Article
Pediatrics
Guillaume Dorval, Olivia Boyer, Anne Couderc, Jean-Daniel Delbet, Laurence Heidet, Dominique Debray, Pauline Krug, Muriel Girard, Brigitte Llanas, Marina Charbit, Saoussen Krid, Nathalie Biebuyck, Marc Fila, Cecile Courivaud, Frances Tilley, Nicolas Garcelon, Thomas Blanc, Christophe Chardot, Remi Salomon, Florence Lacaille
Summary: Long-term prognosis of patients with ARPKD is heterogeneous, and age at diagnosis does not play a major role, with few patients requiring liver transplantation mainly due to recurrent cholangitis or uncontrollable portal hypertension. Liver complications after kidney transplantation were not significant in this cohort.
PEDIATRIC NEPHROLOGY
(2021)
Review
Medicine, Research & Experimental
Fatemeh Sabet Sarvestani, Negar Azarpira, Ismail H. Al-Abdullah, Ali-Mohammad Tamaddon
Summary: Ischemia reperfusion injury can lead to tissue damage, especially during organ transplantation. By manipulating miRNAs level, they can be used as a biomarker for early diagnosis of IRI or suggestive to be therapeutic agents in clinical situation in future.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Biochemistry & Molecular Biology
L. Lucchetti, M. Chinali, F. Emma, L. Massella
Summary: Autosomal dominant polycystic kidney disease (ADPKD) and autosomal recessive polycystic kidney disease (ARPKD) are the most common cystic kidney diseases, with significant differences in genetics and clinical manifestations. Hypertension is a main symptom in both diseases, but the age of onset and secondary cardiovascular complications differ. Systematic screening and monitoring of hypertension and secondary cardiovascular damage in childhood can help manage the disease early and limit the burden in adulthood.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2023)
Article
Endocrinology & Metabolism
Luca Dello Strologo, Marco Spada, Carlo Dionisi Vici, Marta Ciofi Degli Atti, Michelle Rheault, Anna Kristina Bjerre, Olivia Boyer, Pier Luigi Calvo, Lorenzo D'Antiga, Lyndsay A. Harshman, Friederike Hoerster, Stefan Koelker, Timo Jahnukainen, Noel Knops, Pauline Krug, Kai Krupka, Angela Lee, Elena Levtchenko, Stephen D. Marks, Jelena Stojanovic, Laura Martelli, George Mazariegos, Giovanni Montini, Mohan Shenoy, Sangeet Sidhu, Marco Spada, Trine Tangeras, Sara Testa, Suresh Vijay, Katarzyna Wac, Lars Wennberg, Waldo Concepcion, Sven F. Garbade, Burkhard Toenshoff
Summary: In isolated MMAemia patients, liver transplantation (LTx) and combined liver-kidney transplantation (LKTx) result in significantly lower plasma MMA levels during the first 2 years post-transplant compared to kidney transplantation (KTx) and are associated with better preservation of kidney function.
MOLECULAR GENETICS AND METABOLISM
(2022)
Article
Immunology
Jef Verbeek, Casper Vrij, Pieter Vermeersch, Jan Van Elslande, Sofie Vets, Katrien Lagrou, Robin Vos, Johan van Cleemput, Ina Jochmans, Diethard Monbaliu, Jacques Pirenne, Dirk Kuypers, Frederik Nevens
Summary: This study investigated the prevalence, timing, and antibody kinetics of solid organ transplantation after SARS-CoV-2 infection. The findings suggest that selected patients can undergo liver or kidney transplantation without complications after a previous SARS-CoV-2 infection, despite lower antibody levels. The patients who seroconverted remained anti-S IgG positive, indicating a persistent immune response.
Article
Pediatrics
Sebastian Loos, Markus J. Kemper, Kaja Schmaeschke, Uta Herden, Lutz Fischer, Bernd Hoppe, Tanja Kersnik Levart, Enke Grabhorn, Raphael Schild, Jun Oh, Florian Brinkert
Summary: This study retrospectively analyzed the long-term outcomes of 18 pediatric patients with primary hyperoxaluria type 1 (PH1) who underwent combined or sequential liver and kidney transplantation (CLKT/SLKT). The results showed a patient survival rate of 94% and liver and kidney survival rates of 90% and 85%, respectively, after CLKT/SLKT. The outcomes tend to be less optimal in patients with infantile PH1 compared to patients with juvenile PH1.
FRONTIERS IN PEDIATRICS
(2023)
Review
Biochemistry & Molecular Biology
Adrian Cordido, Marta Vizoso-Gonzalez, Miguel A. Garcia-Gonzalez
Summary: ARPKD is a rare disorder linked to the PKHD1 and DZIP1L genes, with research elucidating molecular pathways involved in disease progression. However, understanding of the function of ARPKD proteins and the disease's molecular mechanism remains incomplete.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Gastroenterology & Hepatology
Murali K. Yanda, Vartika Tomar, Liudmila Cebotaru
Summary: ARPKD is caused by mutations in the PKHD1 gene, leading to severe complications in neonates. Research shows that FPC malfunction induces cyst formation, and CFTR correctors may be a potential treatment for ARPKD.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Transplantation
Burcin Ekser, William C. Goggins
Summary: CLKT provides a life-saving procedure for patients with both liver and kidney diseases, and the introduction of delayed kidney transplantation approach has shown to be safe and improve outcomes in graft(s) and patient survival, as evidenced by multiple studies.
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Raphael Schild, Simeon Dupont, Jerome Harambat, Enrico Vidal, Ayse Balat, Csaba Bereczki, Beata Bienias, Per Brandstrom, Francoise Broux, Silvia Consolo, Ivana Gojkovic, Jaap W. Groothoff, Kristine Hommel, Holger Hubmann, Fiona E. M. Braddon, Tatiana E. Pankratenko, Fotios Papachristou, Lucy A. Plumb, Ludmila Podracka, Sylwester Prokurat, Anna Bjerre, Carolina Cordinha, Juuso Tainio, Enkelejda Shkurti, Giuseppina Sparta, Karel Vondrak, Kitty J. Jager, Jun Oh, Marjolein Bonthuis
Summary: This study analyzed the prevalence and implications of comorbidities in European children on kidney replacement therapy (KRT) and found that comorbidities have become more frequent and have a negative impact on access to transplantation and survival, especially in low-income countries. It suggests that children with comorbidities in need of kidney replacement therapy should be evaluated for kidney transplantation eligibility.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Multidisciplinary Sciences
Darae Kim, Jin-Oh Choi, Yang Hyun Cho, Kiick Sung, Jaewon Oh, Hyun Jai Cho, Sung-Ho Jung, Hae-Young Lee, Jin Joo Park, Dong-Ju Choi, Seok-Min Kang, Jae-Joong Kim, Eun-Seok Jeon
Summary: The study showed that the need for preoperative renal replacement therapy does not indicate irreversible renal dysfunction in patients awaiting heart transplantation. However, postoperative renal replacement therapy was associated with progression to end-stage renal disease and mortality after heart transplantation.
SCIENTIFIC REPORTS
(2021)
Review
Pediatrics
Amrit Kirpalani, Chia Wei Teoh, Vicky Lee Ng, Anne Dipchand, Mina Matsuda-Abedini
Summary: Children undergoing heart and liver transplantation are at higher risk of kidney disease, which may be caused by various factors such as the underlying disease, associated treatments, and complications from the transplant surgery. Monitoring, recognizing, and reducing the risk of kidney injury is crucial for this population.
PEDIATRIC NEPHROLOGY
(2021)
Article
Transplantation
Ping-Fang Chiu, Pei-Ru Lin, Chun-Chieh Tsai, Yao-Peng Hsieh
Summary: Post-liver transplantation acute kidney injury (AKI) is associated with increased risk of poor liver graft and renal outcomes. This study compared patients with and without AKI, and analyzed the recovery status of AKI patients. It was found that the risk of chronic kidney disease (CKD) was higher in the AKI group, but not in the AKI recovery group.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Adarsh Ghosh, Suraj D. Serai, Shyam Sunder B. Venkatakrishna, Mohini Dutt, Erum A. Hartung
Summary: The study found a correlation between the shape features of the left liver lobe and liver stiffness and portal hypertension in children with ARPKD. The perimeter to surface ratio had the strongest correlation with liver stiffness. A PSR cutoff of <= 0.057 mm(-1) showed high sensitivity and specificity in identifying ARPKD participants with liver stiffness > 2.9 kPa.
ABDOMINAL RADIOLOGY
(2021)
Article
Clinical Neurology
Hanim Kwon, Sung Shin, Chung Hee Baek, Jun Young Chang, Dong-Wha Kang, Sun U. U. Kwon, Jong S. S. Kim, Bum Joon Kim
Summary: This study compared the characteristics and etiologies of stroke after liver transplantation (LT) and kidney transplantation (KT). The results showed that in-hospital, perioperative, and hemorrhagic strokes were more common in the LT group, while the etiologies of ischemic strokes did not significantly differ between the two groups. The 3-month mortality was similar and associated with in-hospital stroke and elevated C-reactive protein in both groups of transplantation patients.
FRONTIERS IN NEUROLOGY
(2023)
Article
Gastroenterology & Hepatology
Bjorn Nashan, Peter Schemmer, Felix Braun, Hans J. Schlitt, Andreas Pascher, Christian G. Klein, Ulf P. Neumann, Irena Kroeger, Peter Wimmer
Summary: The study demonstrated that the use of everolimus in combination with rTAC after liver transplantation may be more advantageous for renal function preservation compared to standard therapy with sTAC. While no significant difference was observed in the full analysis set, renal function was significantly enhanced in the compliance set.
LIVER TRANSPLANTATION
(2022)
Article
Immunology
Jiwei Qin, Hao Zheng, Xuefeng Li, Zhijun Xu, Wei Wu, Dehao Huang, Ning Wang, Yafei Guo, Zebin Zhu, Yang Liu, Ziqin Yao, Jizhou Wang, Ruipeng Song, Lianxin Liu, Bjoern Nashan
Summary: Invasive fungal infections, particularly candidiasis and aspergillosis, are significant complications in solid organ transplantation, with poor penetration of antifungal medications in the central nervous system (CNS) contributing to high morbidity and mortality. Voriconazole may offer high drug concentrations in the CNS, but its use in transplant patients is limited by metabolic interactions with immunosuppression. The case report presented here describes successful long-term conservative medical treatment for CNS fungal infection following emergency liver transplantation for hepatitis B virus-related acute liver failure.
TRANSPLANTATION PROCEEDINGS
(2021)
Article
Immunology
Zebin Zhu, Yang Liu, Wei Wu, Dehao Huang, Yafei Guo, Hao Zheng, Ning Wang, Zhijun Xu, Xuefeng Li, Jiwei Qin, Lianxin Liu, Bjorn Nashan
Summary: Severe neurologic complications greatly affect the quality of life of patients with chronic liver disease. Hepatic myelopathy is a rare but devastating disease, characterized by progressive symmetrical spastic paralysis in the limbs. Timely and effective clinical intervention is required for the management of this severe neurologic complication, although liver transplantation is an effective treatment, the prognosis remains poor.
TRANSPLANTATION PROCEEDINGS
(2022)
Article
Multidisciplinary Sciences
Haibo Wu, Peiqi He, Yong Ren, Shiqi Xiao, Wei Wang, Zhenbang Liu, Heng Li, Zhe Wang, Dingyu Zhang, Jun Cai, Xiangdong Zhou, Dongpo Jiang, Xiaochun Fei, Lei Zhao, Heng Zhang, Zhenhua Liu, Rong Chen, Weiqing Li, Chaofu Wang, Shuyang Zhang, Jiwei Qin, Bjorn Nashan, Cheng Sun
Summary: In this study, comprehensive transcriptional and histological analyses were performed on deceased severe COVID-19 patients. The researchers found correlations between the presence of viral antigens and lymphocyte suppression yet myeloid activation, suggesting distinct functions of these cells during pathogenesis. These findings provide valuable insights for understanding the etiology of COVID-19 and developing targeted therapies.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Xinhao Hou, Chengming Zhu, Mingjing Xu, Xiangyang Chen, Cheng Sun, Bjorn Nashan, Shouhong Guang, Xuezhu Feng
Summary: Starvation enhances trans-splicing of translation-related genes in adult C. elegans by promoting SL1 trans-splicing through the action of SNAPc and TOFU-5. Knocking down these factors extends worm survival under starvation conditions, indicating the importance of SL trans-splicing in nutritional response and survival regulation.
JOURNAL OF GENETICS AND GENOMICS
(2022)
Article
Oncology
Min Li, Tianjiao Zhang, Jing Zhu, Yuebo Li, Wenying Chen, Yanhu Xie, Wei Zhang, Rongzhu Chen, Wei Wei, Guihong Wang, Jiwei Qin, Weidong Zhao, Dabao Wu, Zhen Shen, Bjorn Nashan, Ying Zhou
Summary: The present study evaluated postoperative complications and the impact of an enhanced recovery programme in patients with epithelial ovarian carcinoma. The study found that applying an enhanced recovery programme is feasible in patients undergoing extensive upper abdominal surgery, and certain clinical factors are associated with adverse postoperative outcomes.
Article
Oncology
Mohamed Moustafa, Katarzyna-Krystyna Daehling, Armin Guenther, Leonie Riebandt, Daniel J. Smit, Kristoffer Riecken, Carina Schroeder, Ruimeng Zhuang, Till Krech, Malte Kriegs, Boris Fehse, Jakob R. Izbicki, Lutz Fischer, Bjorn Nashan, Jun Li, Manfred Juecker
Summary: This study verifies the impact of targeting CD90 and EpCAM markers in HCC cells with a combination therapy of AKT and mTOR inhibitors. The results demonstrate that combined targeting of AKT and mTOR effectively reduces the proliferation of CD90 and EpCAM positive HCC cells in vitro, but resistance to the treatment occurs in vivo.
Article
Oncology
Huan Liu, Ronghua Zhao, Rongrong Qin, Haoyu Sun, Qiang Huang, Lianxin Liu, Zhigang Tian, Bjorn Nashan, Cheng Sun, Rui Sun
Summary: This study revealed specific subsets of NK cells in healthy human liver tissues, but only some subsets were present in HCC and peritumor tissues. Cytotoxic NK cell subsets were absent in HCC tissues. The study also identified potential non-invasive prognostic biomarkers in patients with HCC.
CANCER BIOLOGY & MEDICINE
(2022)
Review
Pharmacology & Pharmacy
Wanqing Hou, Bernard Nsengimana, Chuyun Yan, Bjorn Nashan, Shuxin Han
Summary: This article reviews the functional characteristics of endoplasmic reticulum stress and its potentially pathogenic role in liver injury caused by rifampicin.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yong-Shuai Wang, Wei Wang, Sai Zhang, Shen-Yu Zhang, Ai-Zong Shen, Hua-Chuan Song, Huan-Zhang Yao, Rui-Peng Song, Fan-Zheng Meng, Lei Li, Bjoern Nashan, Ji-Zhou Wang, Lian-Xin Liu
Summary: This study compared the clinical efficacy of avatrombopag and rh-TPO in the treatment of severe TCP associated with CLD. The results showed that avatrombopag demonstrated better clinical efficacy and fewer side effects, particularly in patients with Child-Pugh Class A.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Rongrong Qin, Jiwei Qin, Xuefeng Li, Zhijun Xu, Peiqi He, Xiaodong Yuan, Cheng Sun, Bjoern Nashan
Summary: This study analyzed the number and phenotypes of NK cells in liver transplant recipients and simulated the immunosuppressive microenvironment in vitro. It found that cyclosporine A, sirolimus/everolimus, and tacrolimus significantly impaired NK cell cytolytic activity and cytokine secretion. The MMF-containing regimen increased the expression of suppressive genes, while mTOR inhibitors had less impact on NK cell function.
HEPATOBILIARY SURGERY AND NUTRITION
(2023)
Meeting Abstract
Immunology
Rongrong Qin, Cheng Sun, Bjorn Nashan
Meeting Abstract
Immunology
M. B. Krueger, A. Bonifacius, P. Mausberg, R. Taubert, B. Nashan, B. Maecker-Kolhoff, R. Blasczyk, B. Eiz-Vesper
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Surgery
R. R. Qin, C. Sun, B. Nashan
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Meeting Abstract
Surgery
Barbara Suwelack, Wolfgang Arns, Aurelie Philippe, Vanessa Ditt, Ingeborg A. Hauser, Friedrich Thaiss, Claudia Sommerer, Anna Finkel, Christiane Schiedel, Duska Dragun, Bjoern Nashan
TRANSPLANT INTERNATIONAL
(2021)