Article
Chemistry, Medicinal
Shuliang Song, Qiang Wei, Ke Wang, Qiong Yang, Yu Wang, Aiguo Ji, Guanjun Chen
Summary: This study used fluorescently labeled PM to investigate its distribution and pharmacokinetics in vivo. The results showed that FITC-PM had high stability and tended to be distributed in the kidney, liver, and at lower concentrations in the heart, spleen, and lungs after tail vein injection. Pharmacokinetic analysis revealed appropriate elimination rate constant, half-life time, and clearance rate for FITC-PM. The studies of pharmacokinetics and tissue distribution provided basic information that can be used to further clarify the pharmacodynamic mechanisms of PM.
Review
Cell Biology
Gary D. Luker, Jinming Yang, Ann Richmond, Stefania Scala, Claudio Festuccia, Margret Schottelius, Hans-Jurgen Wester, Johann Zimmermann
Summary: Signaling through CXCR4 regulates essential physiological processes and plays crucial roles in tumor growth, invasion, and metastasis. Animal models consistently demonstrate the importance of CXCR4 in cancer initiation and progression.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Chemistry, Multidisciplinary
Abraham Akonnor, Masaki Makise, Akihiko Kuniyasu
Summary: A CXCR4-targeted antitumor peptidomimetic (CTCE-KLAK) was developed and showed cell-selective cytotoxicity against breast cancer cells and induced rapid necrotic cell death. In a mouse model, CTCE-KLAK significantly inhibited tumor growth and lung metastasis, highlighting its potential as a promising agent for treating triple-negative breast cancer.
Article
Chemistry, Medicinal
Iris Cadima-Couto, Alexandra Tauzin, Joao M. Freire, Tiago N. Figueira, Ruben D. M. Silva, Clara Perez-Peinado, Catarina Cunha-Santos, Ines Bartolo, Nuno Taveira, Lurdes Gano, Joao D. G. Correia, Joao Goncalves, Fabrizio Mammano, David Andreu, Miguel A. R. B. Castanho, Ana Salome Veiga
Summary: The anti-HIV-1 peptide pepRF1, derived from the Dengue virus capsid protein, shows promising inhibitory effects with a potential therapeutic window higher than 53,000. It specifically targets CXCR4-tropic strains, preventing viral entry into target cells by acting as an antagonist of the viral coreceptor CXCR4. Compared to T20, a peptide-based HIV-1 entry inhibitor, pepRF1 is more effective and can potentially be used alone or in combination with other anti-HIV drugs, as well as a novel therapeutic strategy for other CXCR4-related diseases.
ACS INFECTIOUS DISEASES
(2021)
Article
Chemistry, Analytical
Mingguang Ren, Dejun Dong, Qingyu Xu, Jingfen Yin, Fangong Kong
Summary: A biotin-guided, two-photon fluorescent probe was developed for sensitive detection of H2O2 in cancer cells, showing potential as a tumor-targeting H2O2 biosensor.
Review
Cell Biology
Miguel Martin, Ingrid A. Mayer, Annemiek M. E. Walenkamp, Constantin Lapa, Michael Andreeff, Alexandra Bobirca
Summary: CXCR4 and CXCL12 play crucial roles in tumor development, with CXCR4 being a potential therapeutic target. While the only marketed CXCR4 inhibitor currently is plerixafor, several new inhibitors are under investigation. Early clinical evidence shows these inhibitors to be effective and well tolerated.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Oncology
Qing Kay Li, Tung-Shing Mamie Lih, Yuefan Wang, Yingwei Hu, Naseruddin Hoti, Daniel W. Chan, Hui Zhang
Summary: This study evaluated the diagnostic utility of 12 protein markers for assessing the aggressiveness of prostate cancer (PCa). Four proteins were found to be over-expressed in aggressive tumors, while three proteins showed stronger staining patterns in non-aggressive tumors. Combining different protein markers improved the accuracy of diagnosing the aggressiveness of PCa.
AMERICAN JOURNAL OF CANCER RESEARCH
(2022)
Article
Pharmacology & Pharmacy
Xiaocui Fang, Kaiyue Zhang, Mei Jiang, Lilusi Ma, Jian Liu, Haiyan Xu, Yanlian Yang, Chen Wang
Summary: The study demonstrated that nanometer-sized PEG-PE micelles can co-deliver CXCR4 antagonistic peptide E5 and doxorubicin, preferentially accumulating in lymph nodes, to better inhibit cancer metastasis and enhance anti-tumor efficacy.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Article
Chemistry, Multidisciplinary
Dipankar Chaudhuri, Tiangong Lu, Binu Jacob, Sojan Abraham, Premlata Shankar, Michael A. Poss, Nouri Neamati, Julio A. Camarero
Summary: The CXCR4 chemokine is a crucial regulator of leukocyte functions, embryonic development, and cancer progression. CXCR4 antagonists show promise as therapeutic agents for cancer and HIV. This study shows that lipidation can improve the half-life of a bioactive cyclotide antagonist, but the choice of lipid may affect its biological activity.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Biophysics
Anh Thi Viet Nguyen, Bao Tuan Duong, Hyun Park, Seon-Ju Yeo
Summary: A novel peptide pair-based flow immunochromatographic test strip was developed to detect Zika virus (ZIKV) with a limit of detection of 2 x 10^4 TCID50/mL, and the test could distinguish ZIKV from Dengue virus (DENV) with high stability and performance in human sera and urine. This study demonstrates the potential of using in silico modeling to develop rapid diagnostic tests for detecting ZIKV.
BIOSENSORS & BIOELECTRONICS
(2022)
Article
Spectroscopy
Mingxi Fang, Xiaoyu Zhou, Shaocai Wang, Yinshuang Yang, Yueting Cheng, Boling Wang, Xiaoqian Rong, Xiuli Zhang, Kai Xu, Yibin Zhang, Shaohui Zheng
Summary: A novel near infrared fluorescent probe (FNIR-pH) was synthesized for measurement of mitochondrial pH, allowing real-time monitoring of changes in cellular mitochondrial pH and sensitive detection of mitophagy. The probe exhibited excellent selectivity, photostability, and low cytotoxicity, making it suitable for in vivo imaging.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Article
Chemistry, Analytical
Fei Jia, Yuehua Wang, Zhiguo Fang, Jierong Dong, Fanghao Shi, Weikai Zhang, Zihua Wang, Zhiyuan Hu
Summary: In recent years, monitoring circulating tumor cells has become a promising method for assessing cancer prognosis and treatment effectiveness. By developing a novel CTCs isolation platform, researchers have successfully improved the capture efficiency of mesenchymal CTCs and enabled single-cell level analysis of CTCs.
ANALYTICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Mariah J. Austin, Hattie Schunk, Carolyn Watkins, Natalie Ling, Jeremy Chauvin, Logan Morton, Adrianne M. Rosales
Summary: This study developed a system of peptomers to investigate the impact of non-natural residues on MMP specificity. The results showed that peptoid residues were well tolerated in certain substrate sites and had a moderate influence on the rate of cleavage. Furthermore, the study demonstrated that peptomers can be used in hydrogels to control degradation kinetics. This work has important implications for diagnostic and prognostic applications.
Article
Oncology
Orsolya Juhasz, Noemi Jakob, Hajnalka Rajnai, Marcell Imrei, Miklos Garami
Summary: The study found that lower vitamin D receptor (VDR) expression is associated with worse prognosis in different types of childhood cancer. Identifying the VDR status provides clinicians with a valuable biomarker to guide additional therapy.
Article
Pathology
Florian Puls, Jodi M. Carter, Nischalan Pillay, Thomas A. McCulloch, Vaiyapuri P. Sumathi, Pehr Rissler, Henrik Fagman, Magnus Hansson, Fernanda Amary, Roberto Tirabosco, Linda Magnusson, Jenny Nilsson, Adrienne M. Flanagan, Andrew L. Folpe, Fredrik Mertens
Summary: Superficial CD34-positive fibroblastic tumor (SCD34FT) is a soft tissue tumor with borderline malignancy, overlapping with PRDM10 gene fusions. The tumors are morphologically indistinguishable and predominantly express CADM3, making them likely to be considered a single entity, SCD34FT. Immunohistochemistry for CADM3, combined with characteristic morphological features, is valuable in diagnosing SCD34FT.
Editorial Material
Urology & Nephrology
Fijs W. B. van Leeuwen, Henk G. van der Poel
Summary: Prostate-specific membrane antigen-targeted positron emission tomography has revolutionized prostate cancer diagnostics and has the potential to advance metastases-directed therapy, including ablative radiotherapy.
NATURE REVIEWS UROLOGY
(2022)
Article
Urology & Nephrology
Lieke Wever, Hielke M. de Vries, Paolo Dell'Oglio, Henk G. van der Poel, Maarten L. Donswijk, Karolina Sikorska, Fijs W. B. van Leeuwen, Simon Horenblas, Oscar R. Brouwer
Summary: The study aims to determine the incidence and types of complications after dynamic sentinel node biopsy (DSNB) in patients with penile cancer (PeCa) and identify risk factors for postoperative complications. The results showed that DSNB is associated with a considerable risk of postoperative mild-to-moderate complications, and the probability of complications increases with the number of removed lymph nodes.
Article
Urology & Nephrology
Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, Jeroen J. M. A. Hendrikx, Andre N. Vis, Tobias Maurer, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Summary: The study shows that robot-assisted minimally invasive surgery combined with PSMA-radioguidance is effective in resecting PSMA-avid lesions, offering potential benefits for the treatment of patients with prostate cancer.
Article
Radiology, Nuclear Medicine & Medical Imaging
William Gondoputro, Matthijs J. Scheltema, Alexander Blazevski, Paul Doan, James E. Thompson, Amer Amin, Bart Geboers, Shikha Agrawal, Amila Siriwardana, Pim J. Van Leeuwen, Matthias N. Van Oosterom, Fijs W. B. Van Leeuwen, Louise Emmett, Phillip D. Stricker
Summary: The safety and feasibility of robot-assisted 99mTc-based PSMA-radioguided surgery for the intraoperative detection of lymph node metastases were evaluated. The results showed that this surgical method can improve lymph node detection and has a certain degree of accuracy.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Urology & Nephrology
Sophie Knipper, Mehrdad Mehdi Irai, Ricarda Simon, Daniel Koehler, Isabel Rauscher, Matthias Eiber, Fijs W. B. van Leeuwen, Pim van Leeuwen, Hilda de Barros, Henk van der Poel, Lars Budaeus, Thomas Steuber, Markus Graefen, Pierre Tennstedt, Matthias M. Heck, Thomas Horn, Tobias Maurer
Summary: This study evaluated the oncological outcomes of salvage PSMA-RGS in patients with recurrent oligometastatic prostate cancer and identified predictive preoperative factors for improved outcomes. The results showed that the 3-month and 2-year tumor survival rates were 32% and 58%, respectively. Preoperative PSA, number of PSMA-avid lesions, and localization of lesions were independent predictors of biochemical recurrence after PSMA-RGS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Samaneh Azargoshasb, Imke Boekestijn, Meta Roestenberg, Gijs H. KleinJan, Jos A. van der Hage, Henk G. van der Poel, Daphne D. D. Rietbergen, Matthias N. van Oosterom, Fijs W. B. van Leeuwen
Summary: This study investigates the impact of signal-to-background ratios (SBR) on surgical performance using kinematics analysis. The results show that below SBR 1.5, task completion time, time spent in fluorescence-imaging mode, and total pathlength increase significantly, and handling errors become more frequent. The values of Dx and DM indicate that proficiency can only be achieved at SBR> 1.55.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Jean-Pierre Pouget, Mark Konijnenberg, Uta Eberlein, Gerhard Glatting, Pablo Minguez Gabina, Ken Herrmann, Soren Holm, Lidia Strigari, Fijs W. B. van Leeuwen, Michael Lassmann
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Urology & Nephrology
Hilda A. de Barros, Matthias N. van Oosterom, Maarten L. Donswijk, Jeroen J. M. A. Hendrikx, Andre N. Vis, Tobias Maurer, Fijs W. B. van Leeuwen, Henk G. van der Poel, Pim J. van Leeuwen
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Anne-Claire Berrens, Matthias N. van Oosterom, Leon J. Slof, Fijs W. B. van Leeuwen, Henk G. van der Poel, Tessa Buckle
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Letter
Urology & Nephrology
Hilda A. de Barros, Anne-Claire Berrens, Maarten L. Donswijk, Esther M. K. Wit, Fijs W. B. van Leeuwen, Pim J. van Leeuwen, Henk G. van der Poel
JOURNAL OF UROLOGY
(2023)
Review
Parasitology
Clarize Maria de Korne, Lisette van Lieshout, Fijs Willem Bernhard van Leeuwen, Meta Roestenberg
Summary: Imaging technology is essential for diagnosing parasitic diseases and has played a crucial role in developing antiparasitic strategies. The advancement of novel imaging technologies has revolutionized various fields of medicine and has also provided new ways to visualize parasites.
TRENDS IN PARASITOLOGY
(2023)
Article
Medicine, Research & Experimental
Marco Erreni, Francesca D'Autilia, Roberta Avigni, Evangelia Bolli, Sana M. Arnouk, Kiavash Movahedi, Pieterjan Debie, Achille Anselmo, Raffaella Parente, Cecile Vincke, Fijs W. B. van Leeuwen, Paola Allavena, Cecilia Garlanda, Alberto Mantovani, Andrea Doni, Sophie Hernot, Jo A. Van Ginderachter
Summary: Nanobodies (Nbs) have been identified as an elegant alternative to conventional monoclonal antibodies for cancer therapy, but there is a lack of detailed microscopic insight into the in vivo pharmacokinetics of different Nb formats in tumor-bearers, especially for the targeting of pro-tumoral tumor-associated macrophages (TAMs) located in less penetrable tumor regions.
Article
Cell & Tissue Engineering
M. M. Welling, K. Warbroek, C. Khurshid, M. N. van Oosterom, D. D. D. Rietbergen, M. G. J. de Boer, R. G. H. H. Nelissen, F. W. B. van Leeuwen, B. G. Pijls, T. Buckle
Summary: In this study, the ability of a bacteria-specific hybrid tracer (99mTc-UBI29-41-Cy5) to visualize the bacterial load on femoral implants using clinical-grade image guidance methods was evaluated. The results showed that this hybrid tracer allowed effective bacterial staining and combined qualitative real-time fluorescence guidance with nuclear imaging for quantitative monitoring of the effectiveness of cleaning strategies.
BONE & JOINT RESEARCH
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Matthias N. van Oosterom, Samaneh Azargoshasb, Leon J. Slof, Fijs W. B. van Leeuwen
Summary: With the increasing use of robotic platforms in laparoscopic surgery, radioguidance has the potential to play a crucial role in improving surgical precision. Although there are challenges and limitations, recent developments have shown progress in integrating radioguidance with robotic laparoscopic surgery.
CLINICAL AND TRANSLATIONAL IMAGING
(2023)
Article
Surgery
Matthias N. van Oosterom, Sven van Leeuwen, Elio Mazzone, Paolo Dell'Oglio, Tessa Buckle, Florian van Beurden, Michael Boonekamp, Huybert van de Stadt, Kevin Bauwens, Herve Simon, Pim J. van Leeuwen, Henk G. van der Poel, Fijs W. B. van Leeuwen
Summary: This study engineered a 'click-on' fluorescence detector that transforms standard robotic instruments into molecular sensing devices, enabling the detection of near-infrared fluorescence in a white-light setting. The detector showed promising performance in detecting blood vessels, assessing vascularization, and localizing lymph nodes during robotic surgery in pigs and human specimen evaluation.
JOURNAL OF ROBOTIC SURGERY
(2023)
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)