Review
Immunology
Brian H. Johnstone, Franka Messner, Gerald Brandacher, Erik J. Woods
Summary: Induction of immune tolerance for solid organ and vascular composite allografts is crucial in transplantation medicine to avoid lifelong immunosuppression. The most promising means of tolerance induction is through transplantation of donor hematopoietic stem cells, but durable immune tolerance has not been achieved on a large scale in other solid organs or vascular composite allografts. Ossium Health has established a bank of cryopreserved bone marrow from deceased organ donor vertebral bodies, which has the potential to be a valuable resource for treating hematological malignancies and inducing transplant tolerance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Dulat Bekbolsynov, Beata Mierzejewska, Sadik Khuder, Obinna Ekwenna, Michael Rees, Robert C. Green, Stanislaw M. Stepkowski
Summary: The study used physicochemical immunogenicity of donor/recipient HLAs to select weakly immunogenic kidney transplants for Black patients, leading to an increase in the number of suitable donors for Black recipients while still providing good options for non-Black recipients.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Hematology
Joseph Cioccio, Kevin Rakszawski, Hong Zheng, Myles Nickolich, Seema Naik, Baldeep Wirk, Witold Rybka, Christopher Ehmann, Brooke Silar, Caitlin Vajdic, Neal Shah, Leonard Tuanquin, Robert Greiner, Valerie Brown, Raymond Hohl, David Claxton, Shin Mineishi, Kentaro Minagawa, Hiroko Shike
Summary: Full donor T-cell chimerism (FDTCC) after allogeneic stem cell transplant (allo-SCT) has been associated with improved outcomes in hematologic malignancy. Donor human leukocyte antigen (HLA) mismatch improves achievement of FDTCC by promoting donor T-cell proliferation in recipients with impaired T-cells.
ANNALS OF HEMATOLOGY
(2023)
Article
Immunology
Sarah J. Dart, Amy C. Prosser, Wen Hua Huang, Liu Liu, Andrew D. Lucas, Luc Delriviere, Silvana Gaudieri, Gary P. Jeffrey, Michaela Lucas
Summary: This study investigated the fate of donor and recipient myeloid cells during solid organ transplantation. The results showed that donor myeloid cells were retained in the graft or persisted in the blood, spleen, and bone marrow depending on the MHC compatibility. Recipient myeloid cells rapidly infiltrated the grafts, and MHC-mismatched grafts experienced a transient rejection episode. Understanding the dynamics of immune responses to transplantation is critical for improving graft outcomes.
Article
Surgery
Tomoki Murata, Naoki Hama, Tomoki Kamatani, Akihiro Mori, Ryo Otsuka, Haruka Wada, Ken-ichiro Seino
Summary: This study investigated the immune regulation in transplantation using allogeneic induced pluripotent stem cells (iPSCs). The researchers found that minor antigen mismatches are a risk factor for graft rejection, highlighting the importance of immune regulation. They demonstrated that iPSC-derived hematopoietic stem/progenitor cells (iHSPCs) can induce allograft tolerance, providing a new approach for transplantation.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Rainer Oberbauer, Matthias Edinger, Gabriela Berlakovich, Peter Kalhs, Nina Worel, Georg Heinze, Michael Wolzt, Thomas Lion, Thomas Wekerle
Summary: This study aims to investigate whether treatment with recipient Tregs and donor BM can lead to transient chimerism in kidney transplant recipients, potentially offering a new therapeutic option for immunomodulation in organ transplantation.
FRONTIERS IN MEDICINE
(2021)
Article
Urology & Nephrology
Aleksandar Senev, Elisabet Van Loon, Evelyne Lerut, Jasper Callemeyn, Maarten Coemans, Vicky Van Sandt, Dirk Kuypers, Marie-Paule Emonds, Maarten Naesens
Summary: Transplant glomerulopathy can occur independently of HLA-DSA, with less inflammation and better graft survival compared to cases with HLA-DSA. The presence of HLA-DSA was identified as a risk factor for glomerulopathy development, and HLA-DSA negative cases had a lower risk of graft failure compared to HLA-DSA positive cases. Landmark analysis showed that HLA-DSA negative patients with glomerulopathy still had a significant increased risk of graft failure, indicating the importance of monitoring and managing transplant glomerulopathy even in the absence of HLA-DSA.
KIDNEY INTERNATIONAL
(2021)
Review
Immunology
Shiva Pathak, Everett H. Meyer
Summary: Pancreatic islet transplantation is a promising method for treating diabetes, but long-term use of immunosuppressive drugs is crucial for islet graft survival. Current ISD regimens have significant side effects, and preclinical studies suggest that using T-regs and hematopoietic mixed chimerism may be the most promising strategies for inducing immune tolerance.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, General & Internal
Michal Gniewkiewicz, Katarzyna Czerwinska, Katarzyna Zielniok, Magdalena Durlik
Summary: This study investigated the association between circulating DSAs and their characteristics with renal allograft long-term outcomes. The detection of DSAs at the time of biopsy and their C1q-binding capacity were found to be independent predictors of inferior renal allograft function and graft failure in kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Immunology
Bruce M. Hall, Nirupama D. Verma, Giang T. Tran, Suzanne J. Hodgkinson
Summary: This article reviews the mechanisms of how allogeneic transplanted tissue is not rejected and how tolerance is induced, focusing on the Clonal Deletion theory, operational tolerance, and alloantigen specific inhibitory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Robert Lowsky, Samuel Strober
Summary: This review examines the definition, mechanisms, and clinical applications of immune tolerance to allogeneic tissue and organ transplants in laboratory animals and humans. The acceptance of transplants can be achieved through the establishment of mixed chimerism or complete chimerism. Additionally, the development of immune-related diseases and anti-tumor activity in mixed and complete chimerism are compared, as well as their application in bone marrow transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Surgery
Yaxun Huang, Xiwei Wu, Shanshan Tang, Huiqing Wu, Ubaydah Nasri, Qi Qin, Qingxiao Song, Bixin Wang, Hansen Tao, Anita S. Chong, Arthur D. Riggs, Defu Zeng
Summary: A radiation-free regimen can establish stable MHC-mismatched mixed chimerism and organ transplant tolerance in murine models. The expression of PD-L1 by donor hematopoietic cells and PD-1 by host cells augments T cell anergy/exhaustion and differentiation into regulatory T cells, playing critical roles in mediating organ transplant tolerance.
AMERICAN JOURNAL OF TRANSPLANTATION
(2023)
Article
Multidisciplinary Sciences
Asuka Tanaka, Kentaro Ide, Yuka Tanaka, Masahiro Ohira, Hiroyuki Tahara, Hideki Ohdan
Summary: Pretransplant desensitization with rituximab was found to enhance anti-donor CD4(+) T cell responses in DSA-positive transplant recipients, while IL-10(+) CD5(+) B cells were shown to suppress excessive responses of anti-donor CD4(+) T cells.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Wensheng Zhang, Yong Wang, Fushun Zhong, Xinghuan Wang, Robert Sucher, Cheng-Hung Lin, Gerald Brandacher, Mario G. G. Solari, Vijay S. S. Gorantla, Xin Xiao Zheng
Summary: In this study, using rodent vascularized composite allotransplantation (VCA) models, it was demonstrated that the presence of donor-derived hematopoietic stem cell (HSC) niches in vascularized bone components facilitates long-term hematopoietic chimerism and promotes tolerance in recipients without harsh myeloablation. The transplanted donor HSC niches also contribute to the maintenance and homeostasis of stable mixed chimerism. Additionally, evidence was provided that chimeric thymus plays a role in the tolerance induced by mixed chimerism through thymic central deletion. This study suggests the potential use of vascularized donor bone with pre-engrafted HSC niches as a safe and effective strategy to induce robust and stable mixed chimerism-mediated tolerance in vascularized composite allotransplantation or solid organ transplantation recipients.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Chemistry, Multidisciplinary
Faezeh Dangkoub, Mojtaba Sankian, Mohsen Tafaghodi, Mahmoud Reza Jaafari, Ali Badiee
Summary: This paper reviews the application of nanocarriers in inducing immunotolerance, with a focus on targeted delivery to APCs and direct targeting of autoreactive lymphocytes. The physicochemical properties and composition of NCs play essential roles in achieving the desired immunological outcome, making them a promising approach for treating autoimmune diseases in humans.
JOURNAL OF CONTROLLED RELEASE
(2021)
