Article
Clinical Neurology
Anita Nitchingham, Jarett Vanz-Brian Pereira, Eva A. Wegner, Vincent Oxenham, Jacqueline Close, Gideon A. Caplan
Summary: In this study, using FDG-PET, researchers found that patients with delirium showed hypometabolism in the bilateral thalami and certain cortical regions. The hypometabolism was correlated with delirium severity and performance on neuropsychological testing.
ALZHEIMERS & DEMENTIA
(2023)
Article
Clinical Neurology
Kai Wang, Xiaobin Zhao, Leilei Yuan, Qian Chen, Qun Wang, Lin Ai
Summary: An asymmetric F-18-FDG metabolic pattern exists in patients with anti-LGI1 encephalitis, and varied regional metabolic differences were revealed bilaterally in specific cerebral areas.
FRONTIERS IN NEUROLOGY
(2023)
Article
Endocrinology & Metabolism
Eleni Rebelos, Andrea Mari, Vesa Oikonen, Hidehiro Iida, Pirjo Nuutila, Ele Ferrannini
Summary: This study aimed to assess whether [18F]FDG-PET can be used in the study of renal glucose metabolism in humans. The results showed that [18F]FDG-PET can still provide relevant physiological information on regional renal glucose uptake, as long as [18F]FDG uptake is corrected for tubular radioactivity.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Oncology
Xue Yang, Guangxia Yang, Ruojun Wang, Yanjuan Wang, Shengyi Zhang, Jian Wang, Chunjing Yu, Zeqin Ren
Summary: This study explored the correlation between the incidence rates of depression and anxiety and cerebral glucose metabolism in cancer patients. The results showed that patients with lung cancer had higher rates of depression and anxiety compared to other tumor patients, and their brain glucose metabolism was different in several areas. Poor pathological differentiation and advanced TNM stage were associated with higher depression and anxiety risk. The study revealed the correlation between brain glucose metabolism and emotional disorders in cancer patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Veterinary Sciences
Xiaoying Yang, Weimin Ding, Xinyu Qian, Pengfei Jiang, Qingqing Chen, Xin Zhang, Yang Lu, Jiacheng Wu, Fenfen Sun, Zhihua Pan, Xiangyang Li, Wei Pan
Summary: Infection with Schistosoma japonicum can induce the reprogramming of glucose and lipid metabolism in the colon of mice, with PTEN playing a vital role in mediating this metabolic reprogramming. These findings offer a new insight into the pathogenicity of S. japonicum in hosts.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Miikka-Juhani Honka, Eleni Rebelos, Simona Malaspina, Pirjo Nuutila
Summary: This review explores the use of PET in evaluating hepatic metabolism, haemodynamics, and cancer. F-18-FDG is the most commonly used tracer for assessing glucose uptake and endogenous glucose production. Other tracers such as F-18-FTHA, C-11-Palmitate, and C-11-Acetate have been applied for measuring fatty acid uptake rates, blood flow, and oxidation in the liver. O-15 labelled water is used for quantifying hepatic perfusion. The challenges and modelling approaches in utilizing PET for assessing hepatic metabolism are also discussed.
Article
Multidisciplinary Sciences
Wen-yu Yin, Jiao Yuan, Zhi-min Zhang, Cheng Mei, Wei Xu, Yong-xiang Tang, Fang Peng, Ning Li
Summary: Stressed red blood cells showed differences in various indicators compared to untreated red blood cells, being more prone to phagocytosis by macrophages and mainly trapped in the spleen as shown by F-18-FDG PET/CT imaging, while the untreated red blood cells continued to circulate in the system.
SCIENTIFIC REPORTS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinming Zhang, Yi Liao, Xiawan Wang, Teng Zhang, Jianhua Feng, Jianing Deng, Kexin Shi, Lin Chen, Liu Feng, Mindi Ma, Le Xue, Haifeng Hou, Xiaofeng Dou, Congcong Yu, Lei Ren, Yao Ding, Yufei Chen, Shuang Wu, Zexin Chen, Hong Zhang, Cheng Zhuo, Mei Tian
Summary: The study developed a novel deep learning framework for accurate and efficient identification of epileptic foci in pediatric patients with temporal lobe epilepsy, outperforming traditional visual assessment and other analysis methods.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Neurosciences
Lidia Emmanuela Wiazowski Spelta, Caroline Cristiano Real, Carlos Alberto Buchpiguel, Daniele de Paula Faria, Tania Marcourakis
Summary: We investigated the effects of cocaine-induced peripheral activation on brain [F-18]FDG uptake and proposed an optimal protocol for measuring cocaine-induced brain metabolic alterations in mice. Our findings suggest that anesthesia is essential for visualizing cocaine-induced changes in brain metabolism using [F-18]FDG PET, providing a valuable preclinical approach for studying cocaine use disorder.
JOURNAL OF NEUROSCIENCE RESEARCH
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Moath Said Alfawara, Ahmed Ibrahim Ahmed, Jean Michel Saad, Yushui Han, Fares Alahdab, Mahmoud Al Rifai, Mahwash Kassi, Talal Alnabelsi, William A. Zoghbi, Mouaz H. Al-Mallah
Summary: This study evaluated the use of serum beta-hydroxybutyrate (BHB) to identify adequate suppression of the left ventricle (LV) in patients undergoing cardiac inflammatory/infectious studies. The results showed that serum BHB level can be used to determine sufficient LV suppression.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Multidisciplinary Sciences
Rakel Nyren, Henrik Scherman, Jan Axelsson, Chuchun L. Chang, Gunilla Olivecrona, Madelene Ericsson
Summary: High-fat diet and diabetes influence substrate preferences and energy demands in the heart and cause diabetic nephropathy. PET/CT has been used to examine energy substrate uptake and metabolic changes. However, conventional PET/CT scanning may be challenging for organs with low uptake, such as the kidney.
Article
Neurosciences
Mengfei Xiong, Sahar Roshanbin, Dag Sehlin, Hanne D. Hansen, Gitte M. Knudsen, Johanna Rokka, Jonas Eriksson, Stina Syvanen
Summary: This study explores the use of SV2A PET to investigate synaptic density at different ages in healthy mice. The results show a decrease in synaptic density in the oldest age group, consistent with previous findings in humans.
Article
Multidisciplinary Sciences
Sachi Sugita, Masanori Yamato, Toshimitsu Hatabu, Yosky Kataoka
Summary: The study reveals that cancer cells undergoing epithelial-mesenchymal transition in hypoxic regions show the highest accumulation of F-18-FDG, suggesting that these regions are a major contributor to increased glucose metabolism.
SCIENTIFIC REPORTS
(2021)
Article
Rheumatology
Kaitlin A. Quinn, Hugh Alessi, Cristina Ponte, Emily Rose, Mark A. Ahlman, Christopher Redmond, Yiming Luo, Ertugrul Cagri Bolek, Carol A. Langford, Peter A. Merkel, Peter C. Grayson
Summary: This study assessed the importance of incorporating FDG-PET data into eligibility criteria for clinical trials in TAK. The results showed that FDG-PET data can influence physicians' decisions about enrollment in trials and improve the accuracy and consistency of clinical assessment. Therefore, future trials in TAK should consider including FDG-PET data in eligibility criteria.
Article
Radiology, Nuclear Medicine & Medical Imaging
Yun Hye Song, Jung Won Moon, Yoo Na Kim, Ji Young Woo, Hye Joo Son, Suk Hyun Lee
Summary: This study aimed to investigate the reduction of [F-18]FDG uptake in dependent lungs by performing [F-18]FDG PET/CT in the prone position. The results showed that dependent lungs had significantly higher SUVmean and HU compared to nondependent lungs on both supine and prone position PET/CT. The study concluded that prone position PET/CT can effectively reduce gravity-dependent opacity-related [F-18]FDG uptake.
EUROPEAN RADIOLOGY
(2023)
Review
Oncology
Eric O. Aboagye, Tara D. Barwick, Uwe Haberkorn
Summary: Theranostics is a rapidly evolving field of medicine that combines diagnosis and treatment using similar tools. It offers the potential for high therapeutic efficacy with minimal toxicity. In oncology, theranostics relies on the identification of unique proteins and factors expressed in cancer cells, advances in imaging technology, and targeted chemicals and nanodevices for imaging and therapy. Radiotheranostics, using radiopharmaceuticals, is becoming routine in prostate cancer and neuroendocrine tumors. Although not all patients benefit from radiotheranostics, those who do often show high response rates.
CA-A CANCER JOURNAL FOR CLINICIANS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xingfeng Li, Diana Marcus, James Russell, Eric O. Aboagye, Laura Burney Ellis, Alexander Sheeka, Won-Ho Edward Park, Nishat Bharwani, Sadaf Ghaem-Maghami, Andrea G. Rockall
Summary: A comprehensive model combining features from MRI and clinical variables can improve the estimation of survival time in women with endometrial cancer.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Cardiac & Cardiovascular Systems
Andrej Corovic, Christopher Wall, Meritxell Nus, Deepa Gopalan, Yuan Huang, Maria Imaz, Michal Zulcinski, Marta Peverelli, Anna Uryga, Jordi Lambert, Dario Bressan, Robert T. Maughan, Charis Pericleous, Suraiya Dubash, Natasha Jordan, David R. Jayne, Stephen P. Hoole, Patrick A. Calvert, Andrew F. Dean, Doris Rassl, Tara Barwick, Mark Iles, Mattia Frontini, Greg Hannon, Roido Manavaki, Tim D. Fryer, Luigi Aloj, Martin J. Graves, Fiona J. Gilbert, Marc R. Dweck, David E. Newby, Zahi A. Fayad, Gary Reynolds, Ann W. Morgan, Eric O. Aboagye, Anthony P. Davenport, Helle F. Jorgensen, Ziad Mallat, Martin R. Bennett, James E. Peters, James H. F. Rudd, Justin C. Mason, Jason M. Tarkin
Summary: This study investigates the feasibility of using somatostatin receptor 2 (SST2) as a molecular imaging target for inflammation in large vessel vasculitis (LVV), and provides evidence for its potential in the diagnosis and therapeutic monitoring of LVV.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Review
Biotechnology & Applied Microbiology
Thomas Talbot, Haonan Lu, Eric O. Aboagye
Summary: High-grade serous ovarian carcinoma is characterized by universal TP53 mutations and widespread copy number alterations, including deletion of tumor suppressors and amplification of driver oncogenes. Amplified driver genes have been proposed as therapeutic targets. However, lack of validation and variable experimental procedures hinder clinical translation. This review collates candidate amplified therapeutic targets in high-grade serous ovarian carcinoma and quantitatively appraises the evidence for each gene.
CANCER GENE THERAPY
(2023)
Article
Oncology
Mitchell Chen, Haonan Lu, Susan J. Copley, Yidong Han, Andrew Logan, Patrizia Viola, Alessio Cortellini, David J. Pinato, Danielle Power, Eric O. Aboagye
Summary: This study developed a radiomic-based signature for predicting disease response in patients with NSCLC undergoing PD-1 or PD-L1 immunotherapy. The radiomic signature was validated in two independent testing cohorts and demonstrated good prediction of treatment response and prognosis.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Article
Cell Biology
Haonan Lu, Hantao Lou, Georg Wengert, Reema Paudel, Naina Patel, Saral Desai, Bill Crum, Kristofer Linton-Reid, Mitchell Chen, Dongyang Li, Jacey Ip, Francesco Mauri, David J. Pinato, Andrea Rockall, Susan J. Copley, Sadaf Ghaem-Maghami, Eric O. Aboagye
Summary: This study confirms that the presence of tertiary lymphoid structure (TLS) in high-grade serous ovarian cancer (HGSOC) is associated with better progression-free survival (PFS). TLS is linked to B cell maturation and activation of cytotoxic tumor-specific T cells in HGSOC tumors. Copy-number loss of genes IL15 and CXCL10 may hinder TLS formation in HGSOC, and a list of dysregulated genes affecting TLS function is proposed. A radiomics-based signature is developed to predict TLS presence, which independently predicts PFS in HGSOC and non-small cell lung cancer (NSCLC) patients treated with immune checkpoint inhibitors (ICIs). Overall, this study reveals the role of TLS in coordinating immune responses in HGSOC and how the cancer genome evolves to counteract TLS formation.
CELL REPORTS MEDICINE
(2023)
Article
Oncology
Benjamin Hunter, Christos Argyros, Marianna Inglese, Kristofer Linton-Reid, Ilaria Pulzato, Andrew G. Nicholson, Samuel V. Kemp, Pallav L. Shah, Philip L. Molyneaux, Cillian Mcnamara, Toby Burn, Emily Guilhem, Marcos Mestas Nunez, Julia Hine, Anika Choraria, Prashanthi Ratnakumar, Susannah Bloch, Simon Jordan, Simon Padley, Carole A. Ridge, Graham Robinson, Hasti Robbie, Joseph Barnett, Mario Silva, Sujal Desai, Richard W. Lee, Eric O. Aboagye, Anand Devaraj
Summary: This study developed a radiomics model to assist in the diagnosis of lung cancer. By extracting radiomics features and using clustering methods, patients were stratified into different risk groups. The model showed high accuracy in predicting malignancy and has potential clinical applications.
BRITISH JOURNAL OF CANCER
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Shahriar Islam, Marianna Inglese, Matthew Grech-Sollars, Preetha Aravind, Suraiya Dubash, Tara D. Barwick, Kevin O'Neill, James Wang, Azeem Saleem, James O'Callaghan, Giulio Anchini, Matthew Williams, Adam Waldman, Eric O. Aboagye
Summary: MRI and PET are used in neuro-oncology to detect and characterize malignant lesions. In this study, the uptake of FPIA in brain tumors was investigated using PET/MRI.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andrea G. Rockall, Xingfeng Li, Nicholas Johnson, Ioannis Lavdas, Shalini Santhakumaran, A. Toby Prevost, Shonit Punwani, Vicky Goh, Tara D. Barwick, Nishat Bharwani, Amandeep Sandhu, Harbir Sidhu, Andrew Plumb, James Burn, Aisling Fagan, Georg J. Wengert, Dow-Mu Koh, Krystyna Reczko, Qi Dou, Jane Warwick, Xinxue Liu, Christina Messiou, Nina Tunariu, Peter Boavida, Neil Soneji, Edward W. Johnston, Christian Kelly-Morland, Katja N. De Paepe, Heminder Sokhi, Kathryn Wallitt, Amish Lakhani, James Russell, Miriam Salib, Sarah Vinnicombe, Adam Haq, Eric O. Aboagye, Stuart Taylor, Ben Glocker
Summary: The study aimed to develop a machine learning algorithm to improve radiologists' sensitivity and specificity for metastasis detection in whole-body magnetic resonance imaging (WB-MRI). The results showed that using the algorithm can enhance the detection accuracy and reduce reading times for radiologists.
INVESTIGATIVE RADIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Stanislav S. Piletsky, Ekaterina Baidyuk, Elena V. Piletska, Larissa Lezina, Konstantin Shevchenko, Donald J. L. Jones, Thong H. Cao, Rajinder Singh, Alan C. Spivey, Eric O. Aboagye, Sergey A. Piletsky, Nickolai A. Barlev
Summary: Molecularly imprinted polymer nanoparticles (nanoMIPs) have shown potential as an alternative to antibodies in diagnostic and therapeutic applications. Targeting intracellular epitopes can modulate protein function, making them a new tool for cancer therapy.
Article
Oncology
Mitchell Chen, Susan J. Copley, Patrizia Viola, Haonan Lu, Eric O. Aboagye
Summary: Lung cancer, the leading cause of cancer-related deaths worldwide, can be captured non-invasively on medical imaging as radiomic features, which can be used in an artificial intelligence paradigm to predict clinical outcomes and improve patient care. Compared to tissue sampling-driven approaches, radiomics-based methods are superior for being non-invasive, reproducible, cheaper, and less susceptible to intra-tumoral heterogeneity.
SEMINARS IN CANCER BIOLOGY
(2023)
Article
Oncology
Preetha Aravind, Sanjay Popat, Tara D. Barwick, Neil Soneji, Mark Lythgoe, Katherina B. Sreter, Jingky P. Lozano-Kuehne, Mattias Bergqvist, Neva Patel, Eric O. Aboagye, Laura M. Kenny
Summary: This study aimed to investigate the early drug action of the antifolate drug pemetrexed on thymidylate synthase (TS) inhibition using F-18-FLT PET/CT imaging. The results showed that patients who exhibited changes in the imaging biomarker had a better therapy response and longer overall survival. These findings suggest the potential use of F-18-FLT PET/CT in understanding the basis of drug action in studies involving TS inhibitors.
Article
Pharmacology & Pharmacy
Jin Hui Teh, Ala Amgheib, Ruisi Fu, Chris Barnes, Joel Abrahams, Ali Ashek, Ning Wang, Zixuan Yang, Muneera Mansoorudeen, Nicholas J. J. Long, Eric O. O. Aboagye
Summary: C-Met, a receptor tyrosine kinase overexpressed in various cancer types, has potential as a biomarker for cancer imaging and therapy. This study synthesized and evaluated an [F-18]AlF-labelled analogue, [F-18]AlF-EMP-105, for c-Met imaging using positron emission tomography. In vitro evaluation showed high specificity of [F-18]AlF-EMP-105 for c-Met-expressing cells. PET imaging in mice demonstrated renal clearance of the tracer predominantly as [F-18]fluoride. [F-18]AlF-EMP-105 shows promise as a diagnostic tool for imaging cancer due to its high specificity for c-Met expressing cells.
Article
Multidisciplinary Sciences
Reza Kalantar, Sumeet Hindocha, Benjamin Hunter, Bhupinder Sharma, Nasir Khan, Dow-Mu Koh, Merina Ahmed, Eric O. O. Aboagye, Richard W. W. Lee, Matthew D. D. Blackledge
Summary: Researchers developed a contrast-based CT image synthesis method to address the contrast heterogeneity issue in real-world datasets and evaluated its performance in COVID-19 research. The results showed that while the generated images demonstrated realism in human assessment, caution is advised when using GAN-synthesized images in medical imaging applications.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Multidisciplinary
Zixuan Yang, Chris Barnes, Juozas Domarkas, Joanna Koch-Paszkowski, John Wright, Ala Amgheib, Isaline Renard, Ruisi Fu, Stephen Archibald, Eric O. Aboagye, Louis Allott
Summary: Sulfur-[F-18]fluoride exchange radiochemistry is a rapid and convenient method for incorporating fluorine-18 into biologically active molecules. We reported a fully automated radiolabelling procedure using the GE FASTLab(TM) cassette-based platform to synthesize a [F-18]SO3F-bearing prostate specific membrane antigen (PSMA) targeted ligand ([F-18](5)), which showed favorable biodistribution and pharmacokinetic profiles correlated with PSMA expression.
REACTION CHEMISTRY & ENGINEERING
(2023)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)