期刊
TRANSPLANTATION
卷 87, 期 9, 页码 S74-S77出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/TP.0b013e3181a2b83b
关键词
Alloreactive memory T cells; Immunosuppression; Organ transplantation; Tolerance
资金
- British Heart Foundation [PG/07/089/23686] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
Clinical and experimental evidences suggest that alloreactive memory T cells may be part of the normal T-cell repertoire and that such cells are detrimental to the survival of foreign organ allografts induced by the administration of conventional immunosuppression or experimental tolerance-inducing therapies. The potential mechanisms by which alloreactive memory T cell may form a barrier to the induction of tolerance will be discussed.
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