Article
Clinical Neurology
Chiara Pavan, Anna L. R. Xavier, Marta Ramos, Jane Fisher, Marios Kritsilis, Adam Linder, Peter Bentzer, Maiken Nedergaard, Iben Lundgaard
Summary: In this study, it was found that NETs disrupt the transport of cerebrospinal fluid through the glymphatic system in pneumococcal meningitis, leading to the formation of cerebral edema. Treatment with DNase can restore glymphatic transport and reduce the increased brain weight in rats, while first-line antibiotic treatment does not have the same effect on restoring fluid dynamics. Therefore, the glymphatic system and NETs may be potential new treatment targets in pneumococcal meningitis.
ANNALS OF NEUROLOGY
(2021)
Article
Psychiatry
Kamilla W. Miskowiak, Anja H. Simonsen, Morten Meyer, Henrik Enghusen Poulsen, Mira Wilkan, Julie Forman, Steen G. Hasselbalch, Lars V. Kessing, Ulla Knorr
Summary: This study aimed to investigate the association of brain erythropoietin (EPO) and oxidative stress with cognitive functions in bipolar disorder (BD) patients, as well as the changes in brain EPO during and after affective episodes. The results showed that verbal memory decreased with increasing concentrations of EPO and oxidative stress, but these associations were not significant after adjusting for multiple testing.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Materials Science, Multidisciplinary
Luiz Otavio Guimaraes-Ervilha, Leoncio Lopes Soares, Isabela da Silva Pereira Bento, Renner Philipe Rodrigues Carvalho, Thaina Iasbik Lima, Fernanda Carolina Ribeiro Dias, Daniel Silva Sena Bastos, Jamile Fernanda Silva Cossolin, Ana Claudia Ferreira Souza, Emily Correna Carlo Reis, Jose Eduardo Serrao, Antonio Jose Natali, Mariana Machado-Neves
Summary: Pulmonary arterial hypertension (PAH) is characterized by elevated arterial pressure and vascular resistance. PAH may cause alterations in the microcirculation of several organs, including the kidney, liver, brain, and testes. This study investigated the impact of PAH on testicular morphology and function and found that PAH has deleterious effects on these parameters. However, resistance exercise training (RT) was shown to attenuate the negative effects of PAH on testicular parameters and improve testosterone levels.
MICROSCOPY AND MICROANALYSIS
(2023)
Article
Immunology
Angharad G. Davis, Anna J. Dreyer, Christine Albertyn, Mpumi Maxebengula, Cari Stek, Sean Wasserman, Suzaan Marais, Kathleen Bateman, Mark Solms, John Joska, Robert J. Wilkinson, Sam Nightingale
Summary: This study systematically assessed the frequency and nature of cognitive impairment in adult tuberculous meningitis patients and found that it has an impact on functioning and medication adherence.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Ran Tao, Xiaorong Peng, Xiang Liu, Lijun Xu, Junwei Su, Guanjing Lang, Ying Huang, Biao Zhu
Summary: This study aimed to evaluate the effects of lenalidomide treatment on neuroinflammation and cognitive impairment in patients with HCM who had completed cryptococcal clearance. The results showed that lenalidomide treatment significantly improved cognitive function in HCM patients, particularly in the domain of memory function.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Neurosciences
Anne T. Kloek, Mercedes Valls Seron, Ben Schmand, Michael W. T. Tanck, Arie van der Ende, Matthijs C. Brouwer, Diederik van de Beek
Summary: The study confirmed the role of MIF in poor outcomes of pneumococcal meningitis. Variability in MIF production among individuals was associated with long-term cognitive impairment after pneumococcal meningitis. The findings suggest MIF could potentially serve as a target for immune-modulating therapy in bacterial meningitis survivors.
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Alexey Sokolov, Nadezhda M. Dubrovskaya, Valeria A. Kostevich, Dmitrii S. Vasilev, Irina V. Voynova, Elena T. Zakharova, Olga L. Runova, Igor Semak, Alexander Budevich, Natalia N. Nalivaeva, Vadim B. Vasilyev
Summary: The protective effects of apo-rhLF on the cognitive functions of rat offspring subjected to prenatal hypoxia have been analyzed. The results showed that apo-rhLF can rescue cognitive deficits caused by prenatal hypoxia and improve memory.
Article
Agriculture, Multidisciplinary
Hao-Ran Wang, Mu-Zi Li, Jia-Gen Cui, Hao Zhang, Yi Zhao, Jin-Long Li
Summary: Lycopene can alleviate DEHP-induced learning and memory impairment by regulating iron metabolism, inhibiting lipid peroxidation, and activating relevant signaling pathways.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Endocrinology & Metabolism
Michelle Lima Garcez, Ricardo Chiengo Sapalo Cassoma, Francielle Mina, Tatiani Bellettini-Santos, Aline Pereira da Luz, Gustavo Luis Schiavo, Eduarda Behenck Medeiros, Ana Carolina Brunatto Falchetti Campos, Sabrina da Silva, Lisienny Campoli Tono Rempel, Amanda Valnier Steckert, Tatiana Barichello, Josiane Budni
Summary: The study evaluated the effect of folic acid treatment in an animal model of aging induced by D-galactose. Folic acid was found to prevent cognitive impairment and brain alterations during aging, but further research is needed to elucidate its mechanisms of action.
METABOLIC BRAIN DISEASE
(2021)
Article
Chemistry, Medicinal
Meng Meng Shi, Xiao Fan Xu, Qiu Min Sun, Mingying Luo, Dan Dan Liu, Dong Min Guo, Ling Chen, Xiao Lin Zhong, Yang Xu, Wen Yu Cao
Summary: In this study, we investigated the efficacy of betaine in alleviating the abnormal behavior induced by chronic social isolation (SI) stress in mice. It was found that long-term betaine administration improved cognitive behavior in SI mice but failed to prevent depression-like behavior. Moreover, betaine treatment inhibited hippocampal microglia over-activation and polarized microglia toward the M2 phenotype, effectively reducing the expression of inflammatory factors in SI mice.
PHYTOTHERAPY RESEARCH
(2023)
Article
Immunology
Benjamin R. Cassidy, Sreemathi Logan, Julie A. Farley, Daniel B. Owen, William E. Sonntag, Douglas A. Drevets
Summary: Neuroinvasive and non-neuroinvasive Listeria monocytogenes infections cause cognitive decline, with more profound deficits observed after neuroinvasive infection. The increased numbers of brain CD8(+) T-lymphocytes, including CD8(+) T-RM cells, are strongly correlated with reduced cognitive performance. Systemic infections that lead to brain leukocytosis trigger a progressive decline in cognitive function, implicating CD8(+) T-lymphocytes in the etiology of this impairment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Nutrition & Dietetics
Suli Zhao, Yebing Zhang, Haoyue Ding, Shouna Hu, Xiaoqing Wu, Aiguo Ma, Yan Ma
Summary: This study evaluated the function and mechanism of lutein administration on chronic ethanol-induced liver and intestinal barrier damage in rats. The results showed that lutein interventions prevented alcohol-induced liver injury, oxidative stress, and inflammation, and upregulated the protein expression of Claudin-1 and Occludin in the intestinal tissues. Lutein can improve chronic alcoholic liver injury and intestinal barrier dysfunction in rats.
Article
Biochemistry & Molecular Biology
Prateek Pathak, Vikas Kumar, Habibullah Khalilullah, Maria Grishina, HariOm Singh, Amita Verma
Summary: The study demonstrates that debelalactone can protect tissues, alleviate chronic hepatic inflammation and oxidative stress induced by diethyl nitrosamine in Wistar rats. It significantly reduces parameters associated with liver and non-liver functions, and improves body weight of treated animals. Moreover, debelalactone restores antioxidant markers and inflammatory mediators to normal levels, reduces liver tissue abnormalities and inflammation, and inhibits precancerous cells.
Article
Nutrition & Dietetics
Liziane da Silva de Vargas, Jeferson Jantsch, Juliana Ribeiro Fontoura, Gilson Pires Dorneles, Alessandra Peres, Renata Padilha Guedes
Summary: This study found that zinc supplementation can partially improve cognitive function in overweight or obese women, suggesting it as an adjunct strategy for enhancing cognitive health in this population.
Article
Food Science & Technology
Beata Nowak, Agnieszka Matuszewska, Adam Szelag, Maciej Danielewski, Wojciech Dziewiszek, Anna Nikodem, Jaroslaw Filipiak, Diana Jedrzejuk, Marek Bolanowski, Alicja Z. Kucharska, Narcyz Piorecki, Tomasz Piasecki, Tomasz Sozanski
Summary: The aim of this study was to investigate the effects of cornelian cherry extract on metabolic changes induced by ovary removal, including bone loss, obesity development, adipokine imbalance, and oxidative stress. The results showed that cornelian cherry extract could improve weight gain, reduce visceral fat accumulation, restore adipokine balance, reduce oxidative stress, and prevent bone loss caused by ovary removal. This study is the first to demonstrate the bone-protective properties of cornelian cherry and its potential benefits for preventing cardiovascular diseases.
JOURNAL OF FUNCTIONAL FOODS
(2022)
Article
Neurosciences
Larissa Silva Joaquim, Lucineia Gainski Danielski, Sandra Bonfante, Erica Biehl, Khiany Mathias, Tais Denicol, Erick Bagio, Everton Venicius Lanzzarin, Richard Simon Machado, Gabriela Costa Bernades, Jaqueline Generoso, Amanda Della Giustina, Tatiana Barichello, Fabricia Petronilho
Summary: The study demonstrates that inhibiting NLRP3 activation with MCC950 can reduce brain oxidative damage after cerebral ischemia/reperfusion in rats.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Gislaine Z. Reus, Morgana S. Abitante, Luana M. Manosso, Airam B. de Moura, Laura A. Borba, Maria Eduarda M. Botelho, Ana Caroline Darabas, Julia P. Demo, Joao Paulo Behenck, Camila O. Arent, Leandro Garbossa, Larissa Joaquim, Taiane A. Cardoso, Fabricia Petronilho, Joao Quevedo
Summary: This study investigated the effects of early stress, represented by maternal deprivation, on behavior and oxidative stress in rats. It was found that maternal deprivation can promote anxiety-like behavior and impair memory, while also increasing oxidative stress and altering antioxidant defenses. However, environmental enrichment was able to reverse these changes, although its effects were dependent on sex and developmental period.
MOLECULAR NEUROBIOLOGY
(2023)
News Item
Biochemistry & Molecular Biology
Giselli Scaini, Joao Quevedo
MOLECULAR PSYCHIATRY
(2023)
Letter
Biochemistry & Molecular Biology
Albert J. Fenoy, Joao Quevedo, Jair C. Soares
MOLECULAR PSYCHIATRY
(2023)
Article
Pharmacology & Pharmacy
Roberta Eduarda Grolli, Amanda Gollo Bertollo, Joao Paulo Behenck, Laura de Araujo Borba, Marcos Eduardo Plissari, Silvio Jose Batista Soares, Aline Manica, Larissa da Silva Joaquim, Fabricia Petronilho, Joao Quevedo, Margarete Dulce Bagatini, Gislaine Zilli Reus, Zuleide Maria Ignacio
Summary: This study evaluated the effects of chronic mild stress on depressive-like behaviors, oxidative stress, and inflammation in rats, as well as the possible antidepressant, antioxidant, and anti-inflammatory effects of quetiapine. The results showed that chronic stress increased depressive-like behaviors, while quetiapine significantly reduced these behaviors. Chronic stress also increased MPO activity and IL-6 levels in the serum of rats, which were both significantly reduced by quetiapine.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Neurosciences
Taise Possamai-Della, Jose Henrique Cararo, Jorge M. Aguiar-Geraldo, Jefte Peper-Nascimento, Alexandra I. Zugno, Gabriel R. Fries, Joao Quevedo, Samira S. Valvassori
Summary: This study evaluated the effects of prenatal stress on behavior, HPA-axis, and epigenetic parameters in stressed dams and their offspring. It found that prenatal stress led to abnormal emotional behavior in female offspring, accompanied by hyperactivity of the HPA-axis and epigenetic adaptations in the activity of HDAC and DNMT, as well as acetylation in H3K9 and H3K14. In addition, prenatal stressed female offspring showed increased levels of ACTH compared to their male counterpart.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Camila N. C. Lima, Emese H. C. Kovacs, Salahudeen Mirza, Alexandra Del Favero-Campbell, Alexandre Paim Diaz, Joao Quevedo, Benney M. R. Argue, Jenny Gringer Richards, Aislinn Williams, John A. Wemmie, Vincent A. Magnotta, Jess G. Fiedorowicz, Jair C. Soares, Marie E. Gaine, Gabriel R. Fries
Summary: Bipolar disorder (BD) is associated with premature mortality and aging, including accelerated epigenetic aging. Suicide attempts (SA) are significantly higher in BD and are linked to decreased lifespan, biological aging, and poorer clinical outcomes. This study investigated the relationship between GrimAge, an epigenetic clock, and SA in BD individuals.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Neurosciences
Jaqueline S. Generoso, Cristiano Julio Faller, Allan Collodel, Carlos Henrique Rocha Catalao, Diogo Dominguini, Fabricia Petronilho, Tatiana Barichello, Vijayasree V. Giridharan
Summary: This study aimed to investigate the role of NLRP3 and its inhibitor MCC950 in neurochemical, immunological, and behavioral parameters in the early and late stages of experimental pneumococcal meningitis. The results showed that the rats in the meningitis group had increased levels of cytokines, NLRP3, and microglial activation markers at 24 hours, and the use of MCC950 significantly reduced those levels. Although free from infection, the animals in the meningitis group at ten days demonstrated elevated cytokine levels and behavioral deficits, which were rescued by a single dose of NLRP3 inhibitor.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rafaela C. Cordeiro, Camila N. C. Lima, Gabriel R. Fries, Giovana Zunta-Soares, Jair C. Soares, Joao Quevedo, Giselli Scaini
Summary: This study investigates the impact of mitochondrial dysfunction on bipolar disorder (BD). The study finds that BD patients have a lower mitochondrial health index (MHI) compared to non-psychiatry controls, with a negative correlation between MHI and cell-free mtDNA levels. The study further reveals that MHI is related to the expression of mitochondria quality control (MQC) proteins, and a longer illness duration, worse functional status, and higher depressive symptoms are associated with lower MHI and higher cell-free mtDNA levels.
MOLECULAR PSYCHIATRY
(2023)
News Item
Biochemistry & Molecular Biology
Samira S. Valvassori, Joao Quevedo, Giselli Scaini
MOLECULAR PSYCHIATRY
(2023)
Review
Psychiatry
Brisa S. Fernandes, Mehmet Enes Inam, Nitesh Enduru, Joao Quevedo, Zhongming Zhao
Summary: The objective of this study was to determine whether tryptophan and kynurenine pathway metabolites are altered in Alzheimer's disease (AD) through a systematic review and meta-analysis. The results showed a shift towards the kynurenine pathway in both the brain and periphery, with increased production of kynurenic acid in the brain but decreased production in peripheral blood. There were also dissociations between central and peripheral levels, as well as between plasma and serum for some metabolites. Overall, changes in the kynurenine pathway are suggested to be a core component of AD, but more research is needed to confirm and consolidate these findings.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Leonardo Baldacara, Cesar Augusto Trinta Weber, Miriam Gorender, Roberta R. Grudtner, Sandra Peu, Ana Luiza Silva Teles, Ives Passos Cavalcante, Joao Quevedo, Antonio Geraldo da Silva
Summary: This article evaluates the effectiveness of crisis hotlines in preventing suicide through a systematic review. The findings indicate that crisis hotlines are effective when included in broader prevention programs and staffed by trained professionals. However, further research is needed to identify key components that enhance effectiveness.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)
Review
Psychiatry
Mehmet Enes Inam, Brisa S. Fernandes, Estela Salagre, Iria Grande, Eduard Vieta, Joao Quevedo, Zhongming Zhao
Summary: This study conducted a systematic review and meta-analysis to examine the KYN pathway metabolites in cerebrospinal fluid samples from patients with schizophrenia, bipolar disorder, and major depressive disorder. The results showed that KA levels were increased in schizophrenia, while the levels of TRP and KYN did not differ significantly. In bipolar disorder and major depressive disorder, there were no significant alterations in TRP and KA levels, although there may be a trend of increased KA levels and elevated QA levels in major depressive disorder. However, more studies are needed to confirm these findings.
BRAZILIAN JOURNAL OF PSYCHIATRY
(2023)