Review
Immunology
Yunshu Yang, Yang Liu, Yunwei Wang, Yongyi Chao, Jinxin Zhang, Yanhui Jia, Jun Tie, Dahai Hu
Summary: This review summarizes the role and regulatory mechanisms of SIRT1 in modulating inflammation and highlights its potential therapeutic value in inflammatory diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Mantia Karampetsou, Kostas Vekrellis, Katerina Melachroinou
Summary: A large body of evidence suggests that the TGF-beta superfamily plays a regulatory role in the central nervous system. It is involved in embryonic brain development, adult brain tissue injury repair, and various processes related to Parkinson's disease, including the differentiation and synaptic function of dopaminergic neurons and the activation state of astrocytes and microglia. Studies using toxin models have explored the dopaminotrophic and protective effects of TGF-beta superfamily members.
NEUROBIOLOGY OF DISEASE
(2022)
Review
Food Science & Technology
Gary M. Bucciarelli, Maren Lechner, Audrey Fontes, Lee B. Kats, Heather L. Eisthen, H. Bradley Shaffer
Summary: TTX is a potent neurotoxin that can be therapeutic at levels below lethal doses, showing promise in treating cancer-related pain, neuropathic pain, and other ailments. Despite its lethal effects on humans, TTX has potential to treat various medical conditions.
Article
Agriculture, Multidisciplinary
Hantao Zhang, Feiyan Chen, Shuyi Xu, Wenjing Zhang, Ruimei Li, Qi Yao, Yunan Zhao, Zhu Zhu, Lin Chen
Summary: Ginseng is consumed as a dietary supplement and its metabolite PPD has been found to enhance cognitive performance. Through various experiments, it was found that PPD directly interacts with CK-BB and promotes its activity, leading to amelioration of cognitive deficits and alterations in oxidative stress and synaptic plasticity in mice.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Cell Biology
Chan Yang, Rong Li, Lin-Chong Su, You-Yu Lan, You-Qiang Wang, Wang-Dong Xu, An-Fang Huang
Summary: This study found that the levels of SHP2 were significantly upregulated in SLE patients and correlated with some clinical and laboratory characteristics, suggesting its potential as a biomarker for SLE. Treatment with a SHP2 inhibitor in a mouse model improved hepatosplenomegaly and histologic severity of the kidney, and reversed differentiation of DCs, Th1, and Th17 cells, as well as downregulated production of inflammatory cytokines and autoantibodies.
INFLAMMATION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Li Yang, Xingxing Wang, Fuyong Zhao, Xianliang Zhang, Wei Li, Junsen Huang, Xiaoyu Pei, Xiang Ren, Yangai Liu, Kunlun He, Fei Zhang, Xiongfeng Ma, Daigang Yang
Summary: Salinity is a significant abiotic stress factor that hampers cotton growth and affects fiber yield and quality. Despite significant progress in understanding salt tolerance in cotton since the completion of cotton genome sequencing, there is still limited knowledge on how cotton adapts to salt stress. This review summarizes the current progress in the biosynthesis and signal transduction pathways of ethylene (ET) and polyamines (PAs) and their regulation of plant growth and development under salt stress. Additionally, the function of a cotton SAM transporter in salt stress response is confirmed, providing insights for breeding salt-tolerant cotton varieties.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Salma M. S. Ahmad, Maryam Al-Mansoob, Allal Ouhtit
Summary: The study found that CD44 activation and SIRT1 overexpression may promote breast cancer cell invasion and metastasis.
FRONTIERS IN ONCOLOGY
(2022)
Review
Immunology
Zhen Yang, Ruxue Liu, Minghan Qiu, Hanwei Mei, Jie Hao, Teng Song, Ke Zhao, Dandan Zou, Huaqing Wang, Ming Gao
Summary: Traditional Chinese medicine has a long history in China and has been recently prioritized in the 14th Five-Year Plan for its development. ERIANIN, a component of Dendrobium, has various pharmacological effects and has shown broad-spectrum antitumor properties. This review aims to systematically summarize the research on ERIANIN and provide insights into its future development in combined immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Medicine, Research & Experimental
Pengcheng Li, Weiqi Xu, Furong Liu, He Zhu, Lu Zhang, Zeyang Ding, Huifang Liang, Jia Song
Summary: Tryptophan metabolism disorder has been found to be crucial in cancer development, with IDO2 playing a significant role in some tumors. Despite limited reviews on the topic, IDO2 is often upregulated in tumors and could serve as a potential therapeutic target for cancer treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Rheumatology
Agner R. Parra Sanchez, Alexandre E. Voskuyl, Ronald E. van Vollenhoven
Summary: The treat-to-target (T2T) concept, which involves choosing a specific target, evaluating the outcomes, and taking action accordingly, has been successful in improving outcomes for patients with diabetes, hypertension, and rheumatoid arthritis. However, the application of this approach in systemic lupus erythematosus (SLE) requires measurable and achievable outcomes, as well as more therapeutic options. Currently, the available therapeutic options for SLE are limited, and there is a need for more effective and safer treatments. Fortunately, there have been significant advancements in clinical trial activity for SLE, especially with the development of novel therapies. With these expected advancements, it is likely that a wider range of treatments will be available for SLE in the near future, allowing for the routine implementation of a treat-to-target approach.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Review
Oncology
Ziyi Wang, Renxiang Jia, Linlin Wang, Qiwei Yang, Xiaohai Hu, Qiang Fu, Xinyu Zhang, Wenya Li, Yi Ren
Summary: Defects in DNA repair pathways are common in cancer and have significant impact on tumor metabolism, metastasis, and drug resistance. Rad51 recombinase, upregulated in many malignant tumors, plays a critical role in these processes.
FRONTIERS IN ONCOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Bing-Hui Yan, Qi-Xuan Xu, Xiao Ge, Ming-Tong Gao, Yun Li, Liang Guo, Po Hu, Yang Pan
Summary: In this study, we investigated the therapeutic effects of Chengshi Beixie Fenqing Decoction (CBFD), a traditional Chinese medicine prescription, on benign prostatic hyperplasia (BPH) through in vivo model and network pharmacology. We identified the bioactives in CBFD and selected target proteins associated with BPH. Through analysis of the bioactive-protein interactive networking and molecular docking test, we found that CBFD may improve BPH condition by activating the relaxin signaling pathways.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Kukhwa Kim, Daniel Lee, Han-Young Kim, Soyeon Kim, Ji-Hyo Lyu, Sujung Park, Young-Chul Park, Hyungwoo Kim
Summary: This study identified the active compounds and target genes in Spirodela polyrhiza through network-based analysis. The effects of an ethanolic extract of S. polyrhiza on contact dermatitis in mice were evaluated, and the inhibitory effects on MAPK signaling pathways were examined. The findings suggest the potential dermatological applications of S. polyrhiza and indicate that its anti-dermatitis action is related to the inhibition of TNF and IL-6 by luteolin and luteolin glycosides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Adriano Bonura, Nicoletta Brunelli, Marilena Marcosano, Gianmarco Iaccarino, Luisa Fofi, Fabrizio Vernieri, Claudia Altamura
Summary: The calcitonin gene-related peptide (CGRP) is a neuropeptide with complex systemic impact beyond nociception. It plays a crucial role in vasodilation, inflammation, intestinal motility, and apoptosis. CGRP has contradictory effects, acting as a potent vasodilator in the cardiovascular system but not inducing arterial hypertension. It also exhibits both anti-inflammatory and pro-inflammatory effects as an immunomodulator.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
George E. Fragoulis, George Bertsias, Bahram Bodaghi, Ahmet Gul, Jan van Laar, Gonca Mumcu, David Saadoun, Ilknur Tugal-Tutkun, Gulen Hatemi, Petros P. Sfikakis
Summary: In recent decades, the effectiveness of biologic agents, particularly anti-TNFs, in managing severe manifestations of Behcet's Disease (BD) has been established. However, the clinical heterogeneity of BD has posed challenges in validating a widely-accepted composite index for disease assessment and treatment goals. This position paper discusses the challenges and potential solutions for developing a treat-to-target strategy in BD, based on a round table discussion at the 19th International Conference on BD.
CLINICAL IMMUNOLOGY
(2023)
