Article
Biochemistry & Molecular Biology
Lincoln Biswas, Junyu Chen, Jessica De Angelis, Amit Singh, Charlotte Owen-Woods, Zhangfan Ding, Joan Mane Pujol, Naveen Kumar, Fanxin Zeng, Saravana K. Ramasamy, Anjali P. Kusumbe
Summary: Blood and lymphatic vessels play important roles in regulating tissue-specific functions. In this study, the presence of lymphatic vessels in mouse and human bones is demonstrated using advanced imaging techniques. The expansion of lymphatic vessels during genotoxic stress and the signaling pathways involved are identified. Lymphangiogenesis is found to stimulate hematopoietic and bone regeneration by promoting the secretion of CXCL12 and the expansion of Myh11-positive cells. However, this response is impaired in aged animals. These findings suggest that targeting lymphangiogenesis could be a potential therapeutic approach for promoting tissue regeneration.
Article
Multidisciplinary Sciences
Stephane Urcun, Pierre-Yves Rohan, Wafa Skalli, Pierre Nassoy, Stephane P. A. Bordas, Giuseppe Sciume
Summary: The study reveals that considering the triphasic nature of spheroids can provide a new perspective for analyzing pressure in Cellular Capsule Technology experiments. Experimentally retrieved pressure cannot directly reflect the pressure sustained by tumor cells and therefore cannot be used to quantify the critical pressure for stress-induced phenotype switch.
Review
Biochemistry & Molecular Biology
Simon Stritt, Katarzyna Koltowska, Taija Makinen
Summary: The lymphatic vasculature is not only a drainage system, but also directly involved in regulating immunity and organ growth, with important roles in development mechanisms and functional characteristics. Understanding the mechanisms that maintain lymphatic vessel integrity in adult tissues and control vessel repair and regeneration is crucial for comprehending disease-related vascular changes.
TRENDS IN MOLECULAR MEDICINE
(2021)
Review
Oncology
Luana Schito, Sergio Rey
Summary: The lymphatic system plays a crucial role in the tumor microenvironment, affecting cancer cell metastasis and the efficacy of immunotherapy. Hypoxia-driven mechanisms of lymphatic remodeling and immunotolerance can be utilized by cancer cells to create a suppressive tumor and metastatic microenvironment. Targeting hypoxia signaling pathways through specific combination approaches could potentially reverse this imbalance and enhance the response to targeted immunotherapies in cancer patients.
Review
Biochemistry & Molecular Biology
Genevieve A. Secker, Natasha L. Harvey
Summary: The importance of lymphatic vessels in human diseases, the initiation of lymphatic vascular development during embryogenesis, and the role of VEGF/VEGFR signaling in driving the construction of lymphatic vessels were discussed in this review.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Tsung-Ming Chang, Pei-Yi Chu, Wen-Chun Hung, Yan-Shen Shan, Hui-You Lin, Kuo-Wei Huang, Jeffrey S. Chang, Li-Tzong Chen, Hui-Jen Tsai
Summary: Pancreatic neuroendocrine tumor (pNET) is a type of pancreatic tumor with neuroendocrine differentiation. Early stage pNET can be treated with surgical resection for long-term survival, while pNET with metastasis has a poor prognosis. In this study, it was found that c-Myc overexpression is associated with lymph node metastasis in pNET xenograft mice. Combination therapy using an mTOR inhibitor and c-Myc inhibitor or VEGFC-neutralizing protein reduced lymph node metastasis in mice with c-Myc overexpression, indicating potential therapeutic targets for pNET.
Review
Immunology
Dipranjan Laha, Robert Grant, Prachi Mishra, Naris Nilubol
Summary: The tumor microenvironment is a complex system consisting of various cells and structures. Tumor necrosis factor-alpha plays a crucial role in the TME, affecting the interaction between tumor cells and immune cells, with significant implications for immune response, tumorigenesis, invasion, and metastasis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Yuyi Wang, Ombretta Salvucci, Hidetaka Ohnuki, Andy D. Tran, Taekyu Ha, Jing-Xin Feng, Michael DiPrima, Hyeongil Kwak, Dunrui Wang, Yanlin Yu, Michael Kruhlak, Giovanna Tosato
Summary: SHP2 is essential for promoting endothelial cell survival and growth in tumor vasculature remodeling. Inhibiting SHP2 activity leads to reduced tumor growth and degeneration of tumor vasculature. Combination of SHP2 inhibitors with Ang2/TIE2 inhibitors shows promise in effectively targeting the tumor endothelium.
EMBO MOLECULAR MEDICINE
(2021)
Article
Oncology
Gwenael Page, Marion Tardieu, Jean-Luc Gennisson, Laurent Besret, Philippe Garteiser, Bernard E. Van Beers
Summary: The biomechanical properties of tumors, including viscoelasticity and pressure, are associated with tumor severity. MR elastography shows potential for non-invasive assessment of tumor viscoelasticity, while the study suggests that compression rate could serve as a non-invasive biomarker for tumor solid stress. The findings highlight the importance of studying tumor biomechanical features for a better understanding of tumor behavior.
Article
Oncology
Fen Xi, Yuyi Feng, Qiaoli Chen, Liping Chen, Jianhua Liu
Summary: This study used microbubbles ultrasonic cavitation to regulate interstitial fluid pressure (IFP) in tumors and evaluate the effects of sonodynamic therapy (SDT). The results showed that microbubbles ultrasonic cavitation increased the accumulation of sonosensitizers in tumor tissues and improved the therapeutic effects of SDT.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biotechnology & Applied Microbiology
Selvaraj Vimalraj, Krishnasamy Naidu Gopal Hariprabu, Mostafizur Rahaman, Periyasami Govindasami, Karthikeyan Perumal, Saravanan Sekaran, Dhanraj Ganapathy
Summary: The cancer-promoting ligand VEGF-C activates VEGFR-3, which is expressed by tumor cells and lymphatic endothelial cells. This signaling pathway promotes metastasis by enhancing lymphangiogenesis and angiogenesis. It plays a role in various types of tumors and further research is needed to fully understand its function.
Article
Computer Science, Information Systems
Md Tauhidul Islam, Songyuan Tang, Ennio Tasciotti, Raffaella Righetti
Summary: Interstitial fluid pressure, interstitial fluid velocity and related parameters play a crucial role in cancer diagnosis, prognosis and treatment. Non-invasive techniques have been developed to estimate these mechanopathological parameters in cancers in vivo. The new ultrasound poroelastography methods were able to accurately estimate fluid pressure, fluid velocity and fluid flow inside tumors under external compression, with validation through finite element and ultrasound simulations.
Article
Cell Biology
Priyanka Banerjee, Subhashree Kumaravel, Sukanya Roy, Niyanshi Gaddam, Johnny Odeh, Kayla J. Bayless, Shannon Glaser, Sanjukta Chakraborty
Summary: Conjugated bile acids (BA) are elevated in liver pathologies and metastatic lymph nodes. This study investigates the effects of BAs on lymphangiogenesis. The results indicate that BAs promote lymphatic network expansion and enhance LEC invasion, migration, and tube formation through ROS-mediated activation of p90RSK and upregulation of VEGFR3. Furthermore, BAs induce YAP expression, a regulator of lymphangiogenesis. Overall, this study establishes a novel mechanism by which BAs promote lymphangiogenesis.
Article
Oncology
Maureen Van de Velde, Marie Ebroin, Tania Durre, Marc Joiret, Lionel Gillot, Silvia Blacher, Liesbet Geris, Frederic Kridelka, Agnes Noel
Summary: This study revealed a new mechanism by which tumor exposed-LEC promote tumor cell proliferation, showcasing their role in enhancing cancer cell invasion and proliferation in vivo. The analysis of teLEC secretome identified IL6 as a key molecule modulated in teLEC, with neutralization of IL6 abolishing the mitogenic effects mediated by teLEC in vivo. The findings suggest a novel function for teLEC beyond their traditional role in lymphatic vessel formation, emphasizing their potential as key stromal determinants in future studies.
Article
Peripheral Vascular Disease
Zhi-He Jin
Summary: This study explores the characteristics of interstitial fluid flow in a solid tumor with partial fluid leakage at the tumor surface under oscillatory microvascular pressure. Results show that partial fluid leakage reduces pore pressure drop and fluid velocity near the surface, while both pore pressure and fluid velocity decrease significantly with an increase in vascular frequency. The amplitude of pore pressure may reach that of vascular pressure under steady state conditions.
MICROVASCULAR RESEARCH
(2021)
Article
Dermatology
Lisa A. Beck, Diamant Thaci, Mette Deleuran, Marjolein de Bruin-Weller, Zhen Chen, Faisal A. Khokhar, Meng Zhang, Zafer E. Ozturk, Brad Shumel
Summary: The study found that adults with moderate-to-severe AD treated with dupilumab for up to 3 years did not experience clinically significant changes in mean laboratory parameters, indicating that continuous long-term use of the treatment is supported without the need for laboratory monitoring.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Dermatology
D. Thaci, K. Eyerich, A. Pinter, M. Sebastian, K. Unnebrink, S. Rubant, D. A. Williams, P. Weisenseel
Summary: This study found that risankizumab was superior to FAEs in treating psoriasis, providing earlier and greater improvement in outcomes that persisted with continued treatment. Risankizumab also showed more favorable safety results with no new safety signals observed for either treatment arm.
BRITISH JOURNAL OF DERMATOLOGY
(2022)
Article
Dermatology
Andrew Blauvelt, April W. Armstrong, Richard G. Langley, Kurt Gebauer, Diamant Thaci, Jerry Bagel, Lyn C. Guenther, Carle Paul, Bruce Randazzo, Susan Flavin, Ming-Chun Hsu, Yin You, Kristian Reich
Summary: In this study, guselkumab showed superior efficacy compared to secukinumab at week 48 in treating patients with moderate-to-severe plaque psoriasis, across various baseline characteristics. The largest differences in efficacy were observed in patients aged 65 and older, as well as in patients weighing over 100 kg.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Review
Dermatology
James Krueger, Lluis Puig, Diamant Thaci
Summary: Generalized pustular psoriasis (GPP) is a rare and severe skin disorder without approved specific therapies. Current treatment options are based on limited evidence and recent advances have identified potential targets for targeted therapy based on improved understanding of the disease mechanisms and gene mutations associated with GPP.
AMERICAN JOURNAL OF CLINICAL DERMATOLOGY
(2022)
Article
Rheumatology
Eugen Feist, Xenofon Baraliakos, Frank Behrens, Diamant Thaci, Thilo Klopsch, Anja Plenske, Lisa K. Blindzellner, Pascal Klaus, Thomas Meng, Peter-Andreas Loeschmann
Summary: This study investigated the proportion of German patients with rheumatoid arthritis who achieved remission or low disease activity after 12 and 24 weeks of etanercept treatment. It found that a considerable proportion of patients attained their treatment targets after 12 weeks, and the proportion further increased with longer treatment duration.
RHEUMATOLOGY AND THERAPY
(2022)
Article
Dermatology
Diamant Thaci, Ron Vender, Menno A. de Rie, Curdin Conrad, David M. Pariser, Bruce Strober, Veerle Vanvoorden, Maggie Wang, Cynthia Madden, Dirk de Cuyper, Alexa B. Kimball
Summary: The clinical and health-related quality of life responses observed during the first 16 weeks of BE SURE were sustained over 2 years of treatment, regardless of bimekizumab maintenance dosing. Switching from adalimumab to bimekizumab also resulted in sustained improvements up to Week 104. Bimekizumab had a good safety profile with no new safety signals.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
Thomas Bieber, Norito Katoh, Eric L. Simpson, Marjolein de Bruin-Weller, Diamant Thaci, Antonio Torrelo, Angelina Sontag, Susanne Grond, Maher Issa, Xiaoyu Lu, Tracy Cardillo, Katrin Holzwarth, Jacob P. Thyssen
Summary: Baricitinib demonstrated a consistent safety profile in the long-term treatment of atopic dermatitis patients, with no new safety signals identified. The incidence rates of major adverse cardiovascular events, deep vein thromboses/pulmonary emboli, malignancies, and serious infections were within the ranges observed in the background population of patients with AD.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2023)
Article
Dermatology
Matthias Augustin, Andrea Bauer, Konstantin Ertner, Ralph von Kiedrowski, Florian Schenck, Jutta Ramaker-Brunke, Sophie Moeller, Anja Fait, Mike Bastian, Diamant Thaci
Summary: The PROLEAD study examined the effectiveness and safety of dupilumab in real-world clinical practice for patients with moderate-to-severe atopic dermatitis (AD). The results showed that dupilumab was more effective and well tolerated in a real-world setting compared to phase 3 clinical trials.
DERMATOLOGY AND THERAPY
(2023)
Article
Dermatology
Mark G. Lebwohl, Joseph F. Merola, Katelyn Rowland, Megan Miller, Ya-Wen Yang, Jenny Yu, Yin You, Daphne Chan, Diamant Thaci, Richard G. Langley
Summary: This study evaluated the safety of guselkumab in 2891 patients with psoriasis who were treated for up to 5 years. The findings showed that guselkumab demonstrated favorable safety, consistent with previous reports. The safety event rates in guselkumab-treated patients were similar to those observed in the placebo group and remained consistent throughout long-term treatment.
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Letter
Dermatology
Andrew Blauvelt, Diamant Thaci, Kim A. Papp, Vincent Ho, Kamran Ghoreschi, Byung Soo Kim, Megan Miller, Yaung-Kaung Shen, Yin You, Daphne Chan, Jenny Yu, Ya-Wen Yang, Mark G. Lebwohl, Alice B. Gottlieb, Jeffrey Crowley, Peter Foley
BRITISH JOURNAL OF DERMATOLOGY
(2023)
Article
Dermatology
A. D. Burden, Y. Okubo, M. Zheng, D. Thaci, P. van de Kerkhof, N. Hu, M. Quaresma, C. Thoma, S. E. Choon
Summary: Effisayil 1 was a study investigating the use of spesolimab in patients with a flare-up of generalized pustular psoriasis (GPP). The study found that patients receiving spesolimab showed rapid clearance of pustules and skin symptoms within 1 week. The effectiveness and safety of spesolimab were consistent across different patient demographic and clinical characteristics.
EXPERIMENTAL DERMATOLOGY
(2023)
Article
Dermatology
Nina Magnolo, Thomas Jaenicke, Athanasios Tsianakas, Wolfgang Czech, Diamant Thaci, Andreas Pinter, Delphine Kerob, Samir Salah, Thomas A. Luger
Summary: This study aimed to investigate the efficacy of skin care products containing emollients and a syndet with the ability to improve skin barrier and microbiome in moderate to severe AD patients. The results showed that patients using this product had significant improvements in itchiness and quality of life after 10 weeks, while using 23% less product compared to the control group.
JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Henning Olbrich, Christian D. Sadik, Ralf J. Ludwig, Diamant Thaci, Katharina Boch
Summary: Dupilumab, approved for atopic dermatitis and prurigo nodularis, has shown effectiveness in treating various dermatologic diseases including bullous autoimmune diseases, eczema, prurigo, and alopecia areata.
Correction
Rheumatology
Eugen Feist, Xenofon Baraliakos, Frank Behrens, Diamant Thaci, Thilo Klopsch, Anja Plenske, Lisa K. Blindzellner, Pascal Klaus, Thomas Meng, Peter-Andreas Loeschmann
RHEUMATOLOGY AND THERAPY
(2023)
Article
Oncology
Kim A. Papp, Mark G. Lebwohl, Diamant Thaci, Janusz Jaworski, Bartlomiej Kwiek, Jakub Trefler, Anna Dudek, Jacek C. Szepietowski, Nataliya Reznichenko, Joanna Narbutt, Wojciech Baran, Joanna Kolinek, Stefan Daniluk, Katarzyna Bartnicka-Maslowska, Adam Reich, Yuriy Andrashko, Sunghyun Kim, Yunju Bae, Dabee Jeon, Jinsun Jung, Hyunseung Lee, Tina Pyo, Woori Ko
Summary: CT-P43 demonstrated equivalent efficacy to originator ustekinumab in adults with moderate to severe plaque psoriasis, with comparable pharmacokinetic, safety, and immunogenicity profiles.
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)