Review
Oncology
Samia Asif, Benjamin A. Teply
Summary: Prostate cancer is a leading cause of cancer-related death among males, and despite many available treatments, advanced prostate cancer remains incurable and fatal. Personalized treatment and the use of biomarkers for decision-making are crucial for optimizing clinical outcomes in managing advanced prostate cancer.
Article
Oncology
Deepa Sharma, Laurentius Oscar Osapoetra, Mateusz Faltyn, Anoja Giles, Martin Stanisz, Gregory J. Czarnota
Summary: The study found that AAC parameters from spherical gaussian and fluid-filled spherical models were efficient imaging biomarkers of cell death. Significant increases in AAC were observed in the combined treatment groups compared to the control. Changes in AAC strongly correlated with cell death fraction quantified from histopathological analysis.
Review
Toxicology
Li Pang, Zhichao Liu, Feng Wei, Chengzhong Cai, Xi Yang
Summary: Early detection strategies and improvements in cancer treatment have significantly reduced cancer mortality rates in the US. However, cardiovascular side effects of cancer therapy are common among cancer survivors, making cardiovascular disease the second leading cause of morbidity and mortality in this population. Circulating biomarkers are ideal for detecting and monitoring these side effects. Novel tools such as genetic testing and Omics technologies can help elucidate underlying molecular mechanisms and improve prediction and management of cancer therapy-related cardiotoxicity.
ARCHIVES OF TOXICOLOGY
(2021)
Article
Oncology
Niklas Kluemper, Jonas Saal, Fiamma Berner, Christa Lichtensteiger, Nina Wyss, Annkristin Heine, Franz Georg Bauernfeind, Joerg Ellinger, Peter Brossart, Stefan Diem, Sabine Schmid, Markus Joerger, Martin Frueh, Manuel Ritter, Michael Hoelzel, Lukas Flatz, Tobias Bald
Summary: Early dynamics of C reactive protein (CRP) can serve as a predictive biomarker for response to anti-PD-1 immune checkpoint blockade (ICB) in non-small cell lung cancer (NSCLC). CRP flare-responders can predict ICB response and survival as early as 4 weeks after therapy initiation. Early CRP kinetics have no predictive value for chemoimmunotherapy or when steroids are administered concurrently.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Medicine, General & Internal
Juncheng Wang, Qingli Zhu, Feng Li, Mengsu Xiao, Jie Liu
Summary: This study investigated the value of dermoscopy and high-frequency ultrasound (HFUS) in monitoring the therapeutic response of psoriasis treated with biologics. The results showed that the scores obtained from dermoscopy and ultrasound evaluation were correlated with clinical assessment, and could effectively monitor the treatment efficacy of psoriasis.
FRONTIERS IN MEDICINE
(2023)
Article
Oncology
Heather Johnson, Zahra El-Schich, Amjad Ali, Xuhui Zhang, Athanasios Simoulis, Anette Gjorloff Wingren, Jenny L. Persson
Summary: We developed a new biomarker model, the 7-Gene Algorithm, using machine learning and gene mutations to predict treatment response in patients with metastatic colorectal cancer (mCRC). The algorithm showed high accuracy in predicting treatment response and has important implications for improving personalized therapies.
Article
Acoustics
Chuhao Yin, Guanzhu Wang, Yuting Xie, Juan Tu, Wei Sun, Xiangqing Kong, Xiasheng Guo, Dong Zhang
Summary: Thermal strain imaging (TSI) is a valuable technique for estimating temperature changes, but physiological motions can introduce artifacts. In this study, a respiration separated TSI (RS-TSI) method is proposed, which uses normalized cross correlation (NXcorr) coefficient and frame selection to improve motion compensation and reduce the output time interval.
IEEE TRANSACTIONS ON ULTRASONICS FERROELECTRICS AND FREQUENCY CONTROL
(2022)
Article
Medicine, Research & Experimental
M. Toledano-Fonseca, M. A. Gomez-Espana, E. Elez, C. Gravalos, P. Garcia-Alfonso, R. Rodriguez, F. Losa, I. Ales Diaz, B. Grana, M. Valladares-Ayerbes, M. V. Garcia-Ortiz, E. Polo, M. Salgado, F. Rivera, M. J. Safont, A. Salud, A. Ruiz-Casado, J. M. Tabernero, M. C. Riesco, A. Rodriguez-Ariza, E. Aranda
Summary: This study examined the profiles of circulating microRNAs (miRNAs) in metastatic colorectal cancer patients and found that certain miRNAs, such as hsa-miR-33b-5p, could serve as valuable biomarkers for predicting response to therapy and disease progression. Combining the levels of circulating VEGF-A with miR-33b-5p further improved the stratification of patients.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Clinical Neurology
Jack Z. Sheen, Jean-Philippe Miron, Farrokh Mansouri, Katharine Dunlop, Thomas Russell, Ryan Zhou, Molly Hyde, Linsay Fox, Helena Voetterl, Zafiris J. Daskalakis, John D. Griffiths, Daniel M. Blumberger, Jonathan Downar
Summary: This study investigated the effect of low frequency right hemisphere dorsolateral prefrontal cortex repetitive transcranial magnetic stimulation (rTMS) on the cardiac activity of major depressive disorder (MDD) patients. The results showed a significant decrease in heart rate during rTMS and a negative correlation between resting heart rate and treatment outcome. The study provides preliminary evidence that electrocardiogram (ECG) may be used as a biomarker of rTMS treatment response in MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Biochemistry & Molecular Biology
Stavros P. Papadakos, Nikolaos Dedes, Alexandros Pergaris, Maria Gazouli, Stamatios Theocharis
Summary: Pancreatic Ductal Adenocarcinoma (PDAC) is a major cause of cancer death worldwide, and its mortality remains unchanged despite significant advancements in diagnostics and treatment. Exosomes have been found to play important roles in carcinogenesis, metastasis, and immune response. Investigating the applications of exosomes in the timely diagnosis, prognosis, and therapeutic management of pancreatic cancer is of great significance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Food Science & Technology
David Lozano-Paniagua, Tesifon Parron, Raquel Alarcon, Mar Requena, Olga Lopez-Guarnido, Marina Lacasana, Antonio F. Hernandez
Summary: A study was conducted on greenhouse workers regularly exposed to pesticides compared to controls, showing a slight increase in AST levels in workers suggestive of subtle hepatocellular toxicity, while other markers like ALP, ARG1, and GST-alpha were decreased possibly due to a regulatory mechanism. These findings do not conclusively demonstrate liver dysfunction due to low-toxicity pesticides used by greenhouse workers.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Review
Oncology
R. Casolino, C. Braconi, G. Malleo, S. Paiella, C. Bassi, M. Milella, S. B. Dreyer, F. E. M. Froeling, D. K. Chang, A. Biankin, T. Golan
Summary: This review emphasizes the importance of personalized therapeutic approaches based on genomic factors in the preoperative setting for pancreatic cancer to reduce mortality rates.
ANNALS OF ONCOLOGY
(2021)
Article
Oncology
Linzhi Yan, Yi Liu, Jianan Zhang, Xin Chen, Jingwei Li, Xueqiong Zhu
Summary: The study explored the composition and potential hazards of cervical cancer surgical smoke generated by ultrasonic scalpels. The results showed that the smoke contained HPV, volatile organic compounds (VOCs), and exhibited cytotoxicity and infectivity in vitro. This poses an occupational hazard to healthcare workers.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Alejandra Bernardini, Marta Duenas, Maria Cruz Martin-Soberon, Carolina Rubio, Cristian Suarez-Cabrera, Raquel Ruiz-Palomares, Ester Munera-Maravilla, Sara Lazaro, Iris Lodewijk, Daniel Rueda, David Gomez-Sanchez, Teresa Alonso-Gordoa, Javier Puente, Alvaro Pinto, Pilar Gonzalez-Peramato, Carlos Aguado, Mercedes Herrera, Flora Lopez, Victor M. G. Martinez, Lucia Morales, Daniel Castellano, Jesus M. Paramio, Guillermo de Velasco
Summary: Metastatic urothelial carcinoma is a difficult-to-cure disease with limited treatment options. Vinflunine has shown some improvement in overall survival and is still used for patients who are refractory to chemotherapy and immunotherapy. However, there is a lack of biomarkers to identify responding patients and alternative therapies after treatment failure.
Article
Oncology
Megan E. Buechel, Danielle Enserro, Robert A. Burger, Mark F. Brady, Katrina Wade, Angeles Alvarez Secord, Andrew B. Nixon, Seyedehnafiseh Mirniaharikandehei, Hong Liu, Bin Zheng, David M. O'Malley, Heidi Gray, Krishnansu S. Tewari, Robert S. Mannel, Michael J. Birrer, Kathleen N. Moore
Summary: The increased subcutaneous fat density and visceral fat density are associated with higher risk of death in patients, and may affect the predictive efficacy of bevacizumab in ovarian cancer treatment.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Biochemical Research Methods
Muhannad N. Fadhel, Sila Appak Baskoy, Yanjie Wang, Eno Hysi, Michael C. Kolios
Summary: Vascular disrupting agents can disrupt tumor vessels and inhibit the growth of tumors. Spectroscopic photoacoustic imaging can be used to monitor the effectiveness of these agents in disrupting tumor vessels and assessing the efficacy of cancer treatments.
JOURNAL OF BIOPHOTONICS
(2023)
Article
Engineering, Biomedical
Khadijeh Saednia, William T. Tran, Ali Sadeghi-Naini
Summary: This study proposes a multi-scale attention-guided deep learning model for accurate classification of breast tissue in digital histology images. By analyzing images at low and high magnifications using parallel convolutional neural networks and incorporating an attention mechanism, the model improves the accuracy of deep learning models in classifying digital histology images.
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING-IMAGING AND VISUALIZATION
(2023)
Article
Engineering, Biomedical
Joseph A. Sebastian, Eric M. Strohm, Emmanuel Cherin, Bahram Mirani, Christine E. M. Demore, Michael C. Kolios, Craig A. Simmons
Summary: High-frequency ultrasound can non-invasively characterize and monitor the acoustic properties of biomaterials and engineered tissues. A new method is proposed to accurately measure the speed of sound, acoustic impedance, and acoustic attenuation of cell-laden hydrogels, taking into account the frequency-dependent effects of attenuation in coupling media, hydrogel thickness, and interfacial transmission/reflection coefficients of ultrasound waves. The acoustic attenuation coefficients were found to increase with increasing cell concentration, reflecting the cellularity of the hydrogel independent of its thickness.
ACTA BIOMATERIALIA
(2023)
Article
Engineering, Biomedical
Chuan Chen, Reshani Perera, Michael C. C. Kolios, Hessel Wijkstra, Agata A. A. Exner, Massimo Mischi, Simona Turco
Summary: Nanobubbles, with their unique physical properties, have shown potential as a new generation ultrasound contrast agent for various applications. The appearance of a second bolus (wave) following the first pass of nanobubbles has been observed, which is not seen with conventional microbubbles and molecular contrast agents. This study aims to develop a new compartmental pharmacokinetic model to analyze the roles of physiological factors in the characteristics of the second-wave phenomenon.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2023)
Article
Oncology
Tara Behroozian, Lauren Milton, Irene Karam, Liying Zhang, Keyue Ding, Julia Lou, Francois Gallant, Eileen Rakovitch, William Tran, Hany Soliman, Eric Leung, Danny Vesprini, Ewa Szumacher, Hanbo Chen, Elysia Donovan, Jacqueline Lam, Silvana Spadafora, Matt Wronski, Chris Lavoie, Natalie Walde, Emily Lam, Gina Wong, Erin McKenzie, Krista Ariello, Samantha Kennedy, Saba Shariati, Katherine Carothers, Glen Gonzales, Yulya Kagan, Edward Chow
Summary: A confirmatory randomized controlled trial was conducted to evaluate the effectiveness of Mepitel film (MF) in reducing radiation dermatitis (RD) in patients undergoing breast radiotherapy. The results showed that MF significantly reduced the incidence of grade 2 or 3 RD and had positive effects on patient-reported outcomes and clinician-reported outcomes.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Niusha Kheirkhah, Sergio Dempsey, Ali Sadeghi-Naini, Abbas Samani
Summary: This study proposes a technique to improve the accuracy of displacement data in ultrasound elastography, especially in the lateral direction. The technique uses mathematical constraints to regularize displacement and strain fields, resulting in substantial improvement in image quality.
Article
Computer Science, Information Systems
Seyed Ali Jalalifar, Hany Soliman, Arjun Sahgal, Ali Sadeghi-Naini
Summary: This study introduces a novel system for automatic assessment of Stereotactic Radiation Therapy (SRT) outcome in brain metastasis using standard serial MRI. The system utilizes a deep learning-based segmentation framework to delineate tumors longitudinally on serial MRI with high precision and analyze the longitudinal changes in tumor size to evaluate therapy outcome and detect adverse radiation effects (ARE). The comparison between automatic evaluation and manual assessments by experts shows a high agreement. This study is of great significance for the workflow in radio-oncology.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2023)
Article
Oncology
Tyler K. Hornsby, Farshad Moradi Kashkooli, Anshuman Jakhmola, Michael C. Kolios, Jahangir (Jahan) Tavakkoli
Summary: Ultrasound can induce the release of anticancer drugs from nanoparticle drug carriers, as observed in previous studies. This study applies the DLVO theory to predict the release of doxorubicin from gold nanoparticle drug carriers under low-intensity pulsed ultrasound exposure. The findings contribute to understanding the mechanism of ultrasound-induced drug release from nanoparticles.
Article
Engineering, Biomedical
Seyed Ali Jalalifar, Hany Soliman, Arjun Sahgal, Ali Sadeghi-Naini
Summary: This study proposes and investigates new explainable deep-learning models for predicting the outcome of radiotherapy for brain metastases. The proposed self-attention-guided 3D residual network outperforms other models in accuracy, F1-score, and AUC. The visualization results demonstrate the importance of lesion characteristics in treatment-planning MRI for predicting local outcome.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2023)
Article
Engineering, Biomedical
Michaela B. Cooley, Eric C. Abenojar, Dana Wegierak, Anirban Sen Gupta, Michael C. Kolios, Agata A. Exner
Summary: This study examined the effects of blood components on the acoustic response of nanobubbles. The results showed that nanobubbles in human whole blood had a gradual increase in signal enhancement and attached to the surface of red blood cells, indicating that direct interaction between nanobubbles and red blood cells may be key to extending their circulation time.
BIOACTIVE MATERIALS
(2023)
Article
Pharmacology & Pharmacy
Farshad Moradi Kashkooli, Mohammad Souri, Jahangir (Jahan) Tavakkoli, Michael C. Kolios
Summary: Through computational investigation, it is found that focused ultrasound-triggered nano-sized drug delivery can enhance localized treatment efficacy for solid tumors. Integrating thermosensitive liposome and focused ultrasound provides a promising drug delivery system.
Review
Chemistry, Multidisciplinary
Farshad Moradi Kashkooli, Anshuman Jakhmola, Tyler K. Hornsby, Jahangir (Jahan) Tavakkoli, Michael C. Kolios
Summary: The application of biocompatible nanocarriers in medicine has provided several benefits over conventional treatment methods. Therapeutic ultrasound (TUS) has shown potential in both standalone anticancer treatment and targeted drug release. By combining nanomedicine and ultrasound as a smart drug delivery system (DDS), it is possible to enhance in situ drug delivery, improve access to impermeable tissues, and achieve targeted drug release. However, further research and clinical trials are needed to understand the physical mechanisms and interactions involved and to overcome the challenges in advancing TUS as an efficient and safe cancer treatment.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Materials Science, Multidisciplinary
K. Sathiyamoorthy, Michael C. Kolios
Summary: We investigated the application of gold nanoshell particles as optical sensors and contrast agents to study the blood functional parameters. Gold nanoshell particles with a core size of 1 mu m that exhibit two prominent plasmonic peaks at 750 and 830 nm were developed. The optical properties of blood samples mixed with gold nanoshells were measured, showing enhanced optical absorption and suggesting their effectiveness as optical sensors/contrast agents for multimodal optical and photoacoustic sensing and imaging.
MATERIALS RESEARCH EXPRESS
(2023)
Review
Nanoscience & Nanotechnology
Farshad Moradi Kashkooli, Tyler K. K. Hornsby, Michael C. C. Kolios, Jahangir (Jahan) Tavakkoli
Summary: Computational modeling is a powerful tool to study and understand complex biological phenomena in anticancer drug delivery systems, especially nano-sized DDSs. The combination of NSDDSs and therapeutic ultrasound has shown great potential for cancer treatment. Mathematical modeling plays a crucial role in developing effective DDSs, as it involves multiple parameters and complex equations governing different phenomena. This study provides an in-depth review of recent advances in the mathematical modeling of TUS-mediated DDSs and discusses their potential for improving cancer treatment through clinical translation.
WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY
(2023)
Article
Chemistry, Physical
Ali A. Paknahad, Intesar O. Zalloum, Raffi Karshafian, Michael C. Kolios, Scott S. H. Tsai
Summary: Microfluidic devices are used to create uniform microbubbles. By controlling lipid concentration and microfluidic geometry, monodisperse bulk nanobubbles can be produced. An interesting observation is that microbubbles above and below a critical diameter experience different shrinkage behaviors.
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)
