期刊
TRANSPLANTATION
卷 87, 期 9, 页码 1300-1304出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e3181a19421
关键词
ES cells; Immunogenicity; Pancreatic
资金
- Medical Research Council
- Wellcome Trust and European Union and Royal Society Wolfson Research Merit Award
Background. The progeny of embryonic stem (ES) cells may eventually be used to replace damaged tissues in transplantation, yet their immunogenicity remains ill-defined. The major histocompatibility complex (MHC) is a determinant of immunogenicity in transplantation. Methods and Results. Herein, we show differences in MHC expression between mouse ES cells and ES cell derived insulin producing cell clusters (IPCCs), including a relatively higher expression of MHC Class I in IPCCs and a faster, more dramatic induction of MHC Class I in IPCCs following challenge with interferon-gamma (IFN-gamma). MHC Class II was induced on IPCCs, but not ES cells, after exposure to IFN-gamma. Transplantation of syngeneic or atlogeneic IPCCs was insufficient to trigger Up-regulation of MHC class I within three days after transplantation. Discussion. These data highlight differences in MHC expression between ES cells and a fully differentiated ES cell derived tissue and suggest how the progeny of ES cells may be susceptible to rejection after transplantation.
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