro, Sonia Pascual, Immaculada Castello, GEMHEP
Summary: Significant heterogeneity in the diagnosis and management of Wilson's disease patients is revealed in this multicenter retrospective cohort study conducted in Spain, and the incorporation of genetic testing may improve the diagnosis.
GASTROENTEROLOGIA Y HEPATOLOGIA
(2023)
Review
Biochemistry & Molecular Biology
Patrice Marques, Vera Francisco, Laura Martinez-Arenas, Angela Carvalho-Gomes, Elena Domingo, Laura Piqueras, Marina Berenguer, Maria-Jesus Sanz
Summary: Non-alcoholic fatty liver disease (NAFLD) is the most prevalent chronic liver disease in Western countries, affecting about 25% of adults. It encompasses a range of liver diseases characterized by abnormal fat accumulation in the liver tissue, which can progress to inflammation and damage. This can ultimately lead to irreversible conditions like cirrhosis and hepatocarcinoma, resulting in high mortality rates and economic burden. Understanding the immune status of NAFLD patients is crucial for therapeutic approaches, early diagnosis, and prevention.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Louis C. Penning, Marina Berenguer, Anna Czlonkowska, Kay L. Double, Petr Dusek, Carmen Espinos, Svetlana Lutsenko, Valentina Medici, Wiebke Papenthin, Wolfgang Stremmel, Jose Willemse, Ralf Weiskirchen
Summary: Wilson disease is a rare inherited metabolic disorder with diverse clinical presentations affecting the liver, neurological system, psychiatric status, and vision, often in combination. Mutations in the ATP7B gene lead to copper accumulation in hepatocytes and/or neurons, making clinical diagnosis challenging. Diagnosis is complicated by mild and non-specific manifestations, mutations with unclear effects on protein function, and ambiguous laboratory tests, particularly concerning serum ceruloplasmin levels. Establishing a global collaboration of researchers, clinicians, and patient advocacy groups is crucial for identifying and addressing the outstanding challenges of Wilson disease.
Review
Biology
Antonio Olveira, Salvador Augustin, Salvador Benlloch, Javier Ampuero, Jorge Alonso Suarez-Perez, Susana Armesto, Eva Vilarrasa, Isabel Belinchon-Romero, Pedro Herranz, Javier Crespo, Francisco Guimera, Lara Gomez-Labrador, Victor Martin, Jose Manuel Carrascosa
Summary: IL-17 plays a crucial role in the pathogenesis of both psoriasis and MAFLD. It is mainly produced by TH17 and Tc17 cells, but other cells also contribute to its production. IL-17 mediates systemic inflammation and the recruitment of inflammatory cells to the liver, and is implicated in the development of fibrosis and insulin resistance. Clinical trials have shown that inhibiting IL-17A in patients with psoriasis could improve metabolic and liver parameters.
Article
Biochemistry & Molecular Biology
Alessandra Fiorillo, Juan-Jose Gallego, Franc Casanova-Ferrer, Carla Gimenez-Garzo, Amparo Urios, Maria-Pilar Ballester, Lucia Durban, Maria-Pilar Rios, Javier Megias, Teresa San Miguel, Elena Kosenko, Desamparados Escudero-Garcia, Salvador Benlloch, Vicente Felipo, Carmina Montoliu
Summary: Patients with NAFLD may experience mild cognitive impairment (MCI), and this study identified specific alterations in the immune system that are associated with neurological changes in MCI patients with NAFLD, which may help improve and restore cognitive functions and quality of life in these patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
David Marti-Aguado, Amadeo Ten-Esteve, Carlos Manuel Baracaldo-Silva, Ana Crespo, Elena Coello, Victor Merino-Murgui, Matias Fernandez-Paton, Clara Alfaro-Cervello, Alba Sanchez-Martin, Monica Bauza, Ana Jimenez-Pastor, Alexandre Perez-Girbes, Salvador Benlloch, Judith Perez-Rojas, Victor Puglia, Antonio Ferrandez, Victoria Aguilera, Mercedes Latorre, Cristina Monton, Desamparados Escudero-Garcia, Ignacio Bosch-Roig, Angel Alberich-Bayarri, Luis Marti-Bonmati
Summary: This study assessed the prevalence of pancreatic steatosis and iron overload in NAFLD and their correlation with liver histology severity and the risk of cardiometabolic diseases. The results showed that pancreatic steatosis and iron overload were associated with increased cardiovascular disease risk in NAFLD patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Zoe Marino, Marina Berenguer, Luis Pena-Quintana, Antonio Olveira, Anna Miralpeix, Isabel Sastre, Ana Reyes-Dominguez, Pilar Castillo, Claudia Garcia-Sola, Ariadna Bono, Miriam Romero, Francisco Javier Perez-Sadaba, Susana Aceituno, Anna Anguera
Summary: Wilson disease (WD) is a rare copper metabolism disorder caused by gene mutations. This study assessed the impact of WD on patients' health-related quality of life (HRQoL), treatment adherence, drug preference, and healthcare resource utilization. The results showed that about 30% of patients experienced a deterioration in emotional status, especially in those with neurological or mixed involvement. Although most patients were satisfied with their current treatment, many expressed dissatisfaction due to having to take too many pills, indicating a need for more patient-friendly therapies. This study highlights the importance of considering the emotional domain in assessing the HRQoL of WD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Lorena Puchades, Julia Herreras, Ana Ibanez, Erick Reyes, Gonzalo Crespo, Manuel Rodriguez-Peralvarez, Luis Cortes, Trinidad Serrano, Ainhoa Fernandez-Yunquera, Eva Montalva, Marina Berenguer
Summary: This study evaluated the predictive value of the liver frailty index in outpatients in the European liver transplant setting, showing that frailty does not impact pretransplant mortality and/or delisting, but is predictive of higher complication rates and longer post-transplant length of stay. The findings highlight the importance of measuring physical frailty systematically during clinic visits and support further research on rehabilitation strategies in liver transplant settings with short waiting times.
Meeting Abstract
Gastroenterology & Hepatology
Victoria Aguilera Sancho, Sonia Garcia-Garcia, Sarai Romero Moreno, Maria Garcia Eliz, Isabel Conde, Javier del Hoyo, Carmen Castillo, Sagrario Gutierrez, Marina Berenguer
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Maria Del Barrio Azaceta, Paula Iruzubieta, Rebeca Siguenza, Carolina Jimenez-Gonzalez, Luis Ibanez, Laura Izquierdo-Sanchez, Jesus Rivera, Javier Abad Guerra, Javier Ampuero, Isabel Graupera, Carmelo Garcia-Monzon, Judith Gomez-Camarero, Rosa M. Morillas, Vanesa Bernal Monterde, Rosa Martin-Mateos, Patricia Aspichueta, Mercedes De La Torre Sanchez, Salvador Benlloch, Juan Turnes, Maria Teresa Arias Loste, Manuel Romero Gomez, Jose Luis Calleja Panero, Juan M. Pericas, Rafael Banares, Jesus M. Banales, Rocio Aller, Javier Crespo
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Jordi Gratacos, Pilar Ruz-Zafra, Miriam Celada-Sendino, Aina Marti-Carretero, Claudia Pujol, Rosa Martin-Mateos, Victor Echavarria, Luis Frisancho, Sonia Garcia-Garcia, Monica Barreales Valbuena, Javier Tejedor-Tejada, Sergio Vaquez Rodriguez, Nuria Canete, Carlos Fernandez-Carrillo, Maria Valenzuela, David Marti-Aguado, Diana Horta, Marta Quinones, Vanesa Bernal Monterde, Silvia Acosta-Lopez, Tomas Artaza Varasa, Jose Pinazo Bandera, Carmen Villar, Ana Clemente, Esther Badia-Aranda, Conrado Fernandez-Rodriguez, Victoria Aguilera Sancho, Pau Sancho-Bru, Joaquin Cabezas, Meritxell Ventura Cots, Santiago Tome, Joan Caballeria, Elisa Pose
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Marta Magaz, Heloise Giudicelli-Lett, Juan Abraldes, Oana Nicoara-Farcau, Neil Rajoriya, Ashish Goel, Karlien Raymenants, Sophie Hilaire, Luis Tellez, Laure Elkrief, Lara Orts, Akash Shukla, Helene Larrue, Helena Degroote, Victoria Aguilera Sancho, Elba Llop, Laura Turco, Stefania Gioia, Giulia Tosetti, Niccolo Bitto, Chiara Becchetti, Edilmar Alvarado-Tapias, Cristina Roig, Raquel Diaz, Michael Praktiknjo, Anna-Lena Konicek, Guillem Soy, Pol Olivas, Jose Ignacio Fortea, Helena Masnou, Angela Puente, Alba Ardevol, Mari Carmen Alvarez-Navascues, Marta Romero-Gutierrez, Bernhard Scheiner, Georg Semmler, Mattias Mandorfer, Filipe de Sousa Damiao, Anna Baiges, Fanny Turon, Macarena Simon-Talero, Carlos Gonzalez-Alayon, Alba Diaz, Maria Angeles Garcia-Criado, Andrea de Gottardi, Joan Genesca, Olivier Roux, Carlos Noronha Ferreira, Thomas Reiberger, Manuel Rodriguez, Rosa M. Morillas, Sarah Shalaby, Javier Crespo, Jonel Trebicka, Rafael Banares, Candid Villanueva, Annalisa Berzigotti, Massimo Primignani, Vincenzo La Mura, Oliviero Riggio, Filippo Schepis, Federica Indulti, Bogdan Procopet, Xavier Verhelst, Jose Luis Calleja Panero, Christophe Bureau, Filipe Gaio Castro Nery, Agustin Albillos, Frederik Nevens, Virginia Hernandez-Gea, Dhiraj Tripathi, Pierre-Emmanuel Rautou, Juan Carlos Garcia Pagan
JOURNAL OF HEPATOLOGY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
David Marti-Aguado, Maria Pilar Ballester, Victor Merino, Salvador Benlloch, Ana Crespo, Elena Coello, Victoria Aguilera Sancho, Cristina Monton, Mercedes De La Torre Sanchez, Moises Diago, Matias Fernandez-Paton, Amadeo Ten-Esteve, Alba Sanchez-Martin, Clara Alfaro-Cervello, Judith Perez, Monica Bauza, Victor Puglia, Alexandre Perez Girbes, Desamparados Escudero-Garcia, Luis Marti-Bonmati
JOURNAL OF HEPATOLOGY
(2023)