Article
Immunology
Jiyue Wu, Feilong Zhang, Xiang Zheng, Jiandong Zhang, Peng Cao, Zejia Sun, Wei Wang
Summary: This study identified two distinct clusters based on NET-related genes during the ischemia reperfusion injury (IRI) process in renal transplantation. Robust prediction strategies for delayed graft function (DGF) and long-term graft survival were constructed. The findings provide references for early prevention and individualized treatment of postoperative complications after renal transplantation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Joseba Salguero, Laura Chamorro, Enrique Gomez-Gomez, Patricia de Benito, Jose E. Robles, Juan P. Campos
Summary: Delayed graft function (DGF) development significantly contributes to graft loss in kidney transplants, particularly in grafts with KDRI >= 1.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Wieteke Kleinherenbrink, Marije Baas, Gizal Nakhsbandi, Dennis A. Hesselink, Joke Roodnat, Brenda C. de Winter, Luuk Hilbrands, Teun van Gelder
Summary: The study found that delayed graft function and rejection significantly increased the risk of CMV disease in renal transplant recipients. Valganciclovir prophylaxis may not provide sufficient protection for CMV IgG-seronegative recipients receiving a kidney from CMV IgG-seropositive donor, especially those with delayed graft function.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Transplantation
Eva Schrezenmeier, Mia Mueller, Frank Friedersdorff, Dmytro Khadzhynov, Fabian Halleck, Oliver Staeck, Michael Durr, Kun Zhang, Kai-Uwe Eckardt, Klemens Budde, Lukas J. Lehner
Summary: This study analyzed the severity of delayed graft function (DGF) and its impact on transplant outcomes in 627 deceased-donor kidney transplant recipients. The results showed that the duration of DGF had a significant effect on 10-year death-censored graft survival, especially in kidneys with a Kidney Donor Profile Index (KDPI) less than 85%. However, short duration DGF (0-1 day) had comparable results to no DGF.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
News Item
Multidisciplinary Sciences
Ewen Callaway
Summary: Analysis of protein shapes reveals unexpected forms and connections.
Editorial Material
Multidisciplinary Sciences
Jeffrey A. Farrell
Summary: CellOracle, a computational tool, can predict the interaction of gene networks in programming cell identity during embryonic development. This tool will contribute to a better understanding of the regulation of development.
Article
Urology & Nephrology
Wujun Xue, Changxi Wang, Jianghua Chen, Xuyong Sun, Xiaotong Wu, Longkai Peng, Zhishui Chen, Qingshan Qu, Xiaodong Zhang, Yaowen Fu, Zhen Dong, Zheng Chen, Guiwen Feng, Tao Lin, Tongyi Men, Lixin Yu, Qiquan Sun, Yongheng Zhao, Jiangqiao Zhou, Li Zeng, Ming Zhao, Jianming Tan, Qifa Ye, Bingyi Shi, Yingzi Ming, Tongyu Zhu, Weiguo Sui, Chibing Huang, Yingxin Fu
Summary: This study investigated the risk factors related to delayed graft function (DGF) after renal transplantation using deceased donor kidneys and developed a donor risk scoring system for DGF prediction. Six donor characteristics were identified as risk factors for DGF, and a 49-point scoring system was established, showing a superior degree of discrimination. External validation of the DGF prediction system revealed an area under the receiver-operating characteristic curve of 0.7552, indicating its diagnostic significance and consistency for clinicians to make evidence-based decisions in renal transplantation therapy.
Article
Cell Biology
Xiangling Wei, Weiming Deng, Zhanwen Dong, Zhenwei Xie, Jinhua Zhang, Ruojiao Wang, Rui Zhang, Ning Na, Yu Zhou
Summary: This study identified subtypes of renal ischemia-reperfusion injury (IRI) and constructed a predictive signature for delayed graft function (DGF) based on ferroptosis-related genes (FRGs). The study found two ferroptosis-related patient clusters based on the expression patterns of BECN1 and NF2 gene clusters. Additionally, a six-gene ferroptosis-associated signature was constructed to predict the occurrence of DGF in renal IRI patients. These findings have important implications for patient stratification and prevention of DGF in kidney transplantation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Paola Pontrelli, Simona Simone, Federica Rascio, Francesco Pesce, Francesca Conserva, Barbara Infante, Giuseppe Castellano, Fabio Sallustio, Marco Fiorentino, Gianluigi Zaza, Anna Gallone, Michele Battaglia, Pasquale Ditonno, Giovanni Stallone, Loreto Gesualdo, Giuseppe Grandaliano
Summary: This study evaluated the recipients' characteristics in the development of delayed graft function (DGF) and found that the recipients' clinical/immunological features are associated with DGF independently of the donors' features.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, General & Internal
Cullan Donnelly, Maria Keller, Liise Kayler
Summary: The study found that prolonged DGF lasting over 20 days indicates a significantly higher risk for reduced eGFR at 1 year compared to lesser degrees of DGF, thus serving as a threshold indicator of increased risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
News Item
Multidisciplinary Sciences
Ewen Callaway
Summary: Microbial molecules from soil, seawater, and human bodies are among the least understood substances on Earth.
Article
Medicine, General & Internal
Nora Jahn, Ulrich Sack, Sebastian Stehr, Maria Theresa Voeelker, Sven Laudi, Daniel Seehofer, Selim Atay, Panagiota Zgoura, Richard Viebahn, Andreas Boldt, Hans-Michael Hau
Summary: Peripheral blood innate immune cells and clinical factors can be used to predict early renal graft injury (eRGI) after kidney transplantation. Monocyte and NK cell levels on postoperative day 7 are highly predictive for eRGI. Patient age, body mass index, cardiovascular disease, donor age, donor source, and cold ischemia time are also associated with eRGI.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Andrzej Konieczny, Jakub Stojanowski, Klaudia Rydzynska, Mariusz Kusztal, Magdalena Krajewska
Summary: In this study, predictive models for DGF were developed using RF and MLP, achieving an accuracy of 84.38% and an AUC of 0.84 with common input parameters. By incorporating additional variables like donor age, gender, KDPI, EPTS, and KDRI, the accuracy of the models improved, showing the potential of machine learning in assessing DGF risk in kidney transplant recipients.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Acoustics
Jieqiong Song, Yao Yao, Yizhou He, Shilong Lin, Simeng Pan, Ming Zhong
Summary: This study evaluated the value of contrast-enhanced ultrasonography (CEUS) in the early prediction of delayed graft function (DGF) after kidney transplantation. The results showed that CEUS parameters have a good value in the early prediction of DGF.
JOURNAL OF ULTRASOUND IN MEDICINE
(2023)
Article
Urology & Nephrology
Flavio Vincenti, Jim Kim, Deborah Gouveia, Gabrielle Pelle, Tracy J. Mayne, John F. Neylan
Summary: The GIFT trial aims to evaluate the efficacy and safety of ANG-3777 in renal transplantation patients with DGF, with the primary endpoint being eGFR at 12 months. The trial will provide important data for advancing the treatment of DGF.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Surgery
Gerd Jomrich, Matthias Paireder, Ivan Kristo, Andreas Baierl, Ayseguel Ilhan-Mutlu, Matthias Preusser, Reza Asari, Sebastian F. Schoppmann
Summary: The study aimed to determine the clinical role of the systemic immune-inflammation index in patients with resectable adenocarcinoma of the gastroesophageal junction treated with or without neoadjuvant therapy. The findings showed that elevated SII is an independent adverse prognostic factor in patients with resectable gastroesophageal adenocarcinomas with and without neoadjuvant treatment.
Article
Surgery
Milena Nikolic, Katrin Schwameis, Ivan Kristo, Matthias Paireder, Aleksa Matic, Georg Semmler, Lorenz Semmler, Sebastian F. Schoppmann
WORLD JOURNAL OF SURGERY
(2020)
Article
Surgery
Ivan Kristo, Matthias Paireder, Gerd Jomrich, Daniel M. Felsenreich, Mario Fischer, Florian P. Hennerbichler, Felix B. Langer, Gerhard Prager, Sebastian F. Schoppmann
Review
Endocrinology & Metabolism
Sara Denicolo, Paul Perco, Stefanie Thoeni, Gert Mayer
Summary: Cardiovascular and renal complications are a major burden for individuals with type 2 diabetes mellitus. Non-adherence to medication is common and associated with worse outcomes and higher healthcare costs in chronic conditions like T2DM. Adherence to drug therapy is crucial for successful disease management and prevention of comorbidities.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Li Li, Pierre Galichon, Xiaoyan Xiao, Ana C. Figueroa-Ramirez, Diana Tamayo, Jake J-K Lee, Marian Kalocsay, David Gonzalez-Sanchez, Maria S. Chancay, Kyle W. McCracken, Nathan N. Lee, Takaharu Ichimura, Yutaro Mori, M. Todd Valerius, Julia Wilflingseder, Dario R. Lemos, Elazer R. Edelman, Joseph Bonventre
Summary: COUP-TFII plays a crucial role in fibrosis, with its overexpression suppressing fatty acid oxidation, enhancing glycolysis pathways, and inducing fibroblasts to produce collagen. Genetic ablation of COUP-TFII can mitigate kidney fibrosis after injury. The regulation of PGC1α by COUP-TFII serves as an important mechanism in fibrosis.
Article
Biochemistry & Molecular Biology
Johannes Leierer, Paul Perco, Benedikt Hofer, Susanne Eder, Alexander Dzien, Julia Kerschbaum, Michael Rudnicki, Gert Mayer
Summary: Changes in protein concentrations in the body fluids of ADPKD patients mainly involve dysregulation of various molecular processes, including markers such as EGF, APLN, VEGFA, and AGT. These markers are significantly correlated with renal function and disease progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Health Care Sciences & Services
Maria Effenberger, Andreas Kronbichler, Erica Bettac, Felix Grabherr, Christoph Grander, Timon Erik Adolph, Gert Mayer, Heinz Zoller, Paul Perco, Herbert Tilg
Summary: Liver transplantation (LT) is the only curative treatment for end-stage liver disease, but public awareness has significantly decreased over the past two decades. Novel awareness programs are needed to address this issue and increase donor acquisition.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2021)
Article
Multidisciplinary Sciences
Jakub Jankowski, Hye Kyung Lee, Julia Wilflingseder, Lothar Hennighausen
Summary: This study reports on the genetic programs activated in kidney cells in response to interferons during COVID-19, and the inhibitory effect of a Janus kinase inhibitor. The findings help identify kidney-specific interferon responses.
Article
Biochemistry & Molecular Biology
Michail Evgeniou, Juan Manuel Sacnun, Klaus Kratochwill, Paul Perco
Summary: This study conducted a meta-analysis of transcriptomics datasets in the context of peritoneal dialysis, identifying dysregulated receptor-ligand interactions associated with PD complications. The study revealed novel receptor-ligand interactions that warrant further investigation in future functional studies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Sara Denicolo, Verena Vogi, Felix Keller, Stefanie Thoni, Susanne Eder, Hiddo J. L. Heerspink, Laszlo Rosivall, Andrzej Wiecek, Patrick B. Mark, Paul Perco, Johannes Leierer, Andreas Kronbichler, Marion Steger, Simon Schwendinger, Johannes Zschocke, Gert Mayer, Emina Jukic
Summary: This study investigates the impact of clonal hematopoiesis of indeterminate potential (CHIP) on the incidence and progression of diabetic kidney disease (DKD). The results show that CHIP is not associated with the development or progression of DKD, while other known risk factors and elevated microinflammation are related to kidney function decline in type 2 diabetes mellitus.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Medicine, Research & Experimental
Glory Ranches, Maximilian Zeidler, Roman Kessler, Martina Hoelzl, Michael W. Hess, Jonathan Vosper, Paul Perco, Herbert Schramek, Kai K. Kummer, Michaela Kress, Anne Krogsdam, Michael Rudnicki, Gert Mayer, Alexander Huettenhofer
Summary: Exosomes are valuable biomarkers for studying chronic kidney disease (CKD). Urinary exosomes and exosomes derived from renal proximal tubular epithelial cells (RPTECs) were analyzed for microRNA (miRNA) profiles. Dysregulated exosomal miRNAs associated with pro-inflammatory and pro-fibrotic pathways were identified in RPTECs, suggesting their potential use in predicting CKD pathogenesis.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Editorial Material
Urology & Nephrology
Paul Perco, Gert Mayer
Summary: With the advancement of single-cell sequencing techniques and bioinformatic analysis, complex physiology and pathophysiology of cell-cell interactions in the kidney can be better understood, leading to the identification of new biomarkers and treatment options.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Sara Denicolo, Viji Nair, Johannes Leierer, Michael Rudnicki, Matthias Kretzler, Gert Mayer, Wenjun Ju, Paul Perco
Summary: The study found that Fibrinogen-like 2 (FGL2) is associated with fibrosis in kidney damage and may be a potential therapeutic target for chronic kidney disease (CKD). Analysis of CKD cohorts showed that higher renal FGL2 mRNA expression is associated with kidney fibrosis and worse outcomes. FGL2 protein expression was detected in specific renal tissue sections. The study also identified regulators of FGL2 expression in renal tissue, as well as factors potentially inducing or counterbalancing FGL2-co-expressed genes. In conclusion, elevated FGL2 levels in human CKD are associated with fibrosis and worse outcomes.
Article
Medical Laboratory Technology
Christoph A. Gebeshuber, Lisa Daniel-Fischer, Heinz Regele, Helga Schachner, Christoph Aufricht, Christoph Kornauth, Matthias Ley, Seth L. Alper, Rebecca Herzog, Klaus Kratochwill, Paul Perco
Summary: Focal segmental glomerulosclerosis (FSGS) is a glomerular lesion associated with nephrotic syndrome and a high risk of end-stage kidney disease. Current treatment options are limited, and there is a need for novel therapies targeting specific molecular pathways. Using a network-based molecular model, the anti-platelet drug clopidogrel was identified as a potential therapeutic option for FSGS. Experimental validation in a mouse model showed that clopidogrel improved FSGS outcome parameters and histopathological damage. Its favorable safety profile and efficacy recommend clopidogrel for clinical trials in FSGS.
TRANSLATIONAL RESEARCH
(2023)
Article
Surgery
Matthias Paireder, Ivan Kristo, Reza Asari, Gerd Jomrich, Johannes Steindl, Erwin Rieder, Sebastian F. Schoppmann
Summary: After undergoing LES-EST treatment, patients with GERD and IEM showed significant improvement in health-related quality of life, but the normalization or significant improvement of esophageal acid exposure was limited.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)