期刊
TRANSPLANT IMMUNOLOGY
卷 18, 期 3, 页码 246-249出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.trim.2007.07.003
关键词
liver transplant; acute rejection; allograft survival; CTLA4 polymorphism
The CTLA4 molecule is a homolog for CD28, and both molecules and their common ligands (CD80 and CD86) constitute the B7/CD28-CTLA4 co-stimulatory pathway for T cells activation. The CTLA4-ligand interaction has an inhibitory effect on T cell activation and might contribute to peripheral tolerance. A recently described CT60 A/G polymorphism affects the production of soluble CTLA4 and is strongly associated with immune-mediated diseases and with allogenic stem cell transplantation outcome. Thus, we examined this marker on. liver transplant outcome by a PCR-RFLP method. The CT60 G allele was significantly associated with acute rejection (Pc=0.038; OR = 1.49; AR vs. NAR). Patients who lacked this allele had the lowest risk of acute rejection development. Allograft survival data did not show statistical differences between genotypes. In conclusion, CT60 A/G dimorphism within the 3'-UTR of CTLA4 gene, which encodes for reduced sCTLA4 production, influence acute rejection development in liver transplantation. (c) 2007 Elsevier B.V. All rights reserved.
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