Review
Biochemistry & Molecular Biology
Reed Berlet, Stefan Anthony, Beverly Brooks, Zhen-Jie Wang, Nadia Sadanandan, Alex Shear, Blaise Cozene, Bella Gonzales-Portillo, Blake Parsons, Felipe Esparza Salazar, Alma R. Lezama Toledo, German Rivera Monroy, Joaquin Vega Gonzales-Portillo, Cesario Borlongan
Summary: Combining stem cell transplantation with rehabilitation therapy presents a promising approach in treating stroke, with potential for better functional outcomes for patients. This comprehensive review assesses the advantages and disadvantages of using this combined therapy to mitigate the devastating effects of stroke.
Article
Biology
Jason T. Long, Abigail Leinroth, Yihan Liao, Yinshi Ren, Anthony J. Mirando, Tuyet Nguyen, Wendi Guo, Deepika Sharma, Douglas Rouse, Colleen Wu, Kathryn Song Eng Cheah, Courtney M. Karner, Matthew J. Hilton
Summary: The study reveals that hypertrophic chondrocytes undergo dedifferentiation to give rise to marrow-associated skeletal stem and progenitor cells (SSPCs), which serve as a primary source of osteoblasts during skeletal development and also contribute to the adipogenic lineage.
Review
Cell Biology
Maria Cristina Vinci, Ermes Carulli, Erica Rurali, Raffaella Rinaldi, Giulia Damiano, Angela Raucci, Giulio Pompilio, Stefano Genovese
Summary: Endothelial progenitor cells (EPCs) have been the subject of extensive research and clinical expectations, but their current status and potential in regenerative medicine remain uncertain. This review explores the past and recent literature on this diverse and intriguing cell population, taking the reader on a chronological journey from their initial discovery to subsequent efforts in understanding their biology and their recent applications in cardiovascular disease and regenerative medicine.
Review
Biochemistry & Molecular Biology
Yi-Hsien Fang, Saprina P. H. Wang, Hsien-Yuan Chang, Pei-Jung Yang, Ping-Yen Liu, Yen-Wen Liu
Summary: Cardiovascular disease is the leading cause of global mortality, and pluripotent stem cells from amniotic fluid show potential for cardiac regeneration therapy with their high immune tolerance. This review highlights the progress of amniotic fluid stem cell therapy in recent years for the treatment of heart diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Rishi Man Chugh, Payel Bhanja, Ximena Diaz Olea, Fang Tao, Kealan Schroeder, Ryan Zitter, Tanu Arora, Harsh Pathak, Bruce F. Kimler, Andrew K. Godwin, John M. Perry, Subhrajit Saha
Summary: The study showed that myeloid committed progenitor cells derived from human peripheral blood mononuclear cells can mitigate radiation-induced bone marrow toxicity and improve survival in mice, offering a natural polypharmacy solution against complex injury processes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell & Tissue Engineering
Gian Paolo Fadini, Mattia Albiero
Summary: During antenatal development, HSPCs arise and migrate to the fetal liver. In adulthood, HSPCs retain migratory activity and circulate to peripheral tissues. Diabetes mellitus jeopardizes HSPC traffic, reducing circulating HSPC levels and increasing the risk for multi-organ damage. The impaired traffic of HSPCs and enhanced generation of pro-inflammatory cells contribute to tissue damage and inflammation.
Article
Biotechnology & Applied Microbiology
Stefania Crippa, Anastasia Conti, Valentina Vavassori, Samuele Ferrari, Stefano Beretta, Silvia Rivis, Roberto Bosotti, Serena Scala, Stefania Pirroni, Raisa Jofra-Hernandez, Ludovica Santi, Luca Basso-Ricci, Ivan Merelli, Pietro Genovese, Alessandro Aiuti, Luigi Naldini, Raffaella Di Micco, Maria Ester Bernardo
Summary: Mesenchymal stromal cells (MSCs) have been shown to play a supportive role in the expansion and engraftment of hematopoietic stem and progenitor cells (HSPCs). In this study, we developed a co-culture system using bone marrow (BM)-MSCs to improve the transplantation outcome of CRISPR-Cas9 gene-edited (GE) human HSPCs. We found that BM-MSCs can produce hematopoietic supportive and anti-inflammatory factors that enhance the expansion and clonogenic potential of GE-HSPCs in vitro, leading to improved engraftment and early phase hematological reconstitution in transplanted mice. This study suggests a potential clinical application of BM-MSCs in promoting successful transplantation of GE-HSPCs.
Article
Biochemistry & Molecular Biology
Laura Grech, Jean-Paul Ebejer, Oriana Mazzitelli, Kevin Schembri, Joseph Borg, Elisa Seria
Summary: The study found that circulating bone marrow mesenchymal progenitors (BMMPs) can modulate the inflammatory response and influence wound repair by regulating the expression of IL-8 and CD73 and the secretion of IL-8 and SCF. This study is of importance for wound repair in scenarios with low skin perfusion.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Amrilmaen Badawi, Osfred C. Jefferson, Brooke M. Huuskes, Sharon D. Ricardo, Peter G. Kerr, Chrishan S. Samuel, Padma Murthi
Summary: Circulating bone marrow-derived endothelial progenitor cells (EPCs) play an important role in kidney repair but are reduced in end-stage kidney disease (ESKD) patients. This study found that combining human bone marrow-derived mesenchymal stromal cells (BM-MSCs) and recombinant human relaxin (RLX) can enhance EPC proliferation and function, suggesting a potential treatment for ESKD patients.
Review
Biochemistry & Molecular Biology
Victor J. Costela-Ruiz, Lucia Melguizo-Rodriguez, Chiara Bellotti, Rebeca Illescas-Montes, Deborah Stanco, Carla Renata Arciola, Enrico Lucarelli
Summary: The success of regenerative medicine depends on the appropriate selection of mesenchymal stem cell (MSC) sources, as they influence the regenerative milieu. MSCs from bone marrow, adipose tissue, and dental tissue are all potential candidates for oral and dental regeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biotechnology & Applied Microbiology
Jehan J. El-Jawhari, Payal Ganguly, Elena Jones, Peter Giannoudis
Summary: This review discusses the application of bone marrow-derived mesenchymal stromal cells in treating osteonecrosis, including donor-related factors, the impact of aging on donor-related variability, and factors influencing the quantity and function of these cells.
BIOENGINEERING-BASEL
(2021)
Article
Biotechnology & Applied Microbiology
Azmeer Sharipol, Maggie L. Lesch, Celia A. Soto, Benjamin J. Frisch
Summary: This study developed a modular murine bone marrow microenvironment-on-chip that can maintain functional hematopoietic stem cells in vitro. The chip model has a better representation of the human bone marrow, which contributes to a deeper understanding of bone marrow pathophysiology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell & Tissue Engineering
Pijus K. Barman, Helen S. Goodridge
Summary: Balanced production of immune cells is important for immune surveillance, and commensal microbes can influence hematopoietic stem and progenitor cell (HSPC) activity. HSPCs sense microbes through pattern recognition receptors and cytokine receptors, and the long-term effects of microbial stimuli on HSPCs are significant. There may be a connection between myeloid-biased hematopoiesis and elevated levels of microbiome-derived components in aging and metabolic stress. Trained immunity-based vaccines that exploit microbial stimulation of HSPCs show promise.
Article
Biotechnology & Applied Microbiology
Francesca Salamanna, Deyanira Contartese, Veronica Borsari, Stefania Pagani, Giovanni Barbanti Brodano, Cristiana Griffoni, Alessandro Ricci, Alessandro Gasbarrini, Milena Fini
Summary: The study compares the characteristics of clotted bone marrow aspirate (BMA) and BMA-derived mesenchymal stem cells (MSCs) from younger and older female donors. Results show that age does not affect the regenerative properties of BMA clot. This suggests that BMA clot can be used as a novel therapeutic alternative.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Doris A. Taylor, Lourdes Chacon-Alberty, Luiz C. Sampaio, Mariana Gonzalez Del Hierro, Emerson C. Perin, Fernanda C. P. Mesquita, Timothy D. Henry, Jay H. Traverse, Carl J. Pepine, Joshua M. Hare, Michael P. Murphy, Phillip C. Yang, Keith L. March, Rachel W. Vojvodic, Ray F. Ebert, Roberto Bolli
Summary: Cell-based therapy lacks standardized definitions and terminology, making comparisons across studies challenging. This article discusses the lack of consistency in descriptive terminology used in cell-based therapies and provides guidelines for standardizing nomenclature and definitions.
CARDIOVASCULAR RESEARCH
(2022)
