Article
Nutrition & Dietetics
Dean M. Cordingley, Stephen M. Cornish, Darren G. Candow
Summary: It is well established that creatine supplementation, especially when combined with resistance training, significantly increases muscle mass and strength. New research also suggests that creatine supplementation has positive effects on bone biology. Creatine influences cellular hydration, energy metabolism, growth factors, muscle protein kinetics, and bone remodeling. It also has anti-inflammatory and anti-catabolic properties, creating a favorable environment for muscle and bone development. Creatine supplementation can decrease inflammation markers and possibly slow down cancerous tumor growth. In terms of musculoskeletal health, creatine supplementation reduces muscle protein breakdown (especially in males) and bone resorption when combined with resistance training.
Article
Nutrition & Dietetics
David C. Nieman, Jongmin Woo, Camila A. Sakaguchi, Ashraf M. Omar, Yang Tang, Kierstin Davis, Alessandra Pecorelli, Giuseppe Valacchi, Qibin Zhang
Summary: The objective of this study was to examine the effects of 4-week astaxanthin supplementation on exercise-induced inflammation and immune dysfunction using a multi-omics approach. The results showed that astaxanthin had no effect on exercise-induced muscle soreness, muscle damage, and increases in plasma cytokines and oxylipins. However, it normalized the levels of immune-related proteins and countered the decrease in plasma immunoglobulins after exercise.
FRONTIERS IN NUTRITION
(2023)
Review
Food Science & Technology
Susmita Barman, Krishnapura Srinivasan
Summary: Zinc plays a crucial role in the synthesis, storage, and secretion of insulin. Studies have shown that supplementing with zinc can reduce hyperglycemia, improve metabolic abnormalities and antioxidant status, and alleviate complications associated with diabetes. Additionally, zinc can also alleviate renal lesions, cataract, cardiovascular disease risk, and restore gastrointestinal health in experimental diabetes.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Endocrinology & Metabolism
Hiba Hasan, Sudhanshu Bhushan, Monika Fijak, Andreas Meinhardt
Summary: Infection and inflammation are relevant factors that can lead to male reproductive disorders, causing damage to the testis and affecting spermatogenesis and steroidogenesis. Increased levels of oxidative stress and pro-inflammatory cytokines negatively impact germ cells. The activation of inflammatory pathways is a common feature in male testicular disorders beyond established infectious/inflammatory cues.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Yoshitaka Hosokawa, Ikuko Hosokawa, Kazumi Ozaki
Summary: The study demonstrates that nobiletin can inhibit inflammatory responses in TNF-stimulated HPDLCs through various mechanisms, including reducing the expression of inflammatory cytokines and matrix metalloproteinases, inhibiting NF-kappa B and AKT1 activation, and enhancing the expression of NFE2L2 and HMOX1.
MEDIATORS OF INFLAMMATION
(2021)
Review
Biochemistry & Molecular Biology
Adekunle E. Alagbe, Igor F. Domingos, Adekunle D. Adekile, Maria H. S. L. Blotta, Magnun N. N. Santos
Summary: Sickle cell disease is a well-studied monogenetic disease characterized by chronic inflammation. Recent studies have shown an imbalance between pro-inflammatory and anti-inflammatory cytokines in patients with sickle cell disease. This review improves understanding of the pathophysiology of the disease and offers insights for the development of new therapeutic options.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Ramona Pap, Edina Pandur, Gergely Janosa, Katalin Sipos, Tamas Nagy, Attila Agocs, Jozsef Deli
Summary: The xanthophyll carotenoid lutein has been shown to have protective effects in light-induced oxidative stress and may also play a neuroprotective role. Glutamate, a major neurotransmitter, can cause oxidative stress and neurotoxicity. This study demonstrates that glutamate affects oxidative stress, inflammation, iron metabolism, and lipid peroxidation in neuroblastoma cells, while lutein attenuates these effects. These findings suggest that lutein could be a beneficial treatment in neurodegenerative disorders.
Review
Biochemistry & Molecular Biology
Hamed Mohammadi, Sepide Talebi, Abed Ghavami, Masoumeh Rafiei, Shima Sharifi, Zahra Faghihimani, Golnaz Ranjbar, Maryam Miraghajani, Gholamreza Askari
Summary: This study found through systematic review and meta-analysis that zinc supplementation may have beneficial anti-inflammatory and antioxidative effects in adults.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2021)
Article
Immunology
Zeynab Kavyani, Vali Musazadeh, Soroor Fathi, Amir Hossein Faghfouri, Parvin Dehghan, Bahareh Sarmadi
Summary: This umbrella meta-analysis found that supplementation of n-3 PUFAs can significantly improve CRP, TNF-alpha, and IL-6 concentrations in adults with various health conditions, suggesting their potential as adjuvant anti-inflammatory agents.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Nutrition & Dietetics
Michal Sienkiewicz, Patrycja Szymanska, Jakub Fichna
Summary: Inflammatory bowel disease is a group of chronic relapsing disorders with insufficient available therapeutic approaches; current treatment strategies target immune system dysfunctions, with auxiliary therapies involving personalized diet and healthy lifestyle.
ADVANCES IN NUTRITION
(2021)
Article
Nutrition & Dietetics
Lufang Zhang, Hui Xiao, Li Zhao, Zeting Liu, Lanmu Chen, Chenzhe Liu
Summary: This study aimed to compare the effects of long-term prebiotic and synbiotic supplementations on the immunosuppression of male football players. Results showed that synbiotic supplementation for six weeks had a more positive effect than prebiotics on immune function and athletic performance.
Article
Virology
Petlada Yongpitakwattana, Atthapan Morchang, Aussara Panya, Nunghathai Sawasdee, Pa-thai Yenchitsomanus
Summary: Dengue virus is transmitted by Aedes mosquitoes and infects various types of cells in the human skin, leading to diseases like dengue fever. Inhibiting virus production and the cytokine storm is critical for effective treatment of DENV infection.
ARCHIVES OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Aziza Alrafiah
Summary: This study found that thymoquinone significantly reduced body weight, cholesterol, triglycerides, improved oxidative stress markers, and reduced inflammation in high-fat diet rats. Thymoquinone treatment could prevent neuronal morphological changes in the cerebellum of obese populations.
Review
Biochemistry & Molecular Biology
Sulagna Dutta, Pallav Sengupta, Petr Slama, Shubhadeep Roychoudhury
Summary: Inflammation and oxidative stress are core causatives of male infertility, with a close connection between the two. Inflammation leads to elevated levels of proinflammatory mediators in the male reproductive tract, while oxidative stress causes oxidative damage to reproductive cells and intracellular components.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Liziane da Silva de Vargas, Jeferson Jantsch, Juliana Ribeiro Fontoura, Gilson Pires Dorneles, Alessandra Peres, Renata Padilha Guedes
Summary: This study found that zinc supplementation can partially improve cognitive function in overweight or obese women, suggesting it as an adjunct strategy for enhancing cognitive health in this population.