Article
Multidisciplinary Sciences
Hyun-Taek Kim, Paolo Panza, Khrievono Kikhi, Yuko Nakamichi, Ann Atzberger, Stefan Guenther, Clemens Ruppert, Andreas Guenther, Didier Y. R. Stainier
Summary: This study reveals that WNT/RYK signaling plays a regulatory role in lung diseases and highlights the anti-inflammatory modulation of RYK signaling in lung development and homeostasis. These findings provide an animal model for further investigation of the etiology and therapeutic approaches to inflammatory lung diseases.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Review
Behavioral Sciences
Milka Martinez, C. Nibaldo Inestrosa
Summary: Alzheimer's disease is a neurological disorder that primarily affects the elderly, characterized by progressive cognitive decline and loss of autonomy. Transcriptional changes in susceptible signaling pathways, particularly the Wnt signaling pathway, have been linked to synaptic dysfunction and neuronal degeneration, highlighting synapse failure as a key pathological event in early stages of the disease.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Danilo Predes, Lorena A. Maia, Isadora Matias, Hannah Paola Mota Araujo, Carolina Soares, Fernanda G. Q. Barros-Aragao, Luiz F. S. Oliveira, Renata R. Reis, Nathalia G. Amado, Alessandro B. C. Simas, Fabio A. Mendes, Flavia C. A. Gomes, Claudia P. Figueiredo, Jose G. Abreu
Summary: This study identifies quercitrin as a novel Wnt signaling potentiator through various experimental models and approaches. Quercitrin enhances the signaling pathway and has positive effects on neuronal function. Moreover, it rescues memory impairment caused by Alzheimer's disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Jianping Chen, Dandan Wang, Hongqiang Chen, Jin Gu, Xiao Jiang, Fei Han, Jia Cao, Wenbin Liu, Jinyi Liu
Summary: Our study reveals that TMEM196 functions as a novel suppressor of lung cancer metastasis through the Wnt/beta-catenin signaling pathway. TMEM196 mRNA and protein expression levels are significantly decreased in lung cancer tissues and cells. Low expression of TMEM196 is associated with poor prognosis in clinical patients. TMEM196 strongly inhibits tumor metastasis and progression in vitro and in vivo. Mechanistically, TMEM196 inhibits the Wnt signaling pathway and represses beta-catenin promoter transcription. Silencing TMEM196 results in upregulation of beta-catenin and downstream target genes MMP2 and MMP7. Inhibition of beta-catenin expression attenuates the antimetastatic effect of TMEM196 in lung cancer cells.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Jinhong Zhu, Kui Cao, Ping Zhang, Jianqun Ma
Summary: Lung cancer is a serious threat to human health, and the discovery of druggable molecular targets is crucial. In this study, a dysregulated long non-coding RNA (lncRNA) called LINC00669 was identified in lung adenocarcinoma (LUAD) through database analysis. The upregulation of LINC00669 was observed in various cancer types, and it was found to be associated with the cell cycle. By establishing a risk signature based on cell cycle genes, the prognostic accuracy of LINC00669 was improved. The risk signature successfully stratified LUAD patients into low- and high-risk subgroups and predicted prognosis and therapy responses.
Article
Oncology
Yang Zhou, Jiang Xu, Haichang Luo, Xiangjing Meng, Ming Chen, Di Zhu
Summary: Abnormal activation of the Wnt/beta-catenin signaling pathway is closely related to tumorigenesis and immune surveillance, leading to increased resistance to immunotherapy.
Article
Medicine, Research & Experimental
Vamshikrishna Malyla, Keshav Raj Paudel, Gabriele De Rubis, Nicole G. Hansbro, Philip M. Hansbro, Kamal Dua
Summary: Lung cancer has the highest mortality rate worldwide, and cigarette smoking is a major etiological factor. This study found that cigarette smoke extract treatment can upregulate WNT/ss-β-catenin signaling and induce tumorigenesis in healthy human bronchial epithelial cells. Furthermore, extracellular vesicles obtained from cigarette smoke exposed cells were found to induce migration and upregulate oncology proteins in recipient cells.
Article
Endocrinology & Metabolism
Margarita M. Ivanova, Julia Dao, Neil Kasaci, Andrew Friedman, Lauren Noll, Ozlem Goker-Alpan
Summary: This study revealed that elevated levels of sclerostin in GD patients are associated with bone pain, BMI, and EM flask deformity. Most patients with elevated sclerostin also have osteopenia. Additionally, sclerostin levels increase with age in GD patients, and are higher compared to healthy controls in the same age group.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Minghan Guan, Yifeng Huang, Xiaowen Lin
Summary: This study found that sufentanil can inhibit the proliferation, migration, invasion, and epithelial-mesenchymal transition of lung cancer cells by regulating the Wnt/beta-catenin signaling pathway.
Article
Biotechnology & Applied Microbiology
Wenping Song, Xuan Wu, Cheng Cheng, Ding Li, Jinhua Chen, Wenzhou Zhang
Summary: This study investigates the impact of ARHGAP9 on lung adenocarcinoma (LUAD) metastasis and sheds light on its molecular mechanism. The findings demonstrate that downregulated ARHGAP9 is correlated with poor prognosis in LUAD patients. ARHGAP9 knockdown enhances LUAD cell proliferation, migration, and invasion while suppressing cell apoptosis and G0G1 cell cycle arrest. RNA sequencing analysis indicates that ARHGAP9 knockdown reduces the expression of DKK2. Silencing ARHGAP9 and overexpressing DKK2 reverses the promoted effects on LUAD cell proliferation, migration, and invasion, and reduces the activity of the Wnt/beta-catenin signaling pathway. Thus, ARHGAP9 knockdown promotes LUAD metastasis by activating the Wnt/beta-catenin signaling pathway through suppressing DKK2, offering a potential strategy for LUAD treatment.
Review
Cell Biology
Rabia Hayat, Maleeha Manzoor, Ali Hussain
Summary: Wnt signaling is an important evolutionary cell-to-cell coordination mechanism that plays a critical role in various physiological processes such as stem cell regeneration, cell division, and migration. This mechanism is regulated by a family of 19 proteins and can impact cellular processes through different pathways, with the Wnt/β-catenin signaling pathway playing a significant role in cancer progression.
CELL BIOLOGY INTERNATIONAL
(2022)
Review
Biochemistry & Molecular Biology
Yongguang Gao, Na Chen, Zhanda Fu, Qing Zhang
Summary: Osteoporosis is a serious health disease characterized by bone mass loss, bone density reduction, and degeneration of bone microstructure, leading to bone fragility and a higher risk of fracture. More than 200 million people worldwide suffer from this condition, with estimated treatment costs of at least $25 billion by 2025. The Wnt signaling pathway plays a crucial role in bone development, metabolism, and the differentiation and proliferation of bone-related cells. Inhibitory proteins Dkk-1 and SOST, which block the activation of the canonical Wnt signaling pathway, have potential as targets for osteoporosis treatment. This review provides an analysis of the mechanisms of Wnt proteins, beta-catenin, and signaling molecules, highlighting the importance of the Wnt signaling pathway in osteoporosis and offering new perspectives and approaches for diagnosis and treatment.
Article
Cell Biology
Domenico Conza, Paola Mirra, Francesca Fiory, Luigi Insabato, Antonella Nicolo, Francesco Beguinot, Luca Ulianich
Summary: Metformin is a widely used drug for type 2 diabetes mellitus therapy, which not only lowers blood glucose levels but also improves various disease states and has anti-tumoral effects. Its anti-tumoral effects are mainly mediated by activating AMPK, but other signaling pathways are also involved.
Article
Biochemistry & Molecular Biology
Yuri Lee, Hai-long Piao, Jongchan Kim
Summary: The Wnt signaling pathway is crucial for regulating various cellular processes, and dysregulation of this pathway has been linked to human diseases, including cancer. In this study, researchers aimed to identify the deubiquitinases (DUBs) that regulate the pathway through the essential component LEF1. They discovered that OTUD7B interacts with LEF1 and activates Wnt signaling. Furthermore, OTUD7B promotes the nuclear localization of LEF1, leading to increased interaction with beta-catenin. This study suggests that OTUD7B may serve as a potential therapeutic target in diseases where Wnt signaling is dysregulated, such as cancer.
Article
Cell Biology
Xue Tan, Lingling Zhang, Tianqi Li, Jianmin Zhan, Kun Qiao, Haili Wu, Shenfei Sun, Meina Huang, Fangxi Zhang, Meixing Zhang, Changwei Li, Runsheng Li, Hongjie Pan
Summary: The WNT signaling pathway plays a crucial role in the development of fallopian tubes in mice, with LGR4 regulating epithelial secretion and affecting tube size and cell number. This regulation is mediated by modulation of the WNT pathway and changes in gene expression profiles of epithelial cells. Additionally, activation of the WNT pathway triggers the expression of steroidogenic genes through the transcription factor NR5A2, facilitating epithelial secretory cell maturation and steroidogenesis for fallopian tube development and function.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Correction
Immunology
Jason M. Fritz, Meredith A. Tennis, David J. Orlicky, Hao Yin, Cynthia Ju, Elizabeth F. Redente, Kevin S. Choo, Taylor A. Staab, Ronald J. Bouchard, Daniel T. Merrick, Alvin M. Malkinson, Lori D. Dwyer-Nield
FRONTIERS IN IMMUNOLOGY
(2015)
Article
Multidisciplinary Sciences
M. A. Tennis, M. L. New, D. G. McArthur, D. T. Merrick, L. D. Dwyer-Nield, R. L. Keith
SCIENTIFIC REPORTS
(2016)
Article
Oncology
Alison K. Bauer, Brad L. Upham, Elizabeth A. Rondini, Meredith A. Tennis, Kalpana Velmuragan, David Wiese
Article
Oncology
Daniel T. Merrick, Michael G. Edwards, Wilbur A. Franklin, Michio Sugita, Robert L. Keith, York E. Miller, Micah B. Friedman, Lori D. Dwyer-Nield, Meredith A. Tennis, Mary C. O'Keefe, Elizabeth J. Donald, Jessica M. Malloy, Adrie van Bokhoven, Storey Wilson, Peter J. Koch, Charlene O'Shea, Christopher Coldren, David J. Orlicky, Xian Lu, Anna E. Baron, Greg Hickey, Timothy C. Kennedy, Roger Powell, Lynn Heasley, Paul A. Bunn, Mark Geraci, Raphael A. Nemenoff
Article
Oncology
Melissa L. New, Collin M. White, Polly McGonigle, Debbie G. McArthur, Lori D. Dwyer-Nield, Daniel T. Merrick, Robert L. Keith, Meredith A. Tennis
CANCER PREVENTION RESEARCH
(2018)
Article
Oncology
M. Tennis, B. Singh, A. Hjerpe, M. Prochazka, K. Czene, P. Hall, P. G. Shields
Article
Oncology
Meredith A. Tennis, Michelle M. Van Scoyk, Scott V. Freeman, Katherine M. Vandervest, Raphael A. Nemenoff, Robert A. Winn
MOLECULAR CANCER RESEARCH
(2010)
Article
Multidisciplinary Sciences
Meredith A. Tennis, Michelle M. VanScoyk, Lora A. Wilson, Nicole Kelley, Robert A. Winn
Article
Medical Laboratory Technology
Meredith A. Tennis, Michelle Vanscoyk, Robert L. Keith, Robert A. Winn
TRANSLATIONAL RESEARCH
(2010)
Article
Immunology
Jason M. Fritz, Meredith A. Tennis, David J. Orlicky, Hao Yin, Cynthia Ju, Elizabeth F. Redente, Kevin S. Choo, Taylor A. Staab, Ronald J. Bouchard, Daniel T. Merrick, Alvin M. Malkinson, Lori D. Dwyer-Nield
FRONTIERS IN IMMUNOLOGY
(2014)
Article
Oncology
Meredith Tennis, Michelle Van Scoyk, Lynn E. Heasley, Katherine Vandervest, Mary Weiser-Evans, Scott Freeman, Robert L. Keith, Pete Simpson, Raphael A. Nemenoff, Robert Winn
Article
Oncology
Kayla Sompel, Alex J. Smith, Caroline Hauer, Alamelu P. Elango, Eric T. Clamby, Robert L. Keith, Meredith A. Tennis
Summary: Lung cancer chemoprevention is crucial for addressing cancer burden in high-risk populations. Precision cut lung slices (PCLS) provide an ex vivo model that maintains the structure and function of native tissues, reducing the need for in vivo studies. PCLS can be used for mechanistic investigations, drug screenings, and exploring potential new areas of drug mechanisms.
CANCER PREVENTION RESEARCH
(2023)
Article
Biochemical Research Methods
Lori Dwyer-Nield, Robert L. Keith, Meredith A. Tennis
Summary: This study presents a protocol for intranasal delivery of iloprost in a mouse model of lung adenocarcinoma, which is consistent with an ongoing clinical trial. The protocol diversifies options for chemoprevention studies and provides a relevant and translatable model.
Article
Oncology
Lori Dwyer-Nield, Gregory A. Hickey, Micah Friedman, Kevin Choo, Debbie G. McArthur, Meredith A. Tennis, Melissa L. New, Mark Geraci, Robert L. Keith
CANCER PREVENTION RESEARCH
(2017)
