Article
Medicine, Research & Experimental
Ling-Feng Jiang, Ming Yang, Hong-Wu Meng, Peng-Cheng Jia, Chang-Lin Du, Jin-Yu Liu, Xiong-Wen Lv, Cheng-Huang, Jun Li
Summary: This study investigated the role of IL-11 in hepatic fibrosis and its potential as a therapeutic target. Increased IL-11 levels were found in patients and a mouse model of hepatic fibrosis, and silencing IL-11 reduced its expression. In vitro experiments showed that IL-11 enhanced cell activation and proliferation in LX-2 cells, and promoted apoptosis in LO-2 cells through JNK/ERK signaling pathways.
Article
Biochemistry & Molecular Biology
Hanglu Ying, Long Li, Yufen Zhao, Feng Ni
Summary: This study evaluated the function of ivermectin in regulating liver fibrosis. The results showed that ivermectin alleviated histopathological changes, improved liver function, reduced collagen deposition, and downregulated the expression of profibrotic genes. Mechanistically, it inhibited intrahepatic macrophage accumulation and suppressed the production of proinflammatory factors. Importantly, it also promoted HSC deactivation by reducing the protein levels of alpha-smooth muscle actin (alpha-SMA).
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Ting-Ting Li, Xiao-Wei Su, Lin-Lin Chen, Wan-Nian Zhang, Jun-Ping Zhang, Yan Wang, Wei-Heng Xu
Summary: Hepatic fibrosis is a stage of chronic liver disease that can lead to cirrhosis or liver cancer. The activation of hepatic stellate cells (HSCs) is a crucial event in fibrosis development and inhibiting this activation has been shown to alleviate fibrosis. Roxarsone, an organoarsenic additive used in livestock production, has been found to inhibit HSC activation and improve liver function in a mouse model of fibrosis. These findings suggest that Roxarsone could be a potential treatment for liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Dongkyun Kim, Sohee Kim, Myung-su Kang, Zhinan Yin, Booki Min
Summary: IL-27 is an immunoregulatory cytokine that can modulate inflammatory responses, including autoimmunity. This study found that IL-30 can act as a negative regulator to limit inflammation, and dysregulated IL-30 expression may contribute to the development of encephalitogenic inflammation.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Yang You, Chongqing Gao, Junru Wu, Hengdong Qu, Yang Xiao, Ziwei Kang, Jinying Li, Jian Hong
Summary: ARK5 plays a critical role in liver fibrosis by maintaining the continuous transduction of the TGF-beta signaling pathway in HSCs and inducing epithelial-mesenchymal transition and inflammatory factor secretion in hepatocytes, thereby promoting liver fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zhiman Li, Lijuan Zhao, Yunshi Xia, Jianbo Chen, Mei Hua, Yinshi Sun
Summary: The study demonstrates that Schisandrin B inhibits the activity of hepatic stellate cells induced by TGF-beta 1 by promoting apoptosis.
Article
Biotechnology & Applied Microbiology
Maoying Fu, Weihua Yin, Wei Zhang, Yanfang Zhu, Huihui Ni, Li Gong
Summary: miR-15a inhibits LX-2 cell viability and HF pathogenesis by targeting SOX9. This study suggests that miR-15a may play an important role in HF.
Article
Gastroenterology & Hepatology
Taixiong Xue, Lin Yue, Guonian Zhu, Zui Tan, Hongyao Liu, Cailing Gan, Chen Fan, Xingping Su, Yuting Xie, Tinghong Ye
Summary: In this study, a phenylacrylic acid derivative, FA11, was synthesized and found to have excellent antifibrotic activity, making it a potential candidate for the treatment of liver fibrosis.
LIVER INTERNATIONAL
(2023)
Article
Food Science & Technology
Liyan Shi, Xiuli Zhang, Xin Liu, Yunyao Jiang, Yongyan Deng, Junzhi Liu
Summary: Cranberry phytochemicals (CPS) can inhibit HSC activation and liver fibrosis by reducing the expression of inflammatory cytokines and inhibiting the TGF beta/Smad signaling pathway. In vitro studies have shown significant effects of CPS on HSCs, with promising therapeutic effects in a rat model of liver fibrosis.
Article
Pharmacology & Pharmacy
Chen Shuai, Guo-qing Xia, Fei Yuan, Sheng Wang, Xiong-wen Lv
Summary: CD39 plays a role in alcoholic liver disease by regulating HSC activation and fibrosis development, and its blockade can prevent these processes. The findings suggest that ATP-adenosine signaling is a novel therapeutic target for alcoholic liver disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Food Science & Technology
Guangwen Shu, Xiao Lei, Yecheng Lei, Tiantian Zhang, Hui Sun, Chuo Wang, Anning Song, Xukun Deng
Summary: Our study aimed to investigate the effects and mechanisms of characterized ethanol extract of Rosa rugosa (ERS) on hepatic stellate cells (HSCs) activation and liver fibrosis. ERS suppressed TGF-beta 1-induced activation of LX-2 HSCs by elevating Smad7 and inhibiting phosphorylation of Smad2/3. Knockdown of Smad7 or Hint1 abolished the protective effects of ERS on HSC activation. ERS also mitigated mouse liver fibrosis induced by CCl4 through regulating the Hint1/Smad7 axis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Dermatology
Ryota Tanaka, Yuki Ichimura, Noriko Kubota, Akimasa Saito, Yoshiyuki Nakamura, Yosuke Ishitsuka, Rei Watanabe, Yasuhiro Fujisawa, Seiya Mizuno, Satoru Takahashi, Manabu Fujimoto, Naoko Okiyama
Summary: The study revealed that PD-L1 plays a predominant role in Th1 and Th17 type immunity, while PD-L2 is involved in Th2 type immunity. Experimental validation supported this conclusion.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Article
Microbiology
Sean Turner, Brent Raisley, Kimberly Roach, Sandra Bajana, Melissa E. Munroe, Judith A. James, K. Mark Coggeshall, Susan Kovats
Summary: Gram-positive bacterial infections can cause organ failure and death in sepsis. Bacillus anthracis PGN, a component shed during bacterial replication, can promote sepsis-like pathology. This study found that purified Bacillus anthracis PGN can activate human dendritic cells (DCs), promote the production of proinflammatory cytokines, and induce the differentiation of T(H)17 cells.
Article
Biochemistry & Molecular Biology
Minako Sakurai, Peter Weber, Gretchen Wolff, Annika Wieder, Julia Szendroedi, Stephan Herzig, Bilgen Ekim uestuenel
Summary: Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and liver fibrosis are progressive liver diseases associated with metabolic syndrome. The elevated expression of TSC22D4 in patients with type 2 diabetes, NAFLD, and NASH suggests its involvement in the progression of these diseases. The study reveals that TSC22D4 contributes to the activation, proliferation, and migration of hepatic stellate cells (HSCs), implicating it as a key regulator in the development of liver fibrosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Marta Fortunato, Giada Amodio, Silvia Gregori
Summary: Tolerogenic dendritic cells (tolDC) play a central role in immune homeostasis and peripheral tolerance. We developed a protocol to generate genetically engineered tolDC overexpressing IL-10 (DCIL-10) and found that they can modulate cytotoxic CD8(+) T cell responses by reducing proliferation and activation, and inducing anergic CD8(+) T cells without signs of exhaustion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Editorial Material
Gastroenterology & Hepatology
John Fung, Diego DiSabato, Chih-Yi Liao, Osmanuddin Ahmed, Anjana Pillai
HEPATOBILIARY & PANCREATIC DISEASES INTERNATIONAL
(2023)
Article
Oncology
Aditya Juloori, Rohan R. Katipally, Jeffrey M. Lemons, Anurag K. Singh, Renuka Iyer, Jared R. Robbins, Ben George, William A. Hall, Sean P. Pitroda, Fauzia Arif, John Fung, Anjana Pillai, Chih-Yi Liao, Manish Sharma, Stanley L. Liauw
Summary: This study investigated the safety and efficacy of stereotactic body radiation therapy (SBRT) with immunotherapy in patients with hepatocellular carcinoma (HCC). The results showed that the combination of SBRT with nivolumab plus ipilimumab had better survival and efficacy compared to immunotherapy alone in HCC patients, suggesting the need for further investigation.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2023)
Article
Automation & Control Systems
Lina Rong, Peng Su, Guo-Ping Jiang, Shengyuan Xu
Summary: In this paper, an edge-based augmented system approach is proposed for second-order nodal consensus, utilizing the edge loop transfer matrix of the closed-loop multi-agent system. This approach introduces additional poles and zeros into edges to construct a channel filter with previous data stored in the memories. The effectiveness of the proposed method is verified through illustrative simulations.
Article
Engineering, Electrical & Electronic
Lina Rong, Yuhan Kan, Xiangpeng Xie, Guo-Ping Jiang, Shengyuan Xu
Summary: This study focuses on the problem of edge-preserving consensus in discrete-time multi-agent systems. A method for designing channel filters, consisting of nominal elements and masking elements, is proposed using an edge-based parallel system design approach. Design criteria for edge-preserving protocols are provided based on the edge sensitivity matrix of the multi-agent system being studied. It is demonstrated that the design of masking elements is based on a single parameter of the nominal element and the H-infinity norm of a collapsed system. An algorithm for designing heterogeneous channel filters is also presented, using a cascade realization of several subsystems.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Article
Engineering, Electrical & Electronic
Huifen Hong, Wenwu Yu, Guo-Ping Jiang, He Wang
Summary: In this paper, a novel type of fixed-time algorithms is investigated to solve time-varying convex optimization problems with time-dependent cost function, constraints or both. First, a general framework algorithm is developed for the unconstrained time-varying optimization problem to track its optimal trajectory within fixed time, which includes the gradient flow-based scheme and Newton-type method as special cases. Then, another algorithm with fixed-time convergence is designed for time-varying optimization problems involving equality constraint, including Newton-type scheme as a special case. The simulation result using first-order Euler discretization is provided to verify the fixed-time convergence achieved by the proposed approach.
IEEE TRANSACTIONS ON CIRCUITS AND SYSTEMS II-EXPRESS BRIEFS
(2023)
Article
Automation & Control Systems
Yayong Wu, Xinwei Wang, Guo-Ping Jiang, Mengqi Gu
Summary: In this paper, a completely data-driven method based on compressive sensing is proposed to detect the structure of faulty edges in complex dynamical networks. The method can directly obtain the structure of faulty edges from limited measurements and is more efficient in data processing.
JOURNAL OF THE FRANKLIN INSTITUTE-ENGINEERING AND APPLIED MATHEMATICS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Osman Ahmed, Qian Yu, Mikin Patel, Gloria Hwang, Anjana Pillai, Chih-yi Liao, John Fung, Talia Baker
Summary: A combination therapy of yttrium-90 transarterial radioembolization (TARE) and systemic gemcitabine, cisplatin, and capecitabine is safe and effective for the first-line treatment of locally advanced intrahepatic cholangiocarcinoma (iCCA), resulting in high rates of downstaging and favorable overall survival.
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2023)
Article
Oncology
Gary Wildey, Ashley M. Shay, Karen S. McColl, Suzy Yoon, Mohammad A. Shatat, Ahmad Perwez, Kyle B. Spainhower, Adam M. Kresak, MaryBeth Lipka, Michael Yang, Mohadese Behtaj, Pingfu Fu, Asrar Alahmadi, Wadad Mneimneh, Ata Abbas, Afshin Dowlati
Summary: Genomic studies have found that some small cell lung cancer (SCLC) tumors do not have RB1 mutations, contrary to the canonical model. This study examined RB1 protein expression and its function in SCLC and found that 14% of SCLC tumors expressed abundant RB1 protein, which was associated with neuroendocrine gene expression and enriched in YAP1 expression. SCLC cells with RB1 protein expression were sensitive to growth inhibition by the CDK4/6 inhibitor palbociclib, and a patient with wild-type RB1 SCLC showed a significant decrease in mutant TP53 ctDNA allelic fraction and tumor mass after treatment with the CDK4/6 inhibitor abemaciclib.
MOLECULAR CANCER THERAPEUTICS
(2023)
Article
Physics, Multidisciplinary
Ruqi Li, Yurong Song, Haiyan Wang, Guo-Ping Jiang, Min Xiao
Summary: This study develops a reactive-diffusion epidemic model on human mobility networks to characterize the spatio-temporal propagation of COVID-19 in China. A novel time-dependent function is incorporated to describe the effects of human intervention. The results indicate that human intervention significantly inhibits the correlation between population mobility and infection cases, and spatial diffusion phenomenon of cases from high infection density cities to low infection density cities is revealed.
PHYSICA A-STATISTICAL MECHANICS AND ITS APPLICATIONS
(2023)
Article
Automation & Control Systems
Zhikai Yao, Xianglong Liang, Guo-Ping Jiang, Jianyong Yao
Summary: This article introduces a new model-based reinforcement learning controller to improve the control performance of hydraulic systems. By using a recursive robust integral control approach and an actor-critic structure in the reinforcement learning approach, the proposed controller is able to achieve high-accuracy tracking and asymptotic stability guarantees at the system level.
IEEE-ASME TRANSACTIONS ON MECHATRONICS
(2023)
Article
Mathematics, Interdisciplinary Applications
Y. Wang, H. Yang, X. Y. Yan, G. P. Jiang
Summary: In this paper, a novel coupled code shifted M-ary differential chaos shift keying modulation scheme is proposed for reference removal. The scheme transmits only two information-bearing signals, modulated by selected Walsh code sequences and coupled by the same chaotic message bearer. Theoretical BER expressions are derived and simulations show better performance with lower complexity.
INTERNATIONAL JOURNAL OF BIFURCATION AND CHAOS
(2023)
Article
Green & Sustainable Science & Technology
Chaoyue Zheng, Guoping Jiang, Zhiliang Jin
Summary: This paper studies the doping of phosphorus elements in Co3(PO4)2 during the high-temperature phosphorylation reaction. UV-Vis experiments show that the color of the phosphorylation catalyst changes from pink to black-purple, with significantly increased light absorption range and intensity. SEM images reveal the growth of many nanoparticles on the catalyst surface. XPS experiments demonstrate the growth of a stable P (6- )-Co bond on the catalyst surface. The P (6- )-Co bond can inhibit the complexation of photogenerated electron and hole pairs and enhance the transport efficiency of photogenerated electrons, thus improving the hydrogen production performance. Phosphorus-doped Co3(PO4)2 releases three times more hydrogen than CO3(PO4)2. This paper provides a novel design solution for the photocatalyst preparation method.
JOURNAL OF CLEANER PRODUCTION
(2023)
Article
Engineering, Geological
Yan Wang, Hao-biao Chen, Guo-ping Jiang, Fu-quan Chen
Summary: In this research, a slip-line method and adaptive finite-element software were used to investigate the active earth pressure of narrow and layered backfills against inverted T-type retaining walls rotating around the base mode. Slip-line field calculation models were established for the inverted T-type retaining wall with narrow and layered backfills, considering the effect of the heel bottom plate and the wall characteristics. The proposed method was verified by comparing its results with those from finite-element limit analysis and existing theoretical solutions, and parametric studies were conducted to study the effects of backfill width, heel length, and interface strength.
INTERNATIONAL JOURNAL OF GEOMECHANICS
(2023)
Article
Mathematics
Mengqi Gu, Guo-Ping Jiang
Summary: This paper investigates the observability of discrete-time two-time-scale multi-agent systems with heterogeneous features under leader-follower architecture. It establishes a singular perturbation difference model for the discussed system based on consensus agreement. To eliminate the numerical ill-posed problem, the order of the system model is reduced using the boundary layer theory of the singular perturbation system. Based on matrix theory, algebraic and graphical features that guarantee system observability are obtained. The theoretical results are verified by a numerical example.
Review
Medicine, General & Internal
Kumar Jayant, Thomas G. Cotter, Isabella Reccia, Francesco Virdis, Mauro Podda, Nikolaos Machairas, Ramesh P. Arasaradnam, Diego Di Sabato, John C. LaMattina, Rolf N. Barth, Piotr Witkowski, John J. Fung
Summary: This study compared the outcomes of high-MELD and low-MELD living-donor liver transplant recipients and found no significant differences in patient survival, graft survival, and most complications between the two groups. However, the high-MELD group had a higher risk of pulmonary infection, abdominal fluid collection, and prolonged ICU stay.
JOURNAL OF CLINICAL MEDICINE
(2023)