Article
Cardiac & Cardiovascular Systems
Claudia Ress, Jochen Dobner, Kerstin Rufinatscha, Bart Staels, Maximilian Hofer, Sabrina Folie, Bernhard Radlinger, Timon E. Adolph, Eduard M. Rubin, Michael Roden, Herbert Tilg, Susanne Kaser
Summary: The study found that apoA5 deficiency has a positive regulatory effect on fructose-induced metabolic dysregulation and hepatic lipid deposition, suggesting that apoA5 may be a novel target for treating metabolic diseases.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2021)
Article
Biochemistry & Molecular Biology
Anna Laura Cremonini, Andrea Pasta, Federico Carbone, Luca Visconti, Matteo Casula, Edoardo Elia, Aldo Bonaventura, Luca Liberale, Maria Bertolotto, Nathan Artom, Silvia Minetti, Paola Contini, Daniela Verzola, Roberto Pontremoli, Francesca Viazzi, Giorgio Luciano Viviani, Stefano Bertolini, Aldo Pende, Fabrizio Montecucco, Livia Pisciotta
Summary: This study suggests that Lp(a) is independently associated with the severity of carotid atherosclerosis in the subgroup of patients with metabolic syndrome.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Multidisciplinary Sciences
Paula Rofes, Marta Pineda, Lidia Feliubadalo, Mireia Menendez, Rafael de Cid, Carolina Gomez, Eva Montes, Gabriel Capella, Joan Brunet, Jesus del Valle, Conxi Lazaro
Summary: This study validated that the shorter transcript produced by the BARD1 c.1977A>G variant is a constitutive splicing product rather than an aberrant transcript. Following ACMG/AMP guidelines, this variant should be considered as likely benign.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Haixu Yu, Liyuan Tao, Yan-Guang Li, Lincheng Yang, Dan Liu, Yang Wang, Xiaoyan Hao, Honghai He, Ying Che, Peng Wang, Wei Zhao, Wei Gao
Summary: This study found that the triglyceride-glucose (TyG) index is associated with carotid atherosclerosis (CAS) progression. Higher baseline and moderate-stable trajectories of the TyG index are associated with an increased risk of CAS progression. Long-term trajectories of the TyG index can help identify individuals at higher risk and guide preventive and therapeutic approaches.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Oncology
Wilhelmina C. M. Duivenvoorden, Magda Naeim, Sarah N. Hopmans, Sadiya Yousef, Geoff H. Werstuck, Shawn Dason, Jehonathan H. Pinthus
Summary: This study compared three modes of androgen-deprivation therapy (ADT) in the male ApoE(-/-):Ins2(+/Akita)mouse model, finding that degarelix-treated mice performed the best in terms of weight gain, serum leptin levels, and systolic blood pressure, while also improving dysglycemia and atherosclerosis. GnRH-antagonist significantly improved survival compared to GnRH-agonist.
PROSTATE CANCER AND PROSTATIC DISEASES
(2021)
Article
Cardiac & Cardiovascular Systems
Jiang-Feng Ke, Jun-Wei Wang, Zhi-Hui Zhang, Ming-Yun Chen, Jun-Xi Lu, Lian-Xi Li
Summary: The study found that in patients with type 2 diabetes, those receiving insulin therapy have a significantly increased risk of carotid plaque, with both men and women showing a higher risk compared to those not receiving insulin therapy. Additionally, patients on insulin therapy exhibited more severe insulin resistance.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Endocrinology & Metabolism
Fang Lei, Xiao-Ming Wang, Changquan Wang, Xuewei Huang, Ye-Mao Liu, Juan-Juan Qin, Peng Zhang, Yan-Xiao Ji, Zhi-Gang She, Jingjing Cai, Huo-ping Li, Xiao-Jing Zhang, Hongliang Li
Summary: This study investigated the correlation between metabolic dysfunction-associated fatty liver disease (MAFLD) and subclinical carotid atherosclerosis (SCA) in a nationwide population in China. The results showed a significant association between MAFLD and SCA, particularly in individuals with high hepatic steatosis index and young adults.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Indah K. Murni, Dian C. Sulistyoningrum, Danijela Gasevic, Rina Susilowati, Madarina Julia
Summary: The study found that hyperinsulinemia, higher total cholesterol, and LDL cholesterol were associated with increased CIMT among obese adolescent boys. In contrast, there was no association between vitamin D levels and CIMT, and none of the metabolic risk factors were associated with CIMT in girls.
Review
Immunology
Andrew J. Murphy, Mark A. Febbraio
Summary: This Perspective reflects on the advances made in the past 20 years in developing immune-based therapies for cardiovascular and metabolic diseases, highlighting the central role of the immune system in these disorders and the potential impact of immune-based interventions in reducing death and disability from cardiometabolic disorders.
NATURE REVIEWS IMMUNOLOGY
(2021)
Article
Clinical Neurology
Rebecca C. Thurston, Minjie Wu, Emma Barinas-Mitchell, Yuefang Chang, Howard Aizenstein, Carol A. Derby, Pauline M. Maki
Summary: This study examined the association between carotid atherosclerosis and brain white matter hyperintensities in midlife women, and found that higher carotid intima media thickness is associated with greater WMH volume. The association is stronger among APOE ε4-positive women, indicating the importance of vascular risk for midlife brain health.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Lin Liu, Chen-Xi Liang, Xiao-Wei Wang, Ke-Xin Pei, Xin-Di Ma, Chun-Xi Zhang, Jing-Hui Dong, Ming-Ming Gao, Jia-Wei Liao
Summary: This study found that surgical removal of adipose tissue before obesity onset did not effectively prevent hyperlipidemia, insulin resistance, fatty liver, or atherosclerosis in a mouse model.
CHINESE MEDICAL JOURNAL
(2021)
Article
Medicine, Research & Experimental
Congxiang Shao, Lishu Xu, Pingguang Lei, Wei Wang, Shiting Feng, Junzhao Ye, Bihui Zhong
Summary: Metabolomics was used to identify potential metabolite profiles in nonobese metabolic dysfunction-associated fatty liver disease (MAFLD). Diagnostic models combining different metabolites according to BMI categories could improve the accuracy of identifying subclinical carotid atherosclerosis (CAS).
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Joyce M. S. Chan, Sung-Jin Park, Michael Ng, Way Cherng Chen, Joanne Garnell, Kishore Bhakoo
Summary: This study developed a predictive mouse model that can accurately predict the formation location, time, and type of plaques in the carotid artery, allowing for identification of high-risk asymptomatic atherosclerotic patients.
TRANSLATIONAL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Patricia Recio-Lopez, Ismael Valladolid-Acebes, Philipp Hadwiger, Markus Hossbach, Monika Krampert, Carla Prata, Per-Olof Berggren, Lisa Juntti-Berggren
Summary: In this study, siRNAs were developed to silence apoCIII in vivo and it was found that this approach can result in metabolic improvements. Reduction of apoCIII expression led to increased LPL activity, lower triglyceride levels, reduced liver fat, ceased weight gain, enhanced insulin sensitivity, and improved glucose homeostasis.
Article
Biochemistry & Molecular Biology
Jolanta Neubauer-Geryk, Melanie Wielicka, Grzegorz M. Kozera, Leszek Bieniaszewski
Summary: The levels of angiogenin and carotid intima-media thickness (cIMT) were analyzed in patients with type 1 diabetes (DM1) with and without metabolic syndrome (MS). The study found that angiogenin levels were lower in DM1 patients compared to controls, but not significantly affected by MS. cIMT measurements showed no significant difference between the study subgroups, except when smokers were excluded.
Article
Endocrinology & Metabolism
Heidi T. M. Lai, Fumiaki Imamura, Andres V. Ardisson Korat, Rachel A. Murphy, Nathan Tintle, Julie K. Bassett, Jiaying Chen, Janine Kroeger, Kuo-Liong Chien, Mackenzie Senn, Alexis C. Wood, Nita G. Forouhi, Matthias B. Schulze, William S. Harris, Ramachandran S. Vasan, Frank Hu, Graham G. Giles, Allison Hodge, Luc Djousse, Ingeborg A. Brouwer, Frank Qian, Qi Sun, Jason H. Y. Wu, Matti Marklund, Rozenn N. Lemaitre, David S. Siscovick, Amanda M. Fretts, Aladdin H. Shadyab, JoAnn E. Manson, Barbara Howard, Jennifer G. Robinson, Robert B. Wallace, Nick J. Wareham, Yii-Der Ida Chen, Jerome Rotter, Michael Y. Tsai, Renata Micha, Dariush Mozaffarian
Summary: This study investigates the association between trans fatty acids (TFAs) and type 2 diabetes (T2D). The findings suggest that circulating individual trans-18:2 TFA biomarkers are not associated with the risk of T2D, while trans-16:1n-9, total trans-18:1, and total trans-18:2 are inversely associated.
Article
Cardiac & Cardiovascular Systems
Dony Yugo, Yun-Yu Chen, Yenn-Jiang Lin, Kuo-Liong Chien, Shih-Lin Chang, Li-Wei Lo, Yu-Feng Hu, Tze-Fan Chao, Fa-Po Chung, Jo-Nan Liao, Ting-Yung Chang, Chin-Yu Lin, Ta-Chuan Tuan, Ling Kuo, Cheng- Wu, Chih-Min Liu, Shin-Huei Liu, Cheng-Hung Li, Yu-Cheng Hsieh, Shih-Ann Chen
Summary: This study compared the long-term outcomes of patients with atrial flutter (AFL) who received catheter ablation versus medical therapy, finding that catheter ablation was associated with lower risks of all-cause mortality and cardiovascular events during long-term follow-ups.
Article
Medicine, General & Internal
Cheng-Tzu Hsieh, Kuo-Liong Chien, Hsiu-Ching Hsu, Hung-Ju Lin, Ta-Chen Su, Ming-Fong Chen, Yuan-Teh Lee
Summary: Fibrinogen levels may be a potential risk factor for coronary artery disease (CAD) but not for stroke. Further research is needed to clarify the differences in the role of fibrinogen levels on the risk of cardiovascular disease (CVD) between Asian and Western countries.
Article
Geriatrics & Gerontology
Tao -Chun Peng, Jeng-Min Chiou, Ta-Fu Chen, Yen-Ching Chen, Jen-Hau Chen
Summary: This study examined the associations of sarcopenia and its components with specific domains of cognitive impairment. The results showed that severe sarcopenia was associated with cognitive impairment in older adults, while low grip strength was associated with cognitive impairment in men but not in women.
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION
(2023)
Article
Multidisciplinary Sciences
Tzu-Lin Yeh, Ming-Chieh Tsai, Wen-Hsuan Tsai, Yu-Kang Tu, Kuo-Liong Chien
Summary: The study aimed to investigate the effect of glucagon-like peptide-1 receptor agonist (GLP-1 RAs) on glycemic control and weight reduction in adults. The results showed that long-acting GLP-1 RAs significantly reduced glycated hemoglobin levels and body weight in adults.
Letter
Nutrition & Dietetics
Ling-Wei Chen, Yen-Ching Chen
CLINICAL NUTRITION
(2023)
Article
Cardiac & Cardiovascular Systems
Guan-Yi Li, Yun-Yu Chen, Yenn-Jiang Lin, Kuo-Liong Chien, Yu-Cheng Hsieh, Fa-Po Chung, Li-Wei Lo, Shih-Lin Chang, Tze-Fan Chao, Yu-Feng Hu, Chin-Yu Lin, Shih-Ann Chen
Summary: This study examined the epidemiological characteristics of new-onset dementia in atrial fibrillation (AF) patients and the association between catheter ablation and different subtypes of dementia. A population-based cohort study was conducted using data from the Taiwan National Health Insurance Research Database. The results showed that AF patients had a higher incidence of all types of dementia, with Alzheimer's disease being less likely to occur in AF patients undergoing catheter ablation.
Review
Endocrinology & Metabolism
Ying-Hao Su, Kuo-Liong Chien, Shu-Hua Yang, Wei-Tso Chia, Jen-Hau Chen, Yen-Ching Chen
Summary: This systematic review and meta-analysis found that nonalcoholic fatty liver disease (NAFLD) is associated with decreased bone mineral density (BMD) and increased risks of osteoporosis and osteoporotic fractures in adults. Male sex and the BMD of the femoral neck and total hip are potential risk factors for decreased BMD in adults with NAFLD. Ethnic disparities exist between Asian and non-Asian populations regarding BMD and osteoporotic fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Medicine, General & Internal
Ting-Yu Wu, Yi -Ting Hsieh, Yu-Hsin Wang, Jeng-Min Chiou, Ta-Fu Chen, Liang-Chuan Lai, Jen-Hau Chen, Yen-Ching Chen
Summary: This study explored the association between retinal vascular complexity and cognitive impairment in community-dwelling older adults. The findings suggest that decreased retinal vascular complexity is associated with poor attention and memory performance. Therefore, retinal vascular complexity may serve as a screening tool for detecting cognitive impairment in the preclinical phase of dementia.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2023)
Article
Endocrinology & Metabolism
Hung-Chi Ho, Fu-Sung Lo, Jen-Kuang Lee, Wen-Yu Tsai, Ta-Chen Su
Summary: In healthy adults, there is a stronger association between HbA1c level and IMT in the femoral artery compared to the carotid artery. However, it is unclear if this differential association also applies to adolescents with T1D. This study found that in T1D adolescents, IMT increased in the femoral artery but not in the carotid or popliteal arteries, suggesting that femoral IMT may be a more sensitive marker for hyperglycemia-induced subclinical atherosclerosis.
PEDIATRIC DIABETES
(2023)
Article
Cell Biology
Chien-An Yao, Tsung-Yi Yen, Sandy Huey-Jen Hsu, Ta-Chen Su
Summary: This study examined the association between glycative stress, as measured by glycated hemoglobin (HbA1c), and atherogenic dyslipidemia in hyperlipidemic patients, with and without diabetes. The findings showed that patients with higher HbA1c levels had an increased risk of dyslipidemia and higher levels of advanced glycation end-products (AGEs).
Review
Biochemistry & Molecular Biology
Shizuya Yamashita, Manfredi Rizzo, Ta-Chen Su, Daisaku Masuda
Summary: Statins, ezetimibe, and PCSK9 inhibitors can lower LDL-C levels and reduce cardiovascular events, but residual risk factors like hypertriglyceridemia and low HDL-C still exist. Fibrates, nicotinic acids, and n-3 polyunsaturated fatty acids can be used to treat these risk factors.
Article
Geriatrics & Gerontology
Pei-Iun Hsieh, Yen-Ching Chen, Ta-Fu Chen, Jeng-Min Chiou, Jen-Hau Chen
Summary: This study aims to identify sex-specific multimorbid patterns in Taiwanese older adults and associate them with cognitive performance and dropout risk. The results show that the multimorbid patterns in men are associated with poor global cognition and attention, while in women they are related to poor memory. These findings are important for understanding the relationship between multimorbid patterns and cognitive functioning in older adults.
INNOVATION IN AGING
(2023)
Article
Medicine, General & Internal
C-M Huang, S-J Huang, T-Y Wu, Y-C Chen, S-H Hsiao, D. Chu
Summary: Physicians' recognition of end of life is still overly optimistic. EOL talks can be initiated when the TW-PCST score is high, and comprehensive palliative care training can be integrated into medical education.
QJM-AN INTERNATIONAL JOURNAL OF MEDICINE
(2023)