期刊
TRANSLATIONAL ONCOLOGY
卷 11, 期 6, 页码 1350-1357出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.tranon.2018.08.014
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类别
资金
- Associazione Italiana per la Ricerca sul Cancro (AIRC, Milan, Italy) [20441]
- Special Program Molecular Clinical Oncology 5 per 1000 [9965]
Autophagy is an intracellular self-degradative process that balances cell energy source and regulates tissue homeostasis. In physiological condition, autophagy funnels cytoplasmic constituents to autophagolysosomes for degradation and is an alternative way for cell-death behavior. Here, we inspected autophagy as a prosurvival mechanism essential for drug resistance in multiple myeloma (MM). Accordingly, autophagy inhibitors used in association to conventional anti-MM drugs might enforce the effect against resistant MM plasma cells and render autophagy a new therapeutic target.
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