Article
Materials Science, Biomaterials
Ziyan Wang, Feixue Mi, Jinchen Li, Dandan Chen, Minmin Lin, Xinyu Wang, Siying Wu, Changfeng Wu, Chao Liu
Summary: Bone marrow stromal cells (BMSCs) have great potential in bone defect repair. By using semiconducting polymer dots (Pdots) as markers, we successfully selected BMSCs and evaluated their therapeutic efficacy in a bone defect model.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Review
Cell & Tissue Engineering
Mohammad Reza Kouchakian, Neda Baghban, Seyedeh Farzaneh Moniri, Mandana Baghban, Shabnam Bakhshalizadeh, Vahid Najafzadeh, Zahra Safaei, Safoura Izanlou, Arezoo Khoradmehr, Iraj Nabipour, Reza Shirazi, Amin Tamadon
Summary: Mesenchymal stromal cells (MSCs) hold great potential for treating autoimmune, inflammatory, and degenerative diseases. Despite extensive research on the application of MSCs, a low percentage of studies are related to clinical trials.
STEM CELLS INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Hui Li, Qi Liu, Xiaofeng Gao, Di Zhang, Shengjun Mao, Yongqian Jia
Summary: The study explored the potential of human umbilical mesenchymal stem cells transfected with IFN-γ gene and found that this treatment significantly reduced the incidence and severity of GVHD in vivo, providing a significant survival benefit.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Cell Biology
Sarah Hochmann, Kristy Ou, Rodolphe Poupardin, Michaela Mittermeir, Martin Textor, Salaheddine Ali, Martin Wolf, Agnes Ellinghaus, Dorit Jacobi, Juri A. J. Elmiger, Samantha Donsante, Mara Riminucci, Richard Schaefer, Uwe Kornak, Oliver Klein, Katharina Schallmoser, Katharina Schmidt-Bleek, Georg N. Duda, Julia K. Polansky, Sven Geissler, Dirk Strunk
Summary: Multipotent stromal cells are attractive sources for cell therapy and tissue engineering, but their application is limited due to functional diversity. In this study, we compared the regenerative potential of different stromal cell types in vitro and in vivo and found that only bone marrow stromal cells (BMSCs) could fully regenerate critical-size femoral defects. This ability was attributed to cell type-specific epigenetic landscapes controlling transcriptional stromal differentiation networks. BMSCs initiated defect healing and eventually contributed to tissue remodeling.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Article
Biophysics
Alice Pievani, Valentina Granata, Giacomo Desantis, Laura Antolini, Sara Ornaghi, Antonio Galleu, Andrea Biondi, Bernhard Gentner, Francesco Dazzi, Marta Serafini
Summary: Monocytes are effective at improving engraftment in HSPC transplantation, particularly in cases of limited cell doses such as CB transplantation and HSC gene therapy. Co-culturing monocytes increases survival and stemness of CB-CD34(+) cells. Soluble factors and direct-cell contact interactions play critical roles in the HSC-monocyte crosstalk.
BONE MARROW TRANSPLANTATION
(2022)
Article
Neurosciences
Changyu Li, Jianan Song, Yanping Wang, Yu Shi, Jiayu Ji, Qian Lin, Yumei Liu
Summary: The results show that ASCS can improve cell adhesion and proliferation, suggesting the potential of ASCS-BMSC combination for treating spinal cord injury.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2022)
Article
Cell Biology
Gong Ho Han, Seong Jun Kim, Wan-Kyu Ko, Daye Lee, In-Bo Han, Seung Hun Sheen, Je Beom Hong, Seil Sohn
Summary: In this study, transplantation of TUDCA-induced M2 macrophages was found to promote anti-neuroinflammatory effects and motor function recovery in a spinal cord injury model, indicating a potential alternative cell therapy for SCI.
CELL PROLIFERATION
(2021)
Article
Neurosciences
Xiaoping Ren, Weihua Zhang, Jian Mo, Jie Qin, Yi Chen, Jie Han, Xinjian Feng, Linxuan Han, Sitan Feng, Haibo Liang, Liangjue Cen, Xiaofei Wu, Chunxing Huang, Haixuan Deng, Zhenbin Cao, Huihui Yao, Rongyu Lan, Xiaogang Wang, Shuai Ren
Summary: Sural nerve transplantation (SNT) is a novel surgical procedure that fuses the axonal stumps of the spinal cord and sural nerve, improving function in paraplegic patients. In a clinical trial, most patients showed recovery of sensory and motor functions, with significant relief of postoperative pain symptoms.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cell Biology
Yiyan Zheng, Chrystine M. Gallegos, Haipeng Xue, Shenglan Li, Dong H. Kim, Hongxia Zhou, Xugang Xia, Ying Liu, Qilin Cao
Summary: Recovering locomotor function after spinal cord injury (SCI) is crucial. Stem cell therapy, particularly using patient-specific induced pluripotent stem cells (iPSCs), holds promise as a reparative strategy. This study found that purified iPSC-derived neural progenitor cells (NPCs) were able to improve locomotor function in a rat model of cervical SCI.
Article
Biochemistry & Molecular Biology
Andrei Mircea Vacaru, Ana-Maria Mazilu, Madalina Dumitrescu, Ioana Madalina Fenyo, Anca Violeta Gafencu, Ana-Maria Vacaru
Summary: This study found that treatment with FasL-overexpressing MSC can improve GvHD and increase survival in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Liem Thanh Nguyen, Duc M. Hoang, Kien T. Nguyen, Duc M. Bui, Hieu T. Nguyen, Hong T. A. Le, Van T. Hoang, Hue T. H. Bui, Phuong T. M. Dam, Xuan T. A. Hoang, Anh T. L. Ngo, Hang M. Le, Nhi Y. Phung, Duc M. Vu, Trung T. Duong, Tu D. Nguyen, Lien T. Ha, Hoa T. P. Bui, Hoa K. Nguyen, Michael Heke, Anh Bui
Summary: The study suggests that autologous administration of bone marrow-derived mesenchymal stem/stromal cells (BM-MSCs) is safe in patients with type 2 diabetes mellitus (T2DM), with treatment efficacy dependent on the quality of the stem cell population and administration routes. Short-term therapeutic effects were observed in patients with shorter T2DM duration and lower body weight.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Article
Cell & Tissue Engineering
Jing Li, Heyangzi Li, Simin Cai, Shi Bai, Huabo Cai, Xiaoming Zhang
Summary: The study found that CD157 can regulate the production and transfer of extracellular mitochondrial particles derived from BMSCs, enriching the mechanism of extracellular mitochondrial transfer in BMSCs transplantation and providing a novel strategy to improve stem cell treatment for SCI.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biology
Zheting Liao, Yu Jin, Yuhao Chu, Hansen Wu, Xiaoyu Li, Zhonghao Deng, Shuhao Feng, Nachun Chen, Ziheng Luo, Xiaoyong Zheng, Liangxiao Bao, Yongqing Xu, Hongbo Tan, Liang Zhao
Summary: A study using single-cell RNA sequencing explored the transcriptomic landscape of alcohol-induced osteonecrosis of the femoral head (ONFH). The study revealed the relevance of stromal and endothelial cells to the pathogenesis of the disease and provided resources for developing cell type-specific therapeutic strategies.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hannah L. L. Smith, Juliet C. C. Gray, Stephen A. A. Beers, Janos M. M. Kanczler
Summary: Osteosarcoma, a bone cancer typically found in adolescents, is closely related to the conversion of bone marrow during adolescence. This study compared the differentiation potential of bone marrow cells from different regions with osteosarcoma cell lines. The results showed distinct differences in the differentiation abilities of hematopoietic and adipocyte-rich bone marrow, which correlated with specific characteristics of the osteosarcoma cell lines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Yi-Xuan Wang, Zhu-Li Peng, Zhi-Wen Sun, Yan-Jun Pan, Hong Ai, Zhi-Hui Mai
Summary: This study investigates the role of miR-20 in promoting osteogenic differentiation in BMSCs and accelerating bone formation in a rabbit maxillary sinus bone defect model. Overexpression of miR-20a increased the levels of osteogenic markers and enhanced calcified nodule deposition in BMSCs, while anti-miR-20a treatment had the opposite effect. In the rabbit model, miR-20a delivery significantly improved bone density, osteoblast numbers, and collagen type 1 secretion compared to Bio-Oss bone powder.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Urology & Nephrology
Javier Saenz-Medina, E. Jorge, C. Corbacho, M. Santos, A. Sanchez, P. Soblechero, E. Virumbrales, E. Ramil, M. J. Coronado, I. Castillon, D. Prieto, J. Carballido
Article
Obstetrics & Gynecology
Noelia Gonzalez-Pacheco, Manuel Sanchez-Luna, Paz Chimenti-Camacho, Martin Santos-Gonzalez, Paula Palau-Concejo, Francisco Tendillo-Cortijo
JOURNAL OF PERINATOLOGY
(2019)
Article
Respiratory System
David Gomez de Antonio, Jose Luis Campo-Canaveral de la Cruz, Mercedes Zurita, Martin Santos, Carmen Gonzalez Lois, Andres Varela de Ugarte, Jesus Vaquero
ARCHIVOS DE BRONCONEUMOLOGIA
(2020)
Article
Urology & Nephrology
J. Saenz-Medina, M. Munoz, A. Sanchez, C. Rodriguez, E. Jorge, C. Corbacho, D. Izquierdo, M. Santos, E. Donoso, E. Virumbrales, A. Sanchez, E. Ramil, M. J. Coronado, D. Prieto, J. Carballido
Article
Pediatrics
Noelia Gonzalez-Pacheco, Manuel Sanchez-Luna, Cristina Arribas-Sanchez, Martin Santos-Gonzalez, Cristina Orden-Quinto, Francisco Tendillo-Cortijo
EUROPEAN JOURNAL OF PEDIATRICS
(2020)
Article
Pediatrics
Ana Rodriguez Sanchez de la Blanca, Manuel Sanchez Luna, Noelia Gonzalez Pacheco, Cristina Ramos Navarro, Martin Santos Gonzalez, Francisco Tendillo Cortijo
PEDIATRIC PULMONOLOGY
(2020)
Article
Veterinary Sciences
Cristina Orden, Martin Santos, Maria Ceprian, Francisco J. Tendillo
Summary: In rats, CBD administered alone did not reduce MAC(SEV), but the addition of morphine to different doses of CBD significantly reduced MAC(SEV).
VETERINARY ANAESTHESIA AND ANALGESIA
(2021)
Article
Anesthesiology
Clara Serrano Zueras, Veronica Guillo Moreno, Martin Santos Gonzalez, Francisco Javier Gomez Nieto, Goran Hedenstierna, Javier Garcia Fernandez
Summary: The study evaluated the safety and efficacy of using automatic stepwise lung recruitment maneuver software in a healthy neonatal model. All maneuvers were successfully completed without interruptions, with maintained hemodynamic stability and improved dynamic and static compliance post-operation. No adverse respiratory or hemodynamic events were observed.
PEDIATRIC ANESTHESIA
(2021)
Article
Obstetrics & Gynecology
Manuel Sanchez-Luna, Noelia Gonzalez-Pacheco, Martin Santos-Gonzalez, Francisco Tendillo-Cortijo
CLINICS IN PERINATOLOGY
(2021)
Article
Critical Care Medicine
Alberto Gutierrez Martinez, Veronica Guillo Moreno, Martin Santos, Alvaro Mingote Llado, Patricio Gonzalez-Pizarro, Javier Garcia-Fernandez
Summary: This study aimed to determine the pressure levels at which pneumothorax occurs in an in vivo ARDS neonate model. The study found that asystole, pneumothorax, and cerebral compromise may occur at high intrathoracic pressure ranges. Therefore, hemodynamic monitoring is crucial during lung recruitment maneuvers.
Article
Cell Biology
Javier Saenz-Medina, Mercedes Munoz, Claudia Rodriguez, Cristina Contreras, Ana Sanchez, Maria Jose Coronado, Elvira Ramil, Martin Santos, Joaquin Carballido, Dolores Prieto
Summary: This study found that urolithiasis leads to endothelial dysfunction in preglomerular arteries, accompanied by an increase in renal cortex superoxide generation and the development of vascular inflammation. Pathways involving xanthine oxidase, Nox1, and Nox2 also play a role in this process.
Article
Critical Care Medicine
Veronica Guillo-Moreno, Alberto Gutierrez-Martinez, Clara Serrano-Zueras, Martin Santos-Gonzalez, Antonio Romero-Berrocal, Javier Garcia-Fernandez
Summary: This study aimed to evaluate the safety and efficacy of two protocols for automatic lung recruitment maneuvers (LRMs) using stepwise increases in PEEP in a neonatal ARDS model. The study found that both protocols were effective in improving oxygenation and respiratory mechanics, and that the duration of the maximum opening pressure step was a determining factor for hemodynamic alterations.
Article
Health Care Sciences & Services
Teresa Torre Onate, Antonio Romero Berrocal, Federico Bilotta, Rafael Badenes, Martin Santos Gonzalez, Laura de Reina Perez, Javier Garcia Fernandez
Summary: In an experimental neonatal model, stepwise lung recruitment maneuvers are a safe tool to prevent atelectasis and do not impair cerebral hemodynamics but improve cerebral oxygenation.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Pediatrics
Alba Perez-Perez, Noelia Gonzalez-Pacheco, Maria Arriaga-Redondo, Cristina Ramos-Navarro, Elena Rodriguez-Corrales, Ana Rodriguez-Sanchez de la Blanca, Pablo Gonzalez-Navarro, Martin Santos-Gonzalez, Manuel Sanchez-Luna
Summary: This study evaluated the impact of combining HFOV with VG on cerebral hemodynamics in a neonatal respiratory distress syndrome model. The results showed similar changes in cerebral blood flow dynamics between different ventilation methods, indicating no significant differences.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Critical Care Medicine
Alvaro Mingote, Ramses Marrero Garcia, Martin Santos Gonzalez, Raquel Castejon, Clara Salas Anton, Juan Antonio Vargas Nunez, Javier Garcia-Fernandez
Summary: In this study, researchers investigated the effect of individualizing driving pressure based on pulmonary elastance on ventilatory-induced lung injury in an acute respiratory distress syndrome model. The results showed that individualized mechanical ventilation led to reduced lung inflammation and structural lung injury, without a significant impact on oxygenation.