Article
Biochemistry & Molecular Biology
Irina Gilyazova, Elizaveta Ivanova, Himanshu Gupta, Artur Mustafin, Ruslan Ishemgulov, Adel Izmailov, Gulshat Gilyazova, Elena Pudova, Valentin Pavlov, Elza Khusnutdinova, Bo-Ying Bao, Yung-Hsiang Chen
Summary: This study aimed to investigate the miRNA profile in tissue samples obtained from patients with prostate cancer (PCa) and find potential markers for diagnosis and prognosis. The study found that certain miRNAs were downregulated in early-stage cancer patients, which may be useful for diagnosing and predicting PCa.
Article
Immunology
Modi Safra, Zvi Tamari, Pazit Polak, Shachaf Shiber, Moshe Matan, Hani Karameh, Yigal Helviz, Adva Levy-Barda, Vered Yahalom, Avi Peretz, Eli Ben-Chetrit, Baruch Brenner, Tamir Tuller, Meital Gal-Tanamy, Gur Yaari
Summary: In this study, a machine learning approach was applied to analyze B cell receptor repertoire sequencing data from severely and mildly infected individuals with SARS-CoV2 compared with uninfected controls, successfully differentiating infected from non-infected individuals and assessing disease severity. These findings have potential implications for the development of therapeutic strategies and quantitative assessment of diagnostic and therapeutic antibodies for COVID-19.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medical Laboratory Technology
Lina Wu, Xinpeng Zhang, Lin Luo, Xiaoying Li, Yong Liu, Xiaosong Qin
Summary: The study found that miR-106a, miR-19b, miR-17, and PTEN are involved in the pathogenesis of IMN and may serve as new biomarkers for the diagnosis of IMN.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2021)
Article
Multidisciplinary Sciences
Ngo Tat Trung, Tran Thi Lien, Vu Viet Sang, Nghiem Xuan Hoan, Nguyen Dang Manh, Nguyen Sy Thau, Dao Thanh Quyen, Tran Thi Thu Hien, Phan Quoc Hoan, Mai Hong Bang, Thirumalaisamy P. Velavan, Le Huu Song
Summary: This study validated the diagnostic and prognostic potential of plasma microRNAs in patients with sepsis and septic shock, finding that the expression of these miRNAs was significantly increased in patients with bacterial sepsis and septic shock. Among them, miR-147b could differentiate bacterial sepsis and septic shock, and in combination with procalcitonin, predict septic shock.
Article
Biochemistry & Molecular Biology
Lorena Perez-Carrillo, Isaac Gimenez-Escamilla, Maria Garcia-Manzanares, Juan Carlos Trivino, Sandra Feijoo-Bandin, Alana Aragon-Herrera, Francisca Lago, Luis Martinez-Dolz, Manuel Portoles, Estefania Tarazon, Esther Rosello-Lleti
Summary: Ischemic cardiomyopathy (ICM) is associated with abnormal microRNA expression levels and altered gene expression profile. This study focuses on the analysis of microRNA maturation defects and the role of the microRNA biogenesis pathway and redox-sensitive microRNAs (redoximiRs) in ICM. The findings suggest a decrease in microRNA maturation in ICM patients due to a decrease in pre-microRNA export and cytoplasmic processing, regulated by hypoxia. The study also reveals deregulation of redoximiRs, particularly miR-122-5p, which correlates with ejection fraction.
Article
Clinical Neurology
Siyu Fan, Yue Yu, Yue Wu, Yiao Kai, Hongping Wang, Yue Chen, Meidan Zu, Xiaonan Pang, Yanghua Tian
Summary: This study compared the different entropy features and whole brain resting-state functional connectivity (RSFC) patterns in the resting-state functional magnetic resonance imaging (rs-fMRI) data between patients with generalized anxiety disorder (GAD) and healthy controls. The results showed that GAD patients had increased levels of approximate entropy (ApEn) in the right angular gyrus (AG) and increased levels of sample entropy (SampEn) in the right middle occipital gyrus (MOG) and right inferior occipital gyrus (IOG). Compared to the controls, GAD patients had decreased RSFC between the right AG and the right inferior parietal gyrus (IPG). The linear support vector machine (SVM) classification model achieved good accuracy in discriminating GAD patients and controls. In conclusion, GAD patients have differences in the nonlinear dynamical complexity and linear features of brain signals, and combining these features can effectively diagnose psychiatric disorders.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Clinical Neurology
Maria Munoz-San Martin, Imma Gomez, Ana Quiroga-Varela, Marina Gonzalez-del Rio, Rene Robles Cedeno, Gary Alvarez, Maria Buxo, Albert Miguela, Luisa M. Villar, Jessica Castillo-Villalba, Bonaventura Casanova, Ester Quintana, Lluis Ramio-Torrenta
Summary: By analyzing miRNAs in CSF and serum samples, specific dysregulated miRNAs were found in PPMS patients, which could be potential biomarkers for further study of their role in multiple sclerosis.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2023)
Article
Pathology
Samaneh Vojdani, Sayyed Mohammad Hossein Ghaderian, Alireza Zali, Aazadeh Rakhshan, Saeed Oraee Yazdani, Arash Poursheikhani, Farahnaz Bidari Zerehpoush, Giuve Sharifi
Summary: This study investigated the expression levels of EGFR, miR-34a, and miR-19a in tumor tissues and serum samples of GBM patients, showing that EGFR was highly expressed in GBM tissues, while miR-34a was significantly downregulated in serum samples and tissues of GBM patients. These findings provide hope for the introduction of new non-invasive biomarkers for the early detection of GBM, but large-scale confirmatory studies are needed.
EXPERIMENTAL AND MOLECULAR PATHOLOGY
(2021)
Article
Chemistry, Analytical
Hui Yang, Haoran Shen, Aori Qileng, Guosheng Cui, Yingju Liu, Weipeng Liu
Summary: A novel biosensor for the detection of dual miRNAs was developed by combining a linear ladder-like DNA nanoarchitecture with DNA-based logic gates and a photoelectrode. The biosensor showed a linear relationship between photocurrent signals and logarithm of miRNA concentrations.
ANALYTICAL CHEMISTRY
(2023)
Article
Biology
Anthony Brown, Qingfei Pan, Li Fan, Emilie Indersie, Cheng Tian, Nikolai Timchenko, Liyuan Li, Baranda S. S. Hansen, Haiyan Tan, Meifen Lu, Junmin Peng, Shondra M. M. Pruett-Miller, Jiyang Yu, Stefano Cairo, Liqin Zhu
Summary: In hepatoblastoma, the RRM2 subunit of ribonucleotide reductase is associated with disease progression, but in response to chemotherapy, subunit switching favors the less active RRM2B subunit which supports hepatoblastoma cell survival and relapse.
COMMUNICATIONS BIOLOGY
(2023)
Article
Immunology
Cheng Wang, Yunhua Zhu, Penglu Chen, Chen Wang, Wanqing Zhou, Cuiping Zhang, Jing Wang, Xi Chen, Meng Ding, Chunni Zhang, Jun-Jun Wang, Chen-Yu Zhang
Summary: The majority of HCMV miRNAs were significantly upregulated in the serum of fever patients, suggesting their potential role in monitoring HCMV activation status in patients with immune disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Lining Su, Renqing Li, Zhiqing Zhang, Jijia Liu, Jingkao Du, Huiping Wei
Summary: The study examined the expression patterns of mRNAs and miRNAs in exosomes derived from Alzheimer's disease (AD) and healthy mice, finding differential expression of 1320 mRNAs and 29 miRNAs between the two groups. Key genes such as Chi3l1 and Rhog were validated to be dysregulated in AD mice, along with miR-148a-5p and miR-27a-5p. GO and KEGG analysis helped determine the functions of the differentially expressed mRNAs and potential target genes of miRNAs. Through the ceRNA hypothesis, an integrated ceRNA network of circRNA-lncRNA-miRNA-mRNA was established, indicating the involvement of exosomal lncRNAs, mRNAs, circRNAs, and miRNAs in the progression of AD, potentially serving as biomarkers and therapeutic targets.
AGEING RESEARCH REVIEWS
(2022)
Article
Multidisciplinary Sciences
Alexandros Karagiannopoulos, Jonathan L. S. Esguerra, Morten G. Pedersen, Anna Wendt, Rashmi B. Prasad, Lena Eliasson
Summary: In this study, a miRNA-driven network approach was used to identify miRNAs associated with insulin secretion and T2D. Clustering analysis revealed two islet-specific clusters that were related to key aspects of islet functions and contained a high number of T2D-related genes. Integration of cis-eQTLs and public GWAS data uncovered genomic signals associated with insulin secretion and T2D. These findings contribute to a better understanding of impaired insulin secretion in T2D pathogenesis.
Article
Multidisciplinary Sciences
Enas M. Hefzy, Noha A. Hassuna, Olfat G. Shaker, Mohamed Masoud, Tebyan A. Abelhameed, Tarek I. Ahmed, Nada F. Hemeda, Mohammed A. Abdelhakeem, Rania H. Mahmoud
Summary: Genetic variants in miR-155 and miR-146a genes may act as potential risk factors for Chronic HBV in the Egyptian population, highlighting the importance of studying miRNA polymorphisms in disease development.
Article
Biochemistry & Molecular Biology
Antonio Pellegrino, Sophie-Charlotte Fabig, Dilara Kersebaum, Philipp Huellemann, Ralf Baron, Toralf Roch, Nina Babel, Harald Seitz
Summary: This study identified four microRNAs that may be linked to degenerative processes, blood flow regulation, and signal transduction, potentially leading to chronic painful PNP. These microRNAs may serve as potential novel biomarkers and have therapeutic implications.
Article
Environmental Sciences
Carmine Merola, Anton Vremere, Federico Fanti, Annamaria Iannetta, Giulia Caioni, Manuel Sergi, Dario Compagnone, Stefano Lorenzetti, Monia Perugini, Michele Amorena
Summary: Oxysterols, previously considered as by-products of cholesterol metabolism, are now recognized as bioactive lipids that have multiple effects through their binding to receptors. This study found that exposure to certain chemicals altered the levels of oxysterols in zebrafish embryos.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Sabrina Tait, Gabriele Lori, Roberta Tassinari, Cinzia La Rocca, Francesca Maranghi
Summary: Humans, especially agricultural workers, are daily exposed to multiple residues of pesticides. This study evaluated the toxicological profiles of thirteen pesticide mixtures used for grapevine protection and found potential toxic effects even at lower concentrations. The clustering analysis of the toxicological profiles revealed common and different modes of action of the mixtures.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Pharmacology & Pharmacy
Frauke Naumann-Winter, Franziska Wolter, Ulrike Hermes, Eva Malikova, Nils Lilienthal, Tania Meier, Maria Elisabeth Kalland, Armando Magrelli
Summary: This study analyzes regulatory documents on orphan designated medicinal products in the EU and finds that real-world data is more commonly referenced in marketing authorization applications for rare diseases. The contribution of external data to efficacy aspects can be evaluated in terms of clinical development, regulatory decision making, and post-approval data collection. In the sample analyzed, the majority of medicinal products for rare diseases involve external data on efficacy, while purely administrative data does not play a role in these applications.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Elena Pedrini, Antonella Negro, Eugenio Di Brino, Valentina Pecoraro, Camilla Sculco, Elisabetta Abelli, Maria Gnoli, Armando Magrelli, Luca Sangiorgi, Americo Cicchetti
Summary: This study evaluated the analytical validity and budget impact of an NGS-Ion Torrent(TM) approach for the molecular germline diagnosis of musculoskeletal rare diseases. The results showed that the NGS method reduced diagnosis time and costs, making it beneficial for routine diagnosis, especially for small gene panels and low patient flow.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Biochemistry & Molecular Biology
Elias Dahdouh, Lisa Allander, Linda Falgenhauer, Bogdan I. Iorga, Stefano Lorenzetti, Inigo Marcos-Alcalde, Nathaniel Martin, Luis Martinez-Martinez, Jesus Mingorance, Thierry Naas, Joseph E. Rubin, Francesca Spyrakis, Thomas Tangden, Paulino Gomez-Puertas
Summary: The EPIC consortium brings together experts from various fields to address the best approach for data mining on carbapenemase inhibitors and how to translate this data into experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Aldo Di Nunzio, Antonella Giarra, Maria Toscanesi, Angela Amoresano, Marina Piscopo, Elisabetta Ceretti, Claudia Zani, Stefano Lorenzetti, Marco Trifuoggi, Luigi Montano
Summary: This study evaluates the concentrations of 26 macro and trace elements in semen and blood serum of healthy young men and finds statistically significant differences among three highly polluted areas in Italy. The study suggests that human semen can serve as an early environmental marker.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Review
Biochemistry & Molecular Biology
Chiara Bazzichetto, Michele Milella, Ilaria Zampiva, Francesca Simionato, Carla Azzurra Amoreo, Simonetta Buglioni, Chiara Pacelli, Loredana Le Pera, Teresa Colombo, Emilio Bria, Massimo Zeuli, Donatella Del Bufalo, Isabella Sperduti, Fabiana Conciatori
Summary: Interleukin-8 (IL-8) plays an important role in colorectal cancer and its high levels are significantly correlated with shorter overall survival and progression-free survival. Circulating IL-8 represents an important prognostic factor in colorectal cancer.
Article
Biochemistry & Molecular Biology
Fabrizia Carli, Sabrina Tait, Luca Busani, Demetrio Ciociaro, Veronica Della Latta, Anna Paola Pala, Annalisa Deodati, Andrea Raffaelli, Filippo Pratesi, Raffaele Conte, Francesca Maranghi, Roberta Tassinari, Enrica Fabbrizi, Giacomo Toffol, Stefano Cianfarani, Cinzia La Rocca, Amalia Gastaldelli, LIFE PERSUADED Project Grp
Summary: Phthalates and bisphenol A (BPA) are commonly found in Italian women, with DEHP being higher in the south and BPA being higher in the north. Urban areas have higher BPA levels, while DEHP levels do not differ by region. The BPA intake is significantly lower than the temporary tolerable daily intake, and there is a positive correlation between DEHP and BPA.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell Biology
Roberta Tassinari, Alessia Tammaro, Gabriele Lori, Sabrina Tait, Andrea Martinelli, Luigia Cancemi, Paolo Frassanito, Francesca Maranghi
Summary: This study aims to determine appropriate hormone therapy doses and identify specific biomarkers to implement transgender animal models.
Article
Genetics & Heredity
Marco Salvatore, Paola Torreri, Graziano Grugni, Adele Rocchetti, Mohamad Maghnie, Giuseppa Patti, Antonino Crino, Maurizio Elia, Donatella Greco, Corrado Romano, Adriana Franzese, Enza Mozzillo, Annamaria Colao, Gabriella Pugliese, Uberto Pagotto, Valentina Lo Preiato, Emanuela Scarano, Concetta Schiavariello, Gianluca Tornese, Danilo Fintini, Sarah Bocchini, Sara Osimani, Luisa De Sanctis, Michele Sacco, Irene Rutigliano, Maurizio Delvecchio, Maria Felicia Faienza, Malgorzata Wasniewska, Domenico Corica, Stefano Stagi, Laura Guazzarotti, Pietro Maffei, Francesca Dassie, Domenica Taruscio
Summary: The Italian PWS registry was established to collect clinical and epidemiologic data, assess clinical management, improve patient care, and foster research. It includes six variables and provides important insights into the clinical aspects and natural history of PWS.
ORPHANET JOURNAL OF RARE DISEASES
(2023)
Article
Biochemistry & Molecular Biology
Chiara Pacelli, Alice Rossi, Michele Milella, Teresa Colombo, Loredana Le Pera
Summary: Precision medicine in oncology has made significant progress, but many cancer driver genes are still difficult to target with drugs. RNA-based methods, such as antisense oligonucleotides (ASOs), can induce targeted exon skipping (ES) and provide a promising alternative. This work presents a comprehensive computational procedure for developing ES-based cancer treatments, including target-exon selection, in silico prediction of ES products, and identification of optimal ASOs for experimental validation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Lorenzo Giorgioni, Alessandra Ambrosone, Maria Francesca Cometa, Anna Laura Salvati, Armando Magrelli
Summary: This review discusses the development of CAR-T therapy up to 2023, focusing on the European landscape and its regulatory field. The current state of CAR-T therapy in the EU is analyzed, and potential advancements are explored. The analysis is based on data from scientific literature, the European Medicines Agency, and clinical trial databases. Despite limitations such as access, production, and cost, CAR-T therapy has shown promising results in clinical trials and is expanding beyond cancer treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Valentina Tassinari, Antonella Smeriglio, Virgilio Stillittano, Domenico Trombetta, Romano Zilli, Roberta Tassinari, Francesca Maranghi, Giulia Frank, Daniele Marcoccia, Laura Di Renzo
Summary: Endometriosis is a chronic inflammatory disease that is estrogen-dependent and characterized by the presence of extrauterine endometrial tissue, causing pelvic pain and fertility impairment. The exact cause of endometriosis is not fully understood, and conventional therapies have shown effectiveness but with considerable side effects. There is a growing interest in the use of herbal medicine for endometriosis treatment, particularly polyphenols that have anti-endometriotic and anti-inflammatory properties. This review aims to provide an overview of the anti-inflammatory activity of polyphenols in the treatment of endometriosis.
Letter
Respiratory System
Donatello Salvatore, Angela Pepe, Vincenzo Carnovale, Fabio Majo, Rita Padoan, Serena Quattrucci, Marco Salvatore, Domenica Taruscio, Annalisa Amato, Gianluca Ferrari, Giuseppe Campagna
JOURNAL OF CYSTIC FIBROSIS
(2022)
Article
Health Care Sciences & Services
Daniele Giansanti, Antonia Pirrera, Paola Meli, Mauro Grigioni, Marta De Santis, Domenica Taruscio
Summary: This report presents the design and outcomes of a surveillance activity aimed at monitoring technology usage by individuals with frailty, disabilities, and rare diseases. The results include an international webinar, a full report, an electronic survey tool for periodic monitoring, a preliminary summary of the survey, and an understanding of emerging needs that provide valuable insights for stakeholders.
Article
Oncology
Xiaofan Pu, Chaolei Zhang, Guoping Ding, Hongpeng Gu, Yang Lv, Tao Shen, Tianshu Pang, Liping Cao, Shengnan Jia
Summary: This study demonstrated the potential utility of the sEV-miRNA d-signature in the diagnosis of PDAC via machine learning methods. A novel sEV biomarker, miR-664a-3p, was identified for the diagnosis of PDAC. It can also potentially promote angiogenesis and metastasis, provide insight into PDAC pathogenesis, and reveal novel regulators of this disease.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Jiaping Wang, Zhijuan Xu, Yanli Lai, Yanli Zhang, Ping Zhang, Qitian Mu, Shujun Yang, Yongcheng Sun, Lixia Sheng, Guifang Ouyang
Summary: This study demonstrates the significance of PD-1 in EBV-infected lymphoma cells. Silencing PD-1 enhances the tumor targeting effect of EBV-specific killer T cells on B lymphocytes and attenuates the immune escape effect.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Qiliang Peng, Jialong Tao, Yingjie Xu, Yi Shen, Yong Wang, Yang Jiao, Yiheng Mao, Yaqun Zhu, Yulong Liu, Ye Tian
Summary: This study investigates the potential role of lipid metabolism-associated genes (LMAGs) in neoadjuvant chemoradiotherapy (nCRT) and immunotherapy for rectal cancer. The results suggest that the SREBF2 gene is a highly predictive factor for nCRT in rectal cancer and is associated with favorable prognosis. SREBF2 is also closely associated with immune cell infiltration and immunotherapy-related genes.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Shiquan Li, Nan Zhang, Yongping Yang, Tongjun Liu
Summary: This study investigated the potential molecular mechanism of SPDEF in immune evasion of colorectal cancer (CRC) and found that it suppresses immune evasion by activating CCL28 through the modulation of M2 polarization of macrophages. These findings provide a new research direction and potential therapeutic target for immunotherapy in CRC.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Manas Sehgal, Soundharya Ramu, Joel Markus Vaz, Yogheshwer Raja Ganapathy, Srinath Muralidharan, Sankalpa Venkatraghavan, Mohit Kumar Jolly
Summary: This study investigates the relationship between gene expression patterns and phenotypic plasticity and heterogeneity in colorectal cancer (CRC). The results demonstrate the interconnectedness between different Consensus Molecular Subtypes (CMS) of CRC and specific phenotypes such as epithelial and mesenchymal characteristics. Additionally, the study reveals correlations between metabolic pathways and phenotypic scores, as well as between PD-L1 activity and mesenchymal phenotype. Single-cell RNA sequencing analysis further confirms the heterogeneity of different CMS subtypes. These findings have important implications for understanding CRC heterogeneity and developing targeted therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yutong Zou, Siyao Guo, Yan Liao, Weidong Chen, Ziyun Chen, Junkai Chen, Lili Wen, Xianbiao Xie
Summary: This study found that ceramide metabolism is associated with the progression and clinical outcome of osteosarcoma by analyzing data from osteosarcoma patients. The gene ST3GAL1 plays an important role in osteosarcoma, regulating the tumor immune microenvironment and affecting T cell function. It may become a new target for the treatment of osteosarcoma.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Chuanhui Chen, Mengzhi Wan, Xiong Peng, Qing Zhang, Yu Liu
Summary: This study examines the function and mechanism of the ceRNA network centered around GPR37 in LUAD. The findings show that high expression of GPR37 in LUAD tissue samples is associated with poor prognosis, and it may regulate the expression of downstream target genes by competitively binding to lncRNA DLEU1 and miR-4458.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Junping Li, Hong Hu, Jinping He, Yuling Hu, Manting Liu, Bihui Cao, Dongni Chen, Xiaodie Ye, Jian Zhang, Zhiru Zhang, Wen Long, Hui Lian, Deji Chen, Likun Chen, Lili Yang, Zhenfeng Zhang
Summary: Sequential administration of CDC7 inhibitor XL413 after carboplatin enhances the chemotherapeutic effect of carboplatin on ovarian cancer cells, possibly by inhibiting homologous recombination repair activity and increasing the accumulation of chemotherapy-induced DNA damage.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Madison Catalanotto, Joel Markus Vaz, Camille Abshire, Reneau Youngblood, Min Chu, Herbert Levine, Mohit Kumar Jolly, Ana -Maria Dragoi
Summary: The study demonstrates that loss of FLASH in cancer cells leads to a hybrid E/M phenotype with high epithelial scores, suggesting FLASH acts as a repressor of the epithelial phenotype. Additionally, FLASH expression is inversely correlated with the epithelial score and subsets of mesenchymal markers are distinctly up-regulated in FLASH, NPAT, or SLBP-depleted cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Xiaorui Wang, Na Li, Minying Zheng, Yongjun Yu, Shiwu Zhang
Summary: Adipocytes are derived from pluripotent mesenchymal stem cells and histone modifications play a key role in their differentiation. Recent studies have shown that cancer stem cells can differentiate into adipocytes, reducing the malignancy of cancer cells.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Hana Q. Sadida, Alanoud Abdulla, Sara Al Marzooqi, Sheema Hashem, Muzafar A. Macha, Ammira S. Al-Shabeeb Akil, Ajaz A. Bhat
Summary: Cancer heterogeneity and drug resistance are major obstacles to effective cancer treatment, and epigenetic modifications play a pivotal role in these processes. This review explores essential epigenetic modifications, including DNA methylation, histone modifications, and chromatin remodeling, and discusses their complex contributions to cancer biology. However, the interplay of epigenetic and genetic changes in cancer cells presents unique challenges that must be addressed to fully exploit the potential of epigenetic modifications.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Pedro De Marchi, Leticia Ferro Leal, Luciane Sussuchi da Silva, Rodrigo de Oliveira Cavagna, Flavio Augusto Ferreira da Silva, Vinicius Duval da Silva, Eduardo C. A. da Silva, Augusto O. Saito, Vladmir C. Cordeiro de Lima, Rui Manuel Reis
Summary: The TIS and IFN-gamma signatures are predictive biomarkers for identifying NSCLC patients who could potentially benefit from immune checkpoint inhibitor therapies.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Giovanni Marchi, Anna Rajavuori, Mai T. N. Nguyen, Kaisa Huhtinen, Sinikka Oksa, Sakari Hietanen, Sampsa Hautaniemi, Johanna Hynninen, Jaana Oikkonen
Summary: The study shows that ctDNA can adequately represent high-grade serous ovarian carcinoma (HGSC), and the mutations observed at relapse suggest personalized therapy options.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Yuncang Yuan, Jiawei Fan, Dandan Liang, Shijie Wang, Xu Luo, Yongjie Zhu, Nan Liu, Tingxiu Xiang, Xudong Zhao
Summary: This study demonstrates that csGRP78-directed CAR-T cells can selectively kill pancreatic cancer cells, and the combination with chemotherapy enhances cytotoxicity.
TRANSLATIONAL ONCOLOGY
(2024)
Article
Oncology
Niyati Piplani, Tanusri Roy, Neha Saxena, Shamik Sen
Summary: The glycocalyx, a protective barrier surrounding cells, has been found to play a role in cancer cell proliferation, survival, and metastasis. However, its function in maintaining DNA/nuclear integrity during migration through dense matrices has not been explored. This study shows that the bulkiness of the glycocalyx is inversely associated with nuclear stresses, and highlights its mechanical role in shielding migration-associated stresses.
TRANSLATIONAL ONCOLOGY
(2024)